DRAM1 (DNA damage regulated autophagy modulator 1)

Gene

• Entrez ID: 55332
• Gene name: DNA damage regulated autophagy modulator 1
• Gene symbol: DRAM1
• Synonyms (NCBI Gene): DRAM
• Chromosome: 12
• Chromosome location: 12q23.2
• Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004906	hsa-miR-124-3p	Microarray	15685193
MIRT437763	hsa-miR-199a-5p	Luciferase reporter assay, Western blot	23337876
MIRT437763	hsa-miR-199a-5p	Luciferase reporter assay, Western blot	23337876
MIRT231560	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT231561	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT231563	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT231565	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT945200	hsa-miR-1182	CLIP-seq
MIRT945201	hsa-miR-1202	CLIP-seq
MIRT945202	hsa-miR-1267	CLIP-seq
MIRT945203	hsa-miR-1299	CLIP-seq
MIRT945204	hsa-miR-137	CLIP-seq
MIRT945205	hsa-miR-139-5p	CLIP-seq
MIRT945206	hsa-miR-140-3p	CLIP-seq
MIRT945207	hsa-miR-145	CLIP-seq
MIRT945208	hsa-miR-15a	CLIP-seq
MIRT945209	hsa-miR-15b	CLIP-seq
MIRT945210	hsa-miR-16	CLIP-seq
MIRT945211	hsa-miR-1825	CLIP-seq
MIRT945212	hsa-miR-1827	CLIP-seq
MIRT945213	hsa-miR-195	CLIP-seq
MIRT945214	hsa-miR-199b-5p	CLIP-seq
MIRT945215	hsa-miR-2467-3p	CLIP-seq
MIRT945216	hsa-miR-3152-5p	CLIP-seq
MIRT945217	hsa-miR-3174	CLIP-seq
MIRT945218	hsa-miR-3194-5p	CLIP-seq
MIRT945219	hsa-miR-3612	CLIP-seq
MIRT945220	hsa-miR-3616-3p	CLIP-seq
MIRT945221	hsa-miR-3622b-5p	CLIP-seq
MIRT945222	hsa-miR-3664-5p	CLIP-seq
MIRT945223	hsa-miR-3678-3p	CLIP-seq
MIRT945224	hsa-miR-3934	CLIP-seq
MIRT945225	hsa-miR-3972	CLIP-seq
MIRT945226	hsa-miR-424	CLIP-seq
MIRT945227	hsa-miR-4276	CLIP-seq
MIRT945228	hsa-miR-4277	CLIP-seq
MIRT945229	hsa-miR-4317	CLIP-seq
MIRT945230	hsa-miR-4423-5p	CLIP-seq
MIRT945231	hsa-miR-4446-3p	CLIP-seq
MIRT945232	hsa-miR-4463	CLIP-seq
MIRT945233	hsa-miR-4494	CLIP-seq
MIRT945234	hsa-miR-451b	CLIP-seq
MIRT945235	hsa-miR-4524	CLIP-seq
MIRT945236	hsa-miR-455-5p	CLIP-seq
MIRT945237	hsa-miR-4639-3p	CLIP-seq
MIRT945238	hsa-miR-4642	CLIP-seq
MIRT945239	hsa-miR-4656	CLIP-seq
MIRT945240	hsa-miR-4721	CLIP-seq
MIRT945241	hsa-miR-4774-3p	CLIP-seq
MIRT945242	hsa-miR-4778-3p	CLIP-seq
MIRT945243	hsa-miR-4780	CLIP-seq
MIRT945244	hsa-miR-496	CLIP-seq
MIRT945245	hsa-miR-497	CLIP-seq
MIRT945246	hsa-miR-503	CLIP-seq
MIRT945247	hsa-miR-511	CLIP-seq
MIRT945248	hsa-miR-552	CLIP-seq
MIRT945249	hsa-miR-616	CLIP-seq
MIRT945250	hsa-miR-624	CLIP-seq
MIRT945251	hsa-miR-646	CLIP-seq
MIRT945252	hsa-miR-650	CLIP-seq
MIRT945253	hsa-miR-875-3p	CLIP-seq
