Gene Gene information from NCBI Gene database.
Entrez ID 55326
Gene name 1-acylglycerol-3-phosphate O-acyltransferase 5
Gene symbol AGPAT5
Synonyms (NCBI Gene)
1AGPAT5LPAATELPLAT5
Chromosome 8
Chromosome location 8p23.1
Summary This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is p
miRNA miRNA information provided by mirtarbase database.
606
miRTarBase ID miRNA Experiments Reference
MIRT019915 hsa-miR-375 Microarray 20215506
MIRT024224 hsa-miR-218-5p Sequencing 20371350
MIRT026615 hsa-miR-192-5p Microarray 19074876
MIRT031850 hsa-miR-16-5p Sequencing 20371350
MIRT049613 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0002244 Process Hematopoietic progenitor cell differentiation IEA
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity IDA 21173190
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity NAS 15367102
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614796 20886 ENSG00000155189
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NUQ2
Protein name 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon)
Protein function Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 70 233 Acyltransferase Family
PF16076 Acyltransf_C 249 328 Acyltransferase C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:21173190}.
Sequence
Sequence length 364
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
Phospholipase D signaling pathway
  Synthesis of PA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GILLES DE LA TOURETTE SYNDROME Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEMORRHOID GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Keloid formation Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METASTATIC COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 36845084
★☆☆☆☆
Found in Text Mining only