ZNF654 (zinc finger protein 654)

Gene

• Entrez ID: 55279
• Gene name: Zinc finger protein 654
• Gene symbol: ZNF654
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p11.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016826	hsa-miR-335-5p	Microarray	18185580
MIRT697294	hsa-miR-3133	HITS-CLIP	23313552
MIRT697295	hsa-miR-186-5p	HITS-CLIP	23313552
MIRT697293	hsa-miR-153-5p	HITS-CLIP	23313552
MIRT697292	hsa-miR-6759-3p	HITS-CLIP	23313552
MIRT450637	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT308546	hsa-miR-101-3p	PAR-CLIP	22100165
MIRT308549	hsa-miR-4282	PAR-CLIP	22100165
MIRT450636	hsa-miR-1252-3p	PAR-CLIP	22100165
MIRT450635	hsa-miR-3606-3p	PAR-CLIP	22100165
MIRT450634	hsa-miR-513a-3p	PAR-CLIP	22100165
MIRT450633	hsa-miR-513c-3p	PAR-CLIP	22100165
MIRT308550	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT450632	hsa-miR-4635	PAR-CLIP	22100165
MIRT450631	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450630	hsa-miR-578	PAR-CLIP	22100165
MIRT697294	hsa-miR-3133	HITS-CLIP	23313552
MIRT697295	hsa-miR-186-5p	HITS-CLIP	23313552
MIRT697293	hsa-miR-153-5p	HITS-CLIP	23313552
MIRT697292	hsa-miR-6759-3p	HITS-CLIP	23313552
MIRT450637	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT308546	hsa-miR-101-3p	PAR-CLIP	22100165
MIRT308549	hsa-miR-4282	PAR-CLIP	22100165
MIRT450636	hsa-miR-1252-3p	PAR-CLIP	22100165
MIRT450635	hsa-miR-3606-3p	PAR-CLIP	22100165
MIRT450634	hsa-miR-513a-3p	PAR-CLIP	22100165
MIRT450633	hsa-miR-513c-3p	PAR-CLIP	22100165
MIRT308550	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT450632	hsa-miR-4635	PAR-CLIP	22100165
MIRT450631	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450630	hsa-miR-578	PAR-CLIP	22100165
MIRT1533944	hsa-miR-1182	CLIP-seq
MIRT1533945	hsa-miR-1208	CLIP-seq
MIRT1533946	hsa-miR-1299	CLIP-seq
MIRT1533947	hsa-miR-137	CLIP-seq
MIRT1533948	hsa-miR-141	CLIP-seq
MIRT1533949	hsa-miR-186	CLIP-seq
MIRT1533950	hsa-miR-200a	CLIP-seq
MIRT1533951	hsa-miR-203	CLIP-seq
MIRT1533952	hsa-miR-21	CLIP-seq
MIRT1533953	hsa-miR-24	CLIP-seq
MIRT1533954	hsa-miR-25	CLIP-seq
MIRT1533955	hsa-miR-3117-5p	CLIP-seq
MIRT1533956	hsa-miR-3129-3p	CLIP-seq
MIRT1533957	hsa-miR-3143	CLIP-seq
MIRT1533958	hsa-miR-3148	CLIP-seq
MIRT1533959	hsa-miR-32	CLIP-seq
MIRT1533960	hsa-miR-335	CLIP-seq
MIRT1533961	hsa-miR-363	CLIP-seq
MIRT1533962	hsa-miR-3646	CLIP-seq
MIRT1533963	hsa-miR-367	CLIP-seq
MIRT1533964	hsa-miR-3689a-3p	CLIP-seq
MIRT1533965	hsa-miR-3689c	CLIP-seq
MIRT1533966	hsa-miR-4284	CLIP-seq
MIRT1533967	hsa-miR-4328	CLIP-seq
MIRT1533968	hsa-miR-4420	CLIP-seq
MIRT1533969	hsa-miR-4460	CLIP-seq
MIRT1533970	hsa-miR-4477a	CLIP-seq
MIRT1533971	hsa-miR-4502	CLIP-seq
MIRT1533972	hsa-miR-4686	CLIP-seq
MIRT1533973	hsa-miR-4727-3p	CLIP-seq
MIRT1533974	hsa-miR-4728-5p	CLIP-seq
MIRT1533975	hsa-miR-4735-5p	CLIP-seq
MIRT1533976	hsa-miR-4775	CLIP-seq
MIRT1533977	hsa-miR-4782-5p	CLIP-seq
MIRT1533978	hsa-miR-491-3p	CLIP-seq
MIRT1533979	hsa-miR-499a-5p	CLIP-seq
MIRT1533980	hsa-miR-501-3p	CLIP-seq
MIRT1533981	hsa-miR-502-3p	CLIP-seq
MIRT1533982	hsa-miR-516b	CLIP-seq
MIRT1533983	hsa-miR-526b	CLIP-seq
MIRT1533984	hsa-miR-548u	CLIP-seq
MIRT1533985	hsa-miR-590-5p	CLIP-seq
MIRT1533986	hsa-miR-642b	CLIP-seq
MIRT1533987	hsa-miR-653	CLIP-seq
MIRT1533988	hsa-miR-875-3p	CLIP-seq
MIRT1533989	hsa-miR-922	CLIP-seq
MIRT1533990	hsa-miR-92a	CLIP-seq
MIRT1533991	hsa-miR-92b	CLIP-seq
MIRT1533992	hsa-miR-938	CLIP-seq
MIRT2161521	hsa-miR-1244	CLIP-seq
MIRT2161522	hsa-miR-1302	CLIP-seq
