Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55366
Gene name	Leucine rich repeat containing G protein-coupled receptor 4
Gene symbol	LGR4
Synonyms (NCBI Gene)	BNMD17DPSLGPR48
Chromosome	11
Chromosome location	11p14.1
Summary	The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct

432

Show/Hide all (432)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021855	hsa-miR-132-3p	Microarray	17612493
MIRT026058	hsa-miR-196a-5p	Sequencing	20371350
MIRT027834	hsa-miR-98-5p	Microarray	19088304
MIRT721939	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT721938	hsa-miR-4786-3p	HITS-CLIP	19536157
MIRT440328	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440328	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440328	hsa-miR-218-5p	ELISALuciferase reporter assayqRT-PCRWestern blot	26986507
MIRT440328	hsa-miR-218-5p	ELISALuciferase reporter assayqRT-PCRWestern blot	26986507
MIRT721939	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT721938	hsa-miR-4786-3p	HITS-CLIP	19536157
MIRT1108491	hsa-let-7a	CLIP-seq
MIRT1108492	hsa-let-7b	CLIP-seq
MIRT1108493	hsa-let-7c	CLIP-seq
MIRT1108494	hsa-let-7d	CLIP-seq
MIRT1108495	hsa-let-7e	CLIP-seq
MIRT1108496	hsa-let-7f	CLIP-seq
MIRT1108497	hsa-let-7g	CLIP-seq
MIRT1108498	hsa-let-7i	CLIP-seq
MIRT1108499	hsa-miR-1237	CLIP-seq
MIRT1108500	hsa-miR-1245b-3p	CLIP-seq
MIRT1108501	hsa-miR-1248	CLIP-seq
MIRT1108502	hsa-miR-132	CLIP-seq
MIRT1108503	hsa-miR-141	CLIP-seq
MIRT1108504	hsa-miR-144	CLIP-seq
MIRT1108505	hsa-miR-193a-3p	CLIP-seq
MIRT1108506	hsa-miR-193b	CLIP-seq
MIRT1108507	hsa-miR-200a	CLIP-seq
MIRT1108508	hsa-miR-2115	CLIP-seq
MIRT1108509	hsa-miR-2116	CLIP-seq
MIRT1108510	hsa-miR-212	CLIP-seq
MIRT1108511	hsa-miR-2682	CLIP-seq
MIRT1108512	hsa-miR-296-3p	CLIP-seq
MIRT1108513	hsa-miR-302a	CLIP-seq
MIRT1108514	hsa-miR-302b	CLIP-seq
MIRT1108515	hsa-miR-302c	CLIP-seq
MIRT1108516	hsa-miR-302d	CLIP-seq
MIRT1108517	hsa-miR-302e	CLIP-seq
MIRT1108518	hsa-miR-3163	CLIP-seq
MIRT1108519	hsa-miR-34a	CLIP-seq
MIRT1108520	hsa-miR-34c-5p	CLIP-seq
MIRT1108521	hsa-miR-361-5p	CLIP-seq
MIRT1108522	hsa-miR-3622a-5p	CLIP-seq
MIRT1108523	hsa-miR-3646	CLIP-seq
MIRT1108524	hsa-miR-3662	CLIP-seq
MIRT1108525	hsa-miR-372	CLIP-seq
MIRT1108526	hsa-miR-373	CLIP-seq
MIRT1108527	hsa-miR-374a	CLIP-seq
MIRT1108528	hsa-miR-374b	CLIP-seq
MIRT1108529	hsa-miR-4263	CLIP-seq
MIRT1108530	hsa-miR-4266	CLIP-seq
MIRT1108531	hsa-miR-4423-3p	CLIP-seq
MIRT1108532	hsa-miR-4458	CLIP-seq
MIRT1108533	hsa-miR-4477a	CLIP-seq
MIRT1108534	hsa-miR-449a	CLIP-seq
