Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55167
Gene name Gene Name - the full gene name approved by the HGNC.
MSL complex subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MSL2
Synonyms (NCBI Gene) Gene synonyms aliases
KBHS, MSL-2, MSL2L1, RNF184
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q22.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049962 hsa-miR-30a-5p CLASH 23622248
MIRT047821 hsa-miR-30d-5p CLASH 23622248
MIRT701784 hsa-miR-4323 HITS-CLIP 23313552
MIRT701783 hsa-miR-6808-5p HITS-CLIP 23313552
MIRT701782 hsa-miR-6893-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 21726816, 30930284
GO:0005515 Function Protein binding IPI 16227571, 28514442, 33961781
GO:0005634 Component Nucleus IDA 16227571
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614802 25544 ENSG00000174579
Protein
UniProt ID Q9HCI7
Protein name E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.27) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)
Protein function Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16543150, PubM
PDB 4B7Y , 4B86
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16685 zf-RING_10 42 111 zinc RING finger of MSL2 Domain
PF16682 MSL2-CXC 455 509 CXC domain of E3 ubiquitin-protein ligase MSL2 Domain
Sequence
MNPVNATALYISASRLVLNYDPGDPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNS
TCQHYVCKTCKGKKMMMKPSCSWCKDYEQFEENKQLSILVNCYKKLCEYIT
QTTLARDII
EAVDCSSDILALLNDGSLFCEETEKPSDSSFTLCLTHSPLPSTSEPTTDPQASLSPMSES
TLSIAIGSSVINGLPTYNGLSIDRFGINIPSPEHSNTIDVCNTVDIKTEDLSDSLPPVCD
TVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRSLETVSNTEVCCPNLQPNLEATVSN
GPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSEKVQPLPISTI
IRGPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMKKSHEHGSKKSH
SKTKPGILKKDKAVKEKIPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVLTCRGQR
CPCYSNRKACLDCICRGCQNSYMANGEKK
LEAFAVPEKALEQTRLTLGINVTSIAVRNAS
TSTSVINVTGSPVTTFLAASTHDDKSLDEAIDMRFDC
Sequence length 577
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HATs acetylate histones
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
autism Autism rs1576352885 N/A
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Dementia Dementia N/A N/A GWAS
Myocardial Infarction Myocardial infarction N/A N/A GWAS
Neurodevelopmental Disorders complex neurodevelopmental disorder N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 31332282, 37280359
Bovine Respiratory Disease Complex Associate 29413288
DNA Virus Infections Associate 29413288