RIC8B (RIC8 guanine nucleotide exchange factor B)

Gene

• Entrez ID: 55188
• Gene name: RIC8 guanine nucleotide exchange factor B
• Gene symbol: RIC8B
• Synonyms (NCBI Gene): RIC8, hSyn
• Chromosome: 12
• Chromosome location: 12q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024719	hsa-miR-215-5p	Microarray	19074876
MIRT026881	hsa-miR-192-5p	Microarray	19074876
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515661	hsa-miR-567	PAR-CLIP	21572407
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT515659	hsa-miR-3924	PAR-CLIP	21572407
MIRT515658	hsa-miR-297	PAR-CLIP	21572407
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515661	hsa-miR-567	PAR-CLIP	23446348
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT515659	hsa-miR-3924	PAR-CLIP	23446348
MIRT515658	hsa-miR-297	PAR-CLIP	23446348
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515661	hsa-miR-567	PAR-CLIP	21572407
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT515659	hsa-miR-3924	PAR-CLIP	21572407
MIRT515658	hsa-miR-297	PAR-CLIP	21572407
MIRT515662	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515661	hsa-miR-567	PAR-CLIP	23446348
MIRT515660	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT515659	hsa-miR-3924	PAR-CLIP	23446348
MIRT515658	hsa-miR-297	PAR-CLIP	23446348
MIRT1306482	hsa-miR-1228	CLIP-seq
MIRT1306483	hsa-miR-1233	CLIP-seq
MIRT1306484	hsa-miR-1260	CLIP-seq
MIRT1306485	hsa-miR-1260b	CLIP-seq
MIRT1306486	hsa-miR-188-3p	CLIP-seq
MIRT1306487	hsa-miR-192	CLIP-seq
MIRT1306488	hsa-miR-215	CLIP-seq
MIRT1306489	hsa-miR-3156-3p	CLIP-seq
MIRT1306490	hsa-miR-3171	CLIP-seq
MIRT1306491	hsa-miR-338-3p	CLIP-seq
MIRT1306492	hsa-miR-338-5p	CLIP-seq
MIRT1306493	hsa-miR-342-3p	CLIP-seq
MIRT1306494	hsa-miR-3680	CLIP-seq
MIRT1306495	hsa-miR-3682-5p	CLIP-seq
MIRT1306496	hsa-miR-376a	CLIP-seq
MIRT1306497	hsa-miR-376b	CLIP-seq
MIRT1306498	hsa-miR-3942-3p	CLIP-seq
MIRT1306499	hsa-miR-3945	CLIP-seq
MIRT1306500	hsa-miR-4253	CLIP-seq
MIRT1306501	hsa-miR-4301	CLIP-seq
MIRT1306502	hsa-miR-4310	CLIP-seq
MIRT1306503	hsa-miR-4506	CLIP-seq
MIRT1306504	hsa-miR-4667-3p	CLIP-seq
MIRT1306505	hsa-miR-4766-5p	CLIP-seq
MIRT1306506	hsa-miR-4778-3p	CLIP-seq
MIRT1306507	hsa-miR-488	CLIP-seq
MIRT1306482	hsa-miR-1228	CLIP-seq
MIRT2090800	hsa-miR-146b-3p	CLIP-seq
MIRT2090801	hsa-miR-15a	CLIP-seq
MIRT2090802	hsa-miR-15b	CLIP-seq
MIRT2090803	hsa-miR-16	CLIP-seq
MIRT2090804	hsa-miR-1915	CLIP-seq
MIRT2090805	hsa-miR-195	CLIP-seq
MIRT2090806	hsa-miR-22	CLIP-seq
MIRT2090807	hsa-miR-2467-3p	CLIP-seq
MIRT2090808	hsa-miR-2964a-3p	CLIP-seq
MIRT2090809	hsa-miR-3121-3p	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT2090811	hsa-miR-3173-5p	CLIP-seq
MIRT1306493	hsa-miR-342-3p	CLIP-seq
MIRT2090812	hsa-miR-361-3p	CLIP-seq
