PTPA (protein phosphatase 2 phosphatase activator)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5524
Gene name Protein phosphatase 2 phosphatase activator
Gene symbol PTPA
Synonyms (NCBI Gene)
PARK25PP2APPP2R4PR53
Chromosome 9
Chromosome location 9q34.11
Summary Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subu
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT438392 hsa-miR-183-5p Luciferase reporter assayWestern blotqRT-PCR 25152390
MIRT438392 hsa-miR-183-5p Luciferase reporter assayWestern blotqRT-PCR 25152390
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
HDAC4 Unknown 18045992
SETBP1 Repression 21233840
TP53 Repression 10787423
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex IBA
GO:0000159 Component Protein phosphatase type 2A complex IDA 10318862
GO:0000166 Function Nucleotide binding IEA
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IBA
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600756 9308 ENSG00000119383
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15257
Protein name Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulator
Protein function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:169166
PDB 2G62 , 2HV6 , 2HV7 , 2IXM , 4LAC , 4NY3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03095 PTPA 26 → 352 Phosphotyrosyl phosphate activator (PTPA) protein Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed.
Sequence
Sequence length 358
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Insulin resistance
Diabetic cardiomyopathy 		 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development Pathogenic rs1564202579, rs2490999610 RCV003323317
RCV003323318
Show/Hide Unknown Diseases (8)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs4836639 RCV005903855
Cervical cancer Benign rs4836639 RCV005903857
Familial cancer of breast Benign rs4836639 RCV005903854
Hepatocellular carcinoma Benign rs4836639 RCV005903856
Show/Hide Text Mining Associations (107)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26986830
Alzheimer Disease Associate 15920161, 22732552, 22927204, 35142023
Alzheimer Disease Inhibit 25128526
Arrhythmias Cardiac Associate 30191648
Asthma Inhibit 22205926
Asthma Associate 25985190, 32085629
Breast Diseases Associate 19890961
Breast Neoplasms Associate 15662126, 15965230, 18183590, 19890961, 20669227, 23532252, 24696731, 24927563, 25803781, 26462835, 27574003, 27600565, 29976159, 34298877
Calcinosis Cutis Associate 26023836
Carcinogenesis Associate 20473327, 23723076, 24296757, 24696731, 27469332, 32188705, 34156643, 34933911, 36463234, 36868233