Gene Gene information from NCBI Gene database.
Entrez ID 55313
Gene name Calcineurin like phosphoesterase domain containing 1
Gene symbol CPPED1
Synonyms (NCBI Gene)
CSTP1
Chromosome 16
Chromosome location 16p13.12
miRNA miRNA information provided by mirtarbase database.
651
miRTarBase ID miRNA Experiments Reference
MIRT020291 hsa-miR-130b-3p Sequencing 20371350
MIRT028145 hsa-miR-93-5p Sequencing 20371350
MIRT031270 hsa-miR-19b-3p Sequencing 20371350
MIRT437698 hsa-miR-27a-3p MicroarrayqRT-PCR 22815788
MIRT437707 hsa-miR-27b-3p MicroarrayqRT-PCR 22815788
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615603 25632 ENSG00000103381
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BRF8
Protein name Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1)
Protein function Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269|PubMed:23799035, ECO:0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00149 Metallophos 33 251 Calcineurin-like phosphoesterase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in subcutaneous adipose tissue. {ECO:0000269|PubMed:23939394}.
Sequence
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CEREBRAL AMYLOID ANGIOPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC KETOACIDOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 40471493
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 15991289
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 38174685
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 30918060
★☆☆☆☆
Found in Text Mining only