MIRT1533949	hsa-miR-186	CLIP-seq
MIRT2161523	hsa-miR-3122	CLIP-seq
MIRT1533956	hsa-miR-3129-3p	CLIP-seq
MIRT2161524	hsa-miR-3163	CLIP-seq
MIRT2161525	hsa-miR-3606	CLIP-seq
MIRT2161526	hsa-miR-3607-3p	CLIP-seq
MIRT1533964	hsa-miR-3689a-3p	CLIP-seq
MIRT1533965	hsa-miR-3689c	CLIP-seq
MIRT2161527	hsa-miR-3913-5p	CLIP-seq
MIRT2161528	hsa-miR-4298	CLIP-seq
MIRT2161529	hsa-miR-4694-3p	CLIP-seq
MIRT1533975	hsa-miR-4735-5p	CLIP-seq
MIRT2161530	hsa-miR-494	CLIP-seq
MIRT2161531	hsa-miR-514	CLIP-seq
MIRT2161532	hsa-miR-514b-3p	CLIP-seq
MIRT2161533	hsa-miR-520d-5p	CLIP-seq
MIRT2161534	hsa-miR-524-5p	CLIP-seq
MIRT2161535	hsa-miR-590-3p	CLIP-seq
MIRT1533992	hsa-miR-938	CLIP-seq
MIRT2380320	hsa-miR-1246	CLIP-seq
MIRT2380321	hsa-miR-1290	CLIP-seq
MIRT2380322	hsa-miR-129-5p	CLIP-seq
MIRT2380323	hsa-miR-298	CLIP-seq
MIRT2380324	hsa-miR-3074-3p	CLIP-seq
MIRT1533957	hsa-miR-3143	CLIP-seq
MIRT2161524	hsa-miR-3163	CLIP-seq
MIRT2380325	hsa-miR-3167	CLIP-seq
MIRT2380326	hsa-miR-3622b-5p	CLIP-seq
MIRT2380327	hsa-miR-3647-3p	CLIP-seq
MIRT2380328	hsa-miR-3678-3p	CLIP-seq
MIRT1533964	hsa-miR-3689a-3p	CLIP-seq
MIRT1533965	hsa-miR-3689c	CLIP-seq
MIRT2380329	hsa-miR-374a	CLIP-seq
MIRT2380330	hsa-miR-374b	CLIP-seq
MIRT2380331	hsa-miR-3945	CLIP-seq
MIRT2380332	hsa-miR-4253	CLIP-seq
MIRT2380333	hsa-miR-4264	CLIP-seq
MIRT2380334	hsa-miR-4265	CLIP-seq
MIRT2380335	hsa-miR-4296	CLIP-seq
MIRT2380336	hsa-miR-431	CLIP-seq
MIRT2380337	hsa-miR-4322	CLIP-seq
MIRT2380338	hsa-miR-4417	CLIP-seq
MIRT2380339	hsa-miR-4676-5p	CLIP-seq
MIRT2161529	hsa-miR-4694-3p	CLIP-seq
MIRT1533974	hsa-miR-4728-5p	CLIP-seq
MIRT1533976	hsa-miR-4775	CLIP-seq
MIRT2380340	hsa-miR-4797-3p	CLIP-seq
MIRT2380341	hsa-miR-490-5p	CLIP-seq
MIRT2380342	hsa-miR-500a	CLIP-seq
MIRT2380343	hsa-miR-543	CLIP-seq
MIRT2380344	hsa-miR-548a-5p	CLIP-seq
MIRT2380345	hsa-miR-548ab	CLIP-seq
MIRT2380346	hsa-miR-548ak	CLIP-seq
MIRT2380347	hsa-miR-548b-5p	CLIP-seq
MIRT2380348	hsa-miR-548c-5p	CLIP-seq
MIRT2380349	hsa-miR-548d-5p	CLIP-seq
MIRT2380350	hsa-miR-548h	CLIP-seq
MIRT2380351	hsa-miR-548i	CLIP-seq
MIRT2380352	hsa-miR-548j	CLIP-seq
MIRT2380353	hsa-miR-548n	CLIP-seq
MIRT2380354	hsa-miR-548p	CLIP-seq
MIRT2380355	hsa-miR-548t	CLIP-seq
MIRT2380356	hsa-miR-548w	CLIP-seq
MIRT2380357	hsa-miR-548y	CLIP-seq
MIRT2380358	hsa-miR-559	CLIP-seq
MIRT2380359	hsa-miR-570	CLIP-seq
MIRT2380360	hsa-miR-575	CLIP-seq
MIRT2161535	hsa-miR-590-3p	CLIP-seq
MIRT2380361	hsa-miR-622	CLIP-seq
MIRT1533986	hsa-miR-642b	CLIP-seq
MIRT2380362	hsa-miR-876-5p	CLIP-seq
MIRT1533989	hsa-miR-922	CLIP-seq
MIRT2672395	hsa-miR-1264	CLIP-seq
MIRT1533955	hsa-miR-3117-5p	CLIP-seq
MIRT1533956	hsa-miR-3129-3p	CLIP-seq
MIRT2672396	hsa-miR-329	CLIP-seq
MIRT1533960	hsa-miR-335	CLIP-seq
MIRT2672397	hsa-miR-362-3p	CLIP-seq
MIRT1533964	hsa-miR-3689a-3p	CLIP-seq
MIRT1533965	hsa-miR-3689c	CLIP-seq
MIRT2672398	hsa-miR-3941	CLIP-seq
MIRT1533969	hsa-miR-4460	CLIP-seq
MIRT2672399	hsa-miR-4503	CLIP-seq
MIRT2672400	hsa-miR-466	CLIP-seq
MIRT2672401	hsa-miR-4672	CLIP-seq
MIRT1533973	hsa-miR-4727-3p	CLIP-seq
MIRT1533974	hsa-miR-4728-5p	CLIP-seq
MIRT1533975	hsa-miR-4735-5p	CLIP-seq
MIRT2672402	hsa-miR-603	CLIP-seq
MIRT1533992	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	34673265
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8IZM8
• Protein name: Zinc finger protein 654 (Melanoma-associated antigen)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	25 → 47	Zinc finger, C2H2 type	Domain