MIRT945254	hsa-miR-938	CLIP-seq
MIRT945200	hsa-miR-1182	CLIP-seq
MIRT1979836	hsa-miR-1206	CLIP-seq
MIRT945202	hsa-miR-1267	CLIP-seq
MIRT1979837	hsa-miR-1273f	CLIP-seq
MIRT1979838	hsa-miR-1298	CLIP-seq
MIRT1979839	hsa-miR-205	CLIP-seq
MIRT1979840	hsa-miR-3065-5p	CLIP-seq
MIRT1979841	hsa-miR-3117-3p	CLIP-seq
MIRT1979842	hsa-miR-3149	CLIP-seq
MIRT1979843	hsa-miR-3169	CLIP-seq
MIRT1979844	hsa-miR-3613-5p	CLIP-seq
MIRT1979845	hsa-miR-3614-5p	CLIP-seq
MIRT945222	hsa-miR-3664-5p	CLIP-seq
MIRT1979846	hsa-miR-3672	CLIP-seq
MIRT1979847	hsa-miR-3674	CLIP-seq
MIRT1979848	hsa-miR-3680	CLIP-seq
MIRT1979849	hsa-miR-375	CLIP-seq
MIRT1979850	hsa-miR-4269	CLIP-seq
MIRT945230	hsa-miR-4423-5p	CLIP-seq
MIRT945232	hsa-miR-4463	CLIP-seq
MIRT945233	hsa-miR-4494	CLIP-seq
MIRT945237	hsa-miR-4639-3p	CLIP-seq
MIRT1979851	hsa-miR-4732-5p	CLIP-seq
MIRT1979852	hsa-miR-4735-5p	CLIP-seq
MIRT1979853	hsa-miR-4759	CLIP-seq
MIRT1979854	hsa-miR-4775	CLIP-seq
MIRT1979855	hsa-miR-4798-3p	CLIP-seq
MIRT1979856	hsa-miR-579	CLIP-seq
MIRT1979857	hsa-miR-586	CLIP-seq
MIRT1979858	hsa-miR-590-3p	CLIP-seq
MIRT1979859	hsa-miR-664	CLIP-seq
MIRT945200	hsa-miR-1182	CLIP-seq
MIRT2215029	hsa-miR-125a-3p	CLIP-seq
MIRT2215030	hsa-miR-1343	CLIP-seq
MIRT2215031	hsa-miR-150	CLIP-seq
MIRT2215032	hsa-miR-181a	CLIP-seq
MIRT2215033	hsa-miR-181b	CLIP-seq
MIRT2215034	hsa-miR-181c	CLIP-seq
MIRT2215035	hsa-miR-181d	CLIP-seq
MIRT2215036	hsa-miR-24	CLIP-seq
MIRT945222	hsa-miR-3664-5p	CLIP-seq
MIRT1979846	hsa-miR-3672	CLIP-seq
MIRT2215037	hsa-miR-3683	CLIP-seq
MIRT2215038	hsa-miR-378g	CLIP-seq
MIRT945224	hsa-miR-3934	CLIP-seq
MIRT2215039	hsa-miR-4262	CLIP-seq
MIRT2215040	hsa-miR-4420	CLIP-seq
MIRT2215041	hsa-miR-4437	CLIP-seq
MIRT945233	hsa-miR-4494	CLIP-seq
MIRT2215042	hsa-miR-4499	CLIP-seq
MIRT945237	hsa-miR-4639-3p	CLIP-seq
MIRT2215043	hsa-miR-4674	CLIP-seq
MIRT2215044	hsa-miR-4680-3p	CLIP-seq
MIRT2215045	hsa-miR-4713-5p	CLIP-seq
MIRT2215046	hsa-miR-4765	CLIP-seq
MIRT2215047	hsa-miR-532-3p	CLIP-seq
MIRT2215048	hsa-miR-764	CLIP-seq
MIRT2387111	hsa-miR-1184	CLIP-seq
MIRT2215029	hsa-miR-125a-3p	CLIP-seq
MIRT2215030	hsa-miR-1343	CLIP-seq
MIRT2215036	hsa-miR-24	CLIP-seq
MIRT2215038	hsa-miR-378g	CLIP-seq
MIRT945224	hsa-miR-3934	CLIP-seq
MIRT2387112	hsa-miR-4418	CLIP-seq
MIRT2215041	hsa-miR-4437	CLIP-seq
MIRT2215043	hsa-miR-4674	CLIP-seq
MIRT2387113	hsa-miR-509-3-5p	CLIP-seq
MIRT2387114	hsa-miR-509-5p	CLIP-seq
MIRT2215048	hsa-miR-764	CLIP-seq
MIRT1979836	hsa-miR-1206	CLIP-seq
MIRT2428343	hsa-miR-1208	CLIP-seq
MIRT2428344	hsa-miR-1225-5p	CLIP-seq
MIRT2428345	hsa-miR-1251	CLIP-seq
