IMPACT (impact RWD domain protein)

Gene

• Entrez ID: 55364
• Gene name: Impact RWD domain protein
• Gene symbol: IMPACT
• Synonyms (NCBI Gene): RWDD5
• Chromosome: 18
• Chromosome location: 18q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022642	hsa-miR-124-3p	Microarray	18668037
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT1065819	hsa-miR-1255a	CLIP-seq
MIRT1065820	hsa-miR-1255b	CLIP-seq
MIRT1065821	hsa-miR-150	CLIP-seq
MIRT1065822	hsa-miR-1972	CLIP-seq
MIRT1065823	hsa-miR-2053	CLIP-seq
MIRT1065824	hsa-miR-24	CLIP-seq
MIRT1065825	hsa-miR-3135	CLIP-seq
MIRT1065826	hsa-miR-3146	CLIP-seq
MIRT1065827	hsa-miR-3168	CLIP-seq
MIRT1065828	hsa-miR-3171	CLIP-seq
MIRT1065829	hsa-miR-3202	CLIP-seq
MIRT1065830	hsa-miR-330-3p	CLIP-seq
MIRT1065831	hsa-miR-342-3p	CLIP-seq
MIRT1065832	hsa-miR-3622b-5p	CLIP-seq
MIRT1065833	hsa-miR-3671	CLIP-seq
MIRT1065834	hsa-miR-3922-5p	CLIP-seq
MIRT1065835	hsa-miR-3974	CLIP-seq
MIRT1065836	hsa-miR-409-3p	CLIP-seq
MIRT1065837	hsa-miR-4284	CLIP-seq
MIRT1065838	hsa-miR-4511	CLIP-seq
MIRT1065839	hsa-miR-451b	CLIP-seq
MIRT1065840	hsa-miR-4533	CLIP-seq
MIRT1065841	hsa-miR-4645-5p	CLIP-seq
MIRT1065842	hsa-miR-4673	CLIP-seq
MIRT1065843	hsa-miR-4690-5p	CLIP-seq
MIRT1065844	hsa-miR-4713-5p	CLIP-seq
MIRT1065845	hsa-miR-4731-3p	CLIP-seq
MIRT1065846	hsa-miR-4755-3p	CLIP-seq
MIRT1065847	hsa-miR-4781-3p	CLIP-seq
MIRT1065848	hsa-miR-4799-5p	CLIP-seq
MIRT1065849	hsa-miR-4801	CLIP-seq
MIRT1065850	hsa-miR-491-3p	CLIP-seq
MIRT1065851	hsa-miR-493	CLIP-seq
MIRT1065852	hsa-miR-495	CLIP-seq
MIRT1065853	hsa-miR-513a-3p	CLIP-seq
MIRT1065854	hsa-miR-532-3p	CLIP-seq
MIRT1065855	hsa-miR-548ag	CLIP-seq
MIRT1065856	hsa-miR-548ai	CLIP-seq
MIRT1065857	hsa-miR-548m	CLIP-seq
MIRT1065858	hsa-miR-569	CLIP-seq
MIRT1065859	hsa-miR-582-3p	CLIP-seq
MIRT1065860	hsa-miR-606	CLIP-seq
MIRT1065861	hsa-miR-607	CLIP-seq
MIRT1065862	hsa-miR-633	CLIP-seq
MIRT1065863	hsa-miR-7	CLIP-seq
MIRT1065819	hsa-miR-1255a	CLIP-seq
MIRT1065820	hsa-miR-1255b	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT2015640	hsa-miR-141	CLIP-seq
MIRT2015641	hsa-miR-200a	CLIP-seq
MIRT2015642	hsa-miR-203	CLIP-seq
MIRT2015643	hsa-miR-3065-3p	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT2015646	hsa-miR-34b	CLIP-seq
MIRT2015647	hsa-miR-3607-3p	CLIP-seq
MIRT2015648	hsa-miR-3613-3p	CLIP-seq
MIRT2015649	hsa-miR-3675-3p	CLIP-seq
MIRT2015650	hsa-miR-3686	CLIP-seq
MIRT2015651	hsa-miR-3920	CLIP-seq
MIRT2015652	hsa-miR-3935	CLIP-seq
MIRT1065838	hsa-miR-4511	CLIP-seq
MIRT1065839	hsa-miR-451b	CLIP-seq
MIRT2015653	hsa-miR-4652-3p	CLIP-seq
MIRT2015654	hsa-miR-4771	CLIP-seq
MIRT1065847	hsa-miR-4781-3p	CLIP-seq
MIRT1065852	hsa-miR-495	CLIP-seq
MIRT2015655	hsa-miR-513b	CLIP-seq
MIRT2015656	hsa-miR-548n	CLIP-seq
MIRT2015657	hsa-miR-577	CLIP-seq
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT2248019	hsa-miR-1283	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT1065822	hsa-miR-1972	CLIP-seq
MIRT1065824	hsa-miR-24	CLIP-seq
MIRT2248020	hsa-miR-3064-3p	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT1065825	hsa-miR-3135	CLIP-seq
MIRT2248021	hsa-miR-3156-3p	CLIP-seq
