DCUN1D2 (defective in cullin neddylation 1 domain containing 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 55208 |
| Gene name | Defective in cullin neddylation 1 domain containing 2 |
| Gene symbol | DCUN1D2 |
| Synonyms (NCBI Gene) |
C13orf17DCNL2
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| Chromosome | 13 |
| Chromosome location | 13q34 |
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miRNA
miRNA information provided by mirtarbase database.
431
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6PH85 | |||||||||||||||
| Protein name | DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2) | |||||||||||||||
| Protein function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and plays an essential role in the regulation of SCF (SKP1-CUL1-F-b | |||||||||||||||
| PDB | 4GAO | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Mostly expressed in liver, kidney and brain. {ECO:0000269|PubMed:26906416}. | |||||||||||||||
| Sequence |
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| Sequence length | 259 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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