MIRT2428346	hsa-miR-1283	CLIP-seq
MIRT2428347	hsa-miR-1297	CLIP-seq
MIRT1979838	hsa-miR-1298	CLIP-seq
MIRT945205	hsa-miR-139-5p	CLIP-seq
MIRT2215032	hsa-miR-181a	CLIP-seq
MIRT2215033	hsa-miR-181b	CLIP-seq
MIRT2215034	hsa-miR-181c	CLIP-seq
MIRT2215035	hsa-miR-181d	CLIP-seq
MIRT1979839	hsa-miR-205	CLIP-seq
MIRT2428348	hsa-miR-2053	CLIP-seq
MIRT945215	hsa-miR-2467-3p	CLIP-seq
MIRT2428349	hsa-miR-26a	CLIP-seq
MIRT2428350	hsa-miR-26b	CLIP-seq
MIRT1979840	hsa-miR-3065-5p	CLIP-seq
MIRT2428351	hsa-miR-3163	CLIP-seq
MIRT2428352	hsa-miR-34c-3p	CLIP-seq
MIRT2428353	hsa-miR-3591-5p	CLIP-seq
MIRT2428354	hsa-miR-3646	CLIP-seq
MIRT945223	hsa-miR-3678-3p	CLIP-seq
MIRT1979848	hsa-miR-3680	CLIP-seq
MIRT2428355	hsa-miR-3690	CLIP-seq
MIRT1979849	hsa-miR-375	CLIP-seq
MIRT2428356	hsa-miR-377	CLIP-seq
MIRT2428357	hsa-miR-3914	CLIP-seq
MIRT2428358	hsa-miR-4252	CLIP-seq
MIRT2428359	hsa-miR-4254	CLIP-seq
MIRT2428360	hsa-miR-4255	CLIP-seq
MIRT2428361	hsa-miR-4261	CLIP-seq
MIRT2215039	hsa-miR-4262	CLIP-seq
MIRT945228	hsa-miR-4277	CLIP-seq
MIRT2428362	hsa-miR-4282	CLIP-seq
MIRT2428363	hsa-miR-4422	CLIP-seq
MIRT2428364	hsa-miR-4465	CLIP-seq
MIRT2428365	hsa-miR-4490	CLIP-seq
MIRT2428366	hsa-miR-4496	CLIP-seq
MIRT2428367	hsa-miR-4637	CLIP-seq
MIRT2428368	hsa-miR-4684-5p	CLIP-seq
MIRT2428369	hsa-miR-4718	CLIP-seq
MIRT2428370	hsa-miR-4719	CLIP-seq
MIRT2428371	hsa-miR-4738-3p	CLIP-seq
MIRT2428372	hsa-miR-4764-5p	CLIP-seq
MIRT1979855	hsa-miR-4798-3p	CLIP-seq
MIRT2428373	hsa-miR-499-3p	CLIP-seq
MIRT2428374	hsa-miR-499a-3p	CLIP-seq
MIRT945247	hsa-miR-511	CLIP-seq
MIRT2428375	hsa-miR-520d-5p	CLIP-seq
MIRT2428376	hsa-miR-524-5p	CLIP-seq
MIRT2428377	hsa-miR-548ac	CLIP-seq
MIRT2428378	hsa-miR-548ad	CLIP-seq
MIRT2428379	hsa-miR-548ae	CLIP-seq
MIRT2428380	hsa-miR-548aj	CLIP-seq
MIRT2428381	hsa-miR-548am	CLIP-seq
MIRT2428382	hsa-miR-548c-3p	CLIP-seq
MIRT2428383	hsa-miR-548d-3p	CLIP-seq
MIRT2428384	hsa-miR-548x	CLIP-seq
MIRT2428385	hsa-miR-548z	CLIP-seq
MIRT2428386	hsa-miR-569	CLIP-seq
MIRT1979856	hsa-miR-579	CLIP-seq
MIRT2428387	hsa-miR-582-3p	CLIP-seq
MIRT2428388	hsa-miR-582-5p	CLIP-seq
MIRT2428389	hsa-miR-605	CLIP-seq
MIRT2428390	hsa-miR-656	CLIP-seq
MIRT2428391	hsa-miR-759	CLIP-seq
MIRT1979836	hsa-miR-1206	CLIP-seq
MIRT2519479	hsa-miR-122	CLIP-seq
MIRT2519480	hsa-miR-1224-3p	CLIP-seq
MIRT2215029	hsa-miR-125a-3p	CLIP-seq
MIRT2519481	hsa-miR-1260	CLIP-seq
MIRT2519482	hsa-miR-1260b	CLIP-seq
MIRT2519483	hsa-miR-1280	CLIP-seq
MIRT2428346	hsa-miR-1283	CLIP-seq
MIRT1979838	hsa-miR-1298	CLIP-seq
MIRT2215030	hsa-miR-1343	CLIP-seq
