Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55075
Gene name Gene Name - the full gene name approved by the HGNC.	Uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UACA
Synonyms (NCBI Gene) Gene synonyms aliases	NUCLING
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024757	hsa-miR-215-5p	Microarray	19074876
MIRT026209	hsa-miR-192-5p	Microarray	19074876
MIRT046407	hsa-miR-15b-5p	CLASH	23622248
MIRT036623	hsa-miR-940	CLASH	23622248
MIRT686411	hsa-miR-4438	HITS-CLIP	23313552
MIRT686410	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686409	hsa-miR-6840-5p	HITS-CLIP	23313552
MIRT686408	hsa-miR-4707-5p	HITS-CLIP	23313552
MIRT686407	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT686406	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT686405	hsa-miR-5095	HITS-CLIP	23313552
MIRT686404	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686403	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686402	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT686411	hsa-miR-4438	HITS-CLIP	23313552
MIRT686410	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686409	hsa-miR-6840-5p	HITS-CLIP	23313552
MIRT686408	hsa-miR-4707-5p	HITS-CLIP	23313552
MIRT686407	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT686406	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT686405	hsa-miR-5095	HITS-CLIP	23313552
MIRT686404	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686403	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT686402	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT1466122	hsa-miR-1281	CLIP-seq
MIRT1466123	hsa-miR-1911	CLIP-seq
MIRT1466124	hsa-miR-1915	CLIP-seq
MIRT1466125	hsa-miR-1976	CLIP-seq
MIRT1466126	hsa-miR-4279	CLIP-seq
MIRT1466127	hsa-miR-4284	CLIP-seq
MIRT1466128	hsa-miR-4421	CLIP-seq
MIRT1466129	hsa-miR-4726-3p	CLIP-seq
MIRT1466130	hsa-miR-4740-3p	CLIP-seq
MIRT1466131	hsa-miR-4772-3p	CLIP-seq
MIRT1466132	hsa-miR-498	CLIP-seq
MIRT1466133	hsa-miR-1245b-3p	CLIP-seq
MIRT1466122	hsa-miR-1281	CLIP-seq
MIRT1466134	hsa-miR-1297	CLIP-seq
MIRT1466135	hsa-miR-142-5p	CLIP-seq
MIRT1466136	hsa-miR-186	CLIP-seq
MIRT1466124	hsa-miR-1915	CLIP-seq
MIRT1466125	hsa-miR-1976	CLIP-seq
MIRT1466137	hsa-miR-2110	CLIP-seq
MIRT1466138	hsa-miR-24	CLIP-seq
MIRT1466139	hsa-miR-26a	CLIP-seq
MIRT1466140	hsa-miR-26b	CLIP-seq
MIRT1466141	hsa-miR-3144-3p	CLIP-seq
MIRT1466142	hsa-miR-3162-5p	CLIP-seq
MIRT1466143	hsa-miR-3613-3p	CLIP-seq
MIRT1466144	hsa-miR-3663-5p	CLIP-seq
MIRT1466145	hsa-miR-3680	CLIP-seq
MIRT1466146	hsa-miR-4256	CLIP-seq
MIRT1466147	hsa-miR-4271	CLIP-seq
MIRT1466126	hsa-miR-4279	CLIP-seq
MIRT1466127	hsa-miR-4284	CLIP-seq
MIRT1466148	hsa-miR-4287	CLIP-seq
MIRT1466149	hsa-miR-4307	CLIP-seq
MIRT1466150	hsa-miR-4330	CLIP-seq
MIRT1466128	hsa-miR-4421	CLIP-seq
MIRT1466151	hsa-miR-4465	CLIP-seq
MIRT1466152	hsa-miR-4469	CLIP-seq
MIRT1466153	hsa-miR-4504	CLIP-seq
MIRT1466154	hsa-miR-4635	CLIP-seq
MIRT1466155	hsa-miR-4653-3p	CLIP-seq
MIRT1466156	hsa-miR-4685-3p	CLIP-seq
MIRT1466157	hsa-miR-4713-5p	CLIP-seq
MIRT1466158	hsa-miR-4725-3p	CLIP-seq
MIRT1466129	hsa-miR-4726-3p	CLIP-seq
MIRT1466130	hsa-miR-4740-3p	CLIP-seq
MIRT1466159	hsa-miR-4753-5p	CLIP-seq
MIRT1466131	hsa-miR-4772-3p	CLIP-seq
MIRT1466160	hsa-miR-4780	CLIP-seq
MIRT1466161	hsa-miR-493	CLIP-seq
MIRT1466132	hsa-miR-498	CLIP-seq
MIRT1466162	hsa-miR-513c	CLIP-seq
MIRT1466163	hsa-miR-514b-5p	CLIP-seq
MIRT1466164	hsa-miR-561	CLIP-seq
MIRT1466165	hsa-miR-591	CLIP-seq
MIRT1466166	hsa-miR-623	CLIP-seq
MIRT1466167	hsa-miR-630	CLIP-seq
MIRT1466168	hsa-miR-634	CLIP-seq
MIRT1466169	hsa-miR-944	CLIP-seq
MIRT1466123	hsa-miR-1911	CLIP-seq
MIRT2140174	hsa-miR-3682-5p	CLIP-seq
MIRT2140175	hsa-miR-4699-3p	CLIP-seq
MIRT1466130	hsa-miR-4740-3p	CLIP-seq
MIRT2140176	hsa-miR-496	CLIP-seq
MIRT2140177	hsa-miR-619	CLIP-seq
MIRT2140178	hsa-miR-759	CLIP-seq
MIRT2140179	hsa-miR-3910	CLIP-seq
MIRT2140177	hsa-miR-619	CLIP-seq
