PACC1 (proton activated chloride channel 1)

Gene
Gene Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55248
Gene name Gene Name - the full gene name approved by the HGNC.
Proton activated chloride channel 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PACC1
Synonyms (NCBI Gene) Gene synonyms aliases
ASOR, C1orf75, PAC, PAORAC, TMEM206, hPAC, hTMEM206
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.3
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0005254 Function Chloride channel activity IEA
GO:0005515 Function Protein binding IPI 28514442, 32296183, 33961781
GO:0005886 Component Plasma membrane IDA 31023925, 31318332
GO:0005886 Component Plasma membrane IEA
GO:0006811 Process Monoatomic ion transport IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
618427 25593 ENSG00000065600
Protein
Gene Gene ontology Other IDs Protein
UniProt ID Q9H813
Protein name Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206)
Protein function Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent
PDB 7JNA , 7JNC , 7SQF , 7SQG , 7SQH , 8EQ4 , 8FBL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15122 TMEM206 55 → 349 TMEM206 protein family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest expression in brain. {ECO:0000269|PubMed:31023925}.
Sequence
Sequence length 350
Interactions View interactions
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