Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55356
Gene name	Solute carrier family 22 member 15
Gene symbol	SLC22A15
Synonyms (NCBI Gene)	FLIPT1PRO34686
Chromosome	1
Chromosome location	1p13.1
Summary	Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphil

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017359	hsa-miR-335-5p	Microarray	18185580
MIRT1354347	hsa-miR-1197	CLIP-seq
MIRT1354348	hsa-miR-128	CLIP-seq
MIRT1354349	hsa-miR-1297	CLIP-seq
MIRT1354350	hsa-miR-186	CLIP-seq
MIRT1354351	hsa-miR-1910	CLIP-seq
MIRT1354352	hsa-miR-21	CLIP-seq
MIRT1354353	hsa-miR-26a	CLIP-seq
MIRT1354354	hsa-miR-26b	CLIP-seq
MIRT1354355	hsa-miR-3133	CLIP-seq
MIRT1354356	hsa-miR-3180-5p	CLIP-seq
MIRT1354357	hsa-miR-380	CLIP-seq
MIRT1354358	hsa-miR-4260	CLIP-seq
MIRT1354359	hsa-miR-4272	CLIP-seq
MIRT1354360	hsa-miR-4283	CLIP-seq
MIRT1354361	hsa-miR-433	CLIP-seq
MIRT1354362	hsa-miR-4465	CLIP-seq
MIRT1354363	hsa-miR-4489	CLIP-seq
MIRT1354364	hsa-miR-455-3p	CLIP-seq
MIRT1354365	hsa-miR-4656	CLIP-seq
MIRT1354366	hsa-miR-4686	CLIP-seq
MIRT1354367	hsa-miR-4691-3p	CLIP-seq
MIRT1354368	hsa-miR-4698	CLIP-seq
MIRT1354369	hsa-miR-4710	CLIP-seq
MIRT1354370	hsa-miR-4744	CLIP-seq
MIRT1354371	hsa-miR-4755-3p	CLIP-seq
MIRT1354372	hsa-miR-4792	CLIP-seq
MIRT1354373	hsa-miR-520a-5p	CLIP-seq
MIRT1354374	hsa-miR-522	CLIP-seq
MIRT1354375	hsa-miR-525-5p	CLIP-seq
MIRT1354376	hsa-miR-539	CLIP-seq
MIRT1354377	hsa-miR-548ac	CLIP-seq
MIRT1354378	hsa-miR-548ae	CLIP-seq
MIRT1354379	hsa-miR-548aj	CLIP-seq
MIRT1354380	hsa-miR-548am	CLIP-seq
MIRT1354381	hsa-miR-548c-3p	CLIP-seq
MIRT1354382	hsa-miR-548d-3p	CLIP-seq
MIRT1354383	hsa-miR-548x	CLIP-seq
MIRT1354384	hsa-miR-548z	CLIP-seq
MIRT1354385	hsa-miR-590-3p	CLIP-seq
MIRT1354386	hsa-miR-590-5p	CLIP-seq
MIRT2104823	hsa-miR-3129-3p	CLIP-seq
MIRT1354361	hsa-miR-433	CLIP-seq
MIRT2104824	hsa-miR-4766-5p	CLIP-seq
MIRT2104825	hsa-miR-642b	CLIP-seq
MIRT2329457	hsa-miR-181a	CLIP-seq
MIRT2329458	hsa-miR-181b	CLIP-seq
MIRT2329459	hsa-miR-181c	CLIP-seq
MIRT2329460	hsa-miR-181d	CLIP-seq
MIRT2329461	hsa-miR-183	CLIP-seq
MIRT2329462	hsa-miR-337-3p	CLIP-seq
MIRT2329463	hsa-miR-4262	CLIP-seq
MIRT2329464	hsa-miR-4496	CLIP-seq
MIRT2329465	hsa-miR-4728-3p	CLIP-seq
MIRT2329466	hsa-miR-508-5p	CLIP-seq
MIRT2329467	hsa-miR-605	CLIP-seq
MIRT2433214	hsa-miR-1236	CLIP-seq
MIRT2433215	hsa-miR-125a-5p	CLIP-seq
MIRT2433216	hsa-miR-125b	CLIP-seq
MIRT2433217	hsa-miR-3183	CLIP-seq
MIRT2329462	hsa-miR-337-3p	CLIP-seq
MIRT2433218	hsa-miR-4287	CLIP-seq
MIRT2433219	hsa-miR-4319	CLIP-seq
MIRT2433220	hsa-miR-4469	CLIP-seq
MIRT2433221	hsa-miR-4685-3p	CLIP-seq
MIRT2433222	hsa-miR-4723-3p	CLIP-seq
MIRT2433223	hsa-miR-4732-3p	CLIP-seq
MIRT2433224	hsa-miR-4778-5p	CLIP-seq
MIRT2433225	hsa-miR-670	CLIP-seq
MIRT1354368	hsa-miR-4698	CLIP-seq
MIRT1354369	hsa-miR-4710	CLIP-seq
MIRT1354372	hsa-miR-4792	CLIP-seq
MIRT1354374	hsa-miR-522	CLIP-seq
MIRT1354376	hsa-miR-539	CLIP-seq
MIRT1354385	hsa-miR-590-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IDA	33124720
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006865	Process	Amino acid transport	IEA
GO:0015199	Function	Amino-acid betaine transmembrane transporter activity	IDA	33124720
GO:0015199	Function	Amino-acid betaine transmembrane transporter activity	IEA
GO:0015838	Process	Amino-acid betaine transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
608275	20301	ENSG00000163393

Q8IZD6

Protein name

Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)

Protein function

Organic zwitterion/cation transporter with apparent specificity for amino acids and their derivatives. Has low affinity for its substrates and may regulate their flux across the plasma membrane at high substrate concentrations (PubMed:33124720).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00083	Sugar_tr	59 → 494	Sugar (and other) transporter	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intes

Sequence

MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQS
HGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFS
GVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMS
LVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFL
LSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETGSFLDLFR
YRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQ
KWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYI
YTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLL
LPETLNSPLLETFSDLQVYSYRRLGEEALSLQALDPQQCVDKESSLGSESEEEEEFYDAD
EETQMIK

Sequence length

547

Interactions

View interactions

	Reactome
			Organic cation transport

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Glioma susceptibility 1	Uncertain significance	rs201564754	RCV005930903

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	34128989

SLC22A15 (solute carrier family 22 member 15)