Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55253
Gene name	TRNA-yW synthesizing protein 1 homolog
Gene symbol	TYW1
Synonyms (NCBI Gene)	RSAFD1TYW1AYPL207W
Chromosome	7
Chromosome location	7q11.21
Summary	Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative s

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050089	hsa-miR-26a-5p	CLASH	23622248
MIRT1465768	hsa-miR-1304	CLIP-seq
MIRT1465769	hsa-miR-203	CLIP-seq
MIRT1465770	hsa-miR-205	CLIP-seq
MIRT1465771	hsa-miR-2355-3p	CLIP-seq
MIRT1465772	hsa-miR-3200-3p	CLIP-seq
MIRT1465773	hsa-miR-3691-3p	CLIP-seq
MIRT1465774	hsa-miR-4326	CLIP-seq
MIRT1465775	hsa-miR-4529-5p	CLIP-seq
MIRT1465776	hsa-miR-4646-3p	CLIP-seq
MIRT1465777	hsa-miR-4691-5p	CLIP-seq
MIRT1465778	hsa-miR-4694-5p	CLIP-seq
MIRT1465779	hsa-miR-4703-3p	CLIP-seq
MIRT1465780	hsa-miR-548b-3p	CLIP-seq
MIRT1465781	hsa-miR-676	CLIP-seq
MIRT2139990	hsa-miR-1179	CLIP-seq
MIRT2139991	hsa-miR-1207-5p	CLIP-seq
MIRT2139992	hsa-miR-1266	CLIP-seq
MIRT2139993	hsa-miR-130a	CLIP-seq
MIRT2139994	hsa-miR-130b	CLIP-seq
MIRT2139995	hsa-miR-301a	CLIP-seq
MIRT2139996	hsa-miR-301b	CLIP-seq
MIRT2139997	hsa-miR-3117-5p	CLIP-seq
MIRT2139998	hsa-miR-3128	CLIP-seq
MIRT2139999	hsa-miR-3136-3p	CLIP-seq
MIRT2140000	hsa-miR-34b	CLIP-seq
MIRT2140001	hsa-miR-3615	CLIP-seq
MIRT2140002	hsa-miR-3666	CLIP-seq
MIRT2140003	hsa-miR-369-3p	CLIP-seq
MIRT2140004	hsa-miR-374a	CLIP-seq
MIRT2140005	hsa-miR-374b	CLIP-seq
MIRT2140006	hsa-miR-374c	CLIP-seq
MIRT2140007	hsa-miR-3918	CLIP-seq
MIRT2140008	hsa-miR-3921	CLIP-seq
MIRT2140009	hsa-miR-4295	CLIP-seq
MIRT2140010	hsa-miR-4422	CLIP-seq
MIRT2140011	hsa-miR-4433	CLIP-seq
MIRT2140012	hsa-miR-4461	CLIP-seq
MIRT2140013	hsa-miR-4508	CLIP-seq
MIRT2140014	hsa-miR-4518	CLIP-seq
MIRT2140015	hsa-miR-4536	CLIP-seq
MIRT2140016	hsa-miR-454	CLIP-seq
MIRT2140017	hsa-miR-4639-3p	CLIP-seq
MIRT2140018	hsa-miR-4653-5p	CLIP-seq
MIRT2140019	hsa-miR-4666-5p	CLIP-seq
MIRT2140020	hsa-miR-4671-3p	CLIP-seq
MIRT2140021	hsa-miR-4675	CLIP-seq
MIRT2140022	hsa-miR-4682	CLIP-seq
MIRT2140023	hsa-miR-4685-5p	CLIP-seq
MIRT2140024	hsa-miR-4693-3p	CLIP-seq
MIRT1465779	hsa-miR-4703-3p	CLIP-seq
MIRT2140025	hsa-miR-4720-5p	CLIP-seq
MIRT2140026	hsa-miR-4736	CLIP-seq
MIRT2140027	hsa-miR-4741	CLIP-seq
MIRT2140028	hsa-miR-4763-3p	CLIP-seq
MIRT2140029	hsa-miR-4766-5p	CLIP-seq
MIRT2140030	hsa-miR-4799-3p	CLIP-seq
MIRT2140031	hsa-miR-4802-3p	CLIP-seq
MIRT2140032	hsa-miR-494	CLIP-seq
MIRT2140033	hsa-miR-548aa	CLIP-seq
MIRT2140034	hsa-miR-576-5p	CLIP-seq
MIRT2140035	hsa-miR-577	CLIP-seq
MIRT2140036	hsa-miR-600	CLIP-seq
MIRT2140037	hsa-miR-655	CLIP-seq
MIRT2140038	hsa-miR-663b	CLIP-seq
MIRT2140039	hsa-miR-766	CLIP-seq
MIRT2140040	hsa-miR-892a	CLIP-seq
MIRT2139990	hsa-miR-1179	CLIP-seq
MIRT2139991	hsa-miR-1207-5p	CLIP-seq
MIRT2360688	hsa-miR-1244	CLIP-seq
MIRT2139992	hsa-miR-1266	CLIP-seq
MIRT2360689	hsa-miR-128	CLIP-seq
MIRT1465768	hsa-miR-1304	CLIP-seq
MIRT2139993	hsa-miR-130a	CLIP-seq
MIRT2139994	hsa-miR-130b	CLIP-seq
MIRT1465770	hsa-miR-205	CLIP-seq
MIRT1465771	hsa-miR-2355-3p	CLIP-seq
MIRT2139995	hsa-miR-301a	CLIP-seq
MIRT2139996	hsa-miR-301b	CLIP-seq
MIRT2139997	hsa-miR-3117-5p	CLIP-seq
MIRT2360690	hsa-miR-3124-3p	CLIP-seq
MIRT2139998	hsa-miR-3128	CLIP-seq
MIRT2360691	hsa-miR-325	CLIP-seq
MIRT2140001	hsa-miR-3615	CLIP-seq
MIRT2360692	hsa-miR-3622a-3p	CLIP-seq
MIRT2360693	hsa-miR-3622b-3p	CLIP-seq
MIRT2140002	hsa-miR-3666	CLIP-seq
MIRT1465773	hsa-miR-3691-3p	CLIP-seq
MIRT2140003	hsa-miR-369-3p	CLIP-seq
MIRT2140004	hsa-miR-374a	CLIP-seq
MIRT2140005	hsa-miR-374b	CLIP-seq
MIRT2140006	hsa-miR-374c	CLIP-seq
MIRT2140009	hsa-miR-4295	CLIP-seq
MIRT2140014	hsa-miR-4518	CLIP-seq
MIRT1465775	hsa-miR-4529-5p	CLIP-seq
MIRT2140016	hsa-miR-454	CLIP-seq
MIRT2140017	hsa-miR-4639-3p	CLIP-seq
MIRT1465776	hsa-miR-4646-3p	CLIP-seq
MIRT2140020	hsa-miR-4671-3p	CLIP-seq
MIRT1465778	hsa-miR-4694-5p	CLIP-seq
MIRT2140025	hsa-miR-4720-5p	CLIP-seq
MIRT2140026	hsa-miR-4736	CLIP-seq
MIRT2360694	hsa-miR-4760-5p	CLIP-seq
MIRT2140028	hsa-miR-4763-3p	CLIP-seq
MIRT2140030	hsa-miR-4799-3p	CLIP-seq
MIRT2140033	hsa-miR-548aa	CLIP-seq
MIRT1465780	hsa-miR-548b-3p	CLIP-seq
MIRT2360695	hsa-miR-570	CLIP-seq
MIRT2140035	hsa-miR-577	CLIP-seq
MIRT2140036	hsa-miR-600	CLIP-seq
MIRT2140037	hsa-miR-655	CLIP-seq
MIRT1465781	hsa-miR-676	CLIP-seq
MIRT2139990	hsa-miR-1179	CLIP-seq
MIRT2139991	hsa-miR-1207-5p	CLIP-seq
MIRT2139997	hsa-miR-3117-5p	CLIP-seq
MIRT2139998	hsa-miR-3128	CLIP-seq
MIRT2140001	hsa-miR-3615	CLIP-seq
MIRT2396560	hsa-miR-3660	CLIP-seq
MIRT2140003	hsa-miR-369-3p	CLIP-seq
MIRT2140004	hsa-miR-374a	CLIP-seq
MIRT2140005	hsa-miR-374b	CLIP-seq
MIRT2140006	hsa-miR-374c	CLIP-seq
MIRT2396561	hsa-miR-4526	CLIP-seq
MIRT2140015	hsa-miR-4536	CLIP-seq
MIRT2140017	hsa-miR-4639-3p	CLIP-seq
MIRT2140019	hsa-miR-4666-5p	CLIP-seq
MIRT2140025	hsa-miR-4720-5p	CLIP-seq
MIRT2140026	hsa-miR-4736	CLIP-seq
MIRT2140028	hsa-miR-4763-3p	CLIP-seq
MIRT2140030	hsa-miR-4799-3p	CLIP-seq
MIRT2140031	hsa-miR-4802-3p	CLIP-seq
MIRT2396562	hsa-miR-572	CLIP-seq
MIRT2140036	hsa-miR-600	CLIP-seq
MIRT2140037	hsa-miR-655	CLIP-seq
MIRT2140039	hsa-miR-766	CLIP-seq
MIRT2139990	hsa-miR-1179	CLIP-seq
MIRT2139991	hsa-miR-1207-5p	CLIP-seq
MIRT2139992	hsa-miR-1266	CLIP-seq
MIRT2139993	hsa-miR-130a	CLIP-seq
