Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55191
Gene name Gene Name - the full gene name approved by the HGNC.	NAD synthetase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NADSYN1
Synonyms (NCBI Gene) Gene synonyms aliases	VCRL3
Disease Acronyms (UniProt) Disease acronyms from UniProt database	VCRL3
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.4
Summary Summary of gene provided in NCBI Entrez Gene.	Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the

Show/Hide all(82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT647702	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT647700	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT647699	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT647698	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT647697	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT647696	hsa-miR-4320	HITS-CLIP	23824327
MIRT647695	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT647694	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT647693	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT647692	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT647691	hsa-miR-4503	HITS-CLIP	23824327
MIRT647690	hsa-miR-5004-3p	HITS-CLIP	23824327
MIRT647689	hsa-miR-7856-5p	HITS-CLIP	23824327
MIRT647702	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT647700	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT647699	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT647698	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT647697	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT647696	hsa-miR-4320	HITS-CLIP	23824327
MIRT647695	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT647694	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT647693	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT647692	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT647691	hsa-miR-4503	HITS-CLIP	23824327
MIRT647690	hsa-miR-5004-3p	HITS-CLIP	23824327
MIRT647689	hsa-miR-7856-5p	HITS-CLIP	23824327
MIRT1172974	hsa-miR-338-3p	CLIP-seq
MIRT1172975	hsa-miR-3908	CLIP-seq
MIRT1172976	hsa-miR-4530	CLIP-seq
MIRT1172977	hsa-miR-4728-3p	CLIP-seq
MIRT1172978	hsa-miR-766	CLIP-seq
MIRT2050115	hsa-miR-1272	CLIP-seq
MIRT2050116	hsa-miR-3682-3p	CLIP-seq
MIRT2050117	hsa-miR-4731-5p	CLIP-seq
MIRT2050118	hsa-miR-615-5p	CLIP-seq
MIRT2577195	hsa-miR-1307	CLIP-seq
MIRT2577196	hsa-miR-1343	CLIP-seq
MIRT2577197	hsa-miR-1470	CLIP-seq
MIRT2577198	hsa-miR-3158-3p	CLIP-seq
MIRT2577199	hsa-miR-3195	CLIP-seq
MIRT1172974	hsa-miR-338-3p	CLIP-seq
MIRT2577200	hsa-miR-3615	CLIP-seq
MIRT2577201	hsa-miR-378g	CLIP-seq
MIRT1172975	hsa-miR-3908	CLIP-seq
MIRT2577202	hsa-miR-4280	CLIP-seq
MIRT2577203	hsa-miR-4437	CLIP-seq
MIRT2577204	hsa-miR-4446-3p	CLIP-seq
MIRT2577205	hsa-miR-4469	CLIP-seq
MIRT1172976	hsa-miR-4530	CLIP-seq
MIRT2577206	hsa-miR-4638-5p	CLIP-seq
MIRT2577207	hsa-miR-4667-3p	CLIP-seq
MIRT2577208	hsa-miR-4674	CLIP-seq
MIRT1172977	hsa-miR-4728-3p	CLIP-seq
MIRT2577209	hsa-miR-4787-3p	CLIP-seq
MIRT2577210	hsa-miR-4793-5p	CLIP-seq
MIRT2577211	hsa-miR-642a	CLIP-seq
MIRT1172978	hsa-miR-766	CLIP-seq
MIRT2050115	hsa-miR-1272	CLIP-seq
MIRT2577195	hsa-miR-1307	CLIP-seq
MIRT2577196	hsa-miR-1343	CLIP-seq
MIRT2577197	hsa-miR-1470	CLIP-seq
MIRT2577198	hsa-miR-3158-3p	CLIP-seq
MIRT2577199	hsa-miR-3195	CLIP-seq
MIRT1172974	hsa-miR-338-3p	CLIP-seq
MIRT2577200	hsa-miR-3615	CLIP-seq
MIRT2050116	hsa-miR-3682-3p	CLIP-seq
MIRT2577201	hsa-miR-378g	CLIP-seq
MIRT1172975	hsa-miR-3908	CLIP-seq
MIRT2577202	hsa-miR-4280	CLIP-seq
MIRT2577203	hsa-miR-4437	CLIP-seq
MIRT2577204	hsa-miR-4446-3p	CLIP-seq
MIRT2577205	hsa-miR-4469	CLIP-seq
MIRT2685737	hsa-miR-4502	CLIP-seq
MIRT1172976	hsa-miR-4530	CLIP-seq
MIRT2577206	hsa-miR-4638-5p	CLIP-seq
MIRT2577207	hsa-miR-4667-3p	CLIP-seq
MIRT2577208	hsa-miR-4674	CLIP-seq
MIRT1172977	hsa-miR-4728-3p	CLIP-seq
MIRT2577209	hsa-miR-4787-3p	CLIP-seq
MIRT2577210	hsa-miR-4793-5p	CLIP-seq
MIRT2577211	hsa-miR-642a	CLIP-seq
MIRT1172978	hsa-miR-766	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003952	Function	NAD+ synthase (glutamine-hydrolyzing) activity	IBA	21873635
GO:0003952	Function	NAD+ synthase (glutamine-hydrolyzing) activity	IMP	31883644
GO:0004359	Function	Glutaminase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0009435	Process	NAD biosynthetic process	IBA	21873635
GO:0019674	Process	NAD metabolic process	TAS
GO:0034627	Process	'de novo' NAD biosynthetic process	IMP	31883644

