ABHD10 (abhydrolase domain containing 10, depalmitoylase)

Gene

• Entrez ID: 55347
• Gene name: Abhydrolase domain containing 10, depalmitoylase
• Gene symbol: ABHD10
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q13.2
• Summary: This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing result

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001482	hsa-miR-16-5p	pSILAC	18668040
MIRT001482	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT661009	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT661007	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT661006	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT661005	hsa-miR-6884-3p	HITS-CLIP	23824327
MIRT661004	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT661003	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT661001	hsa-miR-3671	HITS-CLIP	23824327
MIRT661002	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT661000	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT660998	hsa-miR-607	HITS-CLIP	23824327
MIRT660999	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT661009	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT661007	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT661006	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT661005	hsa-miR-6884-3p	HITS-CLIP	23824327
MIRT661004	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT661003	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT661001	hsa-miR-3671	HITS-CLIP	23824327
MIRT661002	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT661000	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT660998	hsa-miR-607	HITS-CLIP	23824327
MIRT660999	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT759355	hsa-miR-1207-3p	CLIP-seq
MIRT759356	hsa-miR-1237	CLIP-seq
MIRT759357	hsa-miR-1248	CLIP-seq
MIRT759358	hsa-miR-1252	CLIP-seq
MIRT759359	hsa-miR-1296	CLIP-seq
MIRT759360	hsa-miR-130a	CLIP-seq
MIRT759361	hsa-miR-130b	CLIP-seq
MIRT759362	hsa-miR-141	CLIP-seq
MIRT759363	hsa-miR-200a	CLIP-seq
MIRT759364	hsa-miR-200b	CLIP-seq
MIRT759365	hsa-miR-200c	CLIP-seq
MIRT759366	hsa-miR-2861	CLIP-seq
MIRT759367	hsa-miR-2909	CLIP-seq
MIRT759368	hsa-miR-301a	CLIP-seq
MIRT759369	hsa-miR-301b	CLIP-seq
MIRT759370	hsa-miR-302a	CLIP-seq
MIRT759371	hsa-miR-302b	CLIP-seq
MIRT759372	hsa-miR-302c	CLIP-seq
MIRT759373	hsa-miR-302d	CLIP-seq
MIRT759374	hsa-miR-302e	CLIP-seq
MIRT759375	hsa-miR-3120-3p	CLIP-seq
MIRT759376	hsa-miR-3130-3p	CLIP-seq
MIRT759377	hsa-miR-3148	CLIP-seq
MIRT759378	hsa-miR-3163	CLIP-seq
MIRT759379	hsa-miR-3180-5p	CLIP-seq
MIRT759380	hsa-miR-3192	CLIP-seq
MIRT759381	hsa-miR-33a	CLIP-seq
MIRT759382	hsa-miR-33b	CLIP-seq
MIRT759383	hsa-miR-342-5p	CLIP-seq
MIRT759384	hsa-miR-3665	CLIP-seq
MIRT759385	hsa-miR-3666	CLIP-seq
MIRT759386	hsa-miR-369-3p	CLIP-seq
MIRT759387	hsa-miR-372	CLIP-seq
MIRT759388	hsa-miR-373	CLIP-seq
MIRT759389	hsa-miR-3934	CLIP-seq
MIRT759390	hsa-miR-412	CLIP-seq
MIRT759391	hsa-miR-4263	CLIP-seq