MIRT1108535	hsa-miR-449b	CLIP-seq
MIRT1108536	hsa-miR-449c	CLIP-seq
MIRT1108537	hsa-miR-4500	CLIP-seq
MIRT1108538	hsa-miR-4514	CLIP-seq
MIRT1108539	hsa-miR-4639-3p	CLIP-seq
MIRT1108540	hsa-miR-4645-5p	CLIP-seq
MIRT1108541	hsa-miR-4659a-3p	CLIP-seq
MIRT1108542	hsa-miR-4659b-3p	CLIP-seq
MIRT1108543	hsa-miR-4673	CLIP-seq
MIRT1108544	hsa-miR-4677-5p	CLIP-seq
MIRT1108545	hsa-miR-4691-3p	CLIP-seq
MIRT1108546	hsa-miR-4692	CLIP-seq
MIRT1108547	hsa-miR-4695-5p	CLIP-seq
MIRT1108548	hsa-miR-4715-3p	CLIP-seq
MIRT1108549	hsa-miR-4733-3p	CLIP-seq
MIRT1108550	hsa-miR-4778-3p	CLIP-seq
MIRT1108551	hsa-miR-4779	CLIP-seq
MIRT1108552	hsa-miR-516a-3p	CLIP-seq
MIRT1108553	hsa-miR-520a-3p	CLIP-seq
MIRT1108554	hsa-miR-520b	CLIP-seq
MIRT1108555	hsa-miR-520c-3p	CLIP-seq
MIRT1108556	hsa-miR-520d-3p	CLIP-seq
MIRT1108557	hsa-miR-520e	CLIP-seq
MIRT1108558	hsa-miR-520f	CLIP-seq
MIRT1108559	hsa-miR-548g	CLIP-seq
MIRT1108560	hsa-miR-563	CLIP-seq
MIRT1108561	hsa-miR-576-3p	CLIP-seq
MIRT1108562	hsa-miR-580	CLIP-seq
MIRT1108563	hsa-miR-582-5p	CLIP-seq
MIRT1108564	hsa-miR-622	CLIP-seq
MIRT1108565	hsa-miR-625	CLIP-seq
MIRT1108566	hsa-miR-651	CLIP-seq
MIRT1108567	hsa-miR-659	CLIP-seq
MIRT1108568	hsa-miR-885-3p	CLIP-seq
MIRT1108569	hsa-miR-889	CLIP-seq
MIRT1108570	hsa-miR-892b	CLIP-seq
MIRT1108571	hsa-miR-944	CLIP-seq
MIRT1108572	hsa-miR-98	CLIP-seq
MIRT1108491	hsa-let-7a	CLIP-seq
MIRT1108492	hsa-let-7b	CLIP-seq
MIRT1108493	hsa-let-7c	CLIP-seq
MIRT1108494	hsa-let-7d	CLIP-seq
MIRT1108495	hsa-let-7e	CLIP-seq
MIRT1108496	hsa-let-7f	CLIP-seq
MIRT1108497	hsa-let-7g	CLIP-seq
MIRT1108498	hsa-let-7i	CLIP-seq
MIRT2029973	hsa-miR-1244	CLIP-seq
MIRT1108500	hsa-miR-1245b-3p	CLIP-seq
MIRT1108502	hsa-miR-132	CLIP-seq
MIRT1108503	hsa-miR-141	CLIP-seq
MIRT2029974	hsa-miR-142-3p	CLIP-seq
MIRT1108505	hsa-miR-193a-3p	CLIP-seq
MIRT1108506	hsa-miR-193b	CLIP-seq
MIRT2029975	hsa-miR-198	CLIP-seq
MIRT1108507	hsa-miR-200a	CLIP-seq
MIRT1108509	hsa-miR-2116	CLIP-seq
MIRT1108510	hsa-miR-212	CLIP-seq
MIRT1108512	hsa-miR-296-3p	CLIP-seq
MIRT2029976	hsa-miR-300	CLIP-seq
MIRT2029977	hsa-miR-325	CLIP-seq
MIRT2029978	hsa-miR-33a	CLIP-seq
MIRT2029979	hsa-miR-33b	CLIP-seq
MIRT1108519	hsa-miR-34a	CLIP-seq
MIRT2029980	hsa-miR-34b	CLIP-seq
MIRT1108520	hsa-miR-34c-5p	CLIP-seq
MIRT1108521	hsa-miR-361-5p	CLIP-seq
MIRT2029981	hsa-miR-3647-3p	CLIP-seq
MIRT1108524	hsa-miR-3662	CLIP-seq
MIRT2029982	hsa-miR-381	CLIP-seq
MIRT1108530	hsa-miR-4266	CLIP-seq
MIRT2029983	hsa-miR-4267	CLIP-seq
MIRT2029984	hsa-miR-4280	CLIP-seq
