Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	55144
Gene name	Leucine rich repeat containing 8 VRAC subunit D
Gene symbol	LRRC8D
Synonyms (NCBI Gene)	HsLRRC8DLRRC5
Chromosome	1
Chromosome location	1p22.2

174

Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005467	kshv-miR-K12-3-5p	ImmunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCR	20413099
MIRT023944	hsa-miR-1-3p	Proteomics	18668040
MIRT029937	hsa-miR-26b-5p	Microarray	19088304
MIRT040025	hsa-miR-615-3p	CLASH	23622248
MIRT039220	hsa-miR-454-3p	CLASH	23622248
MIRT149117	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT149118	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT149119	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT149123	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT149112	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT149121	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT149115	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT149116	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT149122	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120751	hsa-miR-4424	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT1120756	hsa-miR-1208	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120761	hsa-miR-199a-3p	CLIP-seq
MIRT1120762	hsa-miR-199b-3p	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120763	hsa-miR-3074-5p	CLIP-seq
MIRT1120764	hsa-miR-30a	CLIP-seq
MIRT1120765	hsa-miR-30b	CLIP-seq
MIRT1120766	hsa-miR-30c	CLIP-seq
MIRT1120767	hsa-miR-30d	CLIP-seq
MIRT1120768	hsa-miR-30e	CLIP-seq
MIRT1120769	hsa-miR-3129-5p	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT1120770	hsa-miR-3689a-5p	CLIP-seq
MIRT1120771	hsa-miR-3689b	CLIP-seq
MIRT1120772	hsa-miR-3689e	CLIP-seq
MIRT1120773	hsa-miR-3689f	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120751	hsa-miR-4424	CLIP-seq
MIRT1120775	hsa-miR-448	CLIP-seq
MIRT1120776	hsa-miR-4524	CLIP-seq
MIRT1120777	hsa-miR-4690-5p	CLIP-seq
MIRT1120778	hsa-miR-4699-3p	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120779	hsa-miR-4729	CLIP-seq
MIRT1120780	hsa-miR-4742-5p	CLIP-seq
MIRT1120781	hsa-miR-499-3p	CLIP-seq
MIRT1120782	hsa-miR-499a-3p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT1120784	hsa-miR-656	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT1120785	hsa-miR-936	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT2034204	hsa-miR-103a	CLIP-seq
MIRT2034205	hsa-miR-107	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT2034206	hsa-miR-3691-3p	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120751	hsa-miR-4424	CLIP-seq
MIRT1120776	hsa-miR-4524	CLIP-seq
MIRT1120777	hsa-miR-4690-5p	CLIP-seq
MIRT1120778	hsa-miR-4699-3p	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT1120779	hsa-miR-4729	CLIP-seq
MIRT1120780	hsa-miR-4742-5p	CLIP-seq
MIRT2034207	hsa-miR-520d-5p	CLIP-seq
MIRT2034208	hsa-miR-524-5p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT2034204	hsa-miR-103a	CLIP-seq
MIRT2034205	hsa-miR-107	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120761	hsa-miR-199a-3p	CLIP-seq
MIRT1120762	hsa-miR-199b-3p	CLIP-seq
MIRT1120745	hsa-miR-25	CLIP-seq
MIRT1120769	hsa-miR-3129-5p	CLIP-seq
MIRT2264565	hsa-miR-3183	CLIP-seq
MIRT1120746	hsa-miR-32	CLIP-seq
MIRT2264566	hsa-miR-324-5p	CLIP-seq
MIRT2264567	hsa-miR-3614-3p	CLIP-seq
MIRT1120747	hsa-miR-363	CLIP-seq
MIRT1120748	hsa-miR-367	CLIP-seq
MIRT2034206	hsa-miR-3691-3p	CLIP-seq
MIRT1120749	hsa-miR-3942-5p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120750	hsa-miR-4422	CLIP-seq
MIRT1120752	hsa-miR-4703-5p	CLIP-seq
MIRT2264568	hsa-miR-4723-3p	CLIP-seq
MIRT2034207	hsa-miR-520d-5p	CLIP-seq
MIRT2034208	hsa-miR-524-5p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT2264569	hsa-miR-586	CLIP-seq
MIRT2264570	hsa-miR-654-3p	CLIP-seq
MIRT1120753	hsa-miR-767-5p	CLIP-seq
MIRT1120754	hsa-miR-92a	CLIP-seq
MIRT1120755	hsa-miR-92b	CLIP-seq
MIRT1120785	hsa-miR-936	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT2034204	hsa-miR-103a	CLIP-seq
MIRT2034205	hsa-miR-107	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT1120761	hsa-miR-199a-3p	CLIP-seq
MIRT1120762	hsa-miR-199b-3p	CLIP-seq
MIRT1120764	hsa-miR-30a	CLIP-seq
MIRT1120765	hsa-miR-30b	CLIP-seq
MIRT1120766	hsa-miR-30c	CLIP-seq
MIRT1120767	hsa-miR-30d	CLIP-seq
MIRT1120768	hsa-miR-30e	CLIP-seq
MIRT1120769	hsa-miR-3129-5p	CLIP-seq
MIRT2034206	hsa-miR-3691-3p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT1120780	hsa-miR-4742-5p	CLIP-seq
MIRT2034207	hsa-miR-520d-5p	CLIP-seq
MIRT2034208	hsa-miR-524-5p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT1120785	hsa-miR-936	CLIP-seq
MIRT2563518	hsa-miR-1283	CLIP-seq
MIRT1120757	hsa-miR-181a	CLIP-seq
MIRT1120758	hsa-miR-181b	CLIP-seq
MIRT1120759	hsa-miR-181c	CLIP-seq
MIRT1120760	hsa-miR-181d	CLIP-seq
MIRT2264565	hsa-miR-3183	CLIP-seq
MIRT2264566	hsa-miR-324-5p	CLIP-seq
MIRT2264567	hsa-miR-3614-3p	CLIP-seq
MIRT1120774	hsa-miR-4262	CLIP-seq
MIRT2264568	hsa-miR-4723-3p	CLIP-seq
MIRT1120783	hsa-miR-543	CLIP-seq
MIRT2563519	hsa-miR-548aa	CLIP-seq
MIRT2264569	hsa-miR-586	CLIP-seq
MIRT2264570	hsa-miR-654-3p	CLIP-seq
MIRT2563520	hsa-miR-935	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001678	Process	Intracellular glucose homeostasis	IEA
GO:0001678	Process	Intracellular glucose homeostasis	ISS
GO:0005225	Function	Volume-sensitive anion channel activity	IBA
GO:0005225	Function	Volume-sensitive anion channel activity	IDA	32415200
GO:0005225	Function	Volume-sensitive anion channel activity	IEA
GO:0005225	Function	Volume-sensitive anion channel activity	IMP	28193731
GO:0005225	Function	Volume-sensitive anion channel activity	IMP	26824658
GO:0005515	Function	Protein binding	IPI	24790029
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	24790029
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24790029
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	26824658, 28193731
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0015734	Process	Taurine transmembrane transport	IMP	28193731
GO:0015810	Process	Aspartate transmembrane transport	IBA
GO:0015810	Process	Aspartate transmembrane transport	IMP	28193731
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	32415200
GO:0016020	Component	Membrane	IEA
GO:0034214	Process	Protein hexamerization	IDA	32415200
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IBA
GO:0034702	Component	Monoatomic ion channel complex	IMP	28193731
GO:0071470	Process	Cellular response to osmotic stress	IMP	28193731
GO:0098656	Process	Monoatomic anion transmembrane transport	IBA
GO:0098656	Process	Monoatomic anion transmembrane transport	IDA	32415200
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:0098656	Process	Monoatomic anion transmembrane transport	IMP	24790029
GO:0140361	Process	Cyclic-GMP-AMP transmembrane import across plasma membrane	IDA	33171122

MIM	HGNC	e!Ensembl
612890	16992	ENSG00000171492

Q7L1W4

Protein name

Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)

Protein function

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:2

PDB

6M04

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12534	Pannexin_like	1 → 384	Pannexin-like TM region of LRRC8	Family
PF13855	LRR_8	635 → 695	Leucine rich repeat	Repeat
PF13855	LRR_8	683 → 741	Leucine rich repeat	Repeat

Sequence

MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
EVKEALNQDINIPFANGI

Sequence length

858

Interactions

View interactions

	Reactome
			Miscellaneous transport and binding events

LRRC8D (leucine rich repeat containing 8 VRAC subunit D)