MIRT2139994	hsa-miR-130b	CLIP-seq
MIRT2654287	hsa-miR-1324	CLIP-seq
MIRT2139995	hsa-miR-301a	CLIP-seq
MIRT2139996	hsa-miR-301b	CLIP-seq
MIRT2139997	hsa-miR-3117-5p	CLIP-seq
MIRT2654288	hsa-miR-3120-3p	CLIP-seq
MIRT2139998	hsa-miR-3128	CLIP-seq
MIRT2654289	hsa-miR-3166	CLIP-seq
MIRT2140000	hsa-miR-34b	CLIP-seq
MIRT2140001	hsa-miR-3615	CLIP-seq
MIRT2140002	hsa-miR-3666	CLIP-seq
MIRT2654290	hsa-miR-3689d	CLIP-seq
MIRT2140003	hsa-miR-369-3p	CLIP-seq
MIRT2140004	hsa-miR-374a	CLIP-seq
MIRT2140005	hsa-miR-374b	CLIP-seq
MIRT2140006	hsa-miR-374c	CLIP-seq
MIRT2654291	hsa-miR-4290	CLIP-seq
MIRT2140009	hsa-miR-4295	CLIP-seq
MIRT1465774	hsa-miR-4326	CLIP-seq
MIRT2140011	hsa-miR-4433	CLIP-seq
MIRT2654292	hsa-miR-4459	CLIP-seq
MIRT2140014	hsa-miR-4518	CLIP-seq
MIRT2654293	hsa-miR-4521	CLIP-seq
MIRT2140016	hsa-miR-454	CLIP-seq
MIRT2140017	hsa-miR-4639-3p	CLIP-seq
MIRT2654294	hsa-miR-4639-5p	CLIP-seq
MIRT2654295	hsa-miR-4662a-3p	CLIP-seq
MIRT2140020	hsa-miR-4671-3p	CLIP-seq
MIRT1465777	hsa-miR-4691-5p	CLIP-seq
MIRT2654296	hsa-miR-4701-5p	CLIP-seq
MIRT1465779	hsa-miR-4703-3p	CLIP-seq
MIRT2654297	hsa-miR-4717-3p	CLIP-seq
MIRT2140025	hsa-miR-4720-5p	CLIP-seq
MIRT2140026	hsa-miR-4736	CLIP-seq
MIRT2140028	hsa-miR-4763-3p	CLIP-seq
MIRT2654298	hsa-miR-4768-3p	CLIP-seq
MIRT2654299	hsa-miR-4775	CLIP-seq
MIRT2140030	hsa-miR-4799-3p	CLIP-seq
MIRT2654300	hsa-miR-483-3p	CLIP-seq
MIRT2140033	hsa-miR-548aa	CLIP-seq
MIRT2654301	hsa-miR-549	CLIP-seq
MIRT2396562	hsa-miR-572	CLIP-seq
MIRT2140034	hsa-miR-576-5p	CLIP-seq
MIRT2140035	hsa-miR-577	CLIP-seq
MIRT2654302	hsa-miR-588	CLIP-seq
MIRT2654303	hsa-miR-590-3p	CLIP-seq
MIRT2140036	hsa-miR-600	CLIP-seq
MIRT2654304	hsa-miR-604	CLIP-seq
MIRT2654305	hsa-miR-626	CLIP-seq
MIRT2654306	hsa-miR-647	CLIP-seq
MIRT2140037	hsa-miR-655	CLIP-seq
MIRT2140039	hsa-miR-766	CLIP-seq
MIRT2140040	hsa-miR-892a	CLIP-seq
MIRT2654307	hsa-miR-922	CLIP-seq
MIRT2139990	hsa-miR-1179	CLIP-seq
MIRT2139991	hsa-miR-1207-5p	CLIP-seq
MIRT2139992	hsa-miR-1266	CLIP-seq
MIRT2139993	hsa-miR-130a	CLIP-seq
MIRT2139994	hsa-miR-130b	CLIP-seq
MIRT2654287	hsa-miR-1324	CLIP-seq
MIRT1465769	hsa-miR-203	CLIP-seq
MIRT1465770	hsa-miR-205	CLIP-seq
MIRT1465771	hsa-miR-2355-3p	CLIP-seq
MIRT2139995	hsa-miR-301a	CLIP-seq
MIRT2139996	hsa-miR-301b	CLIP-seq
MIRT2139997	hsa-miR-3117-5p	CLIP-seq
MIRT2654288	hsa-miR-3120-3p	CLIP-seq
MIRT2139998	hsa-miR-3128	CLIP-seq
MIRT2654289	hsa-miR-3166	CLIP-seq
MIRT1465772	hsa-miR-3200-3p	CLIP-seq
MIRT2140000	hsa-miR-34b	CLIP-seq
MIRT2140001	hsa-miR-3615	CLIP-seq
MIRT2140002	hsa-miR-3666	CLIP-seq
MIRT2654290	hsa-miR-3689d	CLIP-seq