MIRT2360858	hsa-miR-34a	CLIP-seq
MIRT2360859	hsa-miR-34c-5p	CLIP-seq
MIRT2360860	hsa-miR-3677-5p	CLIP-seq
MIRT2360861	hsa-miR-449a	CLIP-seq
MIRT2360862	hsa-miR-449b	CLIP-seq
MIRT1466122	hsa-miR-1281	CLIP-seq
MIRT1466123	hsa-miR-1911	CLIP-seq
MIRT1466124	hsa-miR-1915	CLIP-seq
MIRT1466138	hsa-miR-24	CLIP-seq
MIRT2360858	hsa-miR-34a	CLIP-seq
MIRT2360859	hsa-miR-34c-5p	CLIP-seq
MIRT2360860	hsa-miR-3677-5p	CLIP-seq
MIRT1466127	hsa-miR-4284	CLIP-seq
MIRT2360861	hsa-miR-449a	CLIP-seq
MIRT2360862	hsa-miR-449b	CLIP-seq
MIRT2360863	hsa-miR-4539	CLIP-seq
MIRT1466129	hsa-miR-4726-3p	CLIP-seq
MIRT2360864	hsa-miR-4762-3p	CLIP-seq
MIRT1466131	hsa-miR-4772-3p	CLIP-seq
MIRT1466132	hsa-miR-498	CLIP-seq
MIRT2140177	hsa-miR-619	CLIP-seq
MIRT2140174	hsa-miR-3682-5p	CLIP-seq
MIRT2140175	hsa-miR-4699-3p	CLIP-seq
MIRT2140176	hsa-miR-496	CLIP-seq
MIRT2140178	hsa-miR-759	CLIP-seq
MIRT1466122	hsa-miR-1281	CLIP-seq
MIRT1466124	hsa-miR-1915	CLIP-seq
MIRT1466125	hsa-miR-1976	CLIP-seq
MIRT1466126	hsa-miR-4279	CLIP-seq
MIRT1466128	hsa-miR-4421	CLIP-seq
MIRT1466129	hsa-miR-4726-3p	CLIP-seq
MIRT1466132	hsa-miR-498	CLIP-seq
MIRT2654425	hsa-miR-548c-3p	CLIP-seq
MIRT1466122	hsa-miR-1281	CLIP-seq
MIRT1466124	hsa-miR-1915	CLIP-seq
MIRT1466125	hsa-miR-1976	CLIP-seq
MIRT1466126	hsa-miR-4279	CLIP-seq
MIRT1466128	hsa-miR-4421	CLIP-seq
MIRT1466129	hsa-miR-4726-3p	CLIP-seq
MIRT1466132	hsa-miR-498	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	17003112, 25416956, 28514442, 31413325, 32296183, 33961781
GO:0005576	Component	Extracellular region	NAS	11162650
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IBA
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	IBA
GO:0050728	Process	Negative regulation of inflammatory response	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IBA

MIM	HGNC	e!Ensembl
612516	15947	ENSG00000137831

Protein

UniProt ID

Q9BZF9

Protein name

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Protein function

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regul

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	38 → 129	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	72 → 164	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	116 → 197	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	166 → 230	Ankyrin repeats (3 copies)	Repeat

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. {ECO:0000269|PubMed:11162650, ECO:0000269|PubMed:15358194}.

Sequence

MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN
PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL
LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP
TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA
RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE
IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHE
ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR
SMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALE
CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE
ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM
EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS
LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE
KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL
EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK
IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI
KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI
VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE
EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYT
EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR
CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE
VSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEE
VLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNK
ITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV
IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC

Sequence length

1416

Interactions

View interactions

UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats)