Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55117
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 6 member 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC6A15
Synonyms (NCBI Gene) Gene synonyms aliases	NTT73, SBAT1, V7-3, hv7-3
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q21.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMI

Show/Hide all(216)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050428	hsa-miR-23a-3p	CLASH	23622248
MIRT046356	hsa-miR-23b-3p	CLASH	23622248
MIRT042665	hsa-miR-196b-5p	CLASH	23622248
MIRT1366058	hsa-miR-101	CLIP-seq
MIRT1366059	hsa-miR-1244	CLIP-seq
MIRT1366060	hsa-miR-128	CLIP-seq
MIRT1366061	hsa-miR-1301	CLIP-seq
MIRT1366062	hsa-miR-186	CLIP-seq
MIRT1366063	hsa-miR-27a	CLIP-seq
MIRT1366064	hsa-miR-27b	CLIP-seq
MIRT1366065	hsa-miR-3133	CLIP-seq
MIRT1366066	hsa-miR-3143	CLIP-seq
MIRT1366067	hsa-miR-3168	CLIP-seq
MIRT1366068	hsa-miR-338-5p	CLIP-seq
MIRT1366069	hsa-miR-3617	CLIP-seq
MIRT1366070	hsa-miR-369-3p	CLIP-seq
MIRT1366071	hsa-miR-374a	CLIP-seq
MIRT1366072	hsa-miR-374b	CLIP-seq
MIRT1366073	hsa-miR-374c	CLIP-seq
MIRT1366074	hsa-miR-4317	CLIP-seq
MIRT1366075	hsa-miR-4437	CLIP-seq
MIRT1366076	hsa-miR-4639-5p	CLIP-seq
MIRT1366077	hsa-miR-4660	CLIP-seq
MIRT1366078	hsa-miR-4666-3p	CLIP-seq
MIRT1366079	hsa-miR-4668-3p	CLIP-seq
MIRT1366080	hsa-miR-4674	CLIP-seq
MIRT1366081	hsa-miR-4684-3p	CLIP-seq
MIRT1366082	hsa-miR-4698	CLIP-seq
MIRT1366083	hsa-miR-491-3p	CLIP-seq
MIRT1366084	hsa-miR-5047	CLIP-seq
MIRT1366085	hsa-miR-543	CLIP-seq
MIRT1366086	hsa-miR-548c-3p	CLIP-seq
MIRT1366087	hsa-miR-548n	CLIP-seq
MIRT1366088	hsa-miR-607	CLIP-seq
MIRT1366089	hsa-miR-641	CLIP-seq
MIRT1366090	hsa-miR-655	CLIP-seq
MIRT1366091	hsa-miR-203	CLIP-seq
MIRT1366092	hsa-miR-302a	CLIP-seq
MIRT1366093	hsa-miR-302b	CLIP-seq
MIRT1366094	hsa-miR-302c	CLIP-seq
MIRT1366095	hsa-miR-302d	CLIP-seq
MIRT1366096	hsa-miR-302e	CLIP-seq
MIRT1366097	hsa-miR-302f	CLIP-seq
MIRT1366098	hsa-miR-3129-3p	CLIP-seq
MIRT1366099	hsa-miR-3136-5p	CLIP-seq
MIRT1366100	hsa-miR-372	CLIP-seq
MIRT1366101	hsa-miR-373	CLIP-seq
MIRT1366102	hsa-miR-4328	CLIP-seq
MIRT1366103	hsa-miR-4439	CLIP-seq
MIRT1366104	hsa-miR-4513	CLIP-seq
MIRT1366105	hsa-miR-4659a-3p	CLIP-seq
MIRT1366106	hsa-miR-4659b-3p	CLIP-seq
MIRT1366107	hsa-miR-4774-3p	CLIP-seq
MIRT1366108	hsa-miR-512-3p	CLIP-seq
MIRT1366109	hsa-miR-519a	CLIP-seq
MIRT1366110	hsa-miR-519b-3p	CLIP-seq
MIRT1366111	hsa-miR-519c-3p	CLIP-seq
MIRT1366112	hsa-miR-520a-3p	CLIP-seq
MIRT1366113	hsa-miR-520b	CLIP-seq
MIRT1366114	hsa-miR-520c-3p	CLIP-seq
MIRT1366115	hsa-miR-520d-3p	CLIP-seq
MIRT1366116	hsa-miR-520e	CLIP-seq
MIRT1366086	hsa-miR-548c-3p	CLIP-seq
MIRT1366117	hsa-miR-628-5p	CLIP-seq
MIRT1366097	hsa-miR-302f	CLIP-seq
MIRT2332283	hsa-miR-30a	CLIP-seq
MIRT2332284	hsa-miR-30b	CLIP-seq
MIRT2332285	hsa-miR-30c	CLIP-seq
MIRT2332286	hsa-miR-30d	CLIP-seq
MIRT2332287	hsa-miR-30e	CLIP-seq
MIRT2332288	hsa-miR-3123	CLIP-seq
