Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55255
Gene name Gene Name - the full gene name approved by the HGNC.	WD repeat domain 41
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	WDR41
Synonyms (NCBI Gene) Gene synonyms aliases	MSTP048
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q13.3-q14.1

Show/Hide all(218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT714579	hsa-miR-3185	HITS-CLIP	19536157
MIRT714580	hsa-miR-1253	HITS-CLIP	19536157
MIRT714577	hsa-miR-3194-5p	HITS-CLIP	19536157
MIRT714578	hsa-miR-1202	HITS-CLIP	19536157
MIRT714576	hsa-miR-3972	HITS-CLIP	19536157
MIRT695397	hsa-miR-125a-3p	HITS-CLIP	23313552
MIRT695396	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT695395	hsa-miR-600	HITS-CLIP	23313552
MIRT695394	hsa-miR-3665	HITS-CLIP	23313552
MIRT695393	hsa-miR-4480	HITS-CLIP	23313552
MIRT695392	hsa-miR-2682-3p	HITS-CLIP	23313552
MIRT695391	hsa-miR-6781-3p	HITS-CLIP	23313552
MIRT695390	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT695389	hsa-miR-491-3p	HITS-CLIP	23313552
MIRT714579	hsa-miR-3185	HITS-CLIP	19536157
MIRT714580	hsa-miR-1253	HITS-CLIP	19536157
MIRT714577	hsa-miR-3194-5p	HITS-CLIP	19536157
MIRT714578	hsa-miR-1202	HITS-CLIP	19536157
MIRT714576	hsa-miR-3972	HITS-CLIP	19536157
MIRT695397	hsa-miR-125a-3p	HITS-CLIP	23313552
MIRT695396	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT695395	hsa-miR-600	HITS-CLIP	23313552
MIRT695394	hsa-miR-3665	HITS-CLIP	23313552
MIRT695393	hsa-miR-4480	HITS-CLIP	23313552
MIRT695392	hsa-miR-2682-3p	HITS-CLIP	23313552
MIRT695391	hsa-miR-6781-3p	HITS-CLIP	23313552
MIRT695390	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT695389	hsa-miR-491-3p	HITS-CLIP	23313552
MIRT1490504	hsa-miR-105	CLIP-seq
MIRT1490505	hsa-miR-197	CLIP-seq
MIRT1490506	hsa-miR-3145-3p	CLIP-seq
MIRT1490507	hsa-miR-3148	CLIP-seq
MIRT1490508	hsa-miR-3688-3p	CLIP-seq
MIRT1490509	hsa-miR-3942-3p	CLIP-seq
MIRT1490510	hsa-miR-3973	CLIP-seq
MIRT1490511	hsa-miR-421	CLIP-seq
MIRT1490512	hsa-miR-4536	CLIP-seq
MIRT1490513	hsa-miR-4660	CLIP-seq
MIRT1490514	hsa-miR-4694-3p	CLIP-seq
MIRT1490515	hsa-miR-4709-5p	CLIP-seq
MIRT1490516	hsa-miR-4777-3p	CLIP-seq
MIRT1490517	hsa-miR-520g	CLIP-seq
MIRT1490518	hsa-miR-520h	CLIP-seq
MIRT1490519	hsa-miR-548ae	CLIP-seq
MIRT1490520	hsa-miR-548aj	CLIP-seq
MIRT1490521	hsa-miR-548am	CLIP-seq
MIRT1490522	hsa-miR-548x	CLIP-seq
MIRT1490523	hsa-miR-556-3p	CLIP-seq
MIRT1490524	hsa-miR-646	CLIP-seq
MIRT1490525	hsa-miR-759	CLIP-seq
MIRT1555578	hsa-miR-3647-3p	CLIP-seq
MIRT1555579	hsa-miR-4496	CLIP-seq
