Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5532
Gene name Gene Name - the full gene name approved by the HGNC.	Protein phosphatase 3 catalytic subunit beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPP3CB
Synonyms (NCBI Gene) Gene synonyms aliases	CALNA2, CALNB, CNA2, PP2Bbeta
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CNA2
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.2

Show/Hide all(202)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047460	hsa-miR-10b-5p	CLASH	23622248
MIRT572809	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT572810	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT572808	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT572807	hsa-miR-875-3p	PAR-CLIP	20371350
MIRT572806	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT572805	hsa-miR-4758-3p	PAR-CLIP	20371350
MIRT572804	hsa-miR-3189-5p	PAR-CLIP	20371350
MIRT572803	hsa-miR-5093	PAR-CLIP	20371350
MIRT572802	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT572801	hsa-miR-1178-3p	PAR-CLIP	20371350
MIRT555308	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT555307	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT555306	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT555305	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT555304	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT555303	hsa-miR-3920	PAR-CLIP	21572407
MIRT555302	hsa-miR-29a-5p	PAR-CLIP	21572407
MIRT555301	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT572809	hsa-miR-6769a-3p	PAR-CLIP	20371350
MIRT572810	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT572808	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT572807	hsa-miR-875-3p	PAR-CLIP	20371350
MIRT572806	hsa-miR-5699-5p	PAR-CLIP	20371350
MIRT572805	hsa-miR-4758-3p	PAR-CLIP	20371350
MIRT572804	hsa-miR-3189-5p	PAR-CLIP	20371350
MIRT572803	hsa-miR-5093	PAR-CLIP	20371350
MIRT572802	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT572801	hsa-miR-1178-3p	PAR-CLIP	20371350
MIRT555308	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT555307	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT555306	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT555305	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT555304	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT555303	hsa-miR-3920	PAR-CLIP	21572407
MIRT555302	hsa-miR-29a-5p	PAR-CLIP	21572407
MIRT555301	hsa-miR-6818-5p	PAR-CLIP	21572407
MIRT1258228	hsa-miR-3149	CLIP-seq
MIRT1258229	hsa-miR-568	CLIP-seq
MIRT1258230	hsa-miR-629	CLIP-seq
MIRT1258231	hsa-miR-3148	CLIP-seq
MIRT1258232	hsa-miR-361-5p	CLIP-seq
MIRT1258233	hsa-miR-3617	CLIP-seq
MIRT1258234	hsa-miR-3688-3p	CLIP-seq
MIRT1258235	hsa-miR-3919	CLIP-seq
MIRT1258236	hsa-miR-4282	CLIP-seq
