CRTAC1 (cartilage acidic protein 1)

Gene

• Entrez ID: 55118
• Gene name: Cartilage acidic protein 1
• Gene symbol: CRTAC1
• Synonyms (NCBI Gene): ASPIC, ASPIC1, CEP-68, CEP68, LOTUS
• Chromosome: 10
• Chromosome location: 10q24.2
• Summary: This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in cultur

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT910550	hsa-miR-1182	CLIP-seq
MIRT910551	hsa-miR-1193	CLIP-seq
MIRT910552	hsa-miR-1197	CLIP-seq
MIRT910553	hsa-miR-2110	CLIP-seq
MIRT910554	hsa-miR-3117-5p	CLIP-seq
MIRT910555	hsa-miR-3150a-3p	CLIP-seq
MIRT910556	hsa-miR-3175	CLIP-seq
MIRT910557	hsa-miR-3545-3p	CLIP-seq
MIRT910558	hsa-miR-3664-3p	CLIP-seq
MIRT910559	hsa-miR-4436a	CLIP-seq
MIRT910560	hsa-miR-4680-5p	CLIP-seq
MIRT910561	hsa-miR-4728-5p	CLIP-seq
MIRT910562	hsa-miR-490-5p	CLIP-seq
MIRT910563	hsa-miR-510	CLIP-seq
MIRT910564	hsa-miR-939	CLIP-seq
MIRT1969926	hsa-miR-2682	CLIP-seq
MIRT1969927	hsa-miR-449c	CLIP-seq
MIRT1969928	hsa-miR-645	CLIP-seq
MIRT1969929	hsa-miR-940	CLIP-seq
MIRT2447688	hsa-miR-1260	CLIP-seq
MIRT2447689	hsa-miR-1260b	CLIP-seq
MIRT2447690	hsa-miR-188-3p	CLIP-seq
MIRT2447691	hsa-miR-3156-3p	CLIP-seq
MIRT2447692	hsa-miR-4301	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0007413	Process	Axonal fasciculation	IBA
GO:0007413	Process	Axonal fasciculation	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0021772	Process	Olfactory bulb development	IEA
GO:0030426	Component	Growth cone	IEA
GO:0051963	Process	Regulation of synapse assembly	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 606276
• HGNC: 14882
• e!Ensembl: ENSG00000095713

Protein

• UniProt ID: Q9NQ79
• Protein name: Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13517	VCBS	62 → 132	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat
  PF13517	VCBS	253 → 310	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat
  PF13517	VCBS	299 → 363	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat
  PF07593	UnbV_ASPIC	458 → 521	ASPIC and UnbV	Family
  PF07645	EGF_CA	559 → 605	Calcium-binding EGF domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondro
• Sequence:

  MAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPTQLNYGVAV
  TDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGNAIGVTAC
  DIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDILSDEVNVARGVASLFAGRSV
  ACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALRDVAAEAGVSKYTGG
  RGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAGVDDPHQHGRGVALADF
  NRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELE
  IFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEPEGRGTGGVVTDFDGDGMLDL
  ILSHGESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFARGAKVVLYTKKSGAHLRIIDGG
  SGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSRNVASGEMNSVLEILYPRDEDTLQDP
  APLECGQGFSQQENGHCMDTNECIQFPFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNE
  DGTACVGTLGQSPGPRPTTPTAAAATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPS
  C

• Sequence length: 661