MIRT1555580	hsa-miR-4744	CLIP-seq
MIRT1555581	hsa-miR-548u	CLIP-seq
MIRT1490504	hsa-miR-105	CLIP-seq
MIRT2147892	hsa-miR-3184	CLIP-seq
MIRT2147893	hsa-miR-3189-3p	CLIP-seq
MIRT2147894	hsa-miR-325	CLIP-seq
MIRT2147895	hsa-miR-362-5p	CLIP-seq
MIRT2147896	hsa-miR-3670	CLIP-seq
MIRT2147897	hsa-miR-423-5p	CLIP-seq
MIRT2147898	hsa-miR-4273	CLIP-seq
MIRT2147899	hsa-miR-4677-5p	CLIP-seq
MIRT2147900	hsa-miR-4688	CLIP-seq
MIRT2147901	hsa-miR-4793-5p	CLIP-seq
MIRT2147902	hsa-miR-486-3p	CLIP-seq
MIRT2147903	hsa-miR-500b	CLIP-seq
MIRT2147904	hsa-miR-628-3p	CLIP-seq
MIRT1490505	hsa-miR-197	CLIP-seq
MIRT1490507	hsa-miR-3148	CLIP-seq
MIRT2368304	hsa-miR-3153	CLIP-seq
MIRT2368305	hsa-miR-377	CLIP-seq
MIRT1490511	hsa-miR-421	CLIP-seq
MIRT2368306	hsa-miR-4457	CLIP-seq
MIRT2368307	hsa-miR-4646-5p	CLIP-seq
MIRT2368308	hsa-miR-4668-5p	CLIP-seq
MIRT1490515	hsa-miR-4709-5p	CLIP-seq
MIRT2368309	hsa-miR-513b	CLIP-seq
MIRT1490524	hsa-miR-646	CLIP-seq
MIRT2396944	hsa-miR-1343	CLIP-seq
MIRT1490504	hsa-miR-105	CLIP-seq
MIRT2661901	hsa-miR-1206	CLIP-seq
MIRT2661902	hsa-miR-1245	CLIP-seq
MIRT2661903	hsa-miR-1286	CLIP-seq
MIRT2661904	hsa-miR-129-5p	CLIP-seq
MIRT2661905	hsa-miR-132	CLIP-seq
MIRT2661906	hsa-miR-141	CLIP-seq
MIRT2661907	hsa-miR-144	CLIP-seq
MIRT2661908	hsa-miR-200a	CLIP-seq
MIRT2661909	hsa-miR-204	CLIP-seq
MIRT2661910	hsa-miR-211	CLIP-seq
MIRT2661911	hsa-miR-212	CLIP-seq
MIRT1490506	hsa-miR-3145-3p	CLIP-seq
MIRT1490507	hsa-miR-3148	CLIP-seq
MIRT2368304	hsa-miR-3153	CLIP-seq
MIRT2147892	hsa-miR-3184	CLIP-seq
MIRT2147893	hsa-miR-3189-3p	CLIP-seq
MIRT2147894	hsa-miR-325	CLIP-seq
MIRT2661912	hsa-miR-329	CLIP-seq
MIRT2661913	hsa-miR-3613-3p	CLIP-seq
MIRT2661914	hsa-miR-362-3p	CLIP-seq
MIRT2147895	hsa-miR-362-5p	CLIP-seq
MIRT1555578	hsa-miR-3647-3p	CLIP-seq
MIRT2147896	hsa-miR-3670	CLIP-seq
MIRT2661915	hsa-miR-371-5p	CLIP-seq
MIRT2661916	hsa-miR-371b-5p	CLIP-seq
MIRT2368305	hsa-miR-377	CLIP-seq
MIRT1490509	hsa-miR-3942-3p	CLIP-seq
MIRT2147897	hsa-miR-423-5p	CLIP-seq
MIRT2661917	hsa-miR-4261	CLIP-seq
MIRT2147898	hsa-miR-4273	CLIP-seq
MIRT2661918	hsa-miR-4282	CLIP-seq
MIRT2368306	hsa-miR-4457	CLIP-seq
MIRT1555579	hsa-miR-4496	CLIP-seq
MIRT2661919	hsa-miR-4509	CLIP-seq
MIRT2661920	hsa-miR-4641	CLIP-seq
MIRT2368307	hsa-miR-4646-5p	CLIP-seq
MIRT2368308	hsa-miR-4668-5p	CLIP-seq
MIRT2147899	hsa-miR-4677-5p	CLIP-seq
MIRT2147900	hsa-miR-4688	CLIP-seq
MIRT2661921	hsa-miR-4722-5p	CLIP-seq
MIRT1555580	hsa-miR-4744	CLIP-seq
MIRT2661922	hsa-miR-4755-5p	CLIP-seq
MIRT2661923	hsa-miR-4761-5p	CLIP-seq