MIM	HGNC	e!Ensembl
608285	29832	ENSG00000172890

Protein

UniProt ID

Q6IA69

Protein name

Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase)

Protein function

Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source.

PDB

6OFB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00795	CN_hydrolase	6 → 283	Carbon-nitrogen hydrolase	Family
PF02540	NAD_synthase	337 → 651	NAD synthase	Domain

Sequence

MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD

Sequence length

706

Interactions

View interactions

	KEGG		Reactome
	Nicotinate and nicotinamide metabolism Metabolic pathways Biosynthesis of cofactors		Nicotinate metabolism

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Congenital vertebral-cardiac-renal anomalies syndrome	Congenital vertebral-cardiac-renal anomalies syndrome	rs1135401744, rs758865880, rs770642379, rs1135401743, rs527656756, rs1232096291, rs144139747, rs1327307171, rs1949650831, rs1008561025, rs769220327
Multiple congenital anomalies	Multiple congenital anomalies	rs1057517732	31883644

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Congenital Vertebral-Cardiac-Renal Anomalies Syndrome	congenital vertebral-cardiac-renal anomalies syndrome	GenCC
Biliary Cirrhosis	Biliary Cirrhosis	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	GWAS
Hyperopia	Hyperopia	GWAS

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma Islet Cell	Associate	23979957
Arthritis Rheumatoid	Associate	23636220, 30796319, 35720397
Astrocytoma	Associate	22740028
Bone Diseases Metabolic	Associate	30150596
Carcinogenesis	Associate	36278823
Carcinoma Hepatocellular	Associate	23734184
Colorectal Neoplasms	Associate	22701574, 31104167
COVID 19	Associate	34835935, 37497655
Diabetes Mellitus Type 1	Associate	32764491, 37170809
Fatty Liver	Associate	29761652
Hereditary leiomyomatosis and renal cell cancer	Associate	24890271
Hyperbilirubinemia Neonatal	Associate	37259065
Inflammation	Associate	29761652
Inflammatory Bowel Diseases	Associate	37834314
Leber Congenital Amaurosis	Associate	22842230
Leukemia Biphenotypic Acute	Associate	36439178
Liver Cirrhosis	Associate	28415985
Lupus Erythematosus Systemic	Associate	28062664
Nasopharyngeal Carcinoma	Associate	34464857
Neoplasm Metastasis	Associate	26959888
Neoplasms	Associate	26959888
Non alcoholic Fatty Liver Disease	Associate	29761652
Osteoporosis	Associate	30150596
Ovarian Neoplasms	Associate	27594614
Post Acute COVID 19 Syndrome	Associate	37497655
Rickets	Associate	24073854
Thyroid Neoplasms	Associate	31357732
Vitamin D Deficiency	Associate	22701574, 22785457, 26149120, 32231377, 34852423, 37259065, 37834314
Weight Loss	Associate	26416604

NADSYN1 (NAD synthetase 1)