• Sequence:

  MLCNKEFLGGHIVRHAQAHQKKGSFACVICGRKFRNRGLMQKHLKNHVKKIQRQQIAAAQ
  QDDQEVTALEEINCSSSSISFENGNSDSKDLEVETLTASSEGNKEVIPEHVAEFIEIPIS
  VPEDVIENVIENGSPNNSLNNVFKPLTECGDDYEEEEDEEGDYEEDDYDLNQETSVIHKI
  NGTVCHPKDIYATDQEGNFKCPALGCVRIFKRIGFLNKHAMTVHPTDLNVRQTVMKWSKG
  KCKFCQRQFEDSQHFIDHLNRHSYPNVYFCLHFNCNESFKLPFQLAQHTKSHRIFQAQCS
  FPECHELFEDLPLLYEHEAQHYLSKTPESSAQPSETILWDVQTDSNPNQEKDSSSNEKQT
  ISLPVSTSKSRKESTEPKTCIESMEKKTDSLVQNGNERSDDTVSNISLIDQKMPDIEPNS
  ENNCSSSDIVNGHSEIEQTPLVSSDPALKIDTNRIRTENGSILPSVVPQEHNTLPVSQAP
  SKPNLTSEHTSYGLILTKPYVRPLPPSYLDERYLSMPKRRKFLTDRVDACSDQDNVYKKS
  VKRLRCGKCLTTYCNAEALEAHLAQKKCQTLFGFDSDDESA

• Sequence length: 581

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations