Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55083
Gene name	Kinesin family member 26B
Gene symbol	KIF26B
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1q44
Summary	The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal ca

Show/Hide all (79)

miRTarBase ID	miRNA	Experiments	Reference
MIRT667705	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT667704	hsa-miR-4279	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT536468	hsa-miR-634	PAR-CLIP	22012620
MIRT536467	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT536466	hsa-miR-5685	PAR-CLIP	22012620
MIRT536464	hsa-miR-4530	PAR-CLIP	22012620
MIRT732249	hsa-miR-20a-5p	Luciferase reporter assayqRT-PCRWestern blot	27499703
MIRT732249	hsa-miR-20a-5p	Luciferase reporter assayqRT-PCRWestern blot	27499703
MIRT667705	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT667704	hsa-miR-4279	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT656874	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT656873	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT656872	hsa-miR-3944-3p	HITS-CLIP	23824327
MIRT656871	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT536468	hsa-miR-634	PAR-CLIP	22012620
MIRT536467	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT536466	hsa-miR-5685	PAR-CLIP	22012620
MIRT536464	hsa-miR-4530	PAR-CLIP	22012620
MIRT1094412	hsa-miR-1253	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT1094416	hsa-miR-3158-3p	CLIP-seq
MIRT1094417	hsa-miR-451b	CLIP-seq
MIRT1094418	hsa-miR-4520a-3p	CLIP-seq
MIRT1094419	hsa-miR-4520b-3p	CLIP-seq
MIRT2025295	hsa-miR-3064-3p	CLIP-seq
MIRT2025296	hsa-miR-4715-3p	CLIP-seq
MIRT2025297	hsa-miR-499a-5p	CLIP-seq
MIRT2256568	hsa-miR-124	CLIP-seq
MIRT2256569	hsa-miR-2116	CLIP-seq
MIRT1094416	hsa-miR-3158-3p	CLIP-seq
MIRT2256570	hsa-miR-342-3p	CLIP-seq
MIRT2256571	hsa-miR-3924	CLIP-seq
MIRT2256572	hsa-miR-4274	CLIP-seq
MIRT2256573	hsa-miR-4277	CLIP-seq
MIRT2256574	hsa-miR-450b-5p	CLIP-seq
MIRT2256575	hsa-miR-4519	CLIP-seq
MIRT2256576	hsa-miR-4708-3p	CLIP-seq
MIRT2256577	hsa-miR-506	CLIP-seq
MIRT2256578	hsa-miR-513a-5p	CLIP-seq
MIRT2256579	hsa-miR-621	CLIP-seq
MIRT2256580	hsa-miR-622	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT2025295	hsa-miR-3064-3p	CLIP-seq
MIRT2025296	hsa-miR-4715-3p	CLIP-seq
MIRT2430433	hsa-miR-4731-3p	CLIP-seq
MIRT2430434	hsa-miR-4801	CLIP-seq
MIRT2025297	hsa-miR-499a-5p	CLIP-seq
MIRT2430435	hsa-miR-548l	CLIP-seq
MIRT2430436	hsa-miR-767-5p	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT2430433	hsa-miR-4731-3p	CLIP-seq
MIRT2430434	hsa-miR-4801	CLIP-seq
MIRT2430435	hsa-miR-548l	CLIP-seq
MIRT2430436	hsa-miR-767-5p	CLIP-seq
MIRT1094413	hsa-miR-29a	CLIP-seq
MIRT1094414	hsa-miR-29b	CLIP-seq
MIRT1094415	hsa-miR-29c	CLIP-seq
MIRT2430433	hsa-miR-4731-3p	CLIP-seq
MIRT2430434	hsa-miR-4801	CLIP-seq
MIRT2430435	hsa-miR-548l	CLIP-seq
MIRT2430436	hsa-miR-767-5p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0022409	Process	Positive regulation of cell-cell adhesion	IEA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0048731	Process	System development	IEA
GO:0072092	Process	Ureteric bud invasion	IEA

MIM	HGNC	e!Ensembl
614026	25484	ENSG00000162849

Q2KJY2

Protein name

Kinesin-like protein KIF26B

Protein function

Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral inte

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00225	Kinesin	472 → 801	Kinesin motor domain	Domain

