Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55312
Gene name Gene Name - the full gene name approved by the HGNC.
Riboflavin kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RFK
Synonyms (NCBI Gene) Gene synonyms aliases
RIFK
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al.,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021169 hsa-miR-186-5p Sequencing 20371350
MIRT027183 hsa-miR-103a-3p Sequencing 20371350
MIRT031929 hsa-miR-16-5p Sequencing 20371350
MIRT706732 hsa-miR-3976 HITS-CLIP 21572407
MIRT706731 hsa-miR-6514-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19641494
GO:0005524 Function ATP binding IEA
GO:0005737 Component Cytoplasm NAS 12623014
GO:0005739 Component Mitochondrion IBA 21873635
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613010 30324 ENSG00000135002
Protein
UniProt ID Q969G6
Protein name Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase)
Protein function Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with bo
PDB 1NB0 , 1NB9 , 1P4M , 1Q9S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01687 Flavokinase 3 130 Riboflavin kinase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in brain, placenta and urinary bladder.
Sequence
Sequence length 155
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Riboflavin metabolism
Metabolic pathways
Biosynthesis of cofactors
  Vitamin B2 (riboflavin) metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 21308351
Associations from Text Mining
Disease Name Relationship Type References
Diabetes Mellitus Type 2 Associate 40026415
Drug Related Side Effects and Adverse Reactions Associate 32054832
Neurodegenerative Diseases Associate 32490968