MIRT1258237	hsa-miR-4452	CLIP-seq
MIRT1258238	hsa-miR-4659a-3p	CLIP-seq
MIRT1258239	hsa-miR-4659b-3p	CLIP-seq
MIRT1258240	hsa-miR-4756-3p	CLIP-seq
MIRT1258241	hsa-miR-490-5p	CLIP-seq
MIRT1258242	hsa-miR-501-5p	CLIP-seq
MIRT1258243	hsa-miR-548u	CLIP-seq
MIRT1258244	hsa-miR-641	CLIP-seq
MIRT1258245	hsa-miR-30a	CLIP-seq
MIRT1258246	hsa-miR-30b	CLIP-seq
MIRT1258247	hsa-miR-30c	CLIP-seq
MIRT1258248	hsa-miR-30d	CLIP-seq
MIRT1258249	hsa-miR-30e	CLIP-seq
MIRT1258231	hsa-miR-3148	CLIP-seq
MIRT1258250	hsa-miR-3163	CLIP-seq
MIRT1258251	hsa-miR-340	CLIP-seq
MIRT1258233	hsa-miR-3617	CLIP-seq
MIRT1258234	hsa-miR-3688-3p	CLIP-seq
MIRT1258252	hsa-miR-4267	CLIP-seq
MIRT1258253	hsa-miR-4453	CLIP-seq
MIRT1258254	hsa-miR-4538	CLIP-seq
MIRT1258255	hsa-miR-4540	CLIP-seq
MIRT1258241	hsa-miR-490-5p	CLIP-seq
MIRT1258242	hsa-miR-501-5p	CLIP-seq
MIRT1258243	hsa-miR-548u	CLIP-seq
MIRT1258256	hsa-miR-582-5p	CLIP-seq
MIRT1258244	hsa-miR-641	CLIP-seq
MIRT1258257	hsa-miR-766	CLIP-seq
MIRT2076111	hsa-miR-1254	CLIP-seq
MIRT2076112	hsa-miR-3116	CLIP-seq
MIRT1258252	hsa-miR-4267	CLIP-seq
MIRT2076113	hsa-miR-4268	CLIP-seq
MIRT1258253	hsa-miR-4453	CLIP-seq
MIRT1258254	hsa-miR-4538	CLIP-seq
MIRT1258256	hsa-miR-582-5p	CLIP-seq
MIRT2076114	hsa-miR-661	CLIP-seq
MIRT1258257	hsa-miR-766	CLIP-seq
MIRT2302706	hsa-miR-1182	CLIP-seq
MIRT2302707	hsa-miR-1290	CLIP-seq
MIRT2302708	hsa-miR-1297	CLIP-seq
MIRT2302709	hsa-miR-208a	CLIP-seq
MIRT2302710	hsa-miR-208b	CLIP-seq
MIRT2302711	hsa-miR-26a	CLIP-seq
MIRT2302712	hsa-miR-26b	CLIP-seq
MIRT2302713	hsa-miR-3150a-5p	CLIP-seq
MIRT2302714	hsa-miR-3150b-5p	CLIP-seq
MIRT1258250	hsa-miR-3163	CLIP-seq
MIRT2302715	hsa-miR-3167	CLIP-seq
MIRT2302716	hsa-miR-3179	CLIP-seq
MIRT2302717	hsa-miR-3202	CLIP-seq
MIRT2302718	hsa-miR-3658	CLIP-seq
MIRT2302719	hsa-miR-3667-5p	CLIP-seq
MIRT1258252	hsa-miR-4267	CLIP-seq
MIRT2076113	hsa-miR-4268	CLIP-seq
MIRT2302720	hsa-miR-4330	CLIP-seq
MIRT1258253	hsa-miR-4453	CLIP-seq
MIRT2302721	hsa-miR-4465	CLIP-seq
MIRT2302722	hsa-miR-4476	CLIP-seq
MIRT2302723	hsa-miR-4489	CLIP-seq
MIRT1258254	hsa-miR-4538	CLIP-seq
MIRT2302724	hsa-miR-4760-3p	CLIP-seq
MIRT2302725	hsa-miR-499-5p	CLIP-seq
MIRT1258256	hsa-miR-582-5p	CLIP-seq
MIRT2302726	hsa-miR-591	CLIP-seq
MIRT2302727	hsa-miR-599	CLIP-seq
MIRT2302728	hsa-miR-628-3p	CLIP-seq
MIRT2302729	hsa-miR-665	CLIP-seq
MIRT1258257	hsa-miR-766	CLIP-seq
MIRT2302730	hsa-miR-802	CLIP-seq
MIRT2302731	hsa-miR-876-5p	CLIP-seq
MIRT2076111	hsa-miR-1254	CLIP-seq
MIRT2599392	hsa-miR-126	CLIP-seq
MIRT2599393	hsa-miR-1284	CLIP-seq
MIRT2599394	hsa-miR-219-1-3p	CLIP-seq
MIRT2076112	hsa-miR-3116	CLIP-seq
MIRT2599395	hsa-miR-3126-5p	CLIP-seq
MIRT2599396	hsa-miR-3128	CLIP-seq
MIRT2599397	hsa-miR-33a	CLIP-seq
MIRT2599398	hsa-miR-33b	CLIP-seq
