Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55254
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane protein 39A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMEM39A
Synonyms (NCBI Gene) Gene synonyms aliases	SUSR2
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q13.33

Show/Hide all(82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052363	hsa-let-7a-5p	CLASH	23622248
MIRT1436969	hsa-miR-1185	CLIP-seq
MIRT1436970	hsa-miR-299-3p	CLIP-seq
MIRT1436971	hsa-miR-3166	CLIP-seq
MIRT1436972	hsa-miR-3605-5p	CLIP-seq
MIRT1436973	hsa-miR-3616-3p	CLIP-seq
MIRT1436974	hsa-miR-3617	CLIP-seq
MIRT1436975	hsa-miR-3679-5p	CLIP-seq
MIRT1436976	hsa-miR-4265	CLIP-seq
MIRT1436977	hsa-miR-4296	CLIP-seq
MIRT1436978	hsa-miR-4322	CLIP-seq
MIRT1436979	hsa-miR-433	CLIP-seq
MIRT1436980	hsa-miR-4417	CLIP-seq
MIRT1436981	hsa-miR-4509	CLIP-seq
MIRT1436982	hsa-miR-4684-5p	CLIP-seq
MIRT1436983	hsa-miR-4721	CLIP-seq
MIRT1436984	hsa-miR-4744	CLIP-seq
MIRT1436985	hsa-miR-4760-5p	CLIP-seq
MIRT1436986	hsa-miR-4764-3p	CLIP-seq
MIRT1436987	hsa-miR-488	CLIP-seq
MIRT1436988	hsa-miR-641	CLIP-seq
MIRT2130990	hsa-miR-1207-3p	CLIP-seq
MIRT2130991	hsa-miR-1224-5p	CLIP-seq
MIRT2130992	hsa-miR-1305	CLIP-seq
MIRT2130993	hsa-miR-150	CLIP-seq
MIRT2130994	hsa-miR-3121-3p	CLIP-seq
MIRT2130995	hsa-miR-3673	CLIP-seq
MIRT2130996	hsa-miR-4639-3p	CLIP-seq
MIRT2130997	hsa-miR-4713-5p	CLIP-seq
MIRT2130998	hsa-miR-4714-3p	CLIP-seq
MIRT2130999	hsa-miR-4751	CLIP-seq
MIRT2131000	hsa-miR-532-3p	CLIP-seq
MIRT2131001	hsa-miR-890	CLIP-seq
MIRT2131002	hsa-miR-935	CLIP-seq
MIRT2130990	hsa-miR-1207-3p	CLIP-seq
MIRT2130991	hsa-miR-1224-5p	CLIP-seq
MIRT2352222	hsa-miR-200b	CLIP-seq
MIRT2352223	hsa-miR-200c	CLIP-seq
MIRT2352224	hsa-miR-429	CLIP-seq
MIRT2352225	hsa-miR-4445	CLIP-seq
MIRT2130999	hsa-miR-4751	CLIP-seq
MIRT2352226	hsa-miR-4803	CLIP-seq
MIRT2396009	hsa-miR-298	CLIP-seq
MIRT2396010	hsa-miR-4261	CLIP-seq
MIRT2396011	hsa-miR-4795-5p	CLIP-seq
MIRT2396012	hsa-miR-671-5p	CLIP-seq
MIRT2646017	hsa-miR-1236	CLIP-seq
MIRT2646018	hsa-miR-1323	CLIP-seq
MIRT2646019	hsa-miR-188-5p	CLIP-seq
MIRT2352222	hsa-miR-200b	CLIP-seq
MIRT2352223	hsa-miR-200c	CLIP-seq
MIRT2646020	hsa-miR-300	CLIP-seq
MIRT2646021	hsa-miR-381	CLIP-seq
MIRT2352224	hsa-miR-429	CLIP-seq
MIRT2646022	hsa-miR-4643	CLIP-seq
MIRT2646023	hsa-miR-4666-3p	CLIP-seq
MIRT2646024	hsa-miR-4788	CLIP-seq
MIRT2352226	hsa-miR-4803	CLIP-seq
MIRT2646025	hsa-miR-499-3p	CLIP-seq
MIRT2646026	hsa-miR-499a-3p	CLIP-seq
MIRT2646027	hsa-miR-548o	CLIP-seq
MIRT2646028	hsa-miR-550b	CLIP-seq
MIRT2646029	hsa-miR-607	CLIP-seq
MIRT2646030	hsa-miR-633	CLIP-seq
MIRT2646031	hsa-miR-889	CLIP-seq
MIRT2646017	hsa-miR-1236	CLIP-seq
MIRT2646018	hsa-miR-1323	CLIP-seq
MIRT2646019	hsa-miR-188-5p	CLIP-seq
MIRT2693519	hsa-miR-338-5p	CLIP-seq
MIRT2693520	hsa-miR-425	CLIP-seq
MIRT2646022	hsa-miR-4643	CLIP-seq
MIRT2646024	hsa-miR-4788	CLIP-seq
MIRT2352226	hsa-miR-4803	CLIP-seq
MIRT2646025	hsa-miR-499-3p	CLIP-seq
MIRT2646026	hsa-miR-499a-3p	CLIP-seq
MIRT2646027	hsa-miR-548o	CLIP-seq
MIRT2693521	hsa-miR-549	CLIP-seq
MIRT2646028	hsa-miR-550b	CLIP-seq
MIRT2693522	hsa-miR-570	CLIP-seq
MIRT2646029	hsa-miR-607	CLIP-seq
MIRT2646030	hsa-miR-633	CLIP-seq
MIRT2646031	hsa-miR-889	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	31806350, 31849860
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	31806350
GO:0006914	Process	Autophagy	IEA
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0045070	Process	Positive regulation of viral genome replication	IDA	31849860
GO:1901097	Process	Negative regulation of autophagosome maturation	IBA	21873635
GO:1901097	Process	Negative regulation of autophagosome maturation	IMP	31806350
GO:1902902	Process	Negative regulation of autophagosome assembly	IBA	21873635
GO:1902902	Process	Negative regulation of autophagosome assembly	IMP	31806350

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q9NV64

Protein name

Transmembrane protein 39A

Protein function

Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (PubMed:31806350). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the pho

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10271	Tmp39	42 → 477	Putative transmembrane protein	Family

Tissue specificity

TISSUE SPECIFICITY: Up-regulated in brain tumor glioblastoma multiforme cells (at protein level). {ECO:0000269|PubMed:28133515}.

Sequence

MPGGRRGPSRQQLSRSALPSLQTLVGGGCGNGTGLRNRNGSAIGLPVPPITALITPGPVR
HCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYH
LAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARLVLLTLCGWVLCWTLVNLFRS
HSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYVVQHEAVEESASTVGGLAKSKDF
LSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVA
FLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLE
HGSYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRL
LNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPL
NSYELKAN

Sequence length

488

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	21833088

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Systemic lupus erythematosus	Systemic lupus erythematosus	GWAS
Biliary Cholangitis	Biliary Cholangitis	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Hepatitis B	Associate	39237981
Lupus Erythematosus Systemic	Stimulate	22464253
Lupus Erythematosus Systemic	Associate	22464253, 25890262, 28427360
Multiple Sclerosis	Associate	20007504

TMEM39A (transmembrane protein 39A)