MIRT759392	hsa-miR-429	CLIP-seq
MIRT759393	hsa-miR-4295	CLIP-seq
MIRT759394	hsa-miR-4300	CLIP-seq
MIRT759395	hsa-miR-4436b-3p	CLIP-seq
MIRT759396	hsa-miR-4487	CLIP-seq
MIRT759397	hsa-miR-4521	CLIP-seq
MIRT759398	hsa-miR-454	CLIP-seq
MIRT759399	hsa-miR-4643	CLIP-seq
MIRT759400	hsa-miR-4651	CLIP-seq
MIRT759401	hsa-miR-4664-5p	CLIP-seq
MIRT759402	hsa-miR-4717-3p	CLIP-seq
MIRT759403	hsa-miR-4719	CLIP-seq
MIRT759404	hsa-miR-4761-3p	CLIP-seq
MIRT759405	hsa-miR-4778-3p	CLIP-seq
MIRT759406	hsa-miR-4793-3p	CLIP-seq
MIRT759407	hsa-miR-4799-5p	CLIP-seq
MIRT759408	hsa-miR-491-3p	CLIP-seq
MIRT759409	hsa-miR-499-3p	CLIP-seq
MIRT759410	hsa-miR-499a-3p	CLIP-seq
MIRT759411	hsa-miR-513b	CLIP-seq
MIRT759412	hsa-miR-519a	CLIP-seq
MIRT759413	hsa-miR-519b-3p	CLIP-seq
MIRT759414	hsa-miR-519c-3p	CLIP-seq
MIRT759415	hsa-miR-520a-3p	CLIP-seq
MIRT759416	hsa-miR-520a-5p	CLIP-seq
MIRT759417	hsa-miR-520b	CLIP-seq
MIRT759418	hsa-miR-520c-3p	CLIP-seq
MIRT759419	hsa-miR-520d-3p	CLIP-seq
MIRT759420	hsa-miR-520e	CLIP-seq
MIRT759421	hsa-miR-525-5p	CLIP-seq
MIRT759422	hsa-miR-544	CLIP-seq
MIRT759423	hsa-miR-545	CLIP-seq
MIRT759424	hsa-miR-562	CLIP-seq
MIRT759425	hsa-miR-576-5p	CLIP-seq
MIRT759426	hsa-miR-590-3p	CLIP-seq
MIRT759427	hsa-miR-608	CLIP-seq
MIRT759428	hsa-miR-642b	CLIP-seq
MIRT759429	hsa-miR-646	CLIP-seq
MIRT759430	hsa-miR-920	CLIP-seq
MIRT1923812	hsa-miR-1178	CLIP-seq
MIRT1923813	hsa-miR-1254	CLIP-seq
MIRT1923814	hsa-miR-1299	CLIP-seq
MIRT1923815	hsa-miR-3116	CLIP-seq
MIRT1923816	hsa-miR-3182	CLIP-seq
MIRT1923817	hsa-miR-323-3p	CLIP-seq
MIRT1923818	hsa-miR-3691-3p	CLIP-seq
MIRT1923819	hsa-miR-410	CLIP-seq
MIRT1923820	hsa-miR-4782-5p	CLIP-seq
MIRT1923821	hsa-miR-4803	CLIP-seq
MIRT1923822	hsa-miR-488	CLIP-seq
MIRT1923823	hsa-miR-516b	CLIP-seq
MIRT1923824	hsa-miR-556-3p	CLIP-seq
MIRT737956	hsa-miR-582-5p	CLIP-seq
MIRT1923825	hsa-miR-661	CLIP-seq
MIRT1923826	hsa-miR-767-3p	CLIP-seq
MIRT759355	hsa-miR-1207-3p	CLIP-seq
MIRT2165288	hsa-miR-1236	CLIP-seq
MIRT759356	hsa-miR-1237	CLIP-seq
MIRT759357	hsa-miR-1248	CLIP-seq
MIRT759358	hsa-miR-1252	CLIP-seq
MIRT2165289	hsa-miR-1255a	CLIP-seq
MIRT2165290	hsa-miR-1255b	CLIP-seq
MIRT2165291	hsa-miR-1264	CLIP-seq
MIRT1923814	hsa-miR-1299	CLIP-seq
MIRT2165292	hsa-miR-1303	CLIP-seq
MIRT759362	hsa-miR-141	CLIP-seq
MIRT2165293	hsa-miR-150	CLIP-seq
MIRT2165294	hsa-miR-188-5p	CLIP-seq
MIRT2165295	hsa-miR-194	CLIP-seq
MIRT759363	hsa-miR-200a	CLIP-seq
MIRT2165296	hsa-miR-3135	CLIP-seq
MIRT2165297	hsa-miR-3165	CLIP-seq
MIRT1923816	hsa-miR-3182	CLIP-seq
MIRT2165298	hsa-miR-3190	CLIP-seq
MIRT759380	hsa-miR-3192	CLIP-seq
MIRT1923817	hsa-miR-323-3p	CLIP-seq
MIRT759381	hsa-miR-33a	CLIP-seq
MIRT759382	hsa-miR-33b	CLIP-seq
MIRT2165299	hsa-miR-34b	CLIP-seq
MIRT2165300	hsa-miR-3605-5p	CLIP-seq
MIRT2165301	hsa-miR-3614-5p	CLIP-seq
MIRT2165302	hsa-miR-3647-3p	CLIP-seq
MIRT759384	hsa-miR-3665	CLIP-seq
MIRT2165303	hsa-miR-3688-5p	CLIP-seq
MIRT2165304	hsa-miR-383	CLIP-seq