MIRT2090813	hsa-miR-3674	CLIP-seq
MIRT2090814	hsa-miR-424	CLIP-seq
MIRT2090815	hsa-miR-4511	CLIP-seq
MIRT2090816	hsa-miR-4524	CLIP-seq
MIRT1306504	hsa-miR-4667-3p	CLIP-seq
MIRT2090817	hsa-miR-4668-5p	CLIP-seq
MIRT2090818	hsa-miR-4726-3p	CLIP-seq
MIRT2090819	hsa-miR-4763-5p	CLIP-seq
MIRT2090820	hsa-miR-497	CLIP-seq
MIRT2090821	hsa-miR-503	CLIP-seq
MIRT2090822	hsa-miR-646	CLIP-seq
MIRT2090823	hsa-miR-874	CLIP-seq
MIRT2315460	hsa-miR-1255a	CLIP-seq
MIRT2315461	hsa-miR-1255b	CLIP-seq
MIRT2315462	hsa-miR-1343	CLIP-seq
MIRT2090801	hsa-miR-15a	CLIP-seq
MIRT2090802	hsa-miR-15b	CLIP-seq
MIRT2090803	hsa-miR-16	CLIP-seq
MIRT2090805	hsa-miR-195	CLIP-seq
MIRT2315463	hsa-miR-1972	CLIP-seq
MIRT2315464	hsa-miR-3137	CLIP-seq
MIRT2315465	hsa-miR-3192	CLIP-seq
MIRT2315466	hsa-miR-3689a-3p	CLIP-seq
MIRT2315467	hsa-miR-3689c	CLIP-seq
MIRT2315468	hsa-miR-3689d	CLIP-seq
MIRT2315469	hsa-miR-3907	CLIP-seq
MIRT2090814	hsa-miR-424	CLIP-seq
MIRT2315470	hsa-miR-4326	CLIP-seq
MIRT2315471	hsa-miR-4499	CLIP-seq
MIRT2090816	hsa-miR-4524	CLIP-seq
MIRT2315472	hsa-miR-4528	CLIP-seq
MIRT2315473	hsa-miR-4540	CLIP-seq
MIRT2315474	hsa-miR-4650-5p	CLIP-seq
MIRT2315475	hsa-miR-4660	CLIP-seq
MIRT2315476	hsa-miR-4670-3p	CLIP-seq
MIRT2315477	hsa-miR-4717-5p	CLIP-seq
MIRT2315478	hsa-miR-4728-5p	CLIP-seq
MIRT2315479	hsa-miR-4731-5p	CLIP-seq
MIRT2090820	hsa-miR-497	CLIP-seq
MIRT2090821	hsa-miR-503	CLIP-seq
MIRT2315480	hsa-miR-554	CLIP-seq
MIRT2090822	hsa-miR-646	CLIP-seq
MIRT2458227	hsa-miR-186	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT1306492	hsa-miR-338-5p	CLIP-seq
MIRT2611695	hsa-miR-1226	CLIP-seq
MIRT2611696	hsa-miR-1264	CLIP-seq
MIRT2611697	hsa-miR-1266	CLIP-seq
MIRT2611698	hsa-miR-1289	CLIP-seq
MIRT2611699	hsa-miR-146a	CLIP-seq
MIRT2611700	hsa-miR-146b-5p	CLIP-seq
MIRT2458227	hsa-miR-186	CLIP-seq
MIRT1306487	hsa-miR-192	CLIP-seq
MIRT1306488	hsa-miR-215	CLIP-seq
MIRT2090806	hsa-miR-22	CLIP-seq
MIRT2090807	hsa-miR-2467-3p	CLIP-seq
MIRT2611701	hsa-miR-2467-5p	CLIP-seq
MIRT2090809	hsa-miR-3121-3p	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT2611702	hsa-miR-3162-5p	CLIP-seq
MIRT2611703	hsa-miR-3168	CLIP-seq
MIRT1306490	hsa-miR-3171	CLIP-seq
MIRT2611704	hsa-miR-3188	CLIP-seq
MIRT2611705	hsa-miR-323-3p	CLIP-seq
MIRT2611706	hsa-miR-323-5p	CLIP-seq
MIRT2611707	hsa-miR-329	CLIP-seq
MIRT2611708	hsa-miR-345	CLIP-seq
MIRT2090812	hsa-miR-361-3p	CLIP-seq
MIRT2611709	hsa-miR-361-5p	CLIP-seq
MIRT2611710	hsa-miR-362-3p	CLIP-seq
MIRT2611711	hsa-miR-3662	CLIP-seq
MIRT2090813	hsa-miR-3674	CLIP-seq
MIRT1306494	hsa-miR-3680	CLIP-seq
MIRT1306495	hsa-miR-3682-5p	CLIP-seq
MIRT1306496	hsa-miR-376a	CLIP-seq
MIRT1306497	hsa-miR-376b	CLIP-seq
MIRT2611712	hsa-miR-377	CLIP-seq
MIRT2611713	hsa-miR-3923	CLIP-seq
MIRT2611714	hsa-miR-3975	CLIP-seq