MIRT1366098	hsa-miR-3129-3p	CLIP-seq
MIRT2332289	hsa-miR-3130-3p	CLIP-seq
MIRT1366102	hsa-miR-4328	CLIP-seq
MIRT2332290	hsa-miR-4495	CLIP-seq
MIRT2332291	hsa-miR-450b-5p	CLIP-seq
MIRT1366105	hsa-miR-4659a-3p	CLIP-seq
MIRT1366106	hsa-miR-4659b-3p	CLIP-seq
MIRT2332292	hsa-miR-4719	CLIP-seq
MIRT2332293	hsa-miR-4793-3p	CLIP-seq
MIRT2332294	hsa-miR-500a	CLIP-seq
MIRT2332295	hsa-miR-501-5p	CLIP-seq
MIRT2332296	hsa-miR-507	CLIP-seq
MIRT2332297	hsa-miR-544	CLIP-seq
MIRT2332298	hsa-miR-557	CLIP-seq
MIRT2459839	hsa-miR-376a	CLIP-seq
MIRT2459840	hsa-miR-376b	CLIP-seq
MIRT2459841	hsa-miR-4663	CLIP-seq
MIRT2626717	hsa-let-7a	CLIP-seq
MIRT2626718	hsa-let-7b	CLIP-seq
MIRT2626719	hsa-let-7c	CLIP-seq
MIRT2626720	hsa-let-7d	CLIP-seq
MIRT2626721	hsa-let-7e	CLIP-seq
MIRT2626722	hsa-let-7f	CLIP-seq
MIRT2626723	hsa-let-7g	CLIP-seq
MIRT2626724	hsa-let-7i	CLIP-seq
MIRT2626725	hsa-miR-10a	CLIP-seq
MIRT2626726	hsa-miR-10b	CLIP-seq
MIRT2626727	hsa-miR-1206	CLIP-seq
MIRT2626728	hsa-miR-1258	CLIP-seq
MIRT2626729	hsa-miR-1296	CLIP-seq
MIRT2626730	hsa-miR-137	CLIP-seq
MIRT2626731	hsa-miR-155	CLIP-seq
MIRT2626732	hsa-miR-1912	CLIP-seq
MIRT2626733	hsa-miR-202	CLIP-seq
MIRT2626734	hsa-miR-216a	CLIP-seq
MIRT2626735	hsa-miR-3117-5p	CLIP-seq
MIRT2626736	hsa-miR-3157-3p	CLIP-seq
MIRT2626737	hsa-miR-3159	CLIP-seq
MIRT2626738	hsa-miR-3161	CLIP-seq
MIRT2626739	hsa-miR-340	CLIP-seq
MIRT2626740	hsa-miR-3622a-3p	CLIP-seq
MIRT2626741	hsa-miR-3622b-3p	CLIP-seq
MIRT2626742	hsa-miR-3646	CLIP-seq
MIRT2626743	hsa-miR-3662	CLIP-seq
MIRT2626744	hsa-miR-371-3p	CLIP-seq
MIRT2626745	hsa-miR-371b-3p	CLIP-seq
MIRT2626746	hsa-miR-377	CLIP-seq
MIRT2626747	hsa-miR-3941	CLIP-seq
MIRT2626748	hsa-miR-4264	CLIP-seq
MIRT2626749	hsa-miR-4279	CLIP-seq
MIRT2626750	hsa-miR-4290	CLIP-seq
MIRT2626751	hsa-miR-4297	CLIP-seq
MIRT2626752	hsa-miR-4324	CLIP-seq
MIRT2626753	hsa-miR-4427	CLIP-seq
MIRT2626754	hsa-miR-4458	CLIP-seq
MIRT2626755	hsa-miR-4470	CLIP-seq
MIRT2626756	hsa-miR-4473	CLIP-seq
MIRT2626757	hsa-miR-4493	CLIP-seq
MIRT2626758	hsa-miR-4500	CLIP-seq
MIRT2626759	hsa-miR-4512	CLIP-seq
MIRT2626760	hsa-miR-452	CLIP-seq
MIRT2626761	hsa-miR-4639-3p	CLIP-seq
MIRT2626762	hsa-miR-466	CLIP-seq
MIRT2626763	hsa-miR-4670-3p	CLIP-seq
MIRT2626764	hsa-miR-4671-3p	CLIP-seq
MIRT2626765	hsa-miR-4672	CLIP-seq
MIRT2626766	hsa-miR-4676-3p	CLIP-seq
MIRT2626767	hsa-miR-4680-3p	CLIP-seq
MIRT2626768	hsa-miR-4691-3p	CLIP-seq
MIRT2626769	hsa-miR-4704-3p	CLIP-seq
MIRT2626770	hsa-miR-4717-3p	CLIP-seq
MIRT2626771	hsa-miR-4731-3p	CLIP-seq
MIRT2626772	hsa-miR-4738-3p	CLIP-seq
MIRT2626773	hsa-miR-4786-3p	CLIP-seq
MIRT2626774	hsa-miR-4789-3p	CLIP-seq
MIRT2626775	hsa-miR-4797-3p	CLIP-seq
MIRT2626776	hsa-miR-4801	CLIP-seq
MIRT2626777	hsa-miR-505	CLIP-seq
MIRT2626778	hsa-miR-5096	CLIP-seq
MIRT2626779	hsa-miR-513a-3p	CLIP-seq
MIRT2626780	hsa-miR-515-3p	CLIP-seq
MIRT2626781	hsa-miR-519e	CLIP-seq
MIRT2626782	hsa-miR-548aa	CLIP-seq
MIRT1366086	hsa-miR-548c-3p	CLIP-seq
