Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55332
Gene name Gene Name - the full gene name approved by the HGNC.
DNA damage regulated autophagy modulator 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DRAM1
Synonyms (NCBI Gene) Gene synonyms aliases
DRAM
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004906 hsa-miR-124-3p Microarray 15685193
MIRT437763 hsa-miR-199a-5p Luciferase reporter assay, Western blot 23337876
MIRT437763 hsa-miR-199a-5p Luciferase reporter assay, Western blot 23337876
MIRT231560 hsa-miR-181a-5p HITS-CLIP 22473208
MIRT231561 hsa-miR-181b-5p HITS-CLIP 22473208
Transcription factors
Transcription factor Regulation Reference
E2F1 Activation 18408756
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005737 Component Cytoplasm IDA 19895784
GO:0005764 Component Lysosome IBA 21873635
GO:0005764 Component Lysosome IDA 19895784
GO:0005765 Component Lysosomal membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610776 25645 ENSG00000136048
Protein
UniProt ID Q8N682
Protein name DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator)
Protein function Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10277 Frag1 7 226 Frag1/DRAM/Sfk1 family Family
Sequence
Sequence length 238
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Intracranial aneurysm Intracranial Aneurysm rs1594095223 30823506
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Intracranial Aneurysm Intracranial Aneurysm GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35529878
Arthritis Rheumatoid Associate 34177888
Breast Neoplasms Associate 27118659
Carcinoma Hepatocellular Associate 23251372, 32265434
Cholangiocarcinoma Associate 40696630
Diabetes Mellitus Type 1 Associate 35773317
Diabetic Foot Associate 38287255
Fatty Liver Stimulate 29367738
Fetal Growth Retardation Associate 22815878
Glioma Associate 38203743