Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55055
Gene name Gene Name - the full gene name approved by the HGNC.
Zwilch kinetochore protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZWILCH
Synonyms (NCBI Gene) Gene synonyms aliases
KNTC1AP, hZwilch
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT723744 hsa-miR-8083 HITS-CLIP 19536157
MIRT723743 hsa-miR-4719 HITS-CLIP 19536157
MIRT723742 hsa-miR-6814-5p HITS-CLIP 19536157
MIRT723741 hsa-miR-3927-5p HITS-CLIP 19536157
MIRT723739 hsa-miR-3124-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000776 Component Kinetochore IDA 12686595, 15824131
GO:0000777 Component Condensed chromosome kinetochore IEA
GO:0005515 Function Protein binding IPI 12686595, 20462495
GO:0005829 Component Cytosol TAS
GO:0034501 Process Protein localization to kinetochore IMP 15824131
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609984 25468 ENSG00000174442
Protein
UniProt ID Q9H900
Protein name Protein zwilch homolog (hZwilch)
Protein function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machin
PDB 3IF8 , 7QPG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09817 Zwilch 31 573 RZZ complex, subunit zwilch Family
Sequence
Sequence length 591
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Autism Spectrum Disorder autism spectrum disorder GenCC
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Testicular Germ Cell Tumor Testicular Germ Cell Tumor GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 31332282
Carcinoma Hepatocellular Associate 31698564