MIRT1065829	hsa-miR-3202	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT1065831	hsa-miR-342-3p	CLIP-seq
MIRT1065832	hsa-miR-3622b-5p	CLIP-seq
MIRT2248022	hsa-miR-3668	CLIP-seq
MIRT1065834	hsa-miR-3922-5p	CLIP-seq
MIRT1065835	hsa-miR-3974	CLIP-seq
MIRT1065837	hsa-miR-4284	CLIP-seq
MIRT2248023	hsa-miR-4287	CLIP-seq
MIRT2248024	hsa-miR-4301	CLIP-seq
MIRT2248025	hsa-miR-4469	CLIP-seq
MIRT2248026	hsa-miR-450b-5p	CLIP-seq
MIRT1065840	hsa-miR-4533	CLIP-seq
MIRT1065841	hsa-miR-4645-5p	CLIP-seq
MIRT1065842	hsa-miR-4673	CLIP-seq
MIRT2248027	hsa-miR-4685-3p	CLIP-seq
MIRT1065843	hsa-miR-4690-5p	CLIP-seq
MIRT2248028	hsa-miR-4699-3p	CLIP-seq
MIRT2248029	hsa-miR-4715-3p	CLIP-seq
MIRT2248030	hsa-miR-4733-5p	CLIP-seq
MIRT1065846	hsa-miR-4755-3p	CLIP-seq
MIRT2248031	hsa-miR-4776-3p	CLIP-seq
MIRT1065848	hsa-miR-4799-5p	CLIP-seq
MIRT1065851	hsa-miR-493	CLIP-seq
MIRT2248032	hsa-miR-507	CLIP-seq
MIRT1065857	hsa-miR-548m	CLIP-seq
MIRT2248033	hsa-miR-557	CLIP-seq
MIRT2248034	hsa-miR-634	CLIP-seq
MIRT2248035	hsa-miR-642a	CLIP-seq
MIRT1065863	hsa-miR-7	CLIP-seq
MIRT2248036	hsa-miR-766	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT1065829	hsa-miR-3202	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT1065834	hsa-miR-3922-5p	CLIP-seq
MIRT1065835	hsa-miR-3974	CLIP-seq
MIRT1065840	hsa-miR-4533	CLIP-seq
MIRT1065851	hsa-miR-493	CLIP-seq
MIRT1065825	hsa-miR-3135	CLIP-seq
MIRT2451804	hsa-miR-3135b	CLIP-seq
MIRT2451805	hsa-miR-3691-3p	CLIP-seq
MIRT2451806	hsa-miR-4434	CLIP-seq
MIRT2451807	hsa-miR-4487	CLIP-seq
MIRT1065838	hsa-miR-4511	CLIP-seq
MIRT2451808	hsa-miR-4516	CLIP-seq
MIRT1065839	hsa-miR-451b	CLIP-seq
MIRT2451809	hsa-miR-4531	CLIP-seq
MIRT2248036	hsa-miR-766	CLIP-seq
MIRT2551751	hsa-miR-1207-5p	CLIP-seq
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT1065819	hsa-miR-1255a	CLIP-seq
MIRT1065820	hsa-miR-1255b	CLIP-seq
MIRT2551752	hsa-miR-1285	CLIP-seq
MIRT2551753	hsa-miR-1304	CLIP-seq
MIRT1065823	hsa-miR-2053	CLIP-seq
MIRT2551754	hsa-miR-28-5p	CLIP-seq
MIRT2248020	hsa-miR-3064-3p	CLIP-seq
MIRT2015643	hsa-miR-3065-3p	CLIP-seq
MIRT2551755	hsa-miR-3139	CLIP-seq
MIRT1065826	hsa-miR-3146	CLIP-seq
MIRT2248021	hsa-miR-3156-3p	CLIP-seq
MIRT1065827	hsa-miR-3168	CLIP-seq
MIRT2551756	hsa-miR-3187-5p	CLIP-seq
MIRT2551757	hsa-miR-323b-3p	CLIP-seq
MIRT2015648	hsa-miR-3613-3p	CLIP-seq
MIRT2551758	hsa-miR-3646	CLIP-seq
MIRT2551759	hsa-miR-3667-5p	CLIP-seq
MIRT2551760	hsa-miR-3670	CLIP-seq
MIRT2551761	hsa-miR-376c	CLIP-seq
MIRT2551762	hsa-miR-4276	CLIP-seq
MIRT2248024	hsa-miR-4301	CLIP-seq
MIRT2551763	hsa-miR-4457	CLIP-seq
MIRT2551764	hsa-miR-4668-3p	CLIP-seq
MIRT2551765	hsa-miR-4699-5p	CLIP-seq
MIRT2248029	hsa-miR-4715-3p	CLIP-seq
MIRT2248030	hsa-miR-4733-5p	CLIP-seq
MIRT2551766	hsa-miR-4735-5p	CLIP-seq
MIRT2551767	hsa-miR-4736	CLIP-seq
MIRT2551768	hsa-miR-4763-3p	CLIP-seq
MIRT2248031	hsa-miR-4776-3p	CLIP-seq
MIRT1065847	hsa-miR-4781-3p	CLIP-seq
MIRT2551769	hsa-miR-487a	CLIP-seq
MIRT1065850	hsa-miR-491-3p	CLIP-seq
MIRT1065852	hsa-miR-495	CLIP-seq
MIRT2015655	hsa-miR-513b	CLIP-seq
MIRT2551770	hsa-miR-515-5p	CLIP-seq
MIRT2551771	hsa-miR-520d-5p	CLIP-seq
MIRT2551772	hsa-miR-524-5p	CLIP-seq
MIRT2551773	hsa-miR-548ae	CLIP-seq
