Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55364
Gene name Gene Name - the full gene name approved by the HGNC.	Impact RWD domain protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IMPACT
Synonyms (NCBI Gene) Gene synonyms aliases	RWDD5
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q11.2

Show/Hide all(203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022642	hsa-miR-124-3p	Microarray	18668037
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT1065819	hsa-miR-1255a	CLIP-seq
MIRT1065820	hsa-miR-1255b	CLIP-seq
MIRT1065821	hsa-miR-150	CLIP-seq
MIRT1065822	hsa-miR-1972	CLIP-seq
MIRT1065823	hsa-miR-2053	CLIP-seq
MIRT1065824	hsa-miR-24	CLIP-seq
MIRT1065825	hsa-miR-3135	CLIP-seq
MIRT1065826	hsa-miR-3146	CLIP-seq
MIRT1065827	hsa-miR-3168	CLIP-seq
MIRT1065828	hsa-miR-3171	CLIP-seq
MIRT1065829	hsa-miR-3202	CLIP-seq
MIRT1065830	hsa-miR-330-3p	CLIP-seq
MIRT1065831	hsa-miR-342-3p	CLIP-seq
MIRT1065832	hsa-miR-3622b-5p	CLIP-seq
MIRT1065833	hsa-miR-3671	CLIP-seq
MIRT1065834	hsa-miR-3922-5p	CLIP-seq
MIRT1065835	hsa-miR-3974	CLIP-seq
MIRT1065836	hsa-miR-409-3p	CLIP-seq
MIRT1065837	hsa-miR-4284	CLIP-seq
MIRT1065838	hsa-miR-4511	CLIP-seq
MIRT1065839	hsa-miR-451b	CLIP-seq
MIRT1065840	hsa-miR-4533	CLIP-seq
MIRT1065841	hsa-miR-4645-5p	CLIP-seq
MIRT1065842	hsa-miR-4673	CLIP-seq
MIRT1065843	hsa-miR-4690-5p	CLIP-seq
MIRT1065844	hsa-miR-4713-5p	CLIP-seq
MIRT1065845	hsa-miR-4731-3p	CLIP-seq
MIRT1065846	hsa-miR-4755-3p	CLIP-seq
MIRT1065847	hsa-miR-4781-3p	CLIP-seq
MIRT1065848	hsa-miR-4799-5p	CLIP-seq
MIRT1065849	hsa-miR-4801	CLIP-seq
MIRT1065850	hsa-miR-491-3p	CLIP-seq
MIRT1065851	hsa-miR-493	CLIP-seq
MIRT1065852	hsa-miR-495	CLIP-seq
MIRT1065853	hsa-miR-513a-3p	CLIP-seq
MIRT1065854	hsa-miR-532-3p	CLIP-seq
MIRT1065855	hsa-miR-548ag	CLIP-seq
MIRT1065856	hsa-miR-548ai	CLIP-seq
MIRT1065857	hsa-miR-548m	CLIP-seq
MIRT1065858	hsa-miR-569	CLIP-seq
MIRT1065859	hsa-miR-582-3p	CLIP-seq
MIRT1065860	hsa-miR-606	CLIP-seq
MIRT1065861	hsa-miR-607	CLIP-seq
MIRT1065862	hsa-miR-633	CLIP-seq
MIRT1065863	hsa-miR-7	CLIP-seq
MIRT1065819	hsa-miR-1255a	CLIP-seq
MIRT1065820	hsa-miR-1255b	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT2015640	hsa-miR-141	CLIP-seq
MIRT2015641	hsa-miR-200a	CLIP-seq
MIRT2015642	hsa-miR-203	CLIP-seq
MIRT2015643	hsa-miR-3065-3p	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT2015646	hsa-miR-34b	CLIP-seq
MIRT2015647	hsa-miR-3607-3p	CLIP-seq
MIRT2015648	hsa-miR-3613-3p	CLIP-seq
MIRT2015649	hsa-miR-3675-3p	CLIP-seq
MIRT2015650	hsa-miR-3686	CLIP-seq
MIRT2015651	hsa-miR-3920	CLIP-seq
MIRT2015652	hsa-miR-3935	CLIP-seq
MIRT1065838	hsa-miR-4511	CLIP-seq
MIRT1065839	hsa-miR-451b	CLIP-seq
MIRT2015653	hsa-miR-4652-3p	CLIP-seq
MIRT2015654	hsa-miR-4771	CLIP-seq
MIRT1065847	hsa-miR-4781-3p	CLIP-seq
MIRT1065852	hsa-miR-495	CLIP-seq
MIRT2015655	hsa-miR-513b	CLIP-seq
MIRT2015656	hsa-miR-548n	CLIP-seq
MIRT2015657	hsa-miR-577	CLIP-seq
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT2248019	hsa-miR-1283	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT1065822	hsa-miR-1972	CLIP-seq
MIRT1065824	hsa-miR-24	CLIP-seq
MIRT2248020	hsa-miR-3064-3p	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT1065825	hsa-miR-3135	CLIP-seq
MIRT2248021	hsa-miR-3156-3p	CLIP-seq
MIRT1065829	hsa-miR-3202	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT1065831	hsa-miR-342-3p	CLIP-seq