MIRT2599399	hsa-miR-3921	CLIP-seq
MIRT2599400	hsa-miR-3929	CLIP-seq
MIRT2599401	hsa-miR-3977	CLIP-seq
MIRT2599402	hsa-miR-4253	CLIP-seq
MIRT2599403	hsa-miR-4254	CLIP-seq
MIRT1258236	hsa-miR-4282	CLIP-seq
MIRT2599404	hsa-miR-4325	CLIP-seq
MIRT2599405	hsa-miR-4419a	CLIP-seq
MIRT2599406	hsa-miR-4419b	CLIP-seq
MIRT2599407	hsa-miR-4427	CLIP-seq
MIRT2599408	hsa-miR-4470	CLIP-seq
MIRT2599409	hsa-miR-4478	CLIP-seq
MIRT2599410	hsa-miR-4510	CLIP-seq
MIRT2599411	hsa-miR-4633-3p	CLIP-seq
MIRT2599412	hsa-miR-4653-5p	CLIP-seq
MIRT2599413	hsa-miR-4666-5p	CLIP-seq
MIRT2599414	hsa-miR-4680-3p	CLIP-seq
MIRT2599415	hsa-miR-4682	CLIP-seq
MIRT2599416	hsa-miR-4685-5p	CLIP-seq
MIRT2599417	hsa-miR-4690-5p	CLIP-seq
MIRT2599418	hsa-miR-4720-3p	CLIP-seq
MIRT2599419	hsa-miR-4720-5p	CLIP-seq
MIRT2599420	hsa-miR-4761-3p	CLIP-seq
MIRT2599421	hsa-miR-4768-3p	CLIP-seq
MIRT2599422	hsa-miR-4786-5p	CLIP-seq
MIRT2599423	hsa-miR-4796-5p	CLIP-seq
MIRT2599424	hsa-miR-4799-3p	CLIP-seq
MIRT2599425	hsa-miR-4804-3p	CLIP-seq
MIRT2599426	hsa-miR-486-5p	CLIP-seq
MIRT2599427	hsa-miR-499-3p	CLIP-seq
MIRT2599428	hsa-miR-499a-3p	CLIP-seq
MIRT2599429	hsa-miR-513a-3p	CLIP-seq
MIRT2599430	hsa-miR-548a-5p	CLIP-seq
MIRT2599431	hsa-miR-548ab	CLIP-seq
MIRT2599432	hsa-miR-548ak	CLIP-seq
MIRT2599433	hsa-miR-548b-5p	CLIP-seq
MIRT2599434	hsa-miR-548c-5p	CLIP-seq
MIRT2599435	hsa-miR-548d-5p	CLIP-seq
MIRT2599436	hsa-miR-548h	CLIP-seq
MIRT2599437	hsa-miR-548i	CLIP-seq
MIRT2599438	hsa-miR-548j	CLIP-seq
MIRT2599439	hsa-miR-548w	CLIP-seq
MIRT2599440	hsa-miR-548y	CLIP-seq
MIRT2599441	hsa-miR-559	CLIP-seq
MIRT2599442	hsa-miR-571	CLIP-seq
MIRT2599443	hsa-miR-572	CLIP-seq
MIRT2599444	hsa-miR-630	CLIP-seq
MIRT2599445	hsa-miR-645	CLIP-seq
MIRT2076114	hsa-miR-661	CLIP-seq
MIRT2076111	hsa-miR-1254	CLIP-seq
MIRT2688486	hsa-miR-1972	CLIP-seq
MIRT2599394	hsa-miR-219-1-3p	CLIP-seq
MIRT2076112	hsa-miR-3116	CLIP-seq
MIRT2599395	hsa-miR-3126-5p	CLIP-seq
MIRT2599396	hsa-miR-3128	CLIP-seq
MIRT2599399	hsa-miR-3921	CLIP-seq
MIRT2599402	hsa-miR-4253	CLIP-seq
MIRT2599403	hsa-miR-4254	CLIP-seq
MIRT2599404	hsa-miR-4325	CLIP-seq
MIRT2599405	hsa-miR-4419a	CLIP-seq
MIRT2599408	hsa-miR-4470	CLIP-seq
MIRT2599410	hsa-miR-4510	CLIP-seq
MIRT2599411	hsa-miR-4633-3p	CLIP-seq
MIRT2599412	hsa-miR-4653-5p	CLIP-seq
MIRT2599415	hsa-miR-4682	CLIP-seq
MIRT2599416	hsa-miR-4685-5p	CLIP-seq
MIRT2599417	hsa-miR-4690-5p	CLIP-seq
MIRT2688487	hsa-miR-4717-5p	CLIP-seq
MIRT2599419	hsa-miR-4720-5p	CLIP-seq
MIRT2599420	hsa-miR-4761-3p	CLIP-seq
MIRT2599421	hsa-miR-4768-3p	CLIP-seq
MIRT2599422	hsa-miR-4786-5p	CLIP-seq
MIRT2599424	hsa-miR-4799-3p	CLIP-seq
MIRT2599442	hsa-miR-571	CLIP-seq
MIRT2599443	hsa-miR-572	CLIP-seq
MIRT2599444	hsa-miR-630	CLIP-seq
MIRT2076114	hsa-miR-661	CLIP-seq