MIRT2611715	hsa-miR-4251	CLIP-seq
MIRT2611716	hsa-miR-4255	CLIP-seq
MIRT2611717	hsa-miR-4270	CLIP-seq
MIRT2611718	hsa-miR-4277	CLIP-seq
MIRT2611719	hsa-miR-4324	CLIP-seq
MIRT2611720	hsa-miR-4328	CLIP-seq
MIRT2611721	hsa-miR-4441	CLIP-seq
MIRT1306503	hsa-miR-4506	CLIP-seq
MIRT2090815	hsa-miR-4511	CLIP-seq
MIRT2611722	hsa-miR-4518	CLIP-seq
MIRT2611723	hsa-miR-4649-3p	CLIP-seq
MIRT2611724	hsa-miR-4729	CLIP-seq
MIRT1306506	hsa-miR-4778-3p	CLIP-seq
MIRT2611725	hsa-miR-4799-5p	CLIP-seq
MIRT2611726	hsa-miR-485-5p	CLIP-seq
MIRT2611727	hsa-miR-510	CLIP-seq
MIRT2611728	hsa-miR-512-5p	CLIP-seq
MIRT2611729	hsa-miR-548a-5p	CLIP-seq
MIRT2611730	hsa-miR-548ab	CLIP-seq
MIRT2611731	hsa-miR-548ak	CLIP-seq
MIRT2611732	hsa-miR-548b-5p	CLIP-seq
MIRT2611733	hsa-miR-548c-3p	CLIP-seq
MIRT2611734	hsa-miR-548c-5p	CLIP-seq
MIRT2611735	hsa-miR-548d-5p	CLIP-seq
MIRT2611736	hsa-miR-548h	CLIP-seq
MIRT2611737	hsa-miR-548i	CLIP-seq
MIRT2611738	hsa-miR-548j	CLIP-seq
MIRT2611739	hsa-miR-548n	CLIP-seq
MIRT2611740	hsa-miR-548t	CLIP-seq
MIRT2611741	hsa-miR-548w	CLIP-seq
MIRT2611742	hsa-miR-548y	CLIP-seq
MIRT2611743	hsa-miR-559	CLIP-seq
MIRT2611744	hsa-miR-589	CLIP-seq
MIRT2611745	hsa-miR-618	CLIP-seq
MIRT2611746	hsa-miR-628-5p	CLIP-seq
MIRT2611747	hsa-miR-634	CLIP-seq
MIRT2611748	hsa-miR-876-3p	CLIP-seq
MIRT2611749	hsa-miR-885-5p	CLIP-seq
MIRT2611695	hsa-miR-1226	CLIP-seq
MIRT2611696	hsa-miR-1264	CLIP-seq
MIRT2611697	hsa-miR-1266	CLIP-seq
MIRT2611698	hsa-miR-1289	CLIP-seq
MIRT2689761	hsa-miR-1303	CLIP-seq
MIRT1306487	hsa-miR-192	CLIP-seq
MIRT1306488	hsa-miR-215	CLIP-seq
MIRT2090807	hsa-miR-2467-3p	CLIP-seq
MIRT2611701	hsa-miR-2467-5p	CLIP-seq
MIRT2090809	hsa-miR-3121-3p	CLIP-seq
MIRT2090810	hsa-miR-3133	CLIP-seq
MIRT2611702	hsa-miR-3162-5p	CLIP-seq
MIRT2611703	hsa-miR-3168	CLIP-seq
MIRT1306490	hsa-miR-3171	CLIP-seq
MIRT2689762	hsa-miR-3182	CLIP-seq
MIRT2689763	hsa-miR-3184	CLIP-seq
MIRT2611704	hsa-miR-3188	CLIP-seq
MIRT2611705	hsa-miR-323-3p	CLIP-seq
MIRT2611706	hsa-miR-323-5p	CLIP-seq
MIRT2611707	hsa-miR-329	CLIP-seq
MIRT2611708	hsa-miR-345	CLIP-seq
MIRT2090812	hsa-miR-361-3p	CLIP-seq
MIRT2611709	hsa-miR-361-5p	CLIP-seq
MIRT2611710	hsa-miR-362-3p	CLIP-seq
MIRT2611711	hsa-miR-3662	CLIP-seq
MIRT1306494	hsa-miR-3680	CLIP-seq
MIRT1306495	hsa-miR-3682-5p	CLIP-seq
MIRT1306496	hsa-miR-376a	CLIP-seq
MIRT1306497	hsa-miR-376b	CLIP-seq
MIRT2611712	hsa-miR-377	CLIP-seq
MIRT2611713	hsa-miR-3923	CLIP-seq
MIRT2611714	hsa-miR-3975	CLIP-seq
MIRT2689764	hsa-miR-423-5p	CLIP-seq
MIRT2611716	hsa-miR-4255	CLIP-seq
MIRT2611717	hsa-miR-4270	CLIP-seq
MIRT2689765	hsa-miR-4271	CLIP-seq
MIRT2611718	hsa-miR-4277	CLIP-seq
MIRT2611720	hsa-miR-4328	CLIP-seq
MIRT2611721	hsa-miR-4441	CLIP-seq
MIRT1306503	hsa-miR-4506	CLIP-seq
MIRT2090815	hsa-miR-4511	CLIP-seq
MIRT2611722	hsa-miR-4518	CLIP-seq
MIRT2689766	hsa-miR-4533	CLIP-seq
MIRT2611723	hsa-miR-4649-3p	CLIP-seq
MIRT2689767	hsa-miR-4725-3p	CLIP-seq
MIRT2689768	hsa-miR-4731-3p	CLIP-seq
MIRT2689769	hsa-miR-4747-5p	CLIP-seq
MIRT1306506	hsa-miR-4778-3p	CLIP-seq
MIRT2611725	hsa-miR-4799-5p	CLIP-seq
MIRT2689770	hsa-miR-4801	CLIP-seq
MIRT2611726	hsa-miR-485-5p	CLIP-seq
MIRT2611727	hsa-miR-510	CLIP-seq
MIRT2611728	hsa-miR-512-5p	CLIP-seq
MIRT2611729	hsa-miR-548a-5p	CLIP-seq
MIRT2611730	hsa-miR-548ab	CLIP-seq
MIRT2611731	hsa-miR-548ak	CLIP-seq
MIRT2611732	hsa-miR-548b-5p	CLIP-seq
MIRT2611733	hsa-miR-548c-3p	CLIP-seq
MIRT2611734	hsa-miR-548c-5p	CLIP-seq
MIRT2611735	hsa-miR-548d-5p	CLIP-seq
MIRT2611736	hsa-miR-548h	CLIP-seq
MIRT2611737	hsa-miR-548i	CLIP-seq
MIRT2611738	hsa-miR-548j	CLIP-seq
MIRT2611739	hsa-miR-548n	CLIP-seq
MIRT2611740	hsa-miR-548t	CLIP-seq
MIRT2611741	hsa-miR-548w	CLIP-seq
MIRT2611742	hsa-miR-548y	CLIP-seq
MIRT2611743	hsa-miR-559	CLIP-seq
MIRT2611746	hsa-miR-628-5p	CLIP-seq
MIRT2611747	hsa-miR-634	CLIP-seq
MIRT2611748	hsa-miR-876-3p	CLIP-seq
MIRT2611749	hsa-miR-885-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001965	Function	G-protein alpha-subunit binding	IBA
GO:0001965	Function	G-protein alpha-subunit binding	IDA	12652642
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA	12652642
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12652642
GO:0005938	Component	Cell cortex	IEA
GO:0006457	Process	Protein folding	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007608	Process	Sensory perception of smell	ISS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IDA	12652642
GO:0044183	Function	Protein folding chaperone	ISS

Other IDs

• MIM: 609147
• HGNC: 25555
• e!Ensembl: ENSG00000111785

Protein

• UniProt ID: Q9NVN3
• Protein name: Chaperone Ric-8B (Brain synembryn) (hSyn) (Synembryn-B)
• Protein function: Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane (By similarity). Also acts as a guanine nucleotide exchange
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10165	Ric8	66 → 485	Guanine nucleotide exchange factor synembryn	Family

• Sequence:

  MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESTDEDKRKKLCEGIFKVLIKDIPT
  TCQVSCLEVLRILSRDKKVLVPVTTKENMQILLRLAKLNELDDSLEKVSEFPVIVESLKC
  LCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFLLSLLHTDIRS
  QLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVD
  SWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPL
  THEETAQEATTLDELPSNKTAEKETVLKNNTMVYNGMNMEAIHVLLNFMEKRIDKGSSYR
  EGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGV
  KQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKN
  AKPKEELLKPMGLKPDGTITPLEEALNQYSVIEETSSDTD

• Sequence length: 520