Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55295
Gene name Gene Name - the full gene name approved by the HGNC.	Kelch like family member 26
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KLHL26
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11

Show/Hide all(210)

miRTarBase ID	miRNA	Experiments	Reference
MIRT723879	hsa-miR-490-3p	HITS-CLIP	19536157
MIRT723878	hsa-miR-649	HITS-CLIP	19536157
MIRT723877	hsa-miR-3155a	HITS-CLIP	19536157
MIRT723876	hsa-miR-3155b	HITS-CLIP	19536157
MIRT723875	hsa-miR-484	HITS-CLIP	19536157
MIRT723874	hsa-miR-6728-3p	HITS-CLIP	19536157
MIRT723873	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT723872	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT723871	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT723870	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT723869	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT714530	hsa-miR-4686	HITS-CLIP	19536157
MIRT714529	hsa-miR-1251-3p	HITS-CLIP	19536157
MIRT675334	hsa-miR-450a-1-3p	HITS-CLIP	19536157
MIRT675333	hsa-miR-3122	HITS-CLIP	19536157
MIRT675332	hsa-miR-3913-5p	HITS-CLIP	19536157
MIRT675331	hsa-miR-887-5p	HITS-CLIP	19536157
MIRT675330	hsa-miR-6513-5p	HITS-CLIP	19536157
MIRT702358	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT702357	hsa-miR-4753-5p	HITS-CLIP	23313552
MIRT702356	hsa-miR-3922-5p	HITS-CLIP	23313552
MIRT702355	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT702354	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT702353	hsa-miR-3194-5p	HITS-CLIP	23313552
MIRT702352	hsa-miR-3926	HITS-CLIP	23313552
MIRT702351	hsa-miR-561-5p	HITS-CLIP	23313552
MIRT702350	hsa-miR-548s	HITS-CLIP	23313552
MIRT675367	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT675366	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT675365	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT675364	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT675363	hsa-miR-940	HITS-CLIP	23824327
MIRT675362	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT675361	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT675360	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT675359	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT675358	hsa-miR-1827	HITS-CLIP	23824327
MIRT675357	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT675356	hsa-miR-3665	HITS-CLIP	23824327
MIRT675355	hsa-miR-3612	HITS-CLIP	23824327
MIRT675354	hsa-miR-650	HITS-CLIP	23824327
MIRT675353	hsa-miR-4736	HITS-CLIP	23824327
MIRT675352	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT675351	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT675350	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT675349	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT675348	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT675347	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT675346	hsa-miR-3165	HITS-CLIP	23824327
MIRT675345	hsa-miR-7977	HITS-CLIP	23824327
MIRT675344	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT675343	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT675342	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT675341	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT675340	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT675339	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT675338	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT675337	hsa-miR-3689c	HITS-CLIP	23824327
MIRT675336	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT675335	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT675334	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT675333	hsa-miR-3122	HITS-CLIP	23824327
MIRT675332	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT675331	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT675330	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT723879	hsa-miR-490-3p	HITS-CLIP	19536157
MIRT723878	hsa-miR-649	HITS-CLIP	19536157
MIRT723877	hsa-miR-3155a	HITS-CLIP	19536157
MIRT723876	hsa-miR-3155b	HITS-CLIP	19536157
MIRT723875	hsa-miR-484	HITS-CLIP	19536157
MIRT723874	hsa-miR-6728-3p	HITS-CLIP	19536157
MIRT723873	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT723872	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT723871	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT723870	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT723869	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT714530	hsa-miR-4686	HITS-CLIP	19536157
MIRT714529	hsa-miR-1251-3p	HITS-CLIP	19536157
MIRT675334	hsa-miR-450a-1-3p	HITS-CLIP	19536157
MIRT675333	hsa-miR-3122	HITS-CLIP	19536157
MIRT675332	hsa-miR-3913-5p	HITS-CLIP	19536157
MIRT675331	hsa-miR-887-5p	HITS-CLIP	19536157
MIRT675330	hsa-miR-6513-5p	HITS-CLIP	19536157
MIRT702358	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT702357	hsa-miR-4753-5p	HITS-CLIP	23313552
MIRT702356	hsa-miR-3922-5p	HITS-CLIP	23313552
MIRT702355	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT702354	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT702353	hsa-miR-3194-5p	HITS-CLIP	23313552
