MAGOHB (mago homolog B, exon junction complex subunit)

Gene

• Entrez ID: 55110
• Gene name: Mago homolog B, exon junction complex subunit
• Gene symbol: MAGOHB
• Synonyms (NCBI Gene): MGN2, mago, magoh
• Chromosome: 12
• Chromosome location: 12p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050618	hsa-miR-20a-5p	CLASH	23622248
MIRT1126077	hsa-miR-1208	CLIP-seq
MIRT1126078	hsa-miR-140-5p	CLIP-seq
MIRT1126079	hsa-miR-148a	CLIP-seq
MIRT1126080	hsa-miR-148b	CLIP-seq
MIRT1126081	hsa-miR-152	CLIP-seq
MIRT1126082	hsa-miR-153	CLIP-seq
MIRT1126083	hsa-miR-181a	CLIP-seq
MIRT1126084	hsa-miR-181b	CLIP-seq
MIRT1126085	hsa-miR-181c	CLIP-seq
MIRT1126086	hsa-miR-181d	CLIP-seq
MIRT1126087	hsa-miR-23a	CLIP-seq
MIRT1126088	hsa-miR-23b	CLIP-seq
MIRT1126089	hsa-miR-23c	CLIP-seq
MIRT1126090	hsa-miR-29a	CLIP-seq
MIRT1126091	hsa-miR-29b	CLIP-seq
MIRT1126092	hsa-miR-29c	CLIP-seq
MIRT1126093	hsa-miR-3120-3p	CLIP-seq
MIRT1126094	hsa-miR-3121-3p	CLIP-seq
MIRT1126095	hsa-miR-3182	CLIP-seq
MIRT1126096	hsa-miR-3616-5p	CLIP-seq
MIRT1126097	hsa-miR-3647-5p	CLIP-seq
MIRT1126098	hsa-miR-3936	CLIP-seq
MIRT1126099	hsa-miR-3977	CLIP-seq
MIRT1126100	hsa-miR-4262	CLIP-seq
MIRT1126101	hsa-miR-4263	CLIP-seq
MIRT1126102	hsa-miR-4276	CLIP-seq
MIRT1126103	hsa-miR-4328	CLIP-seq
MIRT1126104	hsa-miR-448	CLIP-seq
MIRT1126105	hsa-miR-455-3p	CLIP-seq
MIRT1126106	hsa-miR-4697-3p	CLIP-seq
MIRT1126107	hsa-miR-4795-5p	CLIP-seq
MIRT1126108	hsa-miR-513a-5p	CLIP-seq
MIRT1126109	hsa-miR-548ac	CLIP-seq
MIRT1126110	hsa-miR-548ae	CLIP-seq
MIRT1126111	hsa-miR-548aj	CLIP-seq
MIRT1126112	hsa-miR-548am	CLIP-seq
MIRT1126113	hsa-miR-548d-3p	CLIP-seq
MIRT1126114	hsa-miR-548x	CLIP-seq
MIRT1126115	hsa-miR-548z	CLIP-seq
MIRT1126116	hsa-miR-573	CLIP-seq
MIRT1126117	hsa-miR-576-5p	CLIP-seq
MIRT1126118	hsa-miR-600	CLIP-seq
MIRT1126119	hsa-miR-767-5p	CLIP-seq
MIRT1126120	hsa-miR-944	CLIP-seq
MIRT2266096	hsa-miR-101	CLIP-seq
MIRT2266097	hsa-miR-1228	CLIP-seq
MIRT2266098	hsa-miR-124	CLIP-seq
MIRT2266099	hsa-miR-1245b-5p	CLIP-seq
MIRT2266100	hsa-miR-1255a	CLIP-seq
MIRT2266101	hsa-miR-1255b	CLIP-seq
MIRT2266102	hsa-miR-1273d	CLIP-seq
MIRT2266103	hsa-miR-1297	CLIP-seq
MIRT2266104	hsa-miR-1303	CLIP-seq
MIRT2266105	hsa-miR-1324	CLIP-seq
MIRT2266106	hsa-miR-199a-3p	CLIP-seq
MIRT2266107	hsa-miR-199b-3p	CLIP-seq
MIRT2266108	hsa-miR-26a	CLIP-seq
MIRT2266109	hsa-miR-26b	CLIP-seq
MIRT2266110	hsa-miR-300	CLIP-seq
MIRT2266111	hsa-miR-3123	CLIP-seq
MIRT2266112	hsa-miR-3129-5p	CLIP-seq
MIRT2266113	hsa-miR-3142	CLIP-seq
MIRT2266114	hsa-miR-3144-5p	CLIP-seq
MIRT2266115	hsa-miR-3148	CLIP-seq
MIRT2266116	hsa-miR-3151	CLIP-seq
MIRT2266117	hsa-miR-3166	CLIP-seq
MIRT2266118	hsa-miR-3191	CLIP-seq
MIRT2266119	hsa-miR-3199	CLIP-seq
MIRT2266120	hsa-miR-381	CLIP-seq
MIRT2266121	hsa-miR-3920	CLIP-seq
MIRT2266122	hsa-miR-3925-5p	CLIP-seq
MIRT2266123	hsa-miR-3978	CLIP-seq
MIRT2266124	hsa-miR-4293	CLIP-seq
MIRT2266125	hsa-miR-4305	CLIP-seq
MIRT1126103	hsa-miR-4328	CLIP-seq
MIRT2266126	hsa-miR-4447	CLIP-seq