MIRT2626783	hsa-miR-579	CLIP-seq
MIRT2626784	hsa-miR-590-3p	CLIP-seq
MIRT2626785	hsa-miR-651	CLIP-seq
MIRT2626786	hsa-miR-874	CLIP-seq
MIRT2626787	hsa-miR-944	CLIP-seq
MIRT2626788	hsa-miR-98	CLIP-seq
MIRT2626725	hsa-miR-10a	CLIP-seq
MIRT2626726	hsa-miR-10b	CLIP-seq
MIRT2626727	hsa-miR-1206	CLIP-seq
MIRT2626728	hsa-miR-1258	CLIP-seq
MIRT2626729	hsa-miR-1296	CLIP-seq
MIRT2626731	hsa-miR-155	CLIP-seq
MIRT2626734	hsa-miR-216a	CLIP-seq
MIRT2626735	hsa-miR-3117-5p	CLIP-seq
MIRT2626736	hsa-miR-3157-3p	CLIP-seq
MIRT2626737	hsa-miR-3159	CLIP-seq
MIRT2626738	hsa-miR-3161	CLIP-seq
MIRT2626739	hsa-miR-340	CLIP-seq
MIRT2626740	hsa-miR-3622a-3p	CLIP-seq
MIRT2626741	hsa-miR-3622b-3p	CLIP-seq
MIRT2626742	hsa-miR-3646	CLIP-seq
MIRT2626743	hsa-miR-3662	CLIP-seq
MIRT2626744	hsa-miR-371-3p	CLIP-seq
MIRT2626745	hsa-miR-371b-3p	CLIP-seq
MIRT2626746	hsa-miR-377	CLIP-seq
MIRT2626747	hsa-miR-3941	CLIP-seq
MIRT2626748	hsa-miR-4264	CLIP-seq
MIRT2626749	hsa-miR-4279	CLIP-seq
MIRT2626750	hsa-miR-4290	CLIP-seq
MIRT2626751	hsa-miR-4297	CLIP-seq
MIRT2626752	hsa-miR-4324	CLIP-seq
MIRT2626753	hsa-miR-4427	CLIP-seq
MIRT2626755	hsa-miR-4470	CLIP-seq
MIRT2626756	hsa-miR-4473	CLIP-seq
MIRT2626757	hsa-miR-4493	CLIP-seq
MIRT2626759	hsa-miR-4512	CLIP-seq
MIRT2626760	hsa-miR-452	CLIP-seq
MIRT2626761	hsa-miR-4639-3p	CLIP-seq
MIRT2626762	hsa-miR-466	CLIP-seq
MIRT2626763	hsa-miR-4670-3p	CLIP-seq
MIRT2626764	hsa-miR-4671-3p	CLIP-seq
MIRT2626765	hsa-miR-4672	CLIP-seq
MIRT2626766	hsa-miR-4676-3p	CLIP-seq
MIRT2626767	hsa-miR-4680-3p	CLIP-seq
MIRT2626768	hsa-miR-4691-3p	CLIP-seq
MIRT2626769	hsa-miR-4704-3p	CLIP-seq
MIRT2626770	hsa-miR-4717-3p	CLIP-seq
MIRT2626771	hsa-miR-4731-3p	CLIP-seq
MIRT2626773	hsa-miR-4786-3p	CLIP-seq
MIRT2626774	hsa-miR-4789-3p	CLIP-seq
MIRT2626775	hsa-miR-4797-3p	CLIP-seq
MIRT2626776	hsa-miR-4801	CLIP-seq
MIRT2626778	hsa-miR-5096	CLIP-seq
MIRT2626779	hsa-miR-513a-3p	CLIP-seq
MIRT2626780	hsa-miR-515-3p	CLIP-seq
MIRT2626781	hsa-miR-519e	CLIP-seq
MIRT1366086	hsa-miR-548c-3p	CLIP-seq
MIRT2626783	hsa-miR-579	CLIP-seq
MIRT2626784	hsa-miR-590-3p	CLIP-seq
MIRT2626785	hsa-miR-651	CLIP-seq
MIRT2626786	hsa-miR-874	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003333	Process	Amino acid transmembrane transport	IEA
GO:0005298	Function	Proline:sodium symporter activity	IBA	21873635
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	NAS	11112352
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0006836	Process	Neurotransmitter transport	NAS	11112352
GO:0006865	Process	Amino acid transport	TAS
GO:0015171	Function	Amino acid transmembrane transporter activity	TAS
GO:0015804	Process	Neutral amino acid transport	IDA	16226721
GO:0015820	Process	Leucine transport	IBA	21873635
GO:0015820	Process	Leucine transport	ISS
GO:0015824	Process	Proline transport	ISS
GO:0016021	Component	Integral component of membrane	NAS	11112352
GO:0035725	Process	Sodium ion transmembrane transport	IBA	21873635

