PRPF38B (pre-mRNA processing factor 38B)

Gene

• Entrez ID: 55119
• Gene name: Pre-mRNA processing factor 38B
• Gene symbol: PRPF38B
• Synonyms (NCBI Gene): NET1
• Chromosome: 1
• Chromosome location: 1p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027254	hsa-miR-101-3p	Sequencing	20371350
MIRT038040	hsa-miR-423-5p	CLASH	23622248
MIRT036833	hsa-miR-877-3p	CLASH	23622248
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT528633	hsa-miR-6073	PAR-CLIP	20371350
MIRT528632	hsa-miR-142-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	22012620
MIRT528633	hsa-miR-6073	PAR-CLIP	22012620
MIRT528632	hsa-miR-142-3p	PAR-CLIP	22012620
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT483517	hsa-miR-136-3p	PAR-CLIP	27292025
MIRT528632	hsa-miR-142-3p	PAR-CLIP	27292025
MIRT528633	hsa-miR-6073	PAR-CLIP	27292025
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT528633	hsa-miR-6073	PAR-CLIP	20371350
MIRT528632	hsa-miR-142-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	22012620
MIRT528633	hsa-miR-6073	PAR-CLIP	22012620
MIRT528632	hsa-miR-142-3p	PAR-CLIP	22012620
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT1265432	hsa-miR-101	CLIP-seq
MIRT1265433	hsa-miR-103a	CLIP-seq
MIRT1265434	hsa-miR-107	CLIP-seq
MIRT1265435	hsa-miR-1179	CLIP-seq
MIRT1265436	hsa-miR-1224-5p	CLIP-seq
MIRT1265437	hsa-miR-1228	CLIP-seq
MIRT1265438	hsa-miR-1248	CLIP-seq
MIRT1265439	hsa-miR-1275	CLIP-seq
MIRT1265440	hsa-miR-1283	CLIP-seq
MIRT1265441	hsa-miR-137	CLIP-seq
MIRT1265442	hsa-miR-144	CLIP-seq
MIRT1265443	hsa-miR-188-3p	CLIP-seq
MIRT1265444	hsa-miR-194	CLIP-seq
MIRT1265445	hsa-miR-200b	CLIP-seq
MIRT1265446	hsa-miR-200c	CLIP-seq
MIRT1265447	hsa-miR-2053	CLIP-seq
MIRT1265448	hsa-miR-216a	CLIP-seq
MIRT1265449	hsa-miR-217	CLIP-seq
MIRT1265450	hsa-miR-2276	CLIP-seq
MIRT1265451	hsa-miR-296-3p	CLIP-seq
MIRT1265452	hsa-miR-300	CLIP-seq
MIRT1265453	hsa-miR-3121-3p	CLIP-seq
MIRT1265454	hsa-miR-3146	CLIP-seq
MIRT1265455	hsa-miR-3148	CLIP-seq
MIRT1265456	hsa-miR-3150b-3p	CLIP-seq
MIRT1265457	hsa-miR-3189-5p	CLIP-seq
MIRT1265458	hsa-miR-34a	CLIP-seq
MIRT1265459	hsa-miR-34c-5p	CLIP-seq
MIRT1265460	hsa-miR-3613-3p	CLIP-seq
MIRT1265461	hsa-miR-3667-5p	CLIP-seq
MIRT1265462	hsa-miR-3677-5p	CLIP-seq
MIRT1265463	hsa-miR-374c	CLIP-seq
MIRT1265464	hsa-miR-381	CLIP-seq
MIRT1265465	hsa-miR-3915	CLIP-seq
MIRT1265466	hsa-miR-3973	CLIP-seq
MIRT1265467	hsa-miR-411	CLIP-seq
MIRT1265468	hsa-miR-4270	CLIP-seq
MIRT1265469	hsa-miR-4282	CLIP-seq
MIRT1265470	hsa-miR-429	CLIP-seq
MIRT1265471	hsa-miR-4297	CLIP-seq
MIRT1265472	hsa-miR-4310	CLIP-seq
MIRT1265473	hsa-miR-4418	CLIP-seq
MIRT1265474	hsa-miR-4436a	CLIP-seq
MIRT1265475	hsa-miR-4441	CLIP-seq
MIRT1265476	hsa-miR-4447	CLIP-seq
MIRT1265477	hsa-miR-4460	CLIP-seq
MIRT1265478	hsa-miR-4471	CLIP-seq
MIRT1265479	hsa-miR-4472	CLIP-seq
MIRT1265480	hsa-miR-4494	CLIP-seq
MIRT1265481	hsa-miR-449a	CLIP-seq
MIRT1265482	hsa-miR-449b	CLIP-seq
MIRT1265483	hsa-miR-4525	CLIP-seq
MIRT1265484	hsa-miR-4665-5p	CLIP-seq
MIRT1265485	hsa-miR-4666-3p	CLIP-seq
MIRT1265486	hsa-miR-4666-5p	CLIP-seq
MIRT1265487	hsa-miR-4668-5p	CLIP-seq
MIRT1265488	hsa-miR-4689	CLIP-seq
MIRT1265489	hsa-miR-4696	CLIP-seq
MIRT1265490	hsa-miR-4723-5p	CLIP-seq
MIRT1265491	hsa-miR-4727-3p	CLIP-seq
MIRT1265492	hsa-miR-4731-3p	CLIP-seq
MIRT1265493	hsa-miR-4758-3p	CLIP-seq
MIRT1265494	hsa-miR-4772-3p	CLIP-seq
MIRT1265495	hsa-miR-4777-5p	CLIP-seq
MIRT1265496	hsa-miR-4784	CLIP-seq
MIRT1265497	hsa-miR-4789-5p	CLIP-seq
MIRT1265498	hsa-miR-4801	CLIP-seq
MIRT1265499	hsa-miR-4802-3p	CLIP-seq
MIRT1265500	hsa-miR-489	CLIP-seq
MIRT1265501	hsa-miR-495	CLIP-seq
MIRT1265502	hsa-miR-500a	CLIP-seq
MIRT1265503	hsa-miR-509-3-5p	CLIP-seq