MIRT2266127	hsa-miR-4465	CLIP-seq
MIRT2266128	hsa-miR-4472	CLIP-seq
MIRT2266129	hsa-miR-4645-3p	CLIP-seq
MIRT2266130	hsa-miR-4652-5p	CLIP-seq
MIRT2266131	hsa-miR-4654	CLIP-seq
MIRT2266132	hsa-miR-4666-3p	CLIP-seq
MIRT2266133	hsa-miR-4670-3p	CLIP-seq
MIRT2266134	hsa-miR-4769-5p	CLIP-seq
MIRT2266135	hsa-miR-4771	CLIP-seq
MIRT2266136	hsa-miR-4789-5p	CLIP-seq
MIRT2266137	hsa-miR-491-5p	CLIP-seq
MIRT2266138	hsa-miR-506	CLIP-seq
MIRT2266139	hsa-miR-512-5p	CLIP-seq
MIRT2266140	hsa-miR-553	CLIP-seq
MIRT2266141	hsa-miR-579	CLIP-seq
MIRT2266142	hsa-miR-624	CLIP-seq
MIRT2266143	hsa-miR-890	CLIP-seq
MIRT2266144	hsa-miR-936	CLIP-seq
MIRT2390466	hsa-miR-1243	CLIP-seq
MIRT2390467	hsa-miR-2861	CLIP-seq
MIRT2390468	hsa-miR-3654	CLIP-seq
MIRT2390469	hsa-miR-4265	CLIP-seq
MIRT2390470	hsa-miR-4296	CLIP-seq
MIRT2390471	hsa-miR-4318	CLIP-seq
MIRT2390472	hsa-miR-4322	CLIP-seq
MIRT2390473	hsa-miR-4417	CLIP-seq
MIRT2453619	hsa-miR-3973	CLIP-seq
MIRT2453620	hsa-miR-520g	CLIP-seq
MIRT2453621	hsa-miR-520h	CLIP-seq
MIRT2453622	hsa-miR-548l	CLIP-seq
MIRT2453619	hsa-miR-3973	CLIP-seq
MIRT2453620	hsa-miR-520g	CLIP-seq
MIRT2453621	hsa-miR-520h	CLIP-seq
MIRT2453622	hsa-miR-548l	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI	23917022
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28502770
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	16189514, 21044950, 21516116, 25416956, 26496610, 32296183
GO:0005634	Component	Nucleus	IDA	28502770
GO:0005654	Component	Nucleoplasm	TAS
GO:0006405	Process	RNA export from nucleus	TAS
GO:0006406	Process	MRNA export from nucleus	TAS
GO:0008380	Process	RNA splicing	IBA	21873635
GO:0031124	Process	MRNA 3'-end processing	TAS
GO:0035145	Component	Exon-exon junction complex	IBA	21873635
GO:0035145	Component	Exon-exon junction complex	IDA	23917022
GO:0043025	Component	Neuronal cell body	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28502770
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IDA	29301961
GO:0071013	Component	Catalytic step 2 spliceosome	IBA	21873635

Other IDs

• MIM: 619552
• HGNC: 25504
• e!Ensembl: ENSG00000111196

Protein

• UniProt ID: Q96A72
• Protein name: Protein mago nashi homolog 2
• Protein function: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022)
• PDB: 5XJC, 5YZG, 6ICZ, 6QDV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02792	Mago_nashi	7 → 148	Mago nashi protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVME
  ELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEG
  LRVFYYLVQDLKCLVFSLIGLHFKIKPI

• Sequence length: 148

Pathways

KEGG:

Nucleocytoplasmic transport
mRNA surveillance pathway
Spliceosome

Reactome:

Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Brain Neoplasms	Associate	37294214
Breast Neoplasms	Associate	28263985
Glioblastoma	Associate	37294214
Glioma	Associate	37294214
Melanoma	Associate	36497117
Melanoma Cutaneous Malignant	Associate	36497117
Neoplasms	Associate	28263985, 37294214
Rectal Neoplasms	Associate	37895091