MIRT945205	hsa-miR-139-5p	CLIP-seq
MIRT2215031	hsa-miR-150	CLIP-seq
MIRT1979839	hsa-miR-205	CLIP-seq
MIRT2215036	hsa-miR-24	CLIP-seq
MIRT1979842	hsa-miR-3149	CLIP-seq
MIRT2519484	hsa-miR-3150b-3p	CLIP-seq
MIRT945217	hsa-miR-3174	CLIP-seq
MIRT2519485	hsa-miR-339-3p	CLIP-seq
MIRT945219	hsa-miR-3612	CLIP-seq
MIRT1979845	hsa-miR-3614-5p	CLIP-seq
MIRT945222	hsa-miR-3664-5p	CLIP-seq
MIRT1979849	hsa-miR-375	CLIP-seq
MIRT2215038	hsa-miR-378g	CLIP-seq
MIRT945224	hsa-miR-3934	CLIP-seq
MIRT945227	hsa-miR-4276	CLIP-seq
MIRT2428363	hsa-miR-4422	CLIP-seq
MIRT2215041	hsa-miR-4437	CLIP-seq
MIRT2519486	hsa-miR-4459	CLIP-seq
MIRT945232	hsa-miR-4463	CLIP-seq
MIRT2428365	hsa-miR-4490	CLIP-seq
MIRT945233	hsa-miR-4494	CLIP-seq
MIRT2428367	hsa-miR-4637	CLIP-seq
MIRT2215043	hsa-miR-4674	CLIP-seq
MIRT2519487	hsa-miR-4689	CLIP-seq
MIRT2519488	hsa-miR-4695-5p	CLIP-seq
MIRT2215045	hsa-miR-4713-5p	CLIP-seq
MIRT1979852	hsa-miR-4735-5p	CLIP-seq
MIRT2428371	hsa-miR-4738-3p	CLIP-seq
MIRT1979854	hsa-miR-4775	CLIP-seq
MIRT2519489	hsa-miR-4784	CLIP-seq
MIRT945244	hsa-miR-496	CLIP-seq
MIRT2215047	hsa-miR-532-3p	CLIP-seq
MIRT1979856	hsa-miR-579	CLIP-seq
MIRT2428387	hsa-miR-582-3p	CLIP-seq
MIRT1979857	hsa-miR-586	CLIP-seq
MIRT1979858	hsa-miR-590-3p	CLIP-seq
MIRT2428389	hsa-miR-605	CLIP-seq
MIRT945252	hsa-miR-650	CLIP-seq
MIRT2428390	hsa-miR-656	CLIP-seq
MIRT1979859	hsa-miR-664	CLIP-seq
MIRT2519490	hsa-miR-665	CLIP-seq
MIRT2215048	hsa-miR-764	CLIP-seq
MIRT2519491	hsa-miR-767-3p	CLIP-seq
MIRT1979836	hsa-miR-1206	CLIP-seq
MIRT2215029	hsa-miR-125a-3p	CLIP-seq
MIRT2428346	hsa-miR-1283	CLIP-seq
MIRT1979838	hsa-miR-1298	CLIP-seq
MIRT2215030	hsa-miR-1343	CLIP-seq
MIRT945205	hsa-miR-139-5p	CLIP-seq
MIRT2679491	hsa-miR-1470	CLIP-seq
MIRT2679492	hsa-miR-1587	CLIP-seq
MIRT2679493	hsa-miR-1913	CLIP-seq
MIRT1979839	hsa-miR-205	CLIP-seq
MIRT2215036	hsa-miR-24	CLIP-seq
MIRT2519484	hsa-miR-3150b-3p	CLIP-seq
MIRT2679494	hsa-miR-3162-3p	CLIP-seq
MIRT945217	hsa-miR-3174	CLIP-seq
MIRT2679495	hsa-miR-3187-3p	CLIP-seq
MIRT2679496	hsa-miR-3194-3p	CLIP-seq
MIRT2679497	hsa-miR-324-3p	CLIP-seq
MIRT2519485	hsa-miR-339-3p	CLIP-seq
MIRT945219	hsa-miR-3612	CLIP-seq
MIRT1979845	hsa-miR-3614-5p	CLIP-seq
MIRT945220	hsa-miR-3616-3p	CLIP-seq
MIRT2679498	hsa-miR-3618	CLIP-seq
MIRT945221	hsa-miR-3622b-5p	CLIP-seq
MIRT1979849	hsa-miR-375	CLIP-seq
MIRT2215038	hsa-miR-378g	CLIP-seq
MIRT945224	hsa-miR-3934	CLIP-seq
MIRT945227	hsa-miR-4276	CLIP-seq
MIRT2679499	hsa-miR-4290	CLIP-seq
MIRT2428363	hsa-miR-4422	CLIP-seq
MIRT2679500	hsa-miR-4435	CLIP-seq
MIRT2215041	hsa-miR-4437	CLIP-seq