MIRT2140003	hsa-miR-369-3p	CLIP-seq
MIRT2140004	hsa-miR-374a	CLIP-seq
MIRT2140005	hsa-miR-374b	CLIP-seq
MIRT2140006	hsa-miR-374c	CLIP-seq
MIRT2694556	hsa-miR-3936	CLIP-seq
MIRT2654291	hsa-miR-4290	CLIP-seq
MIRT2140009	hsa-miR-4295	CLIP-seq
MIRT2140011	hsa-miR-4433	CLIP-seq
MIRT2654292	hsa-miR-4459	CLIP-seq
MIRT2140014	hsa-miR-4518	CLIP-seq
MIRT2654293	hsa-miR-4521	CLIP-seq
MIRT2140016	hsa-miR-454	CLIP-seq
MIRT2140017	hsa-miR-4639-3p	CLIP-seq
MIRT2654294	hsa-miR-4639-5p	CLIP-seq
MIRT1465776	hsa-miR-4646-3p	CLIP-seq
MIRT2654295	hsa-miR-4662a-3p	CLIP-seq
MIRT2140020	hsa-miR-4671-3p	CLIP-seq
MIRT2654296	hsa-miR-4701-5p	CLIP-seq
MIRT2654297	hsa-miR-4717-3p	CLIP-seq
MIRT2140025	hsa-miR-4720-5p	CLIP-seq
MIRT2140026	hsa-miR-4736	CLIP-seq
MIRT2140028	hsa-miR-4763-3p	CLIP-seq
MIRT2654298	hsa-miR-4768-3p	CLIP-seq
MIRT2140030	hsa-miR-4799-3p	CLIP-seq
MIRT2654300	hsa-miR-483-3p	CLIP-seq
MIRT2140033	hsa-miR-548aa	CLIP-seq
MIRT2654301	hsa-miR-549	CLIP-seq
MIRT2694557	hsa-miR-555	CLIP-seq
MIRT2396562	hsa-miR-572	CLIP-seq
MIRT2140034	hsa-miR-576-5p	CLIP-seq
MIRT2140035	hsa-miR-577	CLIP-seq
MIRT2654302	hsa-miR-588	CLIP-seq
MIRT2140036	hsa-miR-600	CLIP-seq
MIRT2654304	hsa-miR-604	CLIP-seq
MIRT2654305	hsa-miR-626	CLIP-seq
MIRT2654306	hsa-miR-647	CLIP-seq
MIRT2140037	hsa-miR-655	CLIP-seq
MIRT1465781	hsa-miR-676	CLIP-seq
MIRT2140039	hsa-miR-766	CLIP-seq
MIRT2140040	hsa-miR-892a	CLIP-seq
MIRT2654307	hsa-miR-922	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0010181	Function	FMN binding	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0031591	Process	Wybutosine biosynthetic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0102521	Function	TRNA-4-demethylwyosine synthase activity	IEA

MIM	HGNC	e!Ensembl
611243	25598	ENSG00000198874

Q9NV66

Protein name

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein)

Protein function

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methyl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00258	Flavodoxin_1	81 → 232	Flavodoxin	Domain
PF04055	Radical_SAM	410 → 592	Radical SAM superfamily	Domain
PF08608	Wyosine_form	594 → 657	Wyosine base formation	Family

Sequence

MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC

Sequence length

732

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Endometriosis	Associate	37058039	★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Associate	32279010	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Associate	39769182	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	37058039	★★★★★ ★☆☆☆☆ Found in Text Mining only

TYW1 (tRNA-yW synthesizing protein 1 homolog)