Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5536
Gene name Gene Name - the full gene name approved by the HGNC.	Protein phosphatase 5 catalytic subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPP5C
Synonyms (NCBI Gene) Gene synonyms aliases	PP5, PPP5, PPT
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these

Show/Hide all(112)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001518	hsa-miR-155-5p	pSILAC	18668040
MIRT039894	hsa-miR-615-3p	CLASH	23622248
MIRT039894	hsa-miR-615-3p	CLASH	23622248
MIRT038528	hsa-miR-99b-3p	CLASH	23622248
MIRT1258599	hsa-miR-4286	CLIP-seq
MIRT2076213	hsa-miR-1913	CLIP-seq
MIRT2076214	hsa-miR-3162-3p	CLIP-seq
MIRT2076215	hsa-miR-3183	CLIP-seq
MIRT2076216	hsa-miR-324-3p	CLIP-seq
MIRT2076217	hsa-miR-345	CLIP-seq
MIRT2076218	hsa-miR-4522	CLIP-seq
MIRT2076219	hsa-miR-4723-3p	CLIP-seq
MIRT2076220	hsa-miR-4732-3p	CLIP-seq
MIRT2076221	hsa-miR-4749-3p	CLIP-seq
MIRT2302803	hsa-miR-1207-5p	CLIP-seq
MIRT2302804	hsa-miR-3131	CLIP-seq
MIRT2302805	hsa-miR-365	CLIP-seq
MIRT1258599	hsa-miR-4286	CLIP-seq
MIRT2302806	hsa-miR-4436b-3p	CLIP-seq
MIRT2302807	hsa-miR-4632	CLIP-seq
MIRT2302808	hsa-miR-4758-3p	CLIP-seq
MIRT2302809	hsa-miR-4763-3p	CLIP-seq
MIRT2302810	hsa-miR-486-3p	CLIP-seq
MIRT2302811	hsa-miR-611	CLIP-seq
MIRT2599482	hsa-miR-1273e	CLIP-seq
MIRT2599483	hsa-miR-1275	CLIP-seq
MIRT2599484	hsa-miR-137	CLIP-seq
MIRT2599485	hsa-miR-146b-3p	CLIP-seq
MIRT2599486	hsa-miR-1908	CLIP-seq
MIRT2076213	hsa-miR-1913	CLIP-seq
MIRT2599487	hsa-miR-193a-5p	CLIP-seq
MIRT2599488	hsa-miR-2276	CLIP-seq
MIRT2599489	hsa-miR-2861	CLIP-seq
MIRT2599490	hsa-miR-3157-3p	CLIP-seq
MIRT2076214	hsa-miR-3162-3p	CLIP-seq
MIRT2599491	hsa-miR-3173-5p	CLIP-seq
MIRT2599492	hsa-miR-3180	CLIP-seq
MIRT2599493	hsa-miR-3180-3p	CLIP-seq
MIRT2076215	hsa-miR-3183	CLIP-seq
MIRT2599494	hsa-miR-3194-3p	CLIP-seq
MIRT2599495	hsa-miR-3196	CLIP-seq
MIRT2076216	hsa-miR-324-3p	CLIP-seq
MIRT2599496	hsa-miR-326	CLIP-seq
MIRT2599497	hsa-miR-330-5p	CLIP-seq
MIRT2599498	hsa-miR-337-3p	CLIP-seq
MIRT2599499	hsa-miR-3973	CLIP-seq
MIRT2599500	hsa-miR-4292	CLIP-seq
MIRT2599501	hsa-miR-4317	CLIP-seq
MIRT2599502	hsa-miR-4447	CLIP-seq
MIRT2599503	hsa-miR-4472	CLIP-seq
MIRT2599504	hsa-miR-4481	CLIP-seq
MIRT2599505	hsa-miR-4509	CLIP-seq
MIRT2076218	hsa-miR-4522	CLIP-seq
MIRT2599506	hsa-miR-4525	CLIP-seq
MIRT2599507	hsa-miR-4640-3p	CLIP-seq
MIRT2599508	hsa-miR-4658	CLIP-seq
MIRT2599509	hsa-miR-4665-5p	CLIP-seq
MIRT2599510	hsa-miR-4667-5p	CLIP-seq
MIRT2599511	hsa-miR-4700-5p	CLIP-seq
MIRT2076219	hsa-miR-4723-3p	CLIP-seq
MIRT2599512	hsa-miR-4723-5p	CLIP-seq
MIRT2599513	hsa-miR-4725-5p	CLIP-seq
MIRT2599514	hsa-miR-4745-5p	CLIP-seq
MIRT2076221	hsa-miR-4749-3p	CLIP-seq
MIRT2599515	hsa-miR-4758-5p	CLIP-seq
MIRT2599516	hsa-miR-4772-3p	CLIP-seq
MIRT2599517	hsa-miR-504	CLIP-seq
MIRT2599518	hsa-miR-520d-5p	CLIP-seq
MIRT2599519	hsa-miR-524-5p	CLIP-seq
MIRT2599520	hsa-miR-548a-5p	CLIP-seq
MIRT2599521	hsa-miR-548ab	CLIP-seq
MIRT2599522	hsa-miR-548ak	CLIP-seq
MIRT2599523	hsa-miR-548b-5p	CLIP-seq
MIRT2599524	hsa-miR-548c-5p	CLIP-seq
MIRT2599525	hsa-miR-548d-5p	CLIP-seq
MIRT2599526	hsa-miR-548h	CLIP-seq
MIRT2599527	hsa-miR-548i	CLIP-seq
MIRT2599528	hsa-miR-548j	CLIP-seq
MIRT2599529	hsa-miR-548w	CLIP-seq
MIRT2599530	hsa-miR-548y	CLIP-seq
MIRT2599531	hsa-miR-559	CLIP-seq
MIRT2599532	hsa-miR-615-5p	CLIP-seq
MIRT2599533	hsa-miR-625	CLIP-seq
MIRT2599534	hsa-miR-637	CLIP-seq
MIRT2599535	hsa-miR-652	CLIP-seq
MIRT2599536	hsa-miR-663	CLIP-seq
MIRT2599537	hsa-miR-744	CLIP-seq
MIRT2599538	hsa-miR-874	CLIP-seq
MIRT2076213	hsa-miR-1913	CLIP-seq
MIRT2599488	hsa-miR-2276	CLIP-seq
MIRT2076214	hsa-miR-3162-3p	CLIP-seq
MIRT2076216	hsa-miR-324-3p	CLIP-seq
MIRT2599499	hsa-miR-3973	CLIP-seq
MIRT2599505	hsa-miR-4509	CLIP-seq
MIRT2076218	hsa-miR-4522	CLIP-seq
MIRT2599507	hsa-miR-4640-3p	CLIP-seq
MIRT2076221	hsa-miR-4749-3p	CLIP-seq
MIRT2599516	hsa-miR-4772-3p	CLIP-seq
MIRT2599518	hsa-miR-520d-5p	CLIP-seq
MIRT2599519	hsa-miR-524-5p	CLIP-seq
MIRT2599520	hsa-miR-548a-5p	CLIP-seq
MIRT2599521	hsa-miR-548ab	CLIP-seq
MIRT2599522	hsa-miR-548ak	CLIP-seq
MIRT2599523	hsa-miR-548b-5p	CLIP-seq
MIRT2599524	hsa-miR-548c-5p	CLIP-seq
MIRT2599525	hsa-miR-548d-5p	CLIP-seq
MIRT2599526	hsa-miR-548h	CLIP-seq
MIRT2599527	hsa-miR-548i	CLIP-seq
MIRT2599528	hsa-miR-548j	CLIP-seq
MIRT2599529	hsa-miR-548w	CLIP-seq
MIRT2599530	hsa-miR-548y	CLIP-seq
MIRT2599531	hsa-miR-559	CLIP-seq

Show/Hide all(61)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000278	Process	Mitotic cell cycle	TAS	7925273
GO:0001965	Function	G-protein alpha-subunit binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	ISS	9383998
GO:0004721	Function	Phosphoprotein phosphatase activity	TAS	28386764
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	30699359
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	ISS	15546861
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS	7925273, 15546861, 16262633
GO:0005515	Function	Protein binding	IPI	9383998, 11504734, 14764652, 16531226, 16790549, 19875381, 21360678, 25036637, 26496610, 27353360, 27880917, 28330616, 30699359, 33961781, 35271311
GO:0005524	Function	ATP binding	IDA	23184943
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7925273
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006302	Process	Double-strand break repair	TAS
GO:0006351	Process	DNA-templated transcription	TAS	7925273
GO:0006974	Process	DNA damage response	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0010288	Process	Response to lead ion	IEA
GO:0010288	Process	Response to lead ion	ISS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	15546861
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031435	Function	Mitogen-activated protein kinase kinase kinase binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	23184943
GO:0042802	Function	Identical protein binding	IPI	21360678
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0043204	Component	Perikaryon	IEA
GO:0043278	Process	Response to morphine	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0043531	Function	ADP binding	IDA	23184943
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0051879	Function	Hsp90 protein binding	IEA
GO:0051879	Function	Hsp90 protein binding	IPI	15713458
GO:0070262	Process	Peptidyl-serine dephosphorylation	IDA	30699359
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071276	Process	Cellular response to cadmium ion	IEA
GO:0101031	Component	Protein folding chaperone complex	IDA	29127155
GO:1904550	Process	Response to arachidonate	IEA
GO:1904550	Process	Response to arachidonate	ISS	15546861
GO:1990635	Component	Proximal dendrite	IEA
GO:2000324	Process	Positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway	IEA

MIM	HGNC	e!Ensembl
600658	9322	ENSG00000011485

Protein

UniProt ID

P53041

Protein name

Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)

Protein function

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins

PDB

1A17 , 1S95 , 1WAO , 2BUG , 3H60 , 3H61 , 3H62 , 3H63 , 3H64 , 3H66 , 3H67 , 3H68 , 3H69 , 4ZVZ , 4ZX2 , 5HPE , 5UI1 , 5WG8 , 7ZR5 , 7ZR6 , 8GAE , 8GFT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00515	TPR_1	28 → 61	Tetratricopeptide repeat	Repeat
PF08321	PPP5	136 → 228	PPP5 TPR repeat region	Family
PF00149	Metallophos	235 → 431	Calcineurin-like phosphoesterase	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15546861}.

Sequence

MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPS
NAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYE
TVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVC
GDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLL
RGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDG
VTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNL
DYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP
HPNVKPMAYANTLLQLGMM

Sequence length

499

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway		Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthma	Associate	27501780
Breast Neoplasms	Associate	11331294
Carcinoma Hepatocellular	Associate	28453226
Carcinoma Renal Cell	Associate	29141220
Colitis Ulcerative	Associate	38302916
Colorectal Neoplasms	Associate	15004035
Glioma	Associate	25796168
Glucocorticoid Receptor Deficiency	Associate	27742828
Kidney Neoplasms	Associate	29141220
Lymphoma Mantle Cell	Associate	15650054
Neoplasms	Inhibit	11240142
Neoplasms	Associate	22298641, 28453226, 29141220, 30679389
Osteosarcoma	Associate	28090608
Pancreatic Neoplasms	Associate	33270085
Status Asthmaticus	Associate	27501780

PPP5C (protein phosphatase 5 catalytic subunit)