Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5534
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 3 regulatory subunit B, alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPP3R1
Synonyms (NCBI Gene) Gene synonyms aliases
CALNB1, CNB, CNB1
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p14
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005180 hsa-miR-30a-5p pSILAC 18668040
MIRT025005 hsa-miR-183-5p Sequencing 20371350
MIRT025426 hsa-miR-34a-5p Sequencing 20371350
MIRT005180 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT029303 hsa-miR-26b-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004723 Function Calcium-dependent protein serine/threonine phosphatase activity NAS 2558868
GO:0005509 Function Calcium ion binding NAS 2558868
GO:0005515 Function Protein binding IPI 8524402, 12218175, 12357034, 12809556, 16648474, 19896943, 22343722, 23468591, 24954618, 25416956, 26871637, 28514442, 32296183, 32814053
GO:0005516 Function Calmodulin binding NAS 2558868
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601302 9317 ENSG00000221823
Protein
UniProt ID P63098
Protein name Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Protein function Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
PDB 1AUI , 1M63 , 1MF8 , 2P6B , 3LL8 , 4F0Z , 4OR9 , 4ORA , 4ORC , 5SVE , 6NUC , 6NUF , 6NUU , 7U0T , 9B9G , 9CHU , 9CHV , 9CHX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13499 EF-hand_7 20 80 EF-hand domain pair Domain
PF13499 EF-hand_7 89 158 EF-hand domain pair Domain
PF00036 EF-hand_1 132 160 EF hand Domain
Sequence
Sequence length 170
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Cellular senescence
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
C-type lectin receptor signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Alzheimer disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Tuberculosis
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis
  Activation of BAD and translocation to mitochondria
Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CLEC7A (Dectin-1) induces NFAT activation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Left ventricular hypertrophy Left Ventricular Hypertrophy rs397516037 18344631
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
28991256, 12851458
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 23727081, 31745181, 36569892
Atrial Fibrillation Associate 34198460
Cardiomyopathy Dilated Associate 15012912
Cardiomyopathy Hypertrophic Familial Associate 31754133
Dementia Associate 23727081
Hearing Loss Associate 37595341
Hypertension Associate 31754133
Lymphatic Metastasis Associate 33912138
Mitral Valve Insufficiency Inhibit 27907007
Neoplasms Second Primary Stimulate 25807342