MIRT702352	hsa-miR-3926	HITS-CLIP	23313552
MIRT702351	hsa-miR-561-5p	HITS-CLIP	23313552
MIRT702350	hsa-miR-548s	HITS-CLIP	23313552
MIRT675367	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT675366	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT675365	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT675364	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT675363	hsa-miR-940	HITS-CLIP	23824327
MIRT675362	hsa-miR-3622a-3p	HITS-CLIP	23824327
MIRT675361	hsa-miR-3622b-3p	HITS-CLIP	23824327
MIRT675360	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT675359	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT675358	hsa-miR-1827	HITS-CLIP	23824327
MIRT675357	hsa-miR-2467-3p	HITS-CLIP	23824327
MIRT675356	hsa-miR-3665	HITS-CLIP	23824327
MIRT675355	hsa-miR-3612	HITS-CLIP	23824327
MIRT675354	hsa-miR-650	HITS-CLIP	23824327
MIRT675353	hsa-miR-4736	HITS-CLIP	23824327
MIRT675352	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT675351	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT675350	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT675349	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT675348	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT675347	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT675346	hsa-miR-3165	HITS-CLIP	23824327
MIRT675345	hsa-miR-7977	HITS-CLIP	23824327
MIRT675344	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT675343	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT675342	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT675341	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT675340	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT675339	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT675338	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT675337	hsa-miR-3689c	HITS-CLIP	23824327
MIRT675336	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT675335	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT675334	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT675333	hsa-miR-3122	HITS-CLIP	23824327
MIRT675332	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT675331	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT675330	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT1098136	hsa-miR-148a	CLIP-seq
MIRT1098137	hsa-miR-148b	CLIP-seq
MIRT1098138	hsa-miR-152	CLIP-seq
MIRT1098139	hsa-miR-15a	CLIP-seq
MIRT1098140	hsa-miR-15b	CLIP-seq
MIRT1098141	hsa-miR-16	CLIP-seq
MIRT1098142	hsa-miR-1915	CLIP-seq
MIRT1098143	hsa-miR-195	CLIP-seq
MIRT1098144	hsa-miR-3157-5p	CLIP-seq
MIRT1098145	hsa-miR-3166	CLIP-seq
MIRT1098146	hsa-miR-3189-5p	CLIP-seq
MIRT1098147	hsa-miR-3202	CLIP-seq
MIRT1098148	hsa-miR-3617	CLIP-seq
MIRT1098149	hsa-miR-382	CLIP-seq
MIRT1098150	hsa-miR-3913-3p	CLIP-seq
MIRT1098151	hsa-miR-424	CLIP-seq
MIRT1098152	hsa-miR-4481	CLIP-seq
MIRT1098153	hsa-miR-4524	CLIP-seq
MIRT1098154	hsa-miR-4533	CLIP-seq
MIRT1098155	hsa-miR-4666-5p	CLIP-seq
MIRT1098156	hsa-miR-4676-5p	CLIP-seq
MIRT1098157	hsa-miR-4691-3p	CLIP-seq
MIRT1098158	hsa-miR-4694-3p	CLIP-seq
MIRT1098159	hsa-miR-4710	CLIP-seq
MIRT1098160	hsa-miR-4745-5p	CLIP-seq
MIRT1098161	hsa-miR-4758-3p	CLIP-seq
MIRT1098162	hsa-miR-4758-5p	CLIP-seq
MIRT1098163	hsa-miR-4792	CLIP-seq
MIRT1098164	hsa-miR-4802-3p	CLIP-seq
MIRT1098165	hsa-miR-497	CLIP-seq
MIRT1098166	hsa-miR-503	CLIP-seq
MIRT1098167	hsa-miR-575	CLIP-seq
MIRT1098168	hsa-miR-641	CLIP-seq
MIRT1098169	hsa-miR-646	CLIP-seq
MIRT1098139	hsa-miR-15a	CLIP-seq
MIRT1098140	hsa-miR-15b	CLIP-seq
MIRT1098141	hsa-miR-16	CLIP-seq
MIRT1098143	hsa-miR-195	CLIP-seq
MIRT2026689	hsa-miR-3153	CLIP-seq
MIRT2026690	hsa-miR-3179	CLIP-seq
MIRT1098148	hsa-miR-3617	CLIP-seq
MIRT1098149	hsa-miR-382	CLIP-seq
MIRT1098150	hsa-miR-3913-3p	CLIP-seq
MIRT1098151	hsa-miR-424	CLIP-seq
MIRT1098152	hsa-miR-4481	CLIP-seq
MIRT1098153	hsa-miR-4524	CLIP-seq
MIRT2026691	hsa-miR-4635	CLIP-seq
MIRT1098160	hsa-miR-4745-5p	CLIP-seq
MIRT2026692	hsa-miR-4780	CLIP-seq
MIRT1098165	hsa-miR-497	CLIP-seq
MIRT1098166	hsa-miR-503	CLIP-seq
MIRT1098168	hsa-miR-641	CLIP-seq
MIRT1098169	hsa-miR-646	CLIP-seq
MIRT2257939	hsa-miR-1321	CLIP-seq
MIRT1098139	hsa-miR-15a	CLIP-seq
MIRT1098140	hsa-miR-15b	CLIP-seq
MIRT1098141	hsa-miR-16	CLIP-seq
MIRT1098143	hsa-miR-195	CLIP-seq
MIRT1098146	hsa-miR-3189-5p	CLIP-seq
MIRT2257940	hsa-miR-3192	CLIP-seq
MIRT1098148	hsa-miR-3617	CLIP-seq
MIRT1098149	hsa-miR-382	CLIP-seq
MIRT1098150	hsa-miR-3913-3p	CLIP-seq
MIRT1098151	hsa-miR-424	CLIP-seq
MIRT1098152	hsa-miR-4481	CLIP-seq
MIRT1098153	hsa-miR-4524	CLIP-seq
MIRT1098155	hsa-miR-4666-5p	CLIP-seq
MIRT1098159	hsa-miR-4710	CLIP-seq
MIRT2257941	hsa-miR-4739	CLIP-seq
MIRT1098160	hsa-miR-4745-5p	CLIP-seq
MIRT2257942	hsa-miR-4756-5p	CLIP-seq
MIRT1098161	hsa-miR-4758-3p	CLIP-seq
MIRT1098162	hsa-miR-4758-5p	CLIP-seq
MIRT1098163	hsa-miR-4792	CLIP-seq
MIRT1098164	hsa-miR-4802-3p	CLIP-seq
MIRT1098165	hsa-miR-497	CLIP-seq
MIRT1098166	hsa-miR-503	CLIP-seq
MIRT2257943	hsa-miR-605	CLIP-seq
MIRT1098168	hsa-miR-641	CLIP-seq
MIRT1098169	hsa-miR-646	CLIP-seq