Show/Hide all(54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001915	Process	Negative regulation of T cell mediated cytotoxicity	IEA
GO:0001946	Process	Lymphangiogenesis	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	NAS	8392375
GO:0005509	Function	Calcium ion binding	IDA	8524402
GO:0005515	Function	Protein binding	IPI	21903422, 22688515, 26794871
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005516	Function	Calmodulin binding	IDA	2556704, 11005320, 26794871
GO:0005516	Function	Calmodulin binding	NAS	8524402
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	19154138
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	ISS
GO:0005955	Component	Calcineurin complex	IBA	21873635
GO:0005955	Component	Calcineurin complex	IDA	8524402, 22688515, 26794871
GO:0006468	Process	Protein phosphorylation	ISS
GO:0006470	Process	Protein dephosphorylation	IDA	19154138, 26794871
GO:0006470	Process	Protein dephosphorylation	ISS
GO:0007165	Process	Signal transduction	NAS	8978785
GO:0007223	Process	Wnt signaling pathway, calcium modulating pathway	TAS
GO:0007507	Process	Heart development	IEA
GO:0007612	Process	Learning	TAS	21531385
GO:0007613	Process	Memory	TAS	21531385
GO:0016311	Process	Dephosphorylation	TAS	2556704
GO:0017156	Process	Calcium-ion regulated exocytosis	ISS
GO:0019899	Function	Enzyme binding	IDA	11005320
GO:0030018	Component	Z disc	IEA
GO:0030217	Process	T cell differentiation	IEA
GO:0030315	Component	T-tubule	IEA
GO:0030346	Function	Protein phosphatase 2B binding	IDA	2556704
GO:0031987	Process	Locomotion involved in locomotory behavior	IEA
GO:0033173	Process	Calcineurin-NFAT signaling cascade	IDA	19154138, 22688515
GO:0033192	Function	Calmodulin-dependent protein phosphatase activity	IBA	21873635
GO:0033192	Function	Calmodulin-dependent protein phosphatase activity	IDA	19154138, 26794871
GO:0033192	Function	Calmodulin-dependent protein phosphatase activity	ISS
GO:0033192	Function	Calmodulin-dependent protein phosphatase activity	TAS	2556704
GO:0034097	Process	Response to cytokine	IEA
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042098	Process	T cell proliferation	NAS	8978785
GO:0042110	Process	T cell activation	TAS	11005320
GO:0043029	Process	T cell homeostasis	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	NAS	8978785
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	22688515
GO:0046983	Function	Protein dimerization activity	IPI	11005320
GO:0048167	Process	Regulation of synaptic plasticity	TAS	21531385
GO:0048675	Process	Axon extension	TAS	21531385
GO:0050796	Process	Regulation of insulin secretion	ISS
GO:0097720	Process	Calcineurin-mediated signaling	IBA	21873635
GO:0097720	Process	Calcineurin-mediated signaling	IMP	11005320
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA
GO:1900242	Process	Regulation of synaptic vesicle endocytosis	IEA

MIM	HGNC	e!Ensembl
114106	9315	ENSG00000107758

Protein

UniProt ID

P16298

Protein name

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta)

Protein function

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). Dephosphorylates TFEB i

PDB

4OR9 , 4ORA , 4ORC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00149	Metallophos	92 → 294	Calcineurin-like phosphoesterase	Domain

Sequence

MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLV
KEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANT
RYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLL
WSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMY
RKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFS
VLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFE
EAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ

Sequence length

524

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway Oocyte meiosis Cellular senescence Wnt signaling pathway Axon guidance VEGF signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Long-term potentiation Glutamatergic synapse Dopaminergic synapse Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Tuberculosis Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis		Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation

PPP3CB (protein phosphatase 3 catalytic subunit beta)