Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55110
Gene name Gene Name - the full gene name approved by the HGNC.	Mago homolog B, exon junction complex subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAGOHB
Synonyms (NCBI Gene) Gene synonyms aliases	MGN2, mago, magoh
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.2

Show/Hide all(111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050618	hsa-miR-20a-5p	CLASH	23622248
MIRT1126077	hsa-miR-1208	CLIP-seq
MIRT1126078	hsa-miR-140-5p	CLIP-seq
MIRT1126079	hsa-miR-148a	CLIP-seq
MIRT1126080	hsa-miR-148b	CLIP-seq
MIRT1126081	hsa-miR-152	CLIP-seq
MIRT1126082	hsa-miR-153	CLIP-seq
MIRT1126083	hsa-miR-181a	CLIP-seq
MIRT1126084	hsa-miR-181b	CLIP-seq
MIRT1126085	hsa-miR-181c	CLIP-seq
MIRT1126086	hsa-miR-181d	CLIP-seq
MIRT1126087	hsa-miR-23a	CLIP-seq
MIRT1126088	hsa-miR-23b	CLIP-seq
MIRT1126089	hsa-miR-23c	CLIP-seq
MIRT1126090	hsa-miR-29a	CLIP-seq
MIRT1126091	hsa-miR-29b	CLIP-seq
MIRT1126092	hsa-miR-29c	CLIP-seq
MIRT1126093	hsa-miR-3120-3p	CLIP-seq
MIRT1126094	hsa-miR-3121-3p	CLIP-seq
MIRT1126095	hsa-miR-3182	CLIP-seq
MIRT1126096	hsa-miR-3616-5p	CLIP-seq
MIRT1126097	hsa-miR-3647-5p	CLIP-seq
MIRT1126098	hsa-miR-3936	CLIP-seq
MIRT1126099	hsa-miR-3977	CLIP-seq
MIRT1126100	hsa-miR-4262	CLIP-seq
MIRT1126101	hsa-miR-4263	CLIP-seq
MIRT1126102	hsa-miR-4276	CLIP-seq
MIRT1126103	hsa-miR-4328	CLIP-seq
MIRT1126104	hsa-miR-448	CLIP-seq
MIRT1126105	hsa-miR-455-3p	CLIP-seq
MIRT1126106	hsa-miR-4697-3p	CLIP-seq
MIRT1126107	hsa-miR-4795-5p	CLIP-seq
MIRT1126108	hsa-miR-513a-5p	CLIP-seq
MIRT1126109	hsa-miR-548ac	CLIP-seq
MIRT1126110	hsa-miR-548ae	CLIP-seq
MIRT1126111	hsa-miR-548aj	CLIP-seq
MIRT1126112	hsa-miR-548am	CLIP-seq
MIRT1126113	hsa-miR-548d-3p	CLIP-seq
MIRT1126114	hsa-miR-548x	CLIP-seq
MIRT1126115	hsa-miR-548z	CLIP-seq
MIRT1126116	hsa-miR-573	CLIP-seq
MIRT1126117	hsa-miR-576-5p	CLIP-seq
MIRT1126118	hsa-miR-600	CLIP-seq
MIRT1126119	hsa-miR-767-5p	CLIP-seq
MIRT1126120	hsa-miR-944	CLIP-seq
MIRT2266096	hsa-miR-101	CLIP-seq
MIRT2266097	hsa-miR-1228	CLIP-seq
MIRT2266098	hsa-miR-124	CLIP-seq
MIRT2266099	hsa-miR-1245b-5p	CLIP-seq
MIRT2266100	hsa-miR-1255a	CLIP-seq
MIRT2266101	hsa-miR-1255b	CLIP-seq
MIRT2266102	hsa-miR-1273d	CLIP-seq
MIRT2266103	hsa-miR-1297	CLIP-seq
MIRT2266104	hsa-miR-1303	CLIP-seq
MIRT2266105	hsa-miR-1324	CLIP-seq
MIRT2266106	hsa-miR-199a-3p	CLIP-seq
MIRT2266107	hsa-miR-199b-3p	CLIP-seq
MIRT2266108	hsa-miR-26a	CLIP-seq
MIRT2266109	hsa-miR-26b	CLIP-seq
MIRT2266110	hsa-miR-300	CLIP-seq
MIRT2266111	hsa-miR-3123	CLIP-seq
MIRT2266112	hsa-miR-3129-5p	CLIP-seq
MIRT2266113	hsa-miR-3142	CLIP-seq
MIRT2266114	hsa-miR-3144-5p	CLIP-seq
MIRT2266115	hsa-miR-3148	CLIP-seq
MIRT2266116	hsa-miR-3151	CLIP-seq
MIRT2266117	hsa-miR-3166	CLIP-seq
MIRT2266118	hsa-miR-3191	CLIP-seq
MIRT2266119	hsa-miR-3199	CLIP-seq
MIRT2266120	hsa-miR-381	CLIP-seq
MIRT2266121	hsa-miR-3920	CLIP-seq
MIRT2266122	hsa-miR-3925-5p	CLIP-seq
MIRT2266123	hsa-miR-3978	CLIP-seq
MIRT2266124	hsa-miR-4293	CLIP-seq
MIRT2266125	hsa-miR-4305	CLIP-seq
MIRT1126103	hsa-miR-4328	CLIP-seq
MIRT2266126	hsa-miR-4447	CLIP-seq
MIRT2266127	hsa-miR-4465	CLIP-seq
MIRT2266128	hsa-miR-4472	CLIP-seq
