Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5536
Gene name	Protein phosphatase 5 catalytic subunit
Gene symbol	PPP5C
Synonyms (NCBI Gene)	PP5PPP5PPT
Chromosome	19
Chromosome location	19q13.32
Summary	This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001518	hsa-miR-155-5p	pSILAC	18668040
MIRT039894	hsa-miR-615-3p	CLASH	23622248
MIRT039894	hsa-miR-615-3p	CLASH	23622248
MIRT038528	hsa-miR-99b-3p	CLASH	23622248
MIRT1258599	hsa-miR-4286	CLIP-seq
MIRT2076213	hsa-miR-1913	CLIP-seq
MIRT2076214	hsa-miR-3162-3p	CLIP-seq
MIRT2076215	hsa-miR-3183	CLIP-seq
MIRT2076216	hsa-miR-324-3p	CLIP-seq
MIRT2076217	hsa-miR-345	CLIP-seq
MIRT2076218	hsa-miR-4522	CLIP-seq
MIRT2076219	hsa-miR-4723-3p	CLIP-seq
MIRT2076220	hsa-miR-4732-3p	CLIP-seq
MIRT2076221	hsa-miR-4749-3p	CLIP-seq
MIRT2302803	hsa-miR-1207-5p	CLIP-seq
MIRT2302804	hsa-miR-3131	CLIP-seq
MIRT2302805	hsa-miR-365	CLIP-seq
MIRT1258599	hsa-miR-4286	CLIP-seq
MIRT2302806	hsa-miR-4436b-3p	CLIP-seq
MIRT2302807	hsa-miR-4632	CLIP-seq
MIRT2302808	hsa-miR-4758-3p	CLIP-seq
MIRT2302809	hsa-miR-4763-3p	CLIP-seq
MIRT2302810	hsa-miR-486-3p	CLIP-seq
MIRT2302811	hsa-miR-611	CLIP-seq
MIRT2599482	hsa-miR-1273e	CLIP-seq
MIRT2599483	hsa-miR-1275	CLIP-seq
MIRT2599484	hsa-miR-137	CLIP-seq
MIRT2599485	hsa-miR-146b-3p	CLIP-seq
MIRT2599486	hsa-miR-1908	CLIP-seq
MIRT2076213	hsa-miR-1913	CLIP-seq
MIRT2599487	hsa-miR-193a-5p	CLIP-seq
MIRT2599488	hsa-miR-2276	CLIP-seq
MIRT2599489	hsa-miR-2861	CLIP-seq
MIRT2599490	hsa-miR-3157-3p	CLIP-seq
MIRT2076214	hsa-miR-3162-3p	CLIP-seq
MIRT2599491	hsa-miR-3173-5p	CLIP-seq
MIRT2599492	hsa-miR-3180	CLIP-seq
MIRT2599493	hsa-miR-3180-3p	CLIP-seq
MIRT2076215	hsa-miR-3183	CLIP-seq
MIRT2599494	hsa-miR-3194-3p	CLIP-seq
MIRT2599495	hsa-miR-3196	CLIP-seq
MIRT2076216	hsa-miR-324-3p	CLIP-seq
MIRT2599496	hsa-miR-326	CLIP-seq
MIRT2599497	hsa-miR-330-5p	CLIP-seq
MIRT2599498	hsa-miR-337-3p	CLIP-seq
MIRT2599499	hsa-miR-3973	CLIP-seq
MIRT2599500	hsa-miR-4292	CLIP-seq
MIRT2599501	hsa-miR-4317	CLIP-seq
MIRT2599502	hsa-miR-4447	CLIP-seq
MIRT2599503	hsa-miR-4472	CLIP-seq
MIRT2599504	hsa-miR-4481	CLIP-seq
MIRT2599505	hsa-miR-4509	CLIP-seq
MIRT2076218	hsa-miR-4522	CLIP-seq
MIRT2599506	hsa-miR-4525	CLIP-seq
MIRT2599507	hsa-miR-4640-3p	CLIP-seq
MIRT2599508	hsa-miR-4658	CLIP-seq
MIRT2599509	hsa-miR-4665-5p	CLIP-seq
MIRT2599510	hsa-miR-4667-5p	CLIP-seq
MIRT2599511	hsa-miR-4700-5p	CLIP-seq
MIRT2076219	hsa-miR-4723-3p	CLIP-seq
MIRT2599512	hsa-miR-4723-5p	CLIP-seq
MIRT2599513	hsa-miR-4725-5p	CLIP-seq
MIRT2599514	hsa-miR-4745-5p	CLIP-seq
MIRT2076221	hsa-miR-4749-3p	CLIP-seq
MIRT2599515	hsa-miR-4758-5p	CLIP-seq
MIRT2599516	hsa-miR-4772-3p	CLIP-seq
MIRT2599517	hsa-miR-504	CLIP-seq
MIRT2599518	hsa-miR-520d-5p	CLIP-seq
MIRT2599519	hsa-miR-524-5p	CLIP-seq
MIRT2599520	hsa-miR-548a-5p	CLIP-seq
MIRT2599521	hsa-miR-548ab	CLIP-seq
MIRT2599522	hsa-miR-548ak	CLIP-seq
MIRT2599523	hsa-miR-548b-5p	CLIP-seq
MIRT2599524	hsa-miR-548c-5p	CLIP-seq
MIRT2599525	hsa-miR-548d-5p	CLIP-seq
MIRT2599526	hsa-miR-548h	CLIP-seq
MIRT2599527	hsa-miR-548i	CLIP-seq
MIRT2599528	hsa-miR-548j	CLIP-seq
MIRT2599529	hsa-miR-548w	CLIP-seq
MIRT2599530	hsa-miR-548y	CLIP-seq
MIRT2599531	hsa-miR-559	CLIP-seq
MIRT2599532	hsa-miR-615-5p	CLIP-seq
MIRT2599533	hsa-miR-625	CLIP-seq
MIRT2599534	hsa-miR-637	CLIP-seq
MIRT2599535	hsa-miR-652	CLIP-seq
MIRT2599536	hsa-miR-663	CLIP-seq
MIRT2599537	hsa-miR-744	CLIP-seq
MIRT2599538	hsa-miR-874	CLIP-seq
MIRT2076213	hsa-miR-1913	CLIP-seq
MIRT2599488	hsa-miR-2276	CLIP-seq
MIRT2076214	hsa-miR-3162-3p	CLIP-seq
MIRT2076216	hsa-miR-324-3p	CLIP-seq
MIRT2599499	hsa-miR-3973	CLIP-seq
MIRT2599505	hsa-miR-4509	CLIP-seq
MIRT2076218	hsa-miR-4522	CLIP-seq
MIRT2599507	hsa-miR-4640-3p	CLIP-seq
MIRT2076221	hsa-miR-4749-3p	CLIP-seq
MIRT2599516	hsa-miR-4772-3p	CLIP-seq
MIRT2599518	hsa-miR-520d-5p	CLIP-seq
MIRT2599519	hsa-miR-524-5p	CLIP-seq
MIRT2599520	hsa-miR-548a-5p	CLIP-seq
MIRT2599521	hsa-miR-548ab	CLIP-seq
MIRT2599522	hsa-miR-548ak	CLIP-seq
MIRT2599523	hsa-miR-548b-5p	CLIP-seq
MIRT2599524	hsa-miR-548c-5p	CLIP-seq
MIRT2599525	hsa-miR-548d-5p	CLIP-seq
MIRT2599526	hsa-miR-548h	CLIP-seq
MIRT2599527	hsa-miR-548i	CLIP-seq
MIRT2599528	hsa-miR-548j	CLIP-seq
MIRT2599529	hsa-miR-548w	CLIP-seq
MIRT2599530	hsa-miR-548y	CLIP-seq
MIRT2599531	hsa-miR-559	CLIP-seq