MIRT759389	hsa-miR-3934	CLIP-seq
MIRT2165305	hsa-miR-3943	CLIP-seq
MIRT759390	hsa-miR-412	CLIP-seq
MIRT759391	hsa-miR-4263	CLIP-seq
MIRT2165306	hsa-miR-4277	CLIP-seq
MIRT2165307	hsa-miR-4282	CLIP-seq
MIRT2165308	hsa-miR-4313	CLIP-seq
MIRT2165309	hsa-miR-4314	CLIP-seq
MIRT2165310	hsa-miR-4433	CLIP-seq
MIRT2165311	hsa-miR-4459	CLIP-seq
MIRT2165312	hsa-miR-4646-5p	CLIP-seq
MIRT2165313	hsa-miR-4705	CLIP-seq
MIRT2165314	hsa-miR-4713-5p	CLIP-seq
MIRT737955	hsa-miR-4760-5p	CLIP-seq
MIRT2165315	hsa-miR-4768-3p	CLIP-seq
MIRT2165316	hsa-miR-4772-5p	CLIP-seq
MIRT2165317	hsa-miR-4774-3p	CLIP-seq
MIRT759405	hsa-miR-4778-3p	CLIP-seq
MIRT1923820	hsa-miR-4782-5p	CLIP-seq
MIRT2165318	hsa-miR-4785	CLIP-seq
MIRT2165319	hsa-miR-4790-3p	CLIP-seq
MIRT759407	hsa-miR-4799-5p	CLIP-seq
MIRT1923821	hsa-miR-4803	CLIP-seq
MIRT2165320	hsa-miR-494	CLIP-seq
MIRT2165321	hsa-miR-505	CLIP-seq
MIRT759411	hsa-miR-513b	CLIP-seq
MIRT1923823	hsa-miR-516b	CLIP-seq
MIRT2165322	hsa-miR-532-3p	CLIP-seq
MIRT2165323	hsa-miR-548a-5p	CLIP-seq
MIRT2165324	hsa-miR-548ab	CLIP-seq
MIRT2165325	hsa-miR-548ak	CLIP-seq
MIRT2165326	hsa-miR-548b-5p	CLIP-seq
MIRT2165327	hsa-miR-548c-5p	CLIP-seq
MIRT2165328	hsa-miR-548d-5p	CLIP-seq
MIRT2165329	hsa-miR-548h	CLIP-seq
MIRT2165330	hsa-miR-548i	CLIP-seq
MIRT2165331	hsa-miR-548j	CLIP-seq
MIRT2165332	hsa-miR-548k	CLIP-seq
MIRT2165333	hsa-miR-548l	CLIP-seq
MIRT2165334	hsa-miR-548m	CLIP-seq
MIRT2165335	hsa-miR-548w	CLIP-seq
MIRT2165336	hsa-miR-548y	CLIP-seq
MIRT2165337	hsa-miR-556-5p	CLIP-seq
MIRT2165338	hsa-miR-559	CLIP-seq
MIRT759425	hsa-miR-576-5p	CLIP-seq
MIRT2165339	hsa-miR-579	CLIP-seq
MIRT737956	hsa-miR-582-5p	CLIP-seq
MIRT759426	hsa-miR-590-3p	CLIP-seq
MIRT2165340	hsa-miR-642a	CLIP-seq
MIRT759429	hsa-miR-646	CLIP-seq
MIRT2165341	hsa-miR-671-5p	CLIP-seq
MIRT2165288	hsa-miR-1236	CLIP-seq
MIRT1923814	hsa-miR-1299	CLIP-seq
MIRT759362	hsa-miR-141	CLIP-seq
MIRT2165294	hsa-miR-188-5p	CLIP-seq
MIRT759363	hsa-miR-200a	CLIP-seq
MIRT759375	hsa-miR-3120-3p	CLIP-seq
MIRT759376	hsa-miR-3130-3p	CLIP-seq
MIRT1923816	hsa-miR-3182	CLIP-seq
MIRT1923817	hsa-miR-323-3p	CLIP-seq
MIRT1923820	hsa-miR-4782-5p	CLIP-seq
MIRT759406	hsa-miR-4793-3p	CLIP-seq
MIRT1923823	hsa-miR-516b	CLIP-seq
MIRT759422	hsa-miR-544	CLIP-seq
MIRT2165340	hsa-miR-642a	CLIP-seq
MIRT759358	hsa-miR-1252	CLIP-seq
MIRT2467350	hsa-miR-3145-5p	CLIP-seq
MIRT2165297	hsa-miR-3165	CLIP-seq
MIRT759379	hsa-miR-3180-5p	CLIP-seq
MIRT2165298	hsa-miR-3190	CLIP-seq
MIRT759380	hsa-miR-3192	CLIP-seq
MIRT759384	hsa-miR-3665	CLIP-seq
MIRT2165304	hsa-miR-383	CLIP-seq
MIRT759389	hsa-miR-3934	CLIP-seq
MIRT2165305	hsa-miR-3943	CLIP-seq
MIRT2165306	hsa-miR-4277	CLIP-seq
MIRT2165308	hsa-miR-4313	CLIP-seq
MIRT2165309	hsa-miR-4314	CLIP-seq
MIRT2165310	hsa-miR-4433	CLIP-seq
MIRT2165311	hsa-miR-4459	CLIP-seq
MIRT2467351	hsa-miR-4539	CLIP-seq
MIRT2165312	hsa-miR-4646-5p	CLIP-seq
MIRT2467352	hsa-miR-4680-5p	CLIP-seq
MIRT737955	hsa-miR-4760-5p	CLIP-seq