MIRT2266129	hsa-miR-4645-3p	CLIP-seq
MIRT2266130	hsa-miR-4652-5p	CLIP-seq
MIRT2266131	hsa-miR-4654	CLIP-seq
MIRT2266132	hsa-miR-4666-3p	CLIP-seq
MIRT2266133	hsa-miR-4670-3p	CLIP-seq
MIRT2266134	hsa-miR-4769-5p	CLIP-seq
MIRT2266135	hsa-miR-4771	CLIP-seq
MIRT2266136	hsa-miR-4789-5p	CLIP-seq
MIRT2266137	hsa-miR-491-5p	CLIP-seq
MIRT2266138	hsa-miR-506	CLIP-seq
MIRT2266139	hsa-miR-512-5p	CLIP-seq
MIRT2266140	hsa-miR-553	CLIP-seq
MIRT2266141	hsa-miR-579	CLIP-seq
MIRT2266142	hsa-miR-624	CLIP-seq
MIRT2266143	hsa-miR-890	CLIP-seq
MIRT2266144	hsa-miR-936	CLIP-seq
MIRT2390466	hsa-miR-1243	CLIP-seq
MIRT2390467	hsa-miR-2861	CLIP-seq
MIRT2390468	hsa-miR-3654	CLIP-seq
MIRT2390469	hsa-miR-4265	CLIP-seq
MIRT2390470	hsa-miR-4296	CLIP-seq
MIRT2390471	hsa-miR-4318	CLIP-seq
MIRT2390472	hsa-miR-4322	CLIP-seq
MIRT2390473	hsa-miR-4417	CLIP-seq
MIRT2453619	hsa-miR-3973	CLIP-seq
MIRT2453620	hsa-miR-520g	CLIP-seq
MIRT2453621	hsa-miR-520h	CLIP-seq
MIRT2453622	hsa-miR-548l	CLIP-seq
MIRT2453619	hsa-miR-3973	CLIP-seq
MIRT2453620	hsa-miR-520g	CLIP-seq
MIRT2453621	hsa-miR-520h	CLIP-seq
MIRT2453622	hsa-miR-548l	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI	23917022
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28502770
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21044950, 21516116, 25416956, 26496610, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	28502770
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21289489
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005829	Component	Cytosol	NAS	21289489
GO:0006397	Process	MRNA processing	IEA
GO:0006406	Process	MRNA export from nucleus	NAS	11532962
GO:0008380	Process	RNA splicing	IBA
GO:0008380	Process	RNA splicing	IEA
GO:0035145	Component	Exon-exon junction complex	IBA
GO:0035145	Component	Exon-exon junction complex	IDA	23917022
GO:0035145	Component	Exon-exon junction complex	IEA
GO:0035145	Component	Exon-exon junction complex	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0050684	Process	Regulation of mRNA processing	ISS
GO:0051028	Process	MRNA transport	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28502770
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IDA	29301961
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:1990501	Component	Exon-exon junction subcomplex mago-y14	IEA
GO:1990501	Component	Exon-exon junction subcomplex mago-y14	IPI	25416956
GO:2000622	Process	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISS

MIM	HGNC	e!Ensembl
619552	25504	ENSG00000111196

Protein

UniProt ID

Q96A72

Protein name

Protein mago nashi homolog 2

Protein function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022)

PDB

5XJC , 5YZG , 6ICZ , 6QDV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02792	Mago_nashi	7 → 148	Mago nashi protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVME
ELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEG
LRVFYYLVQDLKCLVFSLIGLHFKIKPI

Sequence length

148

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport mRNA surveillance pathway Spliceosome		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

MAGOHB (mago homolog B, exon junction complex subunit)