MIRT1108532	hsa-miR-4458	CLIP-seq
MIRT1108534	hsa-miR-449a	CLIP-seq
MIRT1108535	hsa-miR-449b	CLIP-seq
MIRT1108537	hsa-miR-4500	CLIP-seq
MIRT1108539	hsa-miR-4639-3p	CLIP-seq
MIRT2029985	hsa-miR-4666-3p	CLIP-seq
MIRT1108544	hsa-miR-4677-5p	CLIP-seq
MIRT1108545	hsa-miR-4691-3p	CLIP-seq
MIRT1108547	hsa-miR-4695-5p	CLIP-seq
MIRT2029986	hsa-miR-4699-3p	CLIP-seq
MIRT2029987	hsa-miR-4719	CLIP-seq
MIRT1108551	hsa-miR-4779	CLIP-seq
MIRT2029988	hsa-miR-548l	CLIP-seq
MIRT1108561	hsa-miR-576-3p	CLIP-seq
MIRT1108562	hsa-miR-580	CLIP-seq
MIRT1108564	hsa-miR-622	CLIP-seq
MIRT2029989	hsa-miR-628-3p	CLIP-seq
MIRT1108566	hsa-miR-651	CLIP-seq
MIRT1108567	hsa-miR-659	CLIP-seq
MIRT1108568	hsa-miR-885-3p	CLIP-seq
MIRT1108569	hsa-miR-889	CLIP-seq
MIRT1108570	hsa-miR-892b	CLIP-seq
MIRT1108572	hsa-miR-98	CLIP-seq
MIRT1108491	hsa-let-7a	CLIP-seq
MIRT1108492	hsa-let-7b	CLIP-seq
MIRT1108493	hsa-let-7c	CLIP-seq
MIRT1108494	hsa-let-7d	CLIP-seq
MIRT1108495	hsa-let-7e	CLIP-seq
MIRT1108496	hsa-let-7f	CLIP-seq
MIRT1108497	hsa-let-7g	CLIP-seq
MIRT1108498	hsa-let-7i	CLIP-seq
MIRT2029973	hsa-miR-1244	CLIP-seq
MIRT1108500	hsa-miR-1245b-3p	CLIP-seq
MIRT2260873	hsa-miR-1260	CLIP-seq
MIRT2260874	hsa-miR-1260b	CLIP-seq
MIRT1108502	hsa-miR-132	CLIP-seq
MIRT2260875	hsa-miR-140-3p	CLIP-seq
MIRT1108503	hsa-miR-141	CLIP-seq
MIRT2260876	hsa-miR-188-3p	CLIP-seq
MIRT1108505	hsa-miR-193a-3p	CLIP-seq
MIRT1108506	hsa-miR-193b	CLIP-seq
MIRT1108507	hsa-miR-200a	CLIP-seq
MIRT1108508	hsa-miR-2115	CLIP-seq
MIRT1108509	hsa-miR-2116	CLIP-seq
MIRT2260877	hsa-miR-2117	CLIP-seq
MIRT1108510	hsa-miR-212	CLIP-seq
MIRT2260878	hsa-miR-2392	CLIP-seq
MIRT1108511	hsa-miR-2682	CLIP-seq
MIRT1108512	hsa-miR-296-3p	CLIP-seq
MIRT2029976	hsa-miR-300	CLIP-seq
MIRT1108513	hsa-miR-302a	CLIP-seq
MIRT1108514	hsa-miR-302b	CLIP-seq
MIRT1108515	hsa-miR-302c	CLIP-seq
MIRT1108516	hsa-miR-302d	CLIP-seq
MIRT1108517	hsa-miR-302e	CLIP-seq
MIRT2260879	hsa-miR-3065-5p	CLIP-seq
MIRT2260880	hsa-miR-31	CLIP-seq
MIRT2260881	hsa-miR-3156-3p	CLIP-seq
MIRT2260882	hsa-miR-3168	CLIP-seq
MIRT2260883	hsa-miR-323-3p	CLIP-seq
MIRT1108519	hsa-miR-34a	CLIP-seq
MIRT1108520	hsa-miR-34c-5p	CLIP-seq
MIRT1108522	hsa-miR-3622a-5p	CLIP-seq
MIRT1108523	hsa-miR-3646	CLIP-seq
MIRT2029981	hsa-miR-3647-3p	CLIP-seq
MIRT2260884	hsa-miR-365	CLIP-seq
MIRT1108524	hsa-miR-3662	CLIP-seq
MIRT2260885	hsa-miR-3667-3p	CLIP-seq
MIRT1108525	hsa-miR-372	CLIP-seq
MIRT1108526	hsa-miR-373	CLIP-seq
MIRT2029982	hsa-miR-381	CLIP-seq
MIRT2260886	hsa-miR-3924	CLIP-seq