Show/Hide all(1)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25036637, 32296183, 32814053, 33961781

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q53HC5

Protein name

Kelch-like protein 26

Protein function

May play a role in endo(sarco)plasmic reticulum (ER/SR) mitochondrial signaling (PubMed:37204873). May be part of the ubiquitin-proteasome system (UPS) and affect ubiquitination and degradation of target substrates in cardiomyocytes (PubMed:3720

PDB

9ETW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00651	BTB	53 → 159	BTB/POZ domain	Domain
PF07707	BACK	165 → 266	BTB And C-terminal Kelch	Domain
PF01344	Kelch_1	402 → 442	Kelch motif	Repeat
PF01344	Kelch_1	452 → 495	Kelch motif	Repeat
PF01344	Kelch_1	497 → 546	Kelch motif	Repeat
PF01344	Kelch_1	550 → 590	Kelch motif	Repeat

Sequence

MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLLQGLATLRAQG
QLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDF
AYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL
RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPAR
RPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSP
RTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD
NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGG
RNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHC
YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT
SVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAG
IACAPVLLPRAGTRR

Sequence length

615

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gastroesophageal Reflux Disease	Gastroesophageal reflux disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Ebstein Anomaly	Associate	31985165, 37204873
Noncompaction of Left Ventricular Myocardium Familial Isolated Autosomal Dominant 1	Associate	31985165, 37204873

KLHL26 (kelch like family member 26)