Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55124
Gene name Gene Name - the full gene name approved by the HGNC.
Piwi like RNA-mediated gene silencing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PIWIL2
Synonyms (NCBI Gene) Gene synonyms aliases
CT80, HILI, PIWIL1L, mili
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.3
Summary Summary of gene provided in NCBI Entrez Gene.
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT608375 hsa-miR-106a-5p HITS-CLIP 23313552
MIRT608374 hsa-miR-106b-5p HITS-CLIP 23313552
MIRT608373 hsa-miR-17-5p HITS-CLIP 23313552
MIRT608372 hsa-miR-20a-5p HITS-CLIP 23313552
MIRT608371 hsa-miR-20b-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000966 Process RNA 5'-end processing ISS
GO:0003729 Function MRNA binding IEA
GO:0004521 Function Endoribonuclease activity ISS
GO:0005515 Function Protein binding IPI 28903391
GO:0005634 Component Nucleus IDA 28025795
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610312 17644 ENSG00000197181
Protein
UniProt ID Q8TC59
Protein name Piwi-like protein 2 (EC 3.1.26.-) (Cancer/testis antigen 80) (CT80)
Protein function Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differenti
PDB 3O7X , 3QIR , 7YFX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08699 ArgoL1 338 387 Argonaute linker 1 domain Domain
PF02170 PAZ 389 524 PAZ domain Domain
PF02171 Piwi 668 959 Piwi domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in adult testis and in most tumors. {ECO:0000269|PubMed:16377660}.
Sequence
MDPFRPSFRGQSPIHPSQCQAVRMPGCWPQASKPLDPALGRGAPAGRGHVFGKPEEPSTQ
RGPAQRESVGLVSMFRGLGIETVSKTPLKREMLPSGRGILGRGLSANLVRKDREELSPTF
WDPKVLAAGDSKMAETSVGWSRTLGRGSSDASLLPLGRAAGGISREVDKPPCTFSTPSRG
PPQLSSPPALPQSPLHSPDRPLVLTVEHKEKELIVKQGSKGTPQSLGLNLVKIQCHNEAV
YQYHVTFSPNVECKSMRFGMLKDHQAVTGNVTAFDGSILYLPVKLQQVLELKSQRKTDSA
EISIKIQMTKILEPCSDLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIW
PGYAASIRRTDGGLFLLADVSHKVIRN
DCVLDVMHAIYQQNKEHFQDECTKLLVGNIVIT
RYNNRTYRIDDVDWNKTPKDSFTMSDGKEITFLEYYSKNYGITVKEEDQPLLIHRPSERQ
DNHGMLLKGEILLLPELSFMTGIPEKMKKDFRAMKDLAQQINLS
PKQHHSALECLLQRIA
KNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLKNTSFITSQELNWVKEVTRDPSILT
IPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRMSPPAWVELKDDRIETYVRTIQSTL
GAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQ
INCKLGGELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVFQMP
HQEIVDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAF
ENYQPKMVVFVVQKKISTNLYLAAPQNFVTPTPGTVVDHTITSCEWVDFYLLAHHVRQGC
GIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGHILH
H
EPAIQLCENLFFL
Sequence length 973
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 30097691 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 27893851
Breast Neoplasms Associate 20490325
Carcinogenesis Associate 22303479, 25113562, 29555935, 34738477
Carcinoma Hepatocellular Associate 27894076
Carcinoma Ovarian Epithelial Associate 24440970, 24932571
Carcinoma Renal Cell Associate 24509249
Carcinoma Squamous Cell Associate 31322538, 34257574
Carcinoma Transitional Cell Associate 29058301
Colitis Ulcerative Associate 38302916
Death Associate 22748119