Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55349
Gene name	Choline dehydrogenase
Gene symbol	CHDH
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p21.1
Summary	The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016262	hsa-miR-193b-3p	Microarray	20304954
MIRT026237	hsa-miR-192-5p	Microarray	19074876
MIRT626439	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT626438	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT626437	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT626436	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT626435	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT626434	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT626433	hsa-miR-3135b	HITS-CLIP	23824327
MIRT626432	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT626431	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT626430	hsa-miR-3652	HITS-CLIP	23824327
MIRT626429	hsa-miR-4430	HITS-CLIP	23824327
MIRT626428	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT626427	hsa-miR-5698	HITS-CLIP	23824327
MIRT626439	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT626438	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT626437	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT626436	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT626435	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT626434	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT626433	hsa-miR-3135b	HITS-CLIP	23824327
MIRT626432	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT626431	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT626430	hsa-miR-3652	HITS-CLIP	23824327
MIRT626429	hsa-miR-4430	HITS-CLIP	23824327
MIRT626428	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT626427	hsa-miR-5698	HITS-CLIP	23824327
MIRT440948	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440948	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT626439	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT626438	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT626437	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT626436	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT626435	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT626434	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT626433	hsa-miR-3135b	HITS-CLIP	23824327
MIRT626432	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT626431	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT626430	hsa-miR-3652	HITS-CLIP	23824327
MIRT626429	hsa-miR-4430	HITS-CLIP	23824327
MIRT626428	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT626427	hsa-miR-5698	HITS-CLIP	23824327
MIRT626439	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT626438	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT626437	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT626436	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT626435	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT626434	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT626433	hsa-miR-3135b	HITS-CLIP	23824327
MIRT626432	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT626431	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT626430	hsa-miR-3652	HITS-CLIP	23824327
MIRT626429	hsa-miR-4430	HITS-CLIP	23824327
MIRT626428	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT626427	hsa-miR-5698	HITS-CLIP	23824327
MIRT889621	hsa-miR-106a	CLIP-seq
MIRT889622	hsa-miR-106b	CLIP-seq
MIRT889623	hsa-miR-1200	CLIP-seq
MIRT889624	hsa-miR-1202	CLIP-seq
MIRT889625	hsa-miR-122	CLIP-seq
MIRT889626	hsa-miR-1225-3p	CLIP-seq
MIRT889627	hsa-miR-1227	CLIP-seq
MIRT889628	hsa-miR-1233	CLIP-seq
MIRT889629	hsa-miR-1245	CLIP-seq
MIRT889630	hsa-miR-17	CLIP-seq
MIRT889631	hsa-miR-199a-3p	CLIP-seq
MIRT889632	hsa-miR-199b-3p	CLIP-seq
MIRT889633	hsa-miR-20a	CLIP-seq
MIRT889634	hsa-miR-20b	CLIP-seq
MIRT889635	hsa-miR-302a	CLIP-seq