MIM	HGNC	e!Ensembl
607971	13621	ENSG00000072041

Protein

UniProt ID

Q9H2J7

Protein name

Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3)

Protein function

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, pheny

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00209	SNF	61 → 644	Sodium:neurotransmitter symporter family	Family

Tissue specificity

TISSUE SPECIFICITY: Almost exclusively expressed in the brain. {ECO:0000269|PubMed:16226721}.

Sequence

MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
IMPDMPESDL

Sequence length

730

Interactions

View interactions

	Reactome
			Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters

Show/Hide Unknown Diseases (13)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Unipolar Depression, Major Depressive Disorder		22475622, 21521612, 23874702	ClinVar
Obsessive-Compulsive Disorder	Obsessive-Compulsive Disorder			GWAS
Hypertension	Hypertension			GWAS
Mental Depression	Mental Depression			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Gastroesophageal Reflux Disease	Gastroesophageal Reflux Disease			GWAS
Insomnia	Insomnia			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Glaucoma	Glaucoma			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Restless Legs Syndrome	Restless Legs Syndrome			GWAS
Diabetes	Diabetes			GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Colonic Neoplasms	Associate	37543674
Colorectal Neoplasms	Associate	21298349, 24485021
Depressive Disorder Major	Associate	23874702
Insulin Resistance	Associate	30913280
Leukemia Large Granular Lymphocytic	Associate	35015834
Mental Disorders	Associate	23874702
Metabolic Syndrome	Associate	30913280
Neoplasms	Inhibit	35659616
Neoplasms	Associate	37543674
Ovarian Neoplasms	Inhibit	28793334
Spheroid body myopathy	Inhibit	28793334

SLC6A15 (solute carrier family 6 member 15)