MIRT2260887	hsa-miR-410	CLIP-seq
MIRT1108530	hsa-miR-4266	CLIP-seq
MIRT1108531	hsa-miR-4423-3p	CLIP-seq
MIRT1108532	hsa-miR-4458	CLIP-seq
MIRT2260888	hsa-miR-4476	CLIP-seq
MIRT1108533	hsa-miR-4477a	CLIP-seq
MIRT1108534	hsa-miR-449a	CLIP-seq
MIRT1108535	hsa-miR-449b	CLIP-seq
MIRT1108536	hsa-miR-449c	CLIP-seq
MIRT1108537	hsa-miR-4500	CLIP-seq
MIRT1108538	hsa-miR-4514	CLIP-seq
MIRT1108539	hsa-miR-4639-3p	CLIP-seq
MIRT1108540	hsa-miR-4645-5p	CLIP-seq
MIRT2029985	hsa-miR-4666-3p	CLIP-seq
MIRT2260889	hsa-miR-4666-5p	CLIP-seq
MIRT1108543	hsa-miR-4673	CLIP-seq
MIRT1108544	hsa-miR-4677-5p	CLIP-seq
MIRT1108545	hsa-miR-4691-3p	CLIP-seq
MIRT1108546	hsa-miR-4692	CLIP-seq
MIRT1108547	hsa-miR-4695-5p	CLIP-seq
MIRT1108549	hsa-miR-4733-3p	CLIP-seq
MIRT2260890	hsa-miR-4735-5p	CLIP-seq
MIRT2260891	hsa-miR-4753-3p	CLIP-seq
MIRT1108551	hsa-miR-4779	CLIP-seq
MIRT2260892	hsa-miR-4789-5p	CLIP-seq
MIRT2260893	hsa-miR-500a	CLIP-seq
MIRT1108552	hsa-miR-516a-3p	CLIP-seq
MIRT1108553	hsa-miR-520a-3p	CLIP-seq
MIRT1108554	hsa-miR-520b	CLIP-seq
MIRT1108555	hsa-miR-520c-3p	CLIP-seq
MIRT1108556	hsa-miR-520d-3p	CLIP-seq
MIRT1108557	hsa-miR-520e	CLIP-seq
MIRT1108558	hsa-miR-520f	CLIP-seq
MIRT2260894	hsa-miR-553	CLIP-seq
MIRT2260895	hsa-miR-556-3p	CLIP-seq
MIRT1108560	hsa-miR-563	CLIP-seq
MIRT1108562	hsa-miR-580	CLIP-seq
MIRT2260896	hsa-miR-603	CLIP-seq
MIRT2260897	hsa-miR-605	CLIP-seq
MIRT1108564	hsa-miR-622	CLIP-seq
MIRT1108565	hsa-miR-625	CLIP-seq
MIRT1108566	hsa-miR-651	CLIP-seq
MIRT1108567	hsa-miR-659	CLIP-seq
MIRT2260898	hsa-miR-664	CLIP-seq
MIRT1108568	hsa-miR-885-3p	CLIP-seq
MIRT1108570	hsa-miR-892b	CLIP-seq
MIRT1108572	hsa-miR-98	CLIP-seq
MIRT1108502	hsa-miR-132	CLIP-seq
MIRT1108504	hsa-miR-144	CLIP-seq
MIRT1108505	hsa-miR-193a-3p	CLIP-seq
MIRT1108506	hsa-miR-193b	CLIP-seq
MIRT1108510	hsa-miR-212	CLIP-seq
MIRT2390107	hsa-miR-4528	CLIP-seq
MIRT1108545	hsa-miR-4691-3p	CLIP-seq
MIRT2390108	hsa-miR-4760-3p	CLIP-seq
MIRT2390109	hsa-miR-501-3p	CLIP-seq
MIRT2390110	hsa-miR-502-3p	CLIP-seq
MIRT1108564	hsa-miR-622	CLIP-seq
MIRT2260898	hsa-miR-664	CLIP-seq
MIRT1108568	hsa-miR-885-3p	CLIP-seq
MIRT1108570	hsa-miR-892b	CLIP-seq
MIRT2260879	hsa-miR-3065-5p	CLIP-seq
MIRT2029986	hsa-miR-4699-3p	CLIP-seq
MIRT2438349	hsa-miR-548u	CLIP-seq
MIRT2452989	hsa-miR-1291	CLIP-seq
MIRT2452990	hsa-miR-129-5p	CLIP-seq
MIRT2452991	hsa-miR-1302	CLIP-seq
MIRT2452992	hsa-miR-204	CLIP-seq
MIRT2452993	hsa-miR-211	CLIP-seq
MIRT2452994	hsa-miR-2114	CLIP-seq
MIRT2452995	hsa-miR-328	CLIP-seq
MIRT2452996	hsa-miR-4298	CLIP-seq