MIRT2661924	hsa-miR-4768-3p	CLIP-seq
MIRT1490516	hsa-miR-4777-3p	CLIP-seq
MIRT2661925	hsa-miR-4786-3p	CLIP-seq
MIRT2147901	hsa-miR-4793-5p	CLIP-seq
MIRT2661926	hsa-miR-4799-5p	CLIP-seq
MIRT2147902	hsa-miR-486-3p	CLIP-seq
MIRT2661927	hsa-miR-498	CLIP-seq
MIRT2147903	hsa-miR-500b	CLIP-seq
MIRT2368309	hsa-miR-513b	CLIP-seq
MIRT2661928	hsa-miR-518d-5p	CLIP-seq
MIRT2661929	hsa-miR-519b-5p	CLIP-seq
MIRT2661930	hsa-miR-519c-5p	CLIP-seq
MIRT2661931	hsa-miR-520c-5p	CLIP-seq
MIRT2661932	hsa-miR-526a	CLIP-seq
MIRT2661933	hsa-miR-548a-3p	CLIP-seq
MIRT2661934	hsa-miR-548e	CLIP-seq
MIRT2661935	hsa-miR-548f	CLIP-seq
MIRT1555581	hsa-miR-548u	CLIP-seq
MIRT2661936	hsa-miR-550a	CLIP-seq
MIRT1490523	hsa-miR-556-3p	CLIP-seq
MIRT2661937	hsa-miR-576-5p	CLIP-seq
MIRT2661938	hsa-miR-623	CLIP-seq
MIRT2147904	hsa-miR-628-3p	CLIP-seq
MIRT2661939	hsa-miR-656	CLIP-seq
MIRT2661940	hsa-miR-660	CLIP-seq
MIRT2661941	hsa-miR-671-5p	CLIP-seq
MIRT1490525	hsa-miR-759	CLIP-seq
MIRT2661942	hsa-miR-760	CLIP-seq
MIRT2661943	hsa-miR-935	CLIP-seq
MIRT1490504	hsa-miR-105	CLIP-seq
MIRT2661901	hsa-miR-1206	CLIP-seq
MIRT2661902	hsa-miR-1245	CLIP-seq
MIRT2661903	hsa-miR-1286	CLIP-seq
MIRT2661905	hsa-miR-132	CLIP-seq
MIRT2661906	hsa-miR-141	CLIP-seq
MIRT2661908	hsa-miR-200a	CLIP-seq
MIRT2661911	hsa-miR-212	CLIP-seq
MIRT1490506	hsa-miR-3145-3p	CLIP-seq
MIRT1490507	hsa-miR-3148	CLIP-seq
MIRT2368304	hsa-miR-3153	CLIP-seq
MIRT2147892	hsa-miR-3184	CLIP-seq
MIRT2147893	hsa-miR-3189-3p	CLIP-seq
MIRT2147894	hsa-miR-325	CLIP-seq
MIRT2661912	hsa-miR-329	CLIP-seq
MIRT2661913	hsa-miR-3613-3p	CLIP-seq
MIRT2661914	hsa-miR-362-3p	CLIP-seq
MIRT2147895	hsa-miR-362-5p	CLIP-seq
MIRT1555578	hsa-miR-3647-3p	CLIP-seq
MIRT2147896	hsa-miR-3670	CLIP-seq
MIRT2661915	hsa-miR-371-5p	CLIP-seq
MIRT2661916	hsa-miR-371b-5p	CLIP-seq
MIRT2368305	hsa-miR-377	CLIP-seq
MIRT1490509	hsa-miR-3942-3p	CLIP-seq
MIRT2147897	hsa-miR-423-5p	CLIP-seq
MIRT2661917	hsa-miR-4261	CLIP-seq
MIRT2147898	hsa-miR-4273	CLIP-seq
MIRT2661918	hsa-miR-4282	CLIP-seq
MIRT2368306	hsa-miR-4457	CLIP-seq
MIRT1555579	hsa-miR-4496	CLIP-seq
MIRT2661919	hsa-miR-4509	CLIP-seq
MIRT2661920	hsa-miR-4641	CLIP-seq
MIRT2368307	hsa-miR-4646-5p	CLIP-seq
MIRT2368308	hsa-miR-4668-5p	CLIP-seq
MIRT2147899	hsa-miR-4677-5p	CLIP-seq
MIRT2147900	hsa-miR-4688	CLIP-seq
MIRT2661921	hsa-miR-4722-5p	CLIP-seq
MIRT1555580	hsa-miR-4744	CLIP-seq
MIRT2661923	hsa-miR-4761-5p	CLIP-seq
MIRT2661924	hsa-miR-4768-3p	CLIP-seq
MIRT2661925	hsa-miR-4786-3p	CLIP-seq
MIRT2147901	hsa-miR-4793-5p	CLIP-seq
MIRT2661926	hsa-miR-4799-5p	CLIP-seq