Show/Hide all (61)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000278	Process	Mitotic cell cycle	TAS	7925273
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	ISS	9383998
GO:0004721	Function	Phosphoprotein phosphatase activity	TAS	28386764
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	30699359
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	ISS	15546861
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS	7925273, 15546861, 16262633
GO:0005515	Function	Protein binding	IPI	9383998, 11504734, 14764652, 16531226, 16790549, 19875381, 21360678, 25036637, 26496610, 27353360, 27880917, 28330616, 30699359, 33961781, 35271311
GO:0005524	Function	ATP binding	IDA	23184943
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7925273
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006302	Process	Double-strand break repair	TAS
GO:0006351	Process	DNA-templated transcription	TAS	7925273
GO:0006974	Process	DNA damage response	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0010288	Process	Response to lead ion	IEA
GO:0010288	Process	Response to lead ion	ISS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	15546861
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031435	Function	Mitogen-activated protein kinase kinase kinase binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	23184943
GO:0042802	Function	Identical protein binding	IPI	21360678
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0043204	Component	Perikaryon	IEA
GO:0043278	Process	Response to morphine	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0043531	Function	ADP binding	IDA	23184943
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0051879	Function	Hsp90 protein binding	IEA
GO:0051879	Function	Hsp90 protein binding	IPI	15713458
GO:0070262	Process	Peptidyl-serine dephosphorylation	IDA	30699359
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071276	Process	Cellular response to cadmium ion	IEA
GO:0101031	Component	Protein folding chaperone complex	IDA	29127155
GO:1904550	Process	Response to arachidonate	IEA
GO:1904550	Process	Response to arachidonate	ISS	15546861
GO:1990635	Component	Proximal dendrite	IEA
GO:2000324	Process	Positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway	IEA

MIM	HGNC	e!Ensembl
600658	9322	ENSG00000011485

P53041

Protein name

Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)

Protein function

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins

PDB

1A17 , 1S95 , 1WAO , 2BUG , 3H60 , 3H61 , 3H62 , 3H63 , 3H64 , 3H66 , 3H67 , 3H68 , 3H69 , 4ZVZ , 4ZX2 , 5HPE , 5UI1 , 5WG8 , 7ZR5 , 7ZR6 , 8GAE , 8GFT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00515	TPR_1	28 → 61	Tetratricopeptide repeat	Repeat
PF08321	PPP5	136 → 228	PPP5 TPR repeat region	Family
PF00149	Metallophos	235 → 431	Calcineurin-like phosphoesterase	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15546861}.

Sequence

MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPS
NAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYE
TVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVC
GDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLL
RGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDG
VTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNL
DYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP
HPNVKPMAYANTLLQLGMM

Sequence length

499

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway		Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PPP5C-related disorder	Uncertain significance; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE ACUTE RESPIRATORY SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Asthma	Associate	27501780	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	11331294	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	28453226	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	29141220	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Associate	38302916	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	15004035	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	25796168	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glucocorticoid Receptor Deficiency	Associate	27742828	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Associate	29141220	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Mantle Cell	Associate	15650054	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	11240142	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	22298641, 28453226, 29141220, 30679389	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	28090608	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	33270085	★★★★★ ★☆☆☆☆ Found in Text Mining only
Status Asthmaticus	Associate	27501780	★★★★★ ★☆☆☆☆ Found in Text Mining only

PPP5C (protein phosphatase 5 catalytic subunit)