MIRT1108491	hsa-let-7a	CLIP-seq
MIRT1108492	hsa-let-7b	CLIP-seq
MIRT1108493	hsa-let-7c	CLIP-seq
MIRT1108494	hsa-let-7d	CLIP-seq
MIRT1108495	hsa-let-7e	CLIP-seq
MIRT1108496	hsa-let-7f	CLIP-seq
MIRT1108497	hsa-let-7g	CLIP-seq
MIRT1108498	hsa-let-7i	CLIP-seq
MIRT1108500	hsa-miR-1245b-3p	CLIP-seq
MIRT1108502	hsa-miR-132	CLIP-seq
MIRT1108503	hsa-miR-141	CLIP-seq
MIRT2560936	hsa-miR-146a	CLIP-seq
MIRT2560937	hsa-miR-146b-5p	CLIP-seq
MIRT1108505	hsa-miR-193a-3p	CLIP-seq
MIRT1108506	hsa-miR-193b	CLIP-seq
MIRT2029975	hsa-miR-198	CLIP-seq
MIRT1108507	hsa-miR-200a	CLIP-seq
MIRT1108508	hsa-miR-2115	CLIP-seq
MIRT1108510	hsa-miR-212	CLIP-seq
MIRT1108511	hsa-miR-2682	CLIP-seq
MIRT1108512	hsa-miR-296-3p	CLIP-seq
MIRT1108513	hsa-miR-302a	CLIP-seq
MIRT1108514	hsa-miR-302b	CLIP-seq
MIRT1108515	hsa-miR-302c	CLIP-seq
MIRT1108516	hsa-miR-302d	CLIP-seq
MIRT1108517	hsa-miR-302e	CLIP-seq
MIRT2260879	hsa-miR-3065-5p	CLIP-seq
MIRT2560938	hsa-miR-3148	CLIP-seq
MIRT2260883	hsa-miR-323-3p	CLIP-seq
MIRT1108519	hsa-miR-34a	CLIP-seq
MIRT1108520	hsa-miR-34c-5p	CLIP-seq
MIRT1108523	hsa-miR-3646	CLIP-seq
MIRT1108525	hsa-miR-372	CLIP-seq
MIRT1108526	hsa-miR-373	CLIP-seq
MIRT2560939	hsa-miR-3913-3p	CLIP-seq
MIRT2560940	hsa-miR-3978	CLIP-seq
MIRT2260887	hsa-miR-410	CLIP-seq
MIRT2560941	hsa-miR-411	CLIP-seq
MIRT1108530	hsa-miR-4266	CLIP-seq
MIRT2029983	hsa-miR-4267	CLIP-seq
MIRT2560942	hsa-miR-4330	CLIP-seq
MIRT1108532	hsa-miR-4458	CLIP-seq
MIRT2260888	hsa-miR-4476	CLIP-seq
MIRT1108534	hsa-miR-449a	CLIP-seq
MIRT1108535	hsa-miR-449b	CLIP-seq
MIRT1108536	hsa-miR-449c	CLIP-seq
MIRT1108537	hsa-miR-4500	CLIP-seq
MIRT1108538	hsa-miR-4514	CLIP-seq
MIRT1108539	hsa-miR-4639-3p	CLIP-seq
MIRT1108540	hsa-miR-4645-5p	CLIP-seq
MIRT2260889	hsa-miR-4666-5p	CLIP-seq
MIRT1108543	hsa-miR-4673	CLIP-seq
MIRT1108545	hsa-miR-4691-3p	CLIP-seq
MIRT1108546	hsa-miR-4692	CLIP-seq
MIRT1108547	hsa-miR-4695-5p	CLIP-seq
MIRT2029986	hsa-miR-4699-3p	CLIP-seq
MIRT2560943	hsa-miR-4732-5p	CLIP-seq
MIRT1108549	hsa-miR-4733-3p	CLIP-seq
MIRT1108551	hsa-miR-4779	CLIP-seq
MIRT2560944	hsa-miR-489	CLIP-seq
MIRT1108552	hsa-miR-516a-3p	CLIP-seq
MIRT1108553	hsa-miR-520a-3p	CLIP-seq
MIRT1108554	hsa-miR-520b	CLIP-seq
MIRT1108555	hsa-miR-520c-3p	CLIP-seq
MIRT1108556	hsa-miR-520d-3p	CLIP-seq
MIRT1108557	hsa-miR-520e	CLIP-seq
MIRT1108558	hsa-miR-520f	CLIP-seq
MIRT2560945	hsa-miR-545	CLIP-seq
MIRT2029988	hsa-miR-548l	CLIP-seq
MIRT2560946	hsa-miR-548n	CLIP-seq
MIRT2438349	hsa-miR-548u	CLIP-seq
MIRT2560947	hsa-miR-570	CLIP-seq