MIRT2551774	hsa-miR-548aj	CLIP-seq
MIRT2551775	hsa-miR-548am	CLIP-seq
MIRT1065857	hsa-miR-548m	CLIP-seq
MIRT2551776	hsa-miR-548x	CLIP-seq
MIRT2551777	hsa-miR-556-5p	CLIP-seq
MIRT2551778	hsa-miR-576-5p	CLIP-seq
MIRT2551779	hsa-miR-612	CLIP-seq
MIRT2551780	hsa-miR-661	CLIP-seq
MIRT2551781	hsa-miR-665	CLIP-seq
MIRT2551782	hsa-miR-708	CLIP-seq
MIRT2551751	hsa-miR-1207-5p	CLIP-seq
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT2551752	hsa-miR-1285	CLIP-seq
MIRT2551753	hsa-miR-1304	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT2551754	hsa-miR-28-5p	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT2551755	hsa-miR-3139	CLIP-seq
MIRT2551756	hsa-miR-3187-5p	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT2015648	hsa-miR-3613-3p	CLIP-seq
MIRT2551760	hsa-miR-3670	CLIP-seq
MIRT2551761	hsa-miR-376c	CLIP-seq
MIRT2551763	hsa-miR-4457	CLIP-seq
MIRT2551764	hsa-miR-4668-3p	CLIP-seq
MIRT2551767	hsa-miR-4736	CLIP-seq
MIRT2551768	hsa-miR-4763-3p	CLIP-seq
MIRT2015655	hsa-miR-513b	CLIP-seq
MIRT2551779	hsa-miR-612	CLIP-seq
MIRT2551780	hsa-miR-661	CLIP-seq
MIRT2551781	hsa-miR-665	CLIP-seq
MIRT2551782	hsa-miR-708	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006417	Process	Regulation of translation	IEA
GO:0006446	Process	Regulation of translational initiation	IBA
GO:0006446	Process	Regulation of translational initiation	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IEA
GO:0034198	Process	Cellular response to amino acid starvation	ISS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	ISS
GO:0043022	Function	Ribosome binding	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	ISS
GO:0140311	Function	Protein sequestering activity	IEA
GO:0140311	Function	Protein sequestering activity	ISS
GO:0140469	Process	GCN2-mediated signaling	IBA
GO:0140469	Process	GCN2-mediated signaling	IEA
GO:0140469	Process	GCN2-mediated signaling	ISS
GO:1990138	Process	Neuron projection extension	IEA
GO:1990138	Process	Neuron projection extension	ISS
GO:1990611	Process	Regulation of cytoplasmic translational initiation in response to stress	IEA
GO:1990611	Process	Regulation of cytoplasmic translational initiation in response to stress	ISS

Other IDs

• MIM: 615319
• HGNC: 20387
• e!Ensembl: ENSG00000154059

Protein

• UniProt ID: Q9P2X3
• Protein name: Protein IMPACT (Imprinted and ancient gene protein homolog)
• Protein function: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative reg
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05773	RWD	10 → 113	RWD domain	Domain
  PF01205	UPF0029	182 → 289	Uncharacterized protein family UPF0029	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed at high level in brain. {ECO:0000269|PubMed:11116084, ECO:0000269|PubMed:11244491}.
• Sequence:

  MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPN
  EYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMT
  EPGPDVKKKTEEEDVECEDDLILACQPESSLKALDFDISETRTEVEVEELPPIDHGIPIT
  DRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHNIYAYRIYCEDKQTFLQDCEDDG
  ETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNYTNSPEE
  SSKALGKNKKVRKDKKRNEH

• Sequence length: 320