Sequence

MNSVAGNKERLAVSTRGKKYGVNEVCSPTKPAAPFSPESWYRKAYEESRAGSRPTPEGAG
SALGSSGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGGSPGFGTGSPGSGSGGGSS
PGSDRGVWCENCNARLVELKRQALRLLLPGPFPGKDPAFSAVIHDKLQVPNTIRKAWNDR
DNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDASPCSPPPLSNIPTLVGSRHVGGLQ
QPRDWAFVPAPCATSNYTGFANKHGSKPSSLGVSNGAEKKSGSPTHQAKVSLQMATSPSN
GNILNSVAIQAHQYLDGTWSLSRTNGVTLYPYQISQLMTESSREGLTEAVLNRYNADKPS
ACSVPASQGSCVASETSTGTSVAASFFARAAQKLNLSSKKKKHRPSTSSAAEPPLFATSF
SGILQTSPPPAPPCLLRAVNKVKDTPGLGKVKVMLRICSTLARDTSESSSFLKVDPRKKQ
ITLYDPLTCGGQNAFQKRGNQVPPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADG
CVFCFGHAKLGKSYTMIGKDDSMQNLGIIPCAISWLFKLINERKEKTGARFSVRVSAVEV
WGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAA
IASRRSHQQDCDEDDHRNSHVFFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALS
KNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISA
AVGSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHTRATVD
PDFPIAHLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTR
GDSRPAEAGEAAAGKSERDCLKCNTFAELQERLDCIDGSEEPSSFPFEELPAQFGPEQAS
RGPRLSQAAGASPLSESDKEDNGSEGQLTNREGPELPASKMQRSHSPVPAAAPAHSPSPA
SPRSVPGSSSQHSASPLVQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYK
PPSSPSQRCKVYTQKGVLPSPAPLPPSSKDSGVASRESLLQPEVRTPPVGMSPQVLKKSM
SAGSEGFPETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISG
VLDSGRPTSIISFNSDCSARALASGSRPVSIISSISEDLECYSSTAPVSEVSITQFLPLP
KMSLDEKAQDAGSRRSSISSWLSEMSAGSEGEQSCHSFIAQTCFGHGEAMAEPVASEFVS
SLQNTAVVCREKPKASPDNLLILSEMGDDSFNKAAPIKGCKISTVSKAMVTISNTANLSS
CEGYIPMKTNITVYPCIAMSPRNIQEPEAPTATPKAGPTLAQSRESKENSAKKEMKFEDP
WLKREEEVKKETAHPNEEGMMRCETATGPSNAETRAEQEQDGKPSPGDRLSSSSGEVSAS
PVTDNFRRVVDGCEMALPGLATQSPVHPNKSVKSSSLPRAFQKASRQEEPDSLSYYCAAE
TNGVGAASGTPPSKATLEGKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHSASG
SGTSSPLNQPAAFPAGLPDEPSGKTKDASSSSKLFSAKLEQLASRSNSLGRATVSHYECL
SLERAESLSSVSSRLHAGKDGTMPRAGRSLGRSAGTSPPSSGASPKAGQSKISAVSRLLL
ASPRARGPSASTTKTLSFSTKSLPQAVGQGSSSPPGGKHTPWSTQSLSRNRSSGLASKLP
LRAVSGRISELLQGGAGARGLQLRAGPEAEARGGALAEDEPAAAHLLPSPYSKITPPRRP
HRCSSGHGSDNSSVLSGELPPAMGKTALFYHSGGSSGYESVMRDSEATGSASSAQDSTSE
NSSSVGGRCRSLKTPKKRSNPGSQRRRLIPALSLDTSSPVRKPPNSTGVRWVDGPLRSSP
RGLGEPFEIKVYEIDDVERLQRRRGGASKEAMCFNAKLKILEHRQQRIAEVRAKYEWLMK
ELEATKQYLMLDPNKWLSEFDLEQVWELDSLEYLEALECVTERLESRVNFCKAHLMMITC
FDITSRRR

Sequence length

2108

Interactions

View interactions

	KEGG		Reactome
	Motor proteins		COPI-dependent Golgi-to-ER retrograde traffic Kinesins

