TMEM39A (transmembrane protein 39A)

Gene

• Entrez ID: 55254
• Gene name: Transmembrane protein 39A
• Gene symbol: TMEM39A
• Synonyms (NCBI Gene): SUSR2
• Chromosome: 3
• Chromosome location: 3q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052363	hsa-let-7a-5p	CLASH	23622248
MIRT1436969	hsa-miR-1185	CLIP-seq
MIRT1436970	hsa-miR-299-3p	CLIP-seq
MIRT1436971	hsa-miR-3166	CLIP-seq
MIRT1436972	hsa-miR-3605-5p	CLIP-seq
MIRT1436973	hsa-miR-3616-3p	CLIP-seq
MIRT1436974	hsa-miR-3617	CLIP-seq
MIRT1436975	hsa-miR-3679-5p	CLIP-seq
MIRT1436976	hsa-miR-4265	CLIP-seq
MIRT1436977	hsa-miR-4296	CLIP-seq
MIRT1436978	hsa-miR-4322	CLIP-seq
MIRT1436979	hsa-miR-433	CLIP-seq
MIRT1436980	hsa-miR-4417	CLIP-seq
MIRT1436981	hsa-miR-4509	CLIP-seq
MIRT1436982	hsa-miR-4684-5p	CLIP-seq
MIRT1436983	hsa-miR-4721	CLIP-seq
MIRT1436984	hsa-miR-4744	CLIP-seq
MIRT1436985	hsa-miR-4760-5p	CLIP-seq
MIRT1436986	hsa-miR-4764-3p	CLIP-seq
MIRT1436987	hsa-miR-488	CLIP-seq
MIRT1436988	hsa-miR-641	CLIP-seq
MIRT2130990	hsa-miR-1207-3p	CLIP-seq
MIRT2130991	hsa-miR-1224-5p	CLIP-seq
MIRT2130992	hsa-miR-1305	CLIP-seq
MIRT2130993	hsa-miR-150	CLIP-seq
MIRT2130994	hsa-miR-3121-3p	CLIP-seq
MIRT2130995	hsa-miR-3673	CLIP-seq
MIRT2130996	hsa-miR-4639-3p	CLIP-seq
MIRT2130997	hsa-miR-4713-5p	CLIP-seq
MIRT2130998	hsa-miR-4714-3p	CLIP-seq
MIRT2130999	hsa-miR-4751	CLIP-seq
MIRT2131000	hsa-miR-532-3p	CLIP-seq
MIRT2131001	hsa-miR-890	CLIP-seq
MIRT2131002	hsa-miR-935	CLIP-seq
MIRT2130990	hsa-miR-1207-3p	CLIP-seq
MIRT2130991	hsa-miR-1224-5p	CLIP-seq
MIRT2352222	hsa-miR-200b	CLIP-seq
MIRT2352223	hsa-miR-200c	CLIP-seq
MIRT2352224	hsa-miR-429	CLIP-seq
MIRT2352225	hsa-miR-4445	CLIP-seq
MIRT2130999	hsa-miR-4751	CLIP-seq
MIRT2352226	hsa-miR-4803	CLIP-seq
MIRT2396009	hsa-miR-298	CLIP-seq
MIRT2396010	hsa-miR-4261	CLIP-seq
MIRT2396011	hsa-miR-4795-5p	CLIP-seq
MIRT2396012	hsa-miR-671-5p	CLIP-seq
MIRT2646017	hsa-miR-1236	CLIP-seq
MIRT2646018	hsa-miR-1323	CLIP-seq
MIRT2646019	hsa-miR-188-5p	CLIP-seq
MIRT2352222	hsa-miR-200b	CLIP-seq
MIRT2352223	hsa-miR-200c	CLIP-seq
MIRT2646020	hsa-miR-300	CLIP-seq
MIRT2646021	hsa-miR-381	CLIP-seq
MIRT2352224	hsa-miR-429	CLIP-seq
MIRT2646022	hsa-miR-4643	CLIP-seq
MIRT2646023	hsa-miR-4666-3p	CLIP-seq
MIRT2646024	hsa-miR-4788	CLIP-seq
MIRT2352226	hsa-miR-4803	CLIP-seq
MIRT2646025	hsa-miR-499-3p	CLIP-seq
MIRT2646026	hsa-miR-499a-3p	CLIP-seq
MIRT2646027	hsa-miR-548o	CLIP-seq
MIRT2646028	hsa-miR-550b	CLIP-seq
MIRT2646029	hsa-miR-607	CLIP-seq
MIRT2646030	hsa-miR-633	CLIP-seq
MIRT2646031	hsa-miR-889	CLIP-seq
MIRT2646017	hsa-miR-1236	CLIP-seq
MIRT2646018	hsa-miR-1323	CLIP-seq
MIRT2646019	hsa-miR-188-5p	CLIP-seq
MIRT2693519	hsa-miR-338-5p	CLIP-seq
MIRT2693520	hsa-miR-425	CLIP-seq
MIRT2646022	hsa-miR-4643	CLIP-seq
MIRT2646024	hsa-miR-4788	CLIP-seq
MIRT2352226	hsa-miR-4803	CLIP-seq
MIRT2646025	hsa-miR-499-3p	CLIP-seq
MIRT2646026	hsa-miR-499a-3p	CLIP-seq
MIRT2646027	hsa-miR-548o	CLIP-seq
MIRT2693521	hsa-miR-549	CLIP-seq
MIRT2646028	hsa-miR-550b	CLIP-seq
MIRT2693522	hsa-miR-570	CLIP-seq
MIRT2646029	hsa-miR-607	CLIP-seq
MIRT2646030	hsa-miR-633	CLIP-seq
MIRT2646031	hsa-miR-889	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	31806350, 31849860
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	31806350
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006914	Process	Autophagy	IEA
GO:0016020	Component	Membrane	IEA
GO:0045070	Process	Positive regulation of viral genome replication	IDA	31849860
GO:1901097	Process	Negative regulation of autophagosome maturation	IBA
GO:1901097	Process	Negative regulation of autophagosome maturation	IMP	31806350
GO:1902902	Process	Negative regulation of autophagosome assembly	IBA
GO:1902902	Process	Negative regulation of autophagosome assembly	IMP	31806350

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9NV64
• Protein name: Transmembrane protein 39A
• Protein function: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (PubMed:31806350). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the pho
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10271	Tmp39	42 → 477	Putative transmembrane protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Up-regulated in brain tumor glioblastoma multiforme cells (at protein level). {ECO:0000269|PubMed:28133515}.
• Sequence:

  MPGGRRGPSRQQLSRSALPSLQTLVGGGCGNGTGLRNRNGSAIGLPVPPITALITPGPVR
  HCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYH
  LAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARLVLLTLCGWVLCWTLVNLFRS
  HSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYVVQHEAVEESASTVGGLAKSKDF
  LSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVA
  FLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLE
  HGSYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRL
  LNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPL
  NSYELKAN

• Sequence length: 488

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Biliary Cholangitis	Primary biliary cholangitis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Hepatitis B	Associate	39237981
Lupus Erythematosus Systemic	Stimulate	22464253
Lupus Erythematosus Systemic	Associate	22464253, 25890262, 28427360
Multiple Sclerosis	Associate	20007504