MIRT2165315	hsa-miR-4768-3p	CLIP-seq
MIRT2165316	hsa-miR-4772-5p	CLIP-seq
MIRT2165319	hsa-miR-4790-3p	CLIP-seq
MIRT759416	hsa-miR-520a-5p	CLIP-seq
MIRT759421	hsa-miR-525-5p	CLIP-seq
MIRT737956	hsa-miR-582-5p	CLIP-seq
MIRT2165341	hsa-miR-671-5p	CLIP-seq
MIRT759358	hsa-miR-1252	CLIP-seq
MIRT2467350	hsa-miR-3145-5p	CLIP-seq
MIRT2165297	hsa-miR-3165	CLIP-seq
MIRT759379	hsa-miR-3180-5p	CLIP-seq
MIRT2165298	hsa-miR-3190	CLIP-seq
MIRT759380	hsa-miR-3192	CLIP-seq
MIRT759384	hsa-miR-3665	CLIP-seq
MIRT2165304	hsa-miR-383	CLIP-seq
MIRT759389	hsa-miR-3934	CLIP-seq
MIRT2165305	hsa-miR-3943	CLIP-seq
MIRT2165306	hsa-miR-4277	CLIP-seq
MIRT2165308	hsa-miR-4313	CLIP-seq
MIRT2165309	hsa-miR-4314	CLIP-seq
MIRT2165310	hsa-miR-4433	CLIP-seq
MIRT2165311	hsa-miR-4459	CLIP-seq
MIRT2467351	hsa-miR-4539	CLIP-seq
MIRT2165312	hsa-miR-4646-5p	CLIP-seq
MIRT2467352	hsa-miR-4680-5p	CLIP-seq
MIRT737955	hsa-miR-4760-5p	CLIP-seq
MIRT2165315	hsa-miR-4768-3p	CLIP-seq
MIRT2165316	hsa-miR-4772-5p	CLIP-seq
MIRT2165319	hsa-miR-4790-3p	CLIP-seq
MIRT759416	hsa-miR-520a-5p	CLIP-seq
MIRT759421	hsa-miR-525-5p	CLIP-seq
MIRT737956	hsa-miR-582-5p	CLIP-seq
MIRT2165341	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002084	Process	Protein depalmitoylation	IDA	31740833
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IBA
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IDA	22294686
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	TAS
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	31740833
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	IDA	22294686
GO:0006805	Process	Xenobiotic metabolic process	IDA	22294686
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IBA
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IDA	31740833
GO:0008474	Function	Palmitoyl-(protein) hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0102390	Function	Mycophenolic acid acyl-glucuronide esterase activity	IEA

Other IDs

• MIM: 618756
• HGNC: 25656
• e!Ensembl: ENSG00000144827

Protein

• UniProt ID: Q9NUJ1
• Protein name: Palmitoyl-protein thioesterase ABHD10, mitochondrial (EC 3.1.2.22) (Acyl-protein thioesterase ABHD10) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10) (Mycophenolic acid acyl-glucuronide esterase, mitochondria
• Protein function: Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins (PubMed:31740833). Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00561	Abhydrolase_1	76 → 197	alpha/beta hydrolase fold	Domain

• Sequence:

  MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPRWLPACRQKTSLSFLNR
  PDLPNLAYKKLKGKSPGIIFIPGYLSYMNGTKALAIEEFCKSLGHACIRFDYSGVGSSDG
  NSEESTLGKWRKDVLSIIDDLADGPQILVGSSLGGWLMLHAAIARPEKVVALIGVATAAD
  TLVTKFNQLPVELKKEVEMKGVWSMPSKYSEEGVYNVQYSFIKEAEHHCLLHSPIPVNCP
  IRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKHSDHRMREKADIQLLVYTIDDLIDK
  LSTIVN

• Sequence length: 306

Pathways

Reactome:

Glucuronidation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations