Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55178
Gene name	Mitochondrial rRNA methyltransferase 3
Gene symbol	MRM3
Synonyms (NCBI Gene)	RMTL1RNMTL1
Chromosome	17
Chromosome location	17p13.3
Summary	Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRN

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Show/Hide all (119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT695109	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT518122	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT518120	hsa-miR-4459	HITS-CLIP	23313552
MIRT530709	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT518116	hsa-miR-4794	HITS-CLIP	23313552
MIRT518115	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT518114	hsa-miR-4683	HITS-CLIP	23313552
MIRT680211	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT664288	hsa-miR-29a-3p	HITS-CLIP	23824327
MIRT664287	hsa-miR-29b-3p	HITS-CLIP	23824327
MIRT664286	hsa-miR-29c-3p	HITS-CLIP	23824327
MIRT664285	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT664284	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT664283	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT664282	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT664281	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT664280	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT664279	hsa-miR-1976	HITS-CLIP	23824327
MIRT664278	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT664277	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT664276	hsa-miR-5682	HITS-CLIP	23824327
MIRT664275	hsa-miR-4279	HITS-CLIP	23824327
MIRT664274	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT664288	hsa-miR-29a-3p	HITS-CLIP	23824327
MIRT664287	hsa-miR-29b-3p	HITS-CLIP	23824327
MIRT664286	hsa-miR-29c-3p	HITS-CLIP	23824327
MIRT664285	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT664284	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT664283	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT664282	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT664281	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT664280	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT664279	hsa-miR-1976	HITS-CLIP	23824327
MIRT664278	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT664277	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT664276	hsa-miR-5682	HITS-CLIP	23824327
MIRT664275	hsa-miR-4279	HITS-CLIP	23824327
MIRT664274	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT654199	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT654198	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654197	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT654195	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT654196	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT654194	hsa-miR-4287	HITS-CLIP	23824327
MIRT654193	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT654192	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT664273	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT654191	hsa-miR-4419a	HITS-CLIP	23824327
MIRT654190	hsa-miR-4510	HITS-CLIP	23824327
MIRT654189	hsa-miR-6127	HITS-CLIP	23824327
MIRT654188	hsa-miR-6129	HITS-CLIP	23824327
MIRT654187	hsa-miR-6130	HITS-CLIP	23824327
MIRT654186	hsa-miR-6133	HITS-CLIP	23824327
MIRT654185	hsa-miR-1249-5p	HITS-CLIP	23824327
MIRT654184	hsa-miR-6797-5p	HITS-CLIP	23824327
MIRT654183	hsa-miR-8071	HITS-CLIP	23824327
MIRT664272	hsa-miR-6880-5p	HITS-CLIP	23824327
MIRT654182	hsa-miR-3165	HITS-CLIP	23824327
MIRT654181	hsa-miR-7847-3p	HITS-CLIP	23824327
MIRT654180	hsa-miR-95-3p	HITS-CLIP	23824327
MIRT654179	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT654178	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654177	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654176	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT654175	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT654174	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654173	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654172	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT654171	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT654170	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT654169	hsa-miR-1305	HITS-CLIP	23824327
MIRT654199	hsa-miR-6760-5p	HITS-CLIP	23824327
MIRT654198	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT654197	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT654195	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT654196	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT654194	hsa-miR-4287	HITS-CLIP	23824327
MIRT654193	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT654192	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT654191	hsa-miR-4419a	HITS-CLIP	23824327
MIRT654190	hsa-miR-4510	HITS-CLIP	23824327
MIRT654189	hsa-miR-6127	HITS-CLIP	23824327
MIRT654188	hsa-miR-6129	HITS-CLIP	23824327
MIRT654187	hsa-miR-6130	HITS-CLIP	23824327
MIRT654186	hsa-miR-6133	HITS-CLIP	23824327
MIRT654185	hsa-miR-1249-5p	HITS-CLIP	23824327
MIRT654184	hsa-miR-6797-5p	HITS-CLIP	23824327
MIRT654183	hsa-miR-8071	HITS-CLIP	23824327
MIRT654182	hsa-miR-3165	HITS-CLIP	23824327
MIRT654181	hsa-miR-7847-3p	HITS-CLIP	23824327
MIRT654180	hsa-miR-95-3p	HITS-CLIP	23824327
MIRT654179	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT654178	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT654177	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT654176	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT654175	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT654174	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654173	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654172	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT654171	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT654170	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT654169	hsa-miR-1305	HITS-CLIP	23824327
MIRT530710	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT530709	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT530708	hsa-miR-1204	PAR-CLIP	22012620
MIRT530707	hsa-miR-3926	PAR-CLIP	22012620
MIRT530706	hsa-miR-8068	PAR-CLIP	22012620
MIRT530705	hsa-miR-378a-5p	PAR-CLIP	22012620
MIRT530704	hsa-miR-548s	PAR-CLIP	22012620
MIRT530703	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT518122	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT518121	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT518120	hsa-miR-4459	PAR-CLIP	23446348
MIRT518119	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT518118	hsa-miR-221-5p	PAR-CLIP	23446348
MIRT518117	hsa-miR-8073	PAR-CLIP	23446348
MIRT518116	hsa-miR-4794	PAR-CLIP	23446348
MIRT518115	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT518114	hsa-miR-4683	PAR-CLIP	23446348

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000451	Process	RRNA 2'-O-methylation	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32838362, 34029587, 34232536, 36217030
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IMP	35177605
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IMP	35177605
GO:0006396	Process	RNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0070039	Function	RRNA (guanosine-2'-O-)-methyltransferase activity	EXP	24036117, 25074936
GO:0070039	Function	RRNA (guanosine-2'-O-)-methyltransferase activity	IMP	35177605

MIM	HGNC	e!Ensembl
612600	18485	ENSG00000171861

Q9HC36

Protein name

rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)

Protein function

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the pep

PDB

7OI6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00588	SpoU_methylase	209 → 400	SpoU rRNA Methylase family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at same level in normal liver and hepatocarcinoma. {ECO:0000269|PubMed:12296377}.

Sequence

MAALVRPARFVVRPLLQVVQAWDLDARRWVRALRRSPVKVVFPSGEVVEQKRAPGKQPRK
APSEASAQEQREKQPLEESASRAPSTWEESGLRYDKAYPGDRRLSSVMTIVKSRPFREKQ
GKILLEGRRLISDALKAGAVPKMFFFSRLEYLKELPVDKLKGVSLIKVKFEDIKDWSDLV
TPQGIMGIFAKPDHVKMTYPKTQLQHSLPLLLICDNLRDPGNLGTILRSAAGAGCSKVLL
TKGCVDAWEPKVLRAGMGAHFRMPIINNLEWETVPNYLPPDTRVYVADNCGLYAQAEMSN
KASDHGWVCDQRVMKFHKYEEEEDVETGASQDWLPHVEVQSYDSDWTEAPAAVVIGGETY
GVSLESLQLAESTGGKRLLIPVVPGVDSLNSAMAASILLFEGKRQLRGRAEDLSRDRSYH

Sequence length

420

Interactions

View interactions

	Reactome
			rRNA modification in the mitochondrion

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Diabetes Mellitus Type 2	Associate	27655316	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRM3 (mitochondrial rRNA methyltransferase 3)