MIRT1065832	hsa-miR-3622b-5p	CLIP-seq
MIRT2248022	hsa-miR-3668	CLIP-seq
MIRT1065834	hsa-miR-3922-5p	CLIP-seq
MIRT1065835	hsa-miR-3974	CLIP-seq
MIRT1065837	hsa-miR-4284	CLIP-seq
MIRT2248023	hsa-miR-4287	CLIP-seq
MIRT2248024	hsa-miR-4301	CLIP-seq
MIRT2248025	hsa-miR-4469	CLIP-seq
MIRT2248026	hsa-miR-450b-5p	CLIP-seq
MIRT1065840	hsa-miR-4533	CLIP-seq
MIRT1065841	hsa-miR-4645-5p	CLIP-seq
MIRT1065842	hsa-miR-4673	CLIP-seq
MIRT2248027	hsa-miR-4685-3p	CLIP-seq
MIRT1065843	hsa-miR-4690-5p	CLIP-seq
MIRT2248028	hsa-miR-4699-3p	CLIP-seq
MIRT2248029	hsa-miR-4715-3p	CLIP-seq
MIRT2248030	hsa-miR-4733-5p	CLIP-seq
MIRT1065846	hsa-miR-4755-3p	CLIP-seq
MIRT2248031	hsa-miR-4776-3p	CLIP-seq
MIRT1065848	hsa-miR-4799-5p	CLIP-seq
MIRT1065851	hsa-miR-493	CLIP-seq
MIRT2248032	hsa-miR-507	CLIP-seq
MIRT1065857	hsa-miR-548m	CLIP-seq
MIRT2248033	hsa-miR-557	CLIP-seq
MIRT2248034	hsa-miR-634	CLIP-seq
MIRT2248035	hsa-miR-642a	CLIP-seq
MIRT1065863	hsa-miR-7	CLIP-seq
MIRT2248036	hsa-miR-766	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT1065829	hsa-miR-3202	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT1065834	hsa-miR-3922-5p	CLIP-seq
MIRT1065835	hsa-miR-3974	CLIP-seq
MIRT1065840	hsa-miR-4533	CLIP-seq
MIRT1065851	hsa-miR-493	CLIP-seq
MIRT1065825	hsa-miR-3135	CLIP-seq
MIRT2451804	hsa-miR-3135b	CLIP-seq
MIRT2451805	hsa-miR-3691-3p	CLIP-seq
MIRT2451806	hsa-miR-4434	CLIP-seq
MIRT2451807	hsa-miR-4487	CLIP-seq
MIRT1065838	hsa-miR-4511	CLIP-seq
MIRT2451808	hsa-miR-4516	CLIP-seq
MIRT1065839	hsa-miR-451b	CLIP-seq
MIRT2451809	hsa-miR-4531	CLIP-seq
MIRT2248036	hsa-miR-766	CLIP-seq
MIRT2551751	hsa-miR-1207-5p	CLIP-seq
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT1065819	hsa-miR-1255a	CLIP-seq
MIRT1065820	hsa-miR-1255b	CLIP-seq
MIRT2551752	hsa-miR-1285	CLIP-seq
MIRT2551753	hsa-miR-1304	CLIP-seq
MIRT1065823	hsa-miR-2053	CLIP-seq
MIRT2551754	hsa-miR-28-5p	CLIP-seq
MIRT2248020	hsa-miR-3064-3p	CLIP-seq
MIRT2015643	hsa-miR-3065-3p	CLIP-seq
MIRT2551755	hsa-miR-3139	CLIP-seq
MIRT1065826	hsa-miR-3146	CLIP-seq
MIRT2248021	hsa-miR-3156-3p	CLIP-seq
MIRT1065827	hsa-miR-3168	CLIP-seq
MIRT2551756	hsa-miR-3187-5p	CLIP-seq
MIRT2551757	hsa-miR-323b-3p	CLIP-seq
MIRT2015648	hsa-miR-3613-3p	CLIP-seq
MIRT2551758	hsa-miR-3646	CLIP-seq
MIRT2551759	hsa-miR-3667-5p	CLIP-seq
MIRT2551760	hsa-miR-3670	CLIP-seq
MIRT2551761	hsa-miR-376c	CLIP-seq
MIRT2551762	hsa-miR-4276	CLIP-seq
MIRT2248024	hsa-miR-4301	CLIP-seq
MIRT2551763	hsa-miR-4457	CLIP-seq
MIRT2551764	hsa-miR-4668-3p	CLIP-seq
MIRT2551765	hsa-miR-4699-5p	CLIP-seq
MIRT2248029	hsa-miR-4715-3p	CLIP-seq
MIRT2248030	hsa-miR-4733-5p	CLIP-seq
MIRT2551766	hsa-miR-4735-5p	CLIP-seq
MIRT2551767	hsa-miR-4736	CLIP-seq
MIRT2551768	hsa-miR-4763-3p	CLIP-seq
MIRT2248031	hsa-miR-4776-3p	CLIP-seq
MIRT1065847	hsa-miR-4781-3p	CLIP-seq
MIRT2551769	hsa-miR-487a	CLIP-seq
MIRT1065850	hsa-miR-491-3p	CLIP-seq
MIRT1065852	hsa-miR-495	CLIP-seq
MIRT2015655	hsa-miR-513b	CLIP-seq
MIRT2551770	hsa-miR-515-5p	CLIP-seq
MIRT2551771	hsa-miR-520d-5p	CLIP-seq
MIRT2551772	hsa-miR-524-5p	CLIP-seq
MIRT2551773	hsa-miR-548ae	CLIP-seq
MIRT2551774	hsa-miR-548aj	CLIP-seq
MIRT2551775	hsa-miR-548am	CLIP-seq
MIRT1065857	hsa-miR-548m	CLIP-seq
MIRT2551776	hsa-miR-548x	CLIP-seq
MIRT2551777	hsa-miR-556-5p	CLIP-seq
MIRT2551778	hsa-miR-576-5p	CLIP-seq
MIRT2551779	hsa-miR-612	CLIP-seq
MIRT2551780	hsa-miR-661	CLIP-seq
