Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55197
Gene name Gene Name - the full gene name approved by the HGNC.
Regulation of nuclear pre-mRNA domain containing 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPRD1A
Synonyms (NCBI Gene) Gene synonyms aliases
HsT3101, P15RS
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020628 hsa-miR-155-5p Proteomics 18668040
MIRT028472 hsa-miR-30a-5p Proteomics 18668040
MIRT050478 hsa-miR-20a-5p CLASH 23622248
MIRT047673 hsa-miR-10a-5p CLASH 23622248
MIRT047242 hsa-miR-181b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000993 Function RNA polymerase II complex binding IBA 21873635
GO:0005515 Function Protein binding IPI 24981860, 24997600, 25416956, 28514442
GO:0005654 Component Nucleoplasm TAS
GO:0016591 Component RNA polymerase II, holoenzyme IBA 21873635
GO:0016591 Component RNA polymerase II, holoenzyme IDA 22231121
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610347 25560 ENSG00000141425
Protein
UniProt ID Q96P16
Protein name Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)
Protein function Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin
PDB 4JXT , 4NAC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04818 CID 7 125 CID domain Domain
PF16566 CREPT 164 310 Cell-cycle alteration and expression-elevated protein in tumour Domain
Sequence
Sequence length 312
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RNA polymerase II transcribes snRNA genes
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 34921137
Neoplasms Associate 34921137