MIRT2147902	hsa-miR-486-3p	CLIP-seq
MIRT2661927	hsa-miR-498	CLIP-seq
MIRT2147903	hsa-miR-500b	CLIP-seq
MIRT2368309	hsa-miR-513b	CLIP-seq
MIRT2661928	hsa-miR-518d-5p	CLIP-seq
MIRT2661929	hsa-miR-519b-5p	CLIP-seq
MIRT2661930	hsa-miR-519c-5p	CLIP-seq
MIRT2661931	hsa-miR-520c-5p	CLIP-seq
MIRT2661932	hsa-miR-526a	CLIP-seq
MIRT2661933	hsa-miR-548a-3p	CLIP-seq
MIRT2661934	hsa-miR-548e	CLIP-seq
MIRT2661935	hsa-miR-548f	CLIP-seq
MIRT1555581	hsa-miR-548u	CLIP-seq
MIRT2661936	hsa-miR-550a	CLIP-seq
MIRT2661937	hsa-miR-576-5p	CLIP-seq
MIRT2147904	hsa-miR-628-3p	CLIP-seq
MIRT2661939	hsa-miR-656	CLIP-seq
MIRT2661940	hsa-miR-660	CLIP-seq
MIRT2661941	hsa-miR-671-5p	CLIP-seq
MIRT1490525	hsa-miR-759	CLIP-seq
MIRT2661942	hsa-miR-760	CLIP-seq
MIRT2661943	hsa-miR-935	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	27103069
GO:0005515	Function	Protein binding	IPI	28195531
GO:0005737	Component	Cytoplasm	IDA	27193190
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0006914	Process	Autophagy	IEA
GO:0010506	Process	Regulation of autophagy	IMP	27103069
GO:0032045	Component	Guanyl-nucleotide exchange factor complex	IDA	27103069
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:1990316	Component	Atg1/ULK1 kinase complex	IDA	27193190

MIM	HGNC	e!Ensembl
617502	25601	ENSG00000164253

Protein

UniProt ID

Q9HAD4

Protein name

WD repeat-containing protein 41

Protein function

Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27103069, PubMed:27193190, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex pr

PDB

6LT0 , 6V4U , 7MGE , 8W3V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	33 → 70	WD domain, G-beta repeat	Repeat
PF00400	WD40	74 → 119	WD domain, G-beta repeat	Repeat
PF00400	WD40	315 → 350	WD domain, G-beta repeat	Repeat

Sequence

MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASA
GDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDG
DTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSDTGISALV
EIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFVTGS
HVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAV
GRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAE
PVPTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLV
TCSADHLIILWKNGERESGLRSLRLFQKLEENGDLYLAV

Sequence length

459

Interactions

View interactions

	KEGG
	Autophagy - animal Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	26830138

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Disease	Associate	37337823
Myopia	Associate	19324860

WDR41 (WD repeat domain 41)