MIRT889636	hsa-miR-302b	CLIP-seq
MIRT889637	hsa-miR-302c	CLIP-seq
MIRT889638	hsa-miR-302d	CLIP-seq
MIRT889639	hsa-miR-302e	CLIP-seq
MIRT889640	hsa-miR-3129-5p	CLIP-seq
MIRT889641	hsa-miR-3130-3p	CLIP-seq
MIRT889642	hsa-miR-3173-5p	CLIP-seq
MIRT889643	hsa-miR-3177-5p	CLIP-seq
MIRT889644	hsa-miR-3180-5p	CLIP-seq
MIRT889645	hsa-miR-3194-5p	CLIP-seq
MIRT889646	hsa-miR-3199	CLIP-seq
MIRT889647	hsa-miR-3545-3p	CLIP-seq
MIRT889648	hsa-miR-3650	CLIP-seq
MIRT889649	hsa-miR-3670	CLIP-seq
MIRT889650	hsa-miR-372	CLIP-seq
MIRT889651	hsa-miR-373	CLIP-seq
MIRT889652	hsa-miR-3929	CLIP-seq
MIRT889653	hsa-miR-3934	CLIP-seq
MIRT889654	hsa-miR-3972	CLIP-seq
MIRT889655	hsa-miR-3977	CLIP-seq
MIRT889656	hsa-miR-4276	CLIP-seq
MIRT889657	hsa-miR-4324	CLIP-seq
MIRT889658	hsa-miR-4419b	CLIP-seq
MIRT889659	hsa-miR-4478	CLIP-seq
MIRT889660	hsa-miR-4539	CLIP-seq
MIRT889661	hsa-miR-455-5p	CLIP-seq
MIRT889662	hsa-miR-4635	CLIP-seq
MIRT889663	hsa-miR-4680-5p	CLIP-seq
MIRT889664	hsa-miR-4690-3p	CLIP-seq
MIRT889665	hsa-miR-4731-5p	CLIP-seq
MIRT889666	hsa-miR-5095	CLIP-seq
MIRT889667	hsa-miR-512-3p	CLIP-seq
MIRT889668	hsa-miR-519d	CLIP-seq
MIRT889669	hsa-miR-520a-3p	CLIP-seq
MIRT889670	hsa-miR-520a-5p	CLIP-seq
MIRT889671	hsa-miR-520b	CLIP-seq
MIRT889672	hsa-miR-520c-3p	CLIP-seq
MIRT889673	hsa-miR-520d-3p	CLIP-seq
MIRT889674	hsa-miR-520e	CLIP-seq
MIRT889675	hsa-miR-520g	CLIP-seq
MIRT889676	hsa-miR-520h	CLIP-seq
MIRT889677	hsa-miR-525-5p	CLIP-seq
MIRT889678	hsa-miR-544b	CLIP-seq
MIRT889679	hsa-miR-552	CLIP-seq
MIRT889680	hsa-miR-93	CLIP-seq
MIRT889681	hsa-miR-936	CLIP-seq
MIRT889625	hsa-miR-122	CLIP-seq
MIRT889625	hsa-miR-122	CLIP-seq
MIRT1963623	hsa-miR-1276	CLIP-seq
MIRT2199982	hsa-miR-10a	CLIP-seq
MIRT2199983	hsa-miR-10b	CLIP-seq
MIRT889625	hsa-miR-122	CLIP-seq
MIRT2199984	hsa-miR-150	CLIP-seq
MIRT889631	hsa-miR-199a-3p	CLIP-seq
MIRT889632	hsa-miR-199b-3p	CLIP-seq
MIRT2199985	hsa-miR-22	CLIP-seq
MIRT2199986	hsa-miR-24	CLIP-seq
MIRT889640	hsa-miR-3129-5p	CLIP-seq
MIRT889643	hsa-miR-3177-5p	CLIP-seq
MIRT889646	hsa-miR-3199	CLIP-seq
MIRT889647	hsa-miR-3545-3p	CLIP-seq
MIRT2199987	hsa-miR-3620	CLIP-seq
MIRT889648	hsa-miR-3650	CLIP-seq
MIRT2199988	hsa-miR-3663-5p	CLIP-seq
MIRT889653	hsa-miR-3934	CLIP-seq
MIRT2199989	hsa-miR-3944-3p	CLIP-seq
MIRT889655	hsa-miR-3977	CLIP-seq
MIRT2199990	hsa-miR-4258	CLIP-seq
MIRT2199991	hsa-miR-4284	CLIP-seq
MIRT2199992	hsa-miR-4423-5p	CLIP-seq
MIRT889662	hsa-miR-4635	CLIP-seq
MIRT889663	hsa-miR-4680-5p	CLIP-seq
MIRT2199993	hsa-miR-4712-3p	CLIP-seq
MIRT889665	hsa-miR-4731-5p	CLIP-seq
MIRT2199994	hsa-miR-4781-3p	CLIP-seq
MIRT889679	hsa-miR-552	CLIP-seq
MIRT2199995	hsa-miR-562	CLIP-seq
MIRT2199996	hsa-miR-624	CLIP-seq
MIRT889681	hsa-miR-936	CLIP-seq
MIRT2386007	hsa-miR-3130-5p	CLIP-seq
MIRT2386008	hsa-miR-4330	CLIP-seq
MIRT2386009	hsa-miR-4482	CLIP-seq
MIRT2386010	hsa-miR-759	CLIP-seq
MIRT889625	hsa-miR-122	CLIP-seq
MIRT889643	hsa-miR-3177-5p	CLIP-seq
MIRT889646	hsa-miR-3199	CLIP-seq
MIRT2502779	hsa-miR-3606	CLIP-seq
MIRT889648	hsa-miR-3650	CLIP-seq
MIRT889653	hsa-miR-3934	CLIP-seq
MIRT2502780	hsa-miR-4786-3p	CLIP-seq
MIRT2502781	hsa-miR-548aa	CLIP-seq
MIRT889679	hsa-miR-552	CLIP-seq
MIRT2502782	hsa-miR-9	CLIP-seq
MIRT889643	hsa-miR-3177-5p	CLIP-seq
MIRT889648	hsa-miR-3650	CLIP-seq
MIRT889653	hsa-miR-3934	CLIP-seq
MIRT889679	hsa-miR-552	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0008812	Function	Choline dehydrogenase activity	IBA
GO:0008812	Function	Choline dehydrogenase activity	IEA
GO:0008812	Function	Choline dehydrogenase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016614	Function	Oxidoreductase activity, acting on CH-OH group of donors	IEA
GO:0019285	Process	Glycine betaine biosynthetic process from choline	IEA
GO:0042426	Process	Choline catabolic process	TAS
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8NE62

