NEIL3 (nei like DNA glycosylase 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55247
Gene name Gene Name - the full gene name approved by the HGNC.
Nei like DNA glycosylase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NEIL3
Synonyms (NCBI Gene) Gene synonyms aliases
FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q34.3
Summary Summary of gene provided in NCBI Entrez Gene.
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the ass
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT024831 hsa-miR-215-5p Microarray 19074876
MIRT026184 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(44)
GO ID Ontology Definition Evidence Reference
GO:0000012 Process Single strand break repair IDA 19170771
GO:0000405 Function Bubble DNA binding IEA
GO:0000405 Function Bubble DNA binding ISS
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
608934 24573 ENSG00000109674
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways
UniProt ID Q8TAT5
Protein name Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3)
Protein function DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Mediates interstran
PDB 7JL5 , 7TMY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06831 H2TH 153 → 231 Formamidopyrimidine-DNA glycosylase H2TH domain Domain
PF00641 zf-RanBP 317 → 346 Zn-finger in Ran binding protein and others Domain
PF06839 zf-GRF 505 → 550 GRF zinc finger Domain
PF06839 zf-GRF 552 → 596 GRF zinc finger Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. {ECO:0000269|PubMed:12433996, ECO:0000269|PubMed:16428305, ECO:0000269|PubMed:19426544, ECO:00
Sequence 
MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAASTVVVSPQAAALNNDS
SQNVLSLFNGYVYSGVETLGKELFMYFGPKALRIHFGMKGFIMINPLEYKYKNGASPVLE
VQLTKDLICFFDSSVELRNSMESQQRIRMMKELDVCSPEFSFLRAESEVKKQKGRMLGDV
LMDQNVLPGVGNIIKNEALFDSGLHPAVKVCQLTDEQIHHLMKMIRDFSILFYRCRKAGL
ALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFCPHCQKENPQHVDICKLPTRNTIIS
WTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSSKACDACLTSRPIDSVLKSEENSTVFS
HLMKYPCNTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSP
PASVCLNDIQHPSKKTTNDITQPSSKVNISPTISSESKLFSPAHKKPKTAQYSSPELKSC
NPGYSNSELQINMTDGPRTLNPDSPRCSKHNRLCILRVVGKDGENKGRQFYACPLPREAQ
CGFFEWADLSFPFCNHGKRSTMKTVLKIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIK
IIPGC
Sequence length 605
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  Base excision repair   Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Defective Base Excision Repair Associated with NEIL3
NEIL3-mediated resolution of ICLs
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