MIRT1108562	hsa-miR-580	CLIP-seq
MIRT2560948	hsa-miR-589	CLIP-seq
MIRT2260897	hsa-miR-605	CLIP-seq
MIRT1108564	hsa-miR-622	CLIP-seq
MIRT1108566	hsa-miR-651	CLIP-seq
MIRT1108567	hsa-miR-659	CLIP-seq
MIRT2260898	hsa-miR-664	CLIP-seq
MIRT1108568	hsa-miR-885-3p	CLIP-seq
MIRT1108570	hsa-miR-892b	CLIP-seq
MIRT1108572	hsa-miR-98	CLIP-seq
MIRT1108491	hsa-let-7a	CLIP-seq
MIRT1108492	hsa-let-7b	CLIP-seq
MIRT1108493	hsa-let-7c	CLIP-seq
MIRT1108494	hsa-let-7d	CLIP-seq
MIRT1108495	hsa-let-7e	CLIP-seq
MIRT1108496	hsa-let-7f	CLIP-seq
MIRT1108497	hsa-let-7g	CLIP-seq
MIRT1108498	hsa-let-7i	CLIP-seq
MIRT1108500	hsa-miR-1245b-3p	CLIP-seq
MIRT1108502	hsa-miR-132	CLIP-seq
MIRT2560936	hsa-miR-146a	CLIP-seq
MIRT2560937	hsa-miR-146b-5p	CLIP-seq
MIRT1108505	hsa-miR-193a-3p	CLIP-seq
MIRT1108506	hsa-miR-193b	CLIP-seq
MIRT2029975	hsa-miR-198	CLIP-seq
MIRT1108508	hsa-miR-2115	CLIP-seq
MIRT1108510	hsa-miR-212	CLIP-seq
MIRT1108511	hsa-miR-2682	CLIP-seq
MIRT1108512	hsa-miR-296-3p	CLIP-seq
MIRT1108513	hsa-miR-302a	CLIP-seq
MIRT1108514	hsa-miR-302b	CLIP-seq
MIRT1108515	hsa-miR-302c	CLIP-seq
MIRT1108516	hsa-miR-302d	CLIP-seq
MIRT1108517	hsa-miR-302e	CLIP-seq
MIRT2260879	hsa-miR-3065-5p	CLIP-seq
MIRT2560938	hsa-miR-3148	CLIP-seq
MIRT2260883	hsa-miR-323-3p	CLIP-seq
MIRT1108519	hsa-miR-34a	CLIP-seq
MIRT1108520	hsa-miR-34c-5p	CLIP-seq
MIRT1108523	hsa-miR-3646	CLIP-seq
MIRT1108525	hsa-miR-372	CLIP-seq
MIRT1108526	hsa-miR-373	CLIP-seq
MIRT2560939	hsa-miR-3913-3p	CLIP-seq
MIRT2560940	hsa-miR-3978	CLIP-seq
MIRT2260887	hsa-miR-410	CLIP-seq
MIRT2560941	hsa-miR-411	CLIP-seq
MIRT1108530	hsa-miR-4266	CLIP-seq
MIRT2029983	hsa-miR-4267	CLIP-seq
MIRT2560942	hsa-miR-4330	CLIP-seq
MIRT1108532	hsa-miR-4458	CLIP-seq
MIRT2260888	hsa-miR-4476	CLIP-seq
MIRT1108534	hsa-miR-449a	CLIP-seq
MIRT1108535	hsa-miR-449b	CLIP-seq
MIRT1108536	hsa-miR-449c	CLIP-seq
MIRT1108537	hsa-miR-4500	CLIP-seq
MIRT1108538	hsa-miR-4514	CLIP-seq
MIRT1108539	hsa-miR-4639-3p	CLIP-seq
MIRT1108540	hsa-miR-4645-5p	CLIP-seq
MIRT2260889	hsa-miR-4666-5p	CLIP-seq
MIRT1108543	hsa-miR-4673	CLIP-seq
MIRT1108545	hsa-miR-4691-3p	CLIP-seq
MIRT1108546	hsa-miR-4692	CLIP-seq
MIRT1108547	hsa-miR-4695-5p	CLIP-seq
MIRT2029986	hsa-miR-4699-3p	CLIP-seq
MIRT2560943	hsa-miR-4732-5p	CLIP-seq
MIRT1108549	hsa-miR-4733-3p	CLIP-seq
MIRT1108551	hsa-miR-4779	CLIP-seq
MIRT2560944	hsa-miR-489	CLIP-seq
MIRT1108552	hsa-miR-516a-3p	CLIP-seq
MIRT1108553	hsa-miR-520a-3p	CLIP-seq
MIRT1108554	hsa-miR-520b	CLIP-seq
MIRT1108555	hsa-miR-520c-3p	CLIP-seq
MIRT1108556	hsa-miR-520d-3p	CLIP-seq
