Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55218
Gene name Gene Name - the full gene name approved by the HGNC.
Exonuclease 3'-5' domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
EXD2
Synonyms (NCBI Gene) Gene synonyms aliases
C14orf114, EXDL2
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q24.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018552 hsa-miR-335-5p Microarray 18185580
MIRT027148 hsa-miR-103a-3p Sequencing 20371350
MIRT031912 hsa-miR-16-5p Sequencing 20371350
MIRT444861 hsa-miR-548ac PAR-CLIP 22100165
MIRT444860 hsa-miR-548bb-3p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-exoribonuclease activity IDA 31127291
GO:0000287 Function Magnesium ion binding IDA 31127291
GO:0000724 Process Double-strand break repair via homologous recombination IDA 26807646
GO:0000729 Process DNA double-strand break processing IDA 26807646
GO:0003676 Function Nucleic acid binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616940 20217 ENSG00000081177
Protein
UniProt ID Q9NVH0
Protein name Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)
Protein function Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, wh
PDB 6K17 , 6K18 , 6K19 , 6K1A , 6K1B , 6K1C , 6K1D , 6K1E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01612 DNA_pol_A_exo1 79 259 Domain
Sequence
MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQ
LHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASP
LSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYG
LVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQV
IYAARDAQISVALFLHLLG
YPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRL
GEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFL
HAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLC
VVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKE
FQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEM
LQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWS
VDHNHQKLLRKFGEDLPIQLS
Sequence length 621
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 29942085 ClinVar
Neuroticism Neuroticism GWAS