LARP1B (La ribonucleoprotein 1B)

Gene

• Entrez ID: 55132
• Gene name: La ribonucleoprotein 1B
• Gene symbol: LARP1B
• Synonyms (NCBI Gene): LARP2
• Chromosome: 4
• Chromosome location: 4q28.2
• Summary: This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024765	hsa-miR-215-5p	Microarray	19074876
MIRT026553	hsa-miR-192-5p	Microarray	19074876
MIRT042508	hsa-miR-423-3p	CLASH	23622248
MIRT1104462	hsa-miR-1266	CLIP-seq
MIRT1104463	hsa-miR-216a	CLIP-seq
MIRT1104464	hsa-miR-342-3p	CLIP-seq
MIRT1104465	hsa-miR-3664-3p	CLIP-seq
MIRT1104466	hsa-miR-4269	CLIP-seq
MIRT1104467	hsa-miR-4514	CLIP-seq
MIRT1104468	hsa-miR-4518	CLIP-seq
MIRT1104469	hsa-miR-4692	CLIP-seq
MIRT1104470	hsa-miR-4719	CLIP-seq
MIRT1104471	hsa-miR-4738-3p	CLIP-seq
MIRT1104472	hsa-miR-4742-5p	CLIP-seq
MIRT1104473	hsa-miR-548a-3p	CLIP-seq
MIRT1104474	hsa-miR-548ae	CLIP-seq
MIRT1104475	hsa-miR-548ag	CLIP-seq
MIRT1104476	hsa-miR-548ai	CLIP-seq
MIRT1104477	hsa-miR-548aj	CLIP-seq
MIRT1104478	hsa-miR-548am	CLIP-seq
MIRT1104479	hsa-miR-548e	CLIP-seq
MIRT1104480	hsa-miR-548f	CLIP-seq
MIRT1104481	hsa-miR-548m	CLIP-seq
MIRT1104482	hsa-miR-548x	CLIP-seq
MIRT739680	hsa-miR-3153	CLIP-seq
MIRT739685	hsa-miR-3192	CLIP-seq
MIRT1104483	hsa-miR-335	CLIP-seq
MIRT1104484	hsa-miR-3653	CLIP-seq
MIRT1104485	hsa-miR-3658	CLIP-seq
MIRT1104486	hsa-miR-3973	CLIP-seq
MIRT739684	hsa-miR-4314	CLIP-seq
MIRT739682	hsa-miR-4646-5p	CLIP-seq
MIRT739681	hsa-miR-4668-5p	CLIP-seq
MIRT1104487	hsa-miR-548k	CLIP-seq
MIRT739683	hsa-miR-888	CLIP-seq
MIRT2028656	hsa-miR-2052	CLIP-seq
MIRT2028657	hsa-miR-3121-5p	CLIP-seq
MIRT2028658	hsa-miR-3671	CLIP-seq
MIRT2028659	hsa-miR-4795-3p	CLIP-seq
MIRT2028660	hsa-miR-607	CLIP-seq
MIRT2259637	hsa-miR-4775	CLIP-seq
MIRT2259638	hsa-miR-590-3p	CLIP-seq
MIRT2259639	hsa-miR-935	CLIP-seq
MIRT2560137	hsa-miR-3672	CLIP-seq
MIRT2560138	hsa-miR-494	CLIP-seq
MIRT2560139	hsa-miR-548c-3p	CLIP-seq
MIRT2560140	hsa-miR-648	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000339	Function	RNA cap binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	IBA
GO:0010494	Component	Cytoplasmic stress granule	IBA
GO:0045727	Process	Positive regulation of translation	IBA
GO:0048255	Process	MRNA stabilization	IEA

Other IDs

• MIM: 620467
• HGNC: 24704
• e!Ensembl: ENSG00000138709

Protein

• UniProt ID: Q659C4
• Protein name: La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05383	La	219 → 275	La domain	Domain

• Sequence:

  MENWPTPSELVNTGFQSVLSQGNKKPQNRKEKEEKVEKRSNSDSKENRETKLNGPGENVS
  EDEAQSSNQRKRANKHKWVPLHLDVVRSESQERPGSRNSSRCQPEANKPTHNNRRNDTRS
  WKRDREKRDDQDDVSSVRSEGGNIRGSFRGRGRGRGRGRGRGRGNPRLNFDYSYGYQEHG
  ERTDQPFQTELNTSMMYYYDDGTGVQVYPVEEALLKEYIKRQIEYYFSVENLERDFFLRG
  KMDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRKKIEPEKWPIPGP
  PPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGL
  STSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPEQEELDFLFDEEIE
  QIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPPYVKKHPGGDRTGTHMSRAKITSEL
  AKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEV
  PVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTR
  TPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDR
  GPGTSSVSTSNASPSEGAPLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCL
  SERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRFY
  SYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLKYSQSKTQSIDPKLQEYLCSF
  KRLEDFRVDPPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINS
  PRRNISPESSDNSH

• Sequence length: 914

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
PERIODONTAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Hepatocellular	Associate	33228611	★☆☆☆☆ Found in Text Mining only