Protein name

Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00732	GMC_oxred_N	41 → 339	GMC oxidoreductase	Domain
PF05199	GMC_oxred_C	429 → 567	GMC oxidoreductase	Domain

Sequence

MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGSAGCVLAGRLT
EDPAERVLLLEAGPKDVLAGSKRLSWKIHMPAALVANLCDDRYNWCYHTEVQRGLDGRVL
YWPRGRVWGGSSSLNAMVYVRGHAEDYERWQRQGARGWDYAHCLPYFRKAQGHELGASRY
RGADGPLRVSRGKTNHPLHCAFLEATQQAGYPLTEDMNGFQQEGFGWMDMTIHEGKRWSA
ACAYLHPALSRTNLKAEAETLVSRVLFEGTRAVGVEYVKNGQSHRAYASKEVILSGGAIN
SPQLLMLSGIGNADDLKKLGIPVVCHLPGVGQNLQDHLEIYIQQACTRPITLHSAQKPLR
KVCIGLEWLWKFTGEGATAHLETGGFIRSQPGVPHPDIQFHFLPSQVIDHGRVPTQQEAY
QVHVGPMRGTSVGWLKLRSANPQDHPVIQPNYLSTETDIEDFRLCVKLTREIFAQEALAP
FRGKELQPGSHIQSDKEIDAFVRAKADSAYHPSCTCKMGQPSDPTAVVDPQTRVLGVENL
RVVDASIMPSMVSGNLNAPTIMIAEKAADIIKGQPALWDKDVPVYKPRTLATQR

Sequence length

594

Interactions

View interactions

	KEGG		Reactome
	Glycine, serine and threonine metabolism One carbon pool by folate Metabolic pathways		Choline catabolism

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Benign	rs115218486	RCV005913358

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Androgen Insensitivity Syndrome	Associate	35732329
Breast Neoplasms	Associate	18230680
Carcinoma Embryonal	Associate	8679447
Carcinoma Squamous Cell	Associate	16917549
Choline Deficiency	Associate	16816108
Esophageal Neoplasms	Associate	36588458
Fibrocartilaginous embolism	Associate	39953636
Gastrointestinal Stromal Tumors	Associate	24133624
Intervertebral Disc Degeneration	Associate	39953636
Multiple Organ Failure	Associate	16816108
Neoplasms	Associate	33204327, 33249526
Pancreatic Neoplasms	Associate	29474406
Squamous Cell Carcinoma of Head and Neck	Associate	33456371
Stomach Neoplasms	Associate	28169308, 35036435, 37608794
Tertiary Lymphoid Structures	Associate	33204327

CHDH (choline dehydrogenase)