MIRT1108557	hsa-miR-520e	CLIP-seq
MIRT1108558	hsa-miR-520f	CLIP-seq
MIRT2560945	hsa-miR-545	CLIP-seq
MIRT2029988	hsa-miR-548l	CLIP-seq
MIRT2560946	hsa-miR-548n	CLIP-seq
MIRT2438349	hsa-miR-548u	CLIP-seq
MIRT2560947	hsa-miR-570	CLIP-seq
MIRT1108562	hsa-miR-580	CLIP-seq
MIRT2560948	hsa-miR-589	CLIP-seq
MIRT2260897	hsa-miR-605	CLIP-seq
MIRT1108564	hsa-miR-622	CLIP-seq
MIRT1108566	hsa-miR-651	CLIP-seq
MIRT2260898	hsa-miR-664	CLIP-seq
MIRT1108568	hsa-miR-885-3p	CLIP-seq
MIRT1108570	hsa-miR-892b	CLIP-seq
MIRT1108572	hsa-miR-98	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001649	Process	Osteoblast differentiation	ISS
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0001818	Process	Negative regulation of cytokine production	ISS
GO:0001942	Process	Hair follicle development	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	21727895, 22815884
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IDA	22815884
GO:0004930	Function	G protein-coupled receptor activity	TAS	10894923
GO:0005515	Function	Protein binding	IPI	21727895, 22575959, 22815884, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22815884
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007623	Process	Circadian rhythm	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016500	Function	Protein-hormone receptor activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IEA
GO:0030282	Process	Bone mineralization	IEA
GO:0030282	Process	Bone mineralization	ISS
GO:0030539	Process	Male genitalia development	IEA
GO:0032922	Process	Circadian regulation of gene expression	IEA
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IEA
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	ISS
GO:0035239	Process	Tube morphogenesis	IEA
GO:0036335	Process	Intestinal stem cell homeostasis	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0046849	Process	Bone remodeling	IEA
GO:0046849	Process	Bone remodeling	ISS
GO:0048511	Process	Rhythmic process	IEA
GO:0048565	Process	Digestive tract development	IEA
GO:0050673	Process	Epithelial cell proliferation	IEA
GO:0072224	Process	Metanephric glomerulus development	IEA
GO:0072282	Process	Metanephric nephron tubule morphogenesis	IEA
GO:0090190	Process	Positive regulation of branching involved in ureteric bud morphogenesis	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IDA	22815884
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	24212090
GO:2001013	Process	Epithelial cell proliferation involved in renal tubule morphogenesis	IEA