MIRT2551781	hsa-miR-665	CLIP-seq
MIRT2551782	hsa-miR-708	CLIP-seq
MIRT2551751	hsa-miR-1207-5p	CLIP-seq
MIRT1065818	hsa-miR-1228	CLIP-seq
MIRT2551752	hsa-miR-1285	CLIP-seq
MIRT2551753	hsa-miR-1304	CLIP-seq
MIRT2015639	hsa-miR-137	CLIP-seq
MIRT2551754	hsa-miR-28-5p	CLIP-seq
MIRT2015644	hsa-miR-3117-5p	CLIP-seq
MIRT2551755	hsa-miR-3139	CLIP-seq
MIRT2551756	hsa-miR-3187-5p	CLIP-seq
MIRT2015645	hsa-miR-323-3p	CLIP-seq
MIRT2015648	hsa-miR-3613-3p	CLIP-seq
MIRT2551760	hsa-miR-3670	CLIP-seq
MIRT2551761	hsa-miR-376c	CLIP-seq
MIRT2551763	hsa-miR-4457	CLIP-seq
MIRT2551764	hsa-miR-4668-3p	CLIP-seq
MIRT2551767	hsa-miR-4736	CLIP-seq
MIRT2551768	hsa-miR-4763-3p	CLIP-seq
MIRT2015655	hsa-miR-513b	CLIP-seq
MIRT2551779	hsa-miR-612	CLIP-seq
MIRT2551780	hsa-miR-661	CLIP-seq
MIRT2551781	hsa-miR-665	CLIP-seq
MIRT2551782	hsa-miR-708	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0001933	Process	Negative regulation of protein phosphorylation	ISS
GO:0003674	Function	Molecular_function	ND
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IEA
GO:0005844	Component	Polysome	ISS
GO:0006446	Process	Regulation of translational initiation	IBA	21873635
GO:0006469	Process	Negative regulation of protein kinase activity	IEA
GO:0008150	Process	Biological_process	ND
GO:0031333	Process	Negative regulation of protein-containing complex assembly	ISS
GO:0031953	Process	Negative regulation of protein autophosphorylation	ISS
GO:0034198	Process	Cellular response to amino acid starvation	ISS
GO:0042149	Process	Cellular response to glucose starvation	ISS
GO:0045666	Process	Positive regulation of neuron differentiation	ISS
GO:0060548	Process	Negative regulation of cell death	ISS
GO:0070301	Process	Cellular response to hydrogen peroxide	ISS
GO:0071264	Process	Positive regulation of translational initiation in response to starvation	ISS
GO:0071468	Process	Cellular response to acidic pH	ISS
GO:0071494	Process	Cellular response to UV-C	ISS
GO:0072755	Process	Cellular response to benomyl	ISS
GO:0097201	Process	Negative regulation of transcription from RNA polymerase II promoter in response to stress	ISS
GO:0140469	Process	GCN2-mediated signaling	ISS
GO:1990138	Process	Neuron projection extension	ISS
GO:1990253	Process	Cellular response to leucine starvation	ISS

MIM	HGNC	e!Ensembl
615319	20387	ENSG00000154059

Protein

UniProt ID

Q9P2X3

Protein name

Protein IMPACT (Imprinted and ancient gene protein homolog)

Protein function

Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative reg

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05773	RWD	10 → 113	RWD domain	Domain
PF01205	UPF0029	182 → 289	Uncharacterized protein family UPF0029	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed at high level in brain. {ECO:0000269|PubMed:11116084, ECO:0000269|PubMed:11244491}.

Sequence

MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPN
EYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMT
EPGPDVKKKTEEEDVECEDDLILACQPESSLKALDFDISETRTEVEVEELPPIDHGIPIT
DRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHNIYAYRIYCEDKQTFLQDCEDDG
ETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNYTNSPEE
SSKALGKNKKVRKDKKRNEH

Sequence length

320

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Major affective disorder	MAJOR AFFECTIVE DISORDER 2		11244491	ClinVar

IMPACT (impact RWD domain protein)