STK32B (serine/threonine kinase 32B)

Gene

• Entrez ID: 55351
• Gene name: Serine/threonine kinase 32B
• Gene symbol: STK32B
• Synonyms (NCBI Gene): HSA250839, STK32, STKG6, YANK2
• Chromosome: 4
• Chromosome location: 4p16.2
• Summary: This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosoma

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1397684	hsa-miR-1231	CLIP-seq
MIRT1397685	hsa-miR-3127-5p	CLIP-seq
MIRT1397686	hsa-miR-3164	CLIP-seq
MIRT1397687	hsa-miR-3619-3p	CLIP-seq
MIRT1397688	hsa-miR-3671	CLIP-seq
MIRT1397689	hsa-miR-3918	CLIP-seq
MIRT1397690	hsa-miR-4288	CLIP-seq
MIRT1397691	hsa-miR-4477a	CLIP-seq
MIRT1397692	hsa-miR-4649-3p	CLIP-seq
MIRT1397693	hsa-miR-4738-3p	CLIP-seq
MIRT1397694	hsa-miR-4769-3p	CLIP-seq
MIRT1397695	hsa-miR-583	CLIP-seq
MIRT1397696	hsa-miR-607	CLIP-seq
MIRT1397697	hsa-miR-632	CLIP-seq
MIRT2119067	hsa-miR-1238	CLIP-seq
MIRT2119068	hsa-miR-1271	CLIP-seq
MIRT2119069	hsa-miR-1273d	CLIP-seq
MIRT2119070	hsa-miR-145	CLIP-seq
MIRT2119071	hsa-miR-182	CLIP-seq
MIRT2119072	hsa-miR-3140-5p	CLIP-seq
MIRT2119073	hsa-miR-4267	CLIP-seq
MIRT2119074	hsa-miR-4691-5p	CLIP-seq
MIRT2119075	hsa-miR-548an	CLIP-seq
MIRT2119076	hsa-miR-660	CLIP-seq
MIRT2119077	hsa-miR-665	CLIP-seq
MIRT2119078	hsa-miR-96	CLIP-seq
MIRT1397684	hsa-miR-1231	CLIP-seq
MIRT2341381	hsa-miR-1267	CLIP-seq
MIRT2341382	hsa-miR-15a	CLIP-seq
MIRT2341383	hsa-miR-15b	CLIP-seq
MIRT2341384	hsa-miR-16	CLIP-seq
MIRT2341385	hsa-miR-1910	CLIP-seq
MIRT2341386	hsa-miR-195	CLIP-seq
MIRT1397686	hsa-miR-3164	CLIP-seq
MIRT2341387	hsa-miR-424	CLIP-seq
MIRT1397690	hsa-miR-4288	CLIP-seq
MIRT2341388	hsa-miR-4468	CLIP-seq
MIRT1397692	hsa-miR-4649-3p	CLIP-seq
MIRT2341389	hsa-miR-497	CLIP-seq
MIRT2341390	hsa-miR-595	CLIP-seq
MIRT1397697	hsa-miR-632	CLIP-seq
MIRT2119077	hsa-miR-665	CLIP-seq
MIRT2460681	hsa-miR-186	CLIP-seq
MIRT2460682	hsa-miR-3133	CLIP-seq
MIRT2460683	hsa-miR-3144-5p	CLIP-seq
MIRT2460684	hsa-miR-3191	CLIP-seq
MIRT2460685	hsa-miR-4652-5p	CLIP-seq
MIRT2460686	hsa-miR-548t	CLIP-seq
MIRT2460681	hsa-miR-186	CLIP-seq
MIRT2460682	hsa-miR-3133	CLIP-seq
MIRT2460683	hsa-miR-3144-5p	CLIP-seq
MIRT2460684	hsa-miR-3191	CLIP-seq
MIRT2635385	hsa-miR-4323	CLIP-seq
MIRT2635386	hsa-miR-4520a-3p	CLIP-seq
MIRT2460685	hsa-miR-4652-5p	CLIP-seq
MIRT2635387	hsa-miR-4802-3p	CLIP-seq
MIRT2460686	hsa-miR-548t	CLIP-seq
MIRT2460681	hsa-miR-186	CLIP-seq
MIRT2460682	hsa-miR-3133	CLIP-seq
MIRT2460683	hsa-miR-3144-5p	CLIP-seq
MIRT2460684	hsa-miR-3191	CLIP-seq
MIRT2635385	hsa-miR-4323	CLIP-seq
MIRT2635386	hsa-miR-4520a-3p	CLIP-seq
MIRT2460685	hsa-miR-4652-5p	CLIP-seq
MIRT2635387	hsa-miR-4802-3p	CLIP-seq
MIRT2460686	hsa-miR-548t	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 621309
• HGNC: 14217
• e!Ensembl: ENSG00000152953

Protein

• UniProt ID: Q9NY57
• Protein name: Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	23 → 283	Protein kinase domain	Domain

• Sequence:

  MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCI
  ERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTE
  GTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSM
  AGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMF
  KVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGF
  VPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVRE
  EFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNLLTHTCTRGCSS

• Sequence length: 414

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Familial cancer of breast	Benign	rs11930847	RCV005913364
Long QT syndrome	Likely benign	rs796052163	RCV000190159

Associations from Text Mining
Disease Name	Relationship Type	References
Calcinosis Cutis	Associate	24885002
Carcinoma Hepatocellular	Associate	35800238
Cleft Lip	Associate	20087401
Cleft Palate	Associate	20087401
Coronary Artery Disease	Associate	21626137
Essential Tremor	Associate	27797806, 28801652
Essential Tremor	Inhibit	28801652
general anxiety disorder	Associate	29604450
Inflammation	Associate	24885002
Neoplasm Metastasis	Associate	24885002
Neoplasms	Associate	24885002