MIRT1265504	hsa-miR-509-5p	CLIP-seq
MIRT1265505	hsa-miR-514	CLIP-seq
MIRT1265506	hsa-miR-514b-3p	CLIP-seq
MIRT1265507	hsa-miR-518d-5p	CLIP-seq
MIRT1265508	hsa-miR-519b-5p	CLIP-seq
MIRT1265509	hsa-miR-519c-5p	CLIP-seq
MIRT1265510	hsa-miR-520c-5p	CLIP-seq
MIRT1265511	hsa-miR-526a	CLIP-seq
MIRT1265512	hsa-miR-544	CLIP-seq
MIRT1265513	hsa-miR-548a-5p	CLIP-seq
MIRT1265514	hsa-miR-548ab	CLIP-seq
MIRT1265515	hsa-miR-548ak	CLIP-seq
MIRT1265516	hsa-miR-548b-5p	CLIP-seq
MIRT1265517	hsa-miR-548c-5p	CLIP-seq
MIRT1265518	hsa-miR-548d-5p	CLIP-seq
MIRT1265519	hsa-miR-548h	CLIP-seq
MIRT1265520	hsa-miR-548i	CLIP-seq
MIRT1265521	hsa-miR-548j	CLIP-seq
MIRT1265522	hsa-miR-548w	CLIP-seq
MIRT1265523	hsa-miR-548y	CLIP-seq
MIRT1265524	hsa-miR-559	CLIP-seq
MIRT1265525	hsa-miR-569	CLIP-seq
MIRT1265526	hsa-miR-578	CLIP-seq
MIRT1265527	hsa-miR-606	CLIP-seq
MIRT1265528	hsa-miR-607	CLIP-seq
MIRT1265529	hsa-miR-625	CLIP-seq
MIRT1265530	hsa-miR-643	CLIP-seq
MIRT1265531	hsa-miR-655	CLIP-seq
MIRT1265532	hsa-miR-885-3p	CLIP-seq
MIRT1265533	hsa-miR-885-5p	CLIP-seq
MIRT1265534	hsa-miR-936	CLIP-seq
MIRT2078039	hsa-miR-186	CLIP-seq
MIRT1265452	hsa-miR-300	CLIP-seq
MIRT1265464	hsa-miR-381	CLIP-seq
MIRT1265433	hsa-miR-103a	CLIP-seq
MIRT1265434	hsa-miR-107	CLIP-seq
MIRT1265436	hsa-miR-1224-5p	CLIP-seq
MIRT1265449	hsa-miR-217	CLIP-seq
MIRT2304540	hsa-miR-3125	CLIP-seq
MIRT1265456	hsa-miR-3150b-3p	CLIP-seq
MIRT2304541	hsa-miR-3162-3p	CLIP-seq
MIRT2304542	hsa-miR-3646	CLIP-seq
MIRT2304543	hsa-miR-3647-3p	CLIP-seq
MIRT1265465	hsa-miR-3915	CLIP-seq
MIRT2304544	hsa-miR-3916	CLIP-seq
MIRT1265468	hsa-miR-4270	CLIP-seq
MIRT1265473	hsa-miR-4418	CLIP-seq
MIRT1265474	hsa-miR-4436a	CLIP-seq
MIRT1265475	hsa-miR-4441	CLIP-seq
MIRT1265488	hsa-miR-4689	CLIP-seq
MIRT1265496	hsa-miR-4784	CLIP-seq
MIRT1265503	hsa-miR-509-3-5p	CLIP-seq
MIRT1265504	hsa-miR-509-5p	CLIP-seq
MIRT2304545	hsa-miR-583	CLIP-seq
MIRT1265527	hsa-miR-606	CLIP-seq
MIRT2601535	hsa-miR-1297	CLIP-seq
MIRT2601536	hsa-miR-26a	CLIP-seq
MIRT2601537	hsa-miR-26b	CLIP-seq
MIRT2601538	hsa-miR-2861	CLIP-seq
MIRT2601539	hsa-miR-3913-3p	CLIP-seq
MIRT2601540	hsa-miR-4465	CLIP-seq
MIRT1265478	hsa-miR-4471	CLIP-seq
MIRT2601541	hsa-miR-4757-5p	CLIP-seq
MIRT2601542	hsa-miR-4769-3p	CLIP-seq
MIRT1265500	hsa-miR-489	CLIP-seq
MIRT2601543	hsa-miR-576-5p	CLIP-seq
MIRT2601544	hsa-miR-630	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005634	Component	Nucleus	IEA
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0071011	Component	Precatalytic spliceosome	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5VTL8
• Protein name: Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27)
• Protein function: May be required for pre-mRNA splicing.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03371	PRP38	47 → 231	PRP38 family	Family

• Sequence:

  MANNSPALTGNSQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNP
  MILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVG
  TGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFES
  FLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKI
  KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE
  RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN
  ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK
  KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTD
  SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK
  NKDETV

• Sequence length: 546

Pathways

KEGG:

Spliceosome

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NASOPHARYNGEAL NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Neoplasms	Associate	34001978	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	34001978	★☆☆☆☆ Found in Text Mining only