Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55054
Gene name Gene Name - the full gene name approved by the HGNC.
Autophagy related 16 like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ATG16L1
Synonyms (NCBI Gene) Gene synonyms aliases
APG16L, ATG16A, ATG16L, IBD10, WDR30
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IBD10
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to infla
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049399 hsa-miR-92a-3p CLASH 23622248
MIRT048211 hsa-miR-196a-5p CLASH 23622248
MIRT038607 hsa-miR-188-3p CLASH 23622248
MIRT053623 hsa-miR-106b-5p HeLa 24036151
MIRT053623 hsa-miR-106b-5p HeLa 24036151
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA 21873635
GO:0000045 Process Autophagosome assembly NAS 15620219
GO:0000421 Component Autophagosome membrane IBA 21873635
GO:0005515 Function Protein binding IPI 20562859, 23202584, 23262492, 23376921, 23392225, 26347139, 28561066, 32296183
GO:0005776 Component Autophagosome ISS 15620219
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610767 21498 ENSG00000085978
Protein
UniProt ID Q676U5
Protein name Autophagy-related protein 16-1 (APG16-like 1)
Protein function Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225
PDB 4GDK , 4GDL , 4NAW , 4TQ0 , 5D7G , 5NPV , 5NPW , 5NUV , 5ZYX , 7F69 , 7W36 , 7XFR , 8ZQG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08614 ATG16 16 206 Autophagy protein 16 (ATG16) Coiled-coil
PF00400 WD40 313 350 WD domain, G-beta repeat Repeat
PF00400 WD40 356 394 WD domain, G-beta repeat Repeat
PF00400 WD40 398 436 WD domain, G-beta repeat Repeat
PF00400 WD40 523 562 WD domain, G-beta repeat Repeat
PF00400 WD40 566 604 WD domain, G-beta repeat Repeat
Sequence
Sequence length 607
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Autophagy - other
Autophagy - animal
NOD-like receptor signaling pathway
Shigellosis
  Macroautophagy
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 26301688
Autoimmune diseases Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 rs869025224 26301688
Common variable immunodeficiency Common Variable Immunodeficiency rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113
View all (35 more)
26301688
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
26301688
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 21150878 ClinVar
Celiac disease Celiac Disease 26301688 ClinVar
Crohn disease Crohn Disease, Regional enteritis, NON RARE IN EUROPE: Crohn disease 17435756, 17554300, 18587394, 18438406, 23128233, 21102463, 26974007, 17684544, 22936669, 28067908, 26301688, 26192919, 22412388 ClinVar
Crohn Disease Crohn Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 29259263
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 36082465
Arterial Occlusive Diseases Associate 33530273
Arthralgia Associate 36082465
Arthritis Associate 34208077
Arthritis Psoriatic Stimulate 21811995
Bacterial Infections Associate 23850724, 27541200
Breast Neoplasms Associate 33731709
Buruli Ulcer Associate 27128681, 32313116
Buruli Ulcer Inhibit 32313116