MIM	HGNC	e!Ensembl
606666	13299	ENSG00000205213

Q9BXB1

Protein name

Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)

Protein function

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptor

PDB

4KT1 , 4QXE , 4QXF , 8WVU , 8WVV , 8WVW , 8WVX , 8WVY , 8XFP , 8XFS , 8XFT , 8XT9 , 8XUM , 8Y69

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01462	LRRNT	29 → 56	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	59 → 117	Leucine rich repeat	Repeat
PF13855	LRR_8	105 → 165	Leucine rich repeat	Repeat
PF13855	LRR_8	177 → 237	Leucine rich repeat	Repeat
PF13855	LRR_8	248 → 307	Leucine rich repeat	Repeat
PF13855	LRR_8	319 → 377	Leucine rich repeat	Repeat
PF13855	LRR_8	365 → 425	Leucine rich repeat	Repeat
PF00001	7tm_1	555 → 801	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in multiple steroidogenic tissues: placenta, ovary, testis and adrenal. Expressed also in spinal cord, thyroid, stomach, trachea, heart, pancreas, kidney, prostate and spleen.

Sequence

MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQ
ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV
PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ
ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF
PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS
LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS
FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV
SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA
NLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWM
IRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAV
SWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLK
QFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLL
MAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPE
IMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQD
FYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPALAVASCQRPEGYWSDCG
TQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVKD

Sequence length

951

Interactions

View interactions

	KEGG		Reactome
	Wnt signaling pathway		Regulation of FZD by ubiquitination

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Delayed puberty, self-limited	Pathogenic	rs757351670, rs34804482	RCV001777185 RCV001777186

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Bone mineral density quantitative trait locus 17	association	rs587777005	RCV000049335
Cervical cancer	Benign	rs182255585	RCV005907641
Clear cell carcinoma of kidney	Benign	rs143913282	RCV005932985
Hepatocellular carcinoma	Likely benign	rs148473042	RCV005932988
LGR4-related disorder	Likely benign; Benign	rs772615898, rs72887882, rs368421205, rs138381781, rs371443871, rs35947785	RCV003903907 RCV003917171 RCV003934376 RCV003947020 RCV003976779 RCV003978348
Ovarian serous cystadenocarcinoma	Benign	rs143913282	RCV005932987
Sarcoma	Benign	rs143913282	RCV005932986
Uterine carcinosarcoma	Likely benign	rs148473042	RCV005932989

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abdominal Injuries	Associate	27925416
Adenocarcinoma of Lung	Associate	37986325
Anonychia congenita	Associate	23809763
Bicuspid Aortic Valve Disease	Associate	36071494
Bone Diseases	Associate	39525853
Carcinoma Hepatocellular	Associate	35170199
Carcinoma Pancreatic Ductal	Associate	38308339
Carcinoma Squamous Cell	Associate	18057535
Colonic Neoplasms	Associate	36008975
Colorectal Neoplasms	Associate	35008827
Diarrhea	Associate	39525853
Fibrosis	Associate	27977785
Fractures Bone	Associate	39525853
Glioma	Associate	24083766
Hypersensitivity Immediate	Stimulate	30803215
Liver Failure	Associate	39525853
Menopause Premature	Associate	39525853
Multiple Myeloma	Associate	29212806
Neoplasm Metastasis	Associate	30803215
Neoplasms	Associate	35170199, 36008975
Obesity	Associate	26449484, 34707566
Obesity Abdominal	Associate	27925416
Osteoarthritis	Associate	28777797
Osteoporosis	Associate	39525853
Osteosarcoma	Associate	24455684
Ovarian Neoplasms	Associate	32176632
Primary Ovarian Insufficiency	Associate	36732629
Stomach Neoplasms	Associate	30803215

LGR4 (leucine rich repeat containing G protein-coupled receptor 4)