Gene Gene information from NCBI Gene database.
Entrez ID 55124
Gene name Piwi like RNA-mediated gene silencing 2
Gene symbol PIWIL2
Synonyms (NCBI Gene)
CT80HILIPIWIL1Lmili
Chromosome 8
Chromosome location 8p21.3
Summary PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
855
miRTarBase ID miRNA Experiments Reference
MIRT608375 hsa-miR-106a-5p HITS-CLIP 23313552
MIRT608374 hsa-miR-106b-5p HITS-CLIP 23313552
MIRT608373 hsa-miR-17-5p HITS-CLIP 23313552
MIRT608372 hsa-miR-20a-5p HITS-CLIP 23313552
MIRT608371 hsa-miR-20b-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
61
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IEA
GO:0004518 Function Nuclease activity IEA
GO:0004519 Function Endonuclease activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610312 17644 ENSG00000197181
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TC59
Protein name Piwi-like protein 2 (EC 3.1.26.-) (Cancer/testis antigen 80) (CT80)
Protein function Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differenti
PDB 3O7X , 3QIR , 7YFX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08699 ArgoL1 338 387 Argonaute linker 1 domain Domain
PF02170 PAZ 389 524 PAZ domain Domain
PF02171 Piwi 668 959 Piwi domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in adult testis and in most tumors. {ECO:0000269|PubMed:16377660}.
Sequence
MDPFRPSFRGQSPIHPSQCQAVRMPGCWPQASKPLDPALGRGAPAGRGHVFGKPEEPSTQ
RGPAQRESVGLVSMFRGLGIETVSKTPLKREMLPSGRGILGRGLSANLVRKDREELSPTF
WDPKVLAAGDSKMAETSVGWSRTLGRGSSDASLLPLGRAAGGISREVDKPPCTFSTPSRG
PPQLSSPPALPQSPLHSPDRPLVLTVEHKEKELIVKQGSKGTPQSLGLNLVKIQCHNEAV
YQYHVTFSPNVECKSMRFGMLKDHQAVTGNVTAFDGSILYLPVKLQQVLELKSQRKTDSA
EISIKIQMTKILEPCSDLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIW
PGYAASIRRTDGGLFLLADVSHKVIRN
DCVLDVMHAIYQQNKEHFQDECTKLLVGNIVIT
RYNNRTYRIDDVDWNKTPKDSFTMSDGKEITFLEYYSKNYGITVKEEDQPLLIHRPSERQ
DNHGMLLKGEILLLPELSFMTGIPEKMKKDFRAMKDLAQQINLS
PKQHHSALECLLQRIA
KNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLKNTSFITSQELNWVKEVTRDPSILT
IPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRMSPPAWVELKDDRIETYVRTIQSTL
GAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQ
INCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVFQMP
HQEIVDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAF
ENYQPKMVVFVVQKKISTNLYLAAPQNFVTPTPGTVVDHTITSCEWVDFYLLAHHVRQGC
GIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGHILH
H
EPAIQLCENLFFL
Sequence length 973
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Uncertain significance rs147192548 RCV005927211
Lung cancer Uncertain significance rs147192548 RCV005927213
Male infertility Uncertain significance rs778911127, rs756790734 RCV004573389
RCV004573390
Sarcoma Uncertain significance rs147192548 RCV005927212
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 27893851
Breast Neoplasms Associate 20490325
Carcinogenesis Associate 22303479, 25113562, 29555935, 34738477
Carcinoma Hepatocellular Associate 27894076
Carcinoma Ovarian Epithelial Associate 24440970, 24932571
Carcinoma Renal Cell Associate 24509249
Carcinoma Squamous Cell Associate 31322538, 34257574
Carcinoma Transitional Cell Associate 29058301
Colitis Ulcerative Associate 38302916
Death Associate 22748119