PTPA (protein phosphatase 2 phosphatase activator)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5524
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 2 phosphatase activator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTPA
Synonyms (NCBI Gene) Gene synonyms aliases
PARK25, PP2A, PPP2R4, PR53
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
Summary Summary of gene provided in NCBI Entrez Gene.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subu
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT438392 hsa-miR-183-5p Luciferase reporter assay, Western blot, qRT-PCR 25152390
MIRT438392 hsa-miR-183-5p Luciferase reporter assay, Western blot, qRT-PCR 25152390
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
HDAC4 Unknown 18045992
SETBP1 Repression 21233840
TP53 Repression 10787423
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000159 Component Protein phosphatase type 2A complex IBA
GO:0000159 Component Protein phosphatase type 2A complex IDA 10318862
GO:0000166 Function Nucleotide binding IEA
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IBA
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600756 9308 ENSG00000119383
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q15257
Protein name Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulator
Protein function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:169166
PDB 2G62 , 2HV6 , 2HV7 , 2IXM , 4LAC , 4NY3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03095 PTPA 26 → 352 Phosphotyrosyl phosphate activator (PTPA) protein Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed.
Sequence
Sequence length 358
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Insulin resistance
Diabetic cardiomyopathy 		 
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Age of onset of adult onset asthma N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Dyslexia Dyslexia N/A N/A GWAS
Show/Hide Text Mining Associations (107)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 26986830
Alzheimer Disease Associate 15920161, 22732552, 22927204, 35142023
Alzheimer Disease Inhibit 25128526
Arrhythmias Cardiac Associate 30191648
Asthma Inhibit 22205926
Asthma Associate 25985190, 32085629
Breast Diseases Associate 19890961
Breast Neoplasms Associate 15662126, 15965230, 18183590, 19890961, 20669227, 23532252, 24696731, 24927563, 25803781, 26462835, 27574003, 27600565, 29976159, 34298877
Calcinosis Cutis Associate 26023836
Carcinogenesis Associate 20473327, 23723076, 24296757, 24696731, 27469332, 32188705, 34156643, 34933911, 36463234, 36868233