MIRT945231	hsa-miR-4446-3p	CLIP-seq
MIRT2519486	hsa-miR-4459	CLIP-seq
MIRT2428365	hsa-miR-4490	CLIP-seq
MIRT2679501	hsa-miR-4492	CLIP-seq
MIRT2679502	hsa-miR-4498	CLIP-seq
MIRT945236	hsa-miR-455-5p	CLIP-seq
MIRT2428367	hsa-miR-4637	CLIP-seq
MIRT945238	hsa-miR-4642	CLIP-seq
MIRT945239	hsa-miR-4656	CLIP-seq
MIRT2679503	hsa-miR-4671-5p	CLIP-seq
MIRT2215043	hsa-miR-4674	CLIP-seq
MIRT2679504	hsa-miR-4675	CLIP-seq
MIRT2519487	hsa-miR-4689	CLIP-seq
MIRT2679505	hsa-miR-4695-3p	CLIP-seq
MIRT2519488	hsa-miR-4695-5p	CLIP-seq
MIRT2679506	hsa-miR-4701-5p	CLIP-seq
MIRT2215045	hsa-miR-4713-5p	CLIP-seq
MIRT945240	hsa-miR-4721	CLIP-seq
MIRT2428371	hsa-miR-4738-3p	CLIP-seq
MIRT2679507	hsa-miR-4741	CLIP-seq
MIRT945243	hsa-miR-4780	CLIP-seq
MIRT2519489	hsa-miR-4784	CLIP-seq
MIRT2679508	hsa-miR-4802-3p	CLIP-seq
MIRT945244	hsa-miR-496	CLIP-seq
MIRT2679509	hsa-miR-548s	CLIP-seq
MIRT1979856	hsa-miR-579	CLIP-seq
MIRT2428387	hsa-miR-582-3p	CLIP-seq
MIRT1979857	hsa-miR-586	CLIP-seq
MIRT2679510	hsa-miR-588	CLIP-seq
MIRT2428389	hsa-miR-605	CLIP-seq
MIRT2679511	hsa-miR-626	CLIP-seq
MIRT945252	hsa-miR-650	CLIP-seq
MIRT2428390	hsa-miR-656	CLIP-seq
MIRT1979859	hsa-miR-664	CLIP-seq
MIRT2519490	hsa-miR-665	CLIP-seq
MIRT2679512	hsa-miR-762	CLIP-seq
MIRT2215048	hsa-miR-764	CLIP-seq
MIRT2519491	hsa-miR-767-3p	CLIP-seq
MIRT2679513	hsa-miR-934	CLIP-seq
MIRT945254	hsa-miR-938	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Activation	18408756

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IDA	19895784
GO:0005764	Component	Lysosome	IBA
GO:0005764	Component	Lysosome	IDA	19895784
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0006914	Process	Autophagy	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0010506	Process	Regulation of autophagy	IBA
GO:0010506	Process	Regulation of autophagy	IDA	19895784
GO:0016020	Component	Membrane	IEA
GO:0090650	Process	Cellular response to oxygen-glucose deprivation	IEA

Other IDs

• MIM: 610776
• HGNC: 25645
• e!Ensembl: ENSG00000136048

Protein

• UniProt ID: Q8N682
• Protein name: DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator)
• Protein function: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10277	Frag1	7 → 226	Frag1/DRAM/Sfk1 family	Family

• Sequence:

  MLCFLRGMAFVPFLLVTWSSAAFIISYVVAVLSGHVNPFLPYISDTGTTPPESGIFGFMI
  NFSAFLGAATMYTRYKIVQKQNQTCYFSTPVFNLVSLVLGLVGCFGMGIVANFQELAVPV
  VHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLSTCHIRMVISAVSCAAVIPMIVCASL
  ISITKLEWNPREKDYVYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINGDI

• Sequence length: 238