TMEM51 (transmembrane protein 51)

Gene

• Entrez ID: 55092
• Gene name: Transmembrane protein 51
• Gene symbol: TMEM51
• Synonyms (NCBI Gene): C1orf72
• Chromosome: 1
• Chromosome location: 1p36.21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044837	hsa-miR-320a	CLASH	23622248
MIRT613873	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613872	hsa-miR-3941	HITS-CLIP	23824327
MIRT613871	hsa-miR-4672	HITS-CLIP	23824327
MIRT613870	hsa-miR-466	HITS-CLIP	23824327
MIRT613869	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT613868	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT613868	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT613872	hsa-miR-3941	HITS-CLIP	27418678
MIRT613870	hsa-miR-466	HITS-CLIP	27418678
MIRT613871	hsa-miR-4672	HITS-CLIP	27418678
MIRT613873	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT613869	hsa-miR-6885-3p	HITS-CLIP	27418678
MIRT613873	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613872	hsa-miR-3941	HITS-CLIP	23824327
MIRT613871	hsa-miR-4672	HITS-CLIP	23824327
MIRT613870	hsa-miR-466	HITS-CLIP	23824327
MIRT613869	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT613868	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT1437870	hsa-miR-1256	CLIP-seq
MIRT1437871	hsa-miR-136	CLIP-seq
MIRT1437872	hsa-miR-139-5p	CLIP-seq
MIRT1437873	hsa-miR-3133	CLIP-seq
MIRT1437874	hsa-miR-3613-3p	CLIP-seq
MIRT1437875	hsa-miR-3685	CLIP-seq
MIRT1437876	hsa-miR-384	CLIP-seq
MIRT1437877	hsa-miR-582-5p	CLIP-seq
MIRT1437878	hsa-miR-607	CLIP-seq
MIRT1437879	hsa-miR-103a	CLIP-seq
MIRT1437880	hsa-miR-107	CLIP-seq
MIRT1437881	hsa-miR-3124-3p	CLIP-seq
MIRT1437882	hsa-miR-330-3p	CLIP-seq
MIRT1437883	hsa-miR-3714	CLIP-seq
MIRT1437884	hsa-miR-4753-3p	CLIP-seq
MIRT2131228	hsa-miR-24	CLIP-seq
MIRT2131229	hsa-miR-4284	CLIP-seq
MIRT2396046	hsa-miR-488	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 30614533, 32296183, 33961781, 37219487
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9NW97
• Protein name: Transmembrane protein 51
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15345	TMEM51	7 → 240		Family

• Sequence:

  MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSAAEKPTAQGSNKTEVGGGILKS
  KTFSVAYVLVGAGVMLLLLSICLSIRDKRKQRQGEDLAHVQHPTGAGPHAQEEDSQEEEE
  EDEEAASRYYVPSYEEVMNTNYSEARGEEQNPRLSISLPSYESLTGLDETTPTSTRADVE
  ASPGNPPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRINLPDKNVPPPSIEPLTPPPQYD
  EVQEKAPDTRPPD

• Sequence length: 253

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RAYNAUD DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	33176066	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	33176066	★☆☆☆☆ Found in Text Mining only