DRAM1 (DNA damage regulated autophagy modulator 1)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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55332 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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DNA damage regulated autophagy modulator 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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DRAM1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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DRAM |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q23.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q8N682 | ||||||||||
| Protein name | DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) | ||||||||||
| Protein function | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 238 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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