111

Show/Hide Unknown Diseases (19)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Adrenocortical carcinoma, hereditary	Benign	rs61754955	RCV005937320
Autosomal dominant cerebellar ataxia	Uncertain significance; Conflicting classifications of pathogenicity	rs199690740, rs2103102844, rs752143373, rs749953234	RCV001849205 RCV001849232 RCV001849233 RCV001849185
Cervical cancer	Benign	rs61754955, rs61734432	RCV005937321 RCV005910080
Cholangiocarcinoma	Benign	rs61754955	RCV005937325
Colon adenocarcinoma	Benign	rs61754955, rs61734432	RCV005937317 RCV005910078
Colorectal cancer	Benign	rs61754955	RCV005937322
Familial cancer of breast	Benign	rs6701084	RCV005937113
Gastric cancer	Benign	rs61734432	RCV005910082
Hepatocellular carcinoma	Benign	rs61754955	RCV005937318
KIF26B-related disorder	Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	rs3205034, rs200317382, rs201717788, rs114860672, rs61754898, rs765071022, rs138077422, rs371384388, rs61831276, rs745665621, rs116468848, rs200504780, rs568690550, rs200109631, rs140210772 View all (67 more)	RCV003968451 RCV003941141 RCV003980867 RCV003966348 RCV003966349 RCV003897238 RCV003907010 RCV003907177 RCV003907313 RCV003907330 RCV003919858 RCV003921877 RCV003924128 RCV003924133 RCV003917279 RCV003929711 RCV003894319 RCV003974201 RCV003974252 RCV003967381 RCV003984735 RCV003984743 RCV003911747 RCV003903843 RCV003904004 RCV003904039 RCV003974059 RCV003977356 RCV003911485 RCV003909644 RCV003941855 RCV003961534 RCV003944612 RCV003964021 RCV003931442 RCV003931630 RCV003914659 RCV003939556 RCV003939613 RCV003951847 RCV003914538 RCV003931400 RCV003958948 RCV003956949 RCV003944620 RCV003979075 RCV003974770 RCV003982030 RCV003971616 RCV003962039 RCV003971800 RCV003972223 RCV003972224 RCV003976538 RCV003964281 RCV003966783 RCV003976279 RCV003983070 RCV003972716 RCV003972715 RCV003960584 RCV003978206 RCV003915940 RCV003926105 RCV003918578 RCV003916041 RCV003928476 RCV003918443 RCV003970831 RCV003928477 RCV003962896 RCV003920582 RCV003910388 RCV003910523 RCV003955794 RCV003940523 RCV003930749 RCV003940634 RCV003940729 RCV003910524 RCV003940610 RCV003923294 RCV003925845
Lung cancer	Benign	rs61754955, rs61734432	RCV005937326 RCV005910085
Malignant tumor of esophagus	Benign	rs61754955	RCV005937319
Melanoma	Benign	rs61754955	RCV005937324
Nonpapillary renal cell carcinoma	Benign	rs61734432	RCV005910079
Ovarian serous cystadenocarcinoma	Benign	rs61754955, rs61734432	RCV005937323 RCV005910083
Sarcoma	Benign	rs61734432	RCV005910081
Thyroid cancer, nonmedullary, 1	Benign	rs61734432	RCV005910084
Uterine corpus endometrial carcinoma	Benign	rs61734432	RCV005910086
Uveal melanoma	Benign	rs6701084	RCV005937114

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	20651033
Anophthalmia with pulmonary hypoplasia	Associate	32799327
Breast Neoplasms	Stimulate	23585914
Breast Neoplasms	Associate	37551622
Carcinogenesis	Associate	23585914, 25652119
Colonic Neoplasms	Stimulate	37436127
Colorectal Neoplasms	Stimulate	25652119
Colorectal Neoplasms	Associate	27935967, 37436127
Leukemia Myeloid Acute	Associate	34579730
Medulloblastoma	Stimulate	35866054
Neoplasm Invasiveness	Stimulate	29880787
Neoplasms	Stimulate	25652119
Neoplasms	Associate	37436127
Neoplasms	Inhibit	37551622
Ovarian Neoplasms	Stimulate	29880787
Ovarian Neoplasms	Associate	32186777
Papillorenal syndrome	Associate	26571382
Recurrence	Associate	27935967
Vesico Ureteral Reflux	Associate	36417404

KIF26B (kinesin family member 26B)