NOL8 (nucleolar protein 8)

Gene

• Entrez ID: 55035
• Gene name: Nucleolar protein 8
• Gene symbol: NOL8
• Synonyms (NCBI Gene): C9orf34, NOP132, bA62C3.3, bA62C3.4
• Chromosome: 9
• Chromosome location: 9q22.31
• Summary: NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022317	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT028453	hsa-miR-30a-5p	Proteomics	18668040
MIRT045291	hsa-miR-186-5p	CLASH	23622248
MIRT052782	hsa-miR-1260b	CLASH	23622248
MIRT1188684	hsa-miR-302a	CLIP-seq
MIRT1188685	hsa-miR-302b	CLIP-seq
MIRT1188686	hsa-miR-302c	CLIP-seq
MIRT1188687	hsa-miR-302d	CLIP-seq
MIRT1188688	hsa-miR-302e	CLIP-seq
MIRT1188689	hsa-miR-372	CLIP-seq
MIRT1188690	hsa-miR-373	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT1188692	hsa-miR-520a-3p	CLIP-seq
MIRT1188693	hsa-miR-520b	CLIP-seq
MIRT1188694	hsa-miR-520c-3p	CLIP-seq
MIRT1188695	hsa-miR-520d-3p	CLIP-seq
MIRT1188696	hsa-miR-520e	CLIP-seq
MIRT1188697	hsa-miR-520f	CLIP-seq
MIRT2054625	hsa-miR-4282	CLIP-seq
MIRT2054626	hsa-miR-4639-3p	CLIP-seq
MIRT2054627	hsa-miR-4659a-3p	CLIP-seq
MIRT2054628	hsa-miR-4659b-3p	CLIP-seq
MIRT2054629	hsa-miR-4714-5p	CLIP-seq
MIRT2054630	hsa-miR-4766-5p	CLIP-seq
MIRT2054631	hsa-miR-4778-3p	CLIP-seq
MIRT2054632	hsa-miR-513a-3p	CLIP-seq
MIRT2581900	hsa-miR-1253	CLIP-seq
MIRT2581901	hsa-miR-1305	CLIP-seq
MIRT2581902	hsa-miR-2964a-5p	CLIP-seq
MIRT2581903	hsa-miR-300	CLIP-seq
MIRT2581904	hsa-miR-3200-3p	CLIP-seq
MIRT2581905	hsa-miR-3616-3p	CLIP-seq
MIRT2581906	hsa-miR-3664-3p	CLIP-seq
MIRT2581907	hsa-miR-381	CLIP-seq
MIRT2581908	hsa-miR-4311	CLIP-seq
MIRT2581909	hsa-miR-4666-3p	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT2581910	hsa-miR-4759	CLIP-seq
MIRT2581911	hsa-miR-498	CLIP-seq
MIRT2581912	hsa-miR-510	CLIP-seq
MIRT2581913	hsa-miR-512-5p	CLIP-seq
MIRT2581914	hsa-miR-548l	CLIP-seq
MIRT2581915	hsa-miR-548n	CLIP-seq
MIRT2581916	hsa-miR-885-5p	CLIP-seq
MIRT2581900	hsa-miR-1253	CLIP-seq
MIRT2581902	hsa-miR-2964a-5p	CLIP-seq
MIRT2581903	hsa-miR-300	CLIP-seq
MIRT2581904	hsa-miR-3200-3p	CLIP-seq
MIRT2581905	hsa-miR-3616-3p	CLIP-seq
MIRT2581906	hsa-miR-3664-3p	CLIP-seq
MIRT2581907	hsa-miR-381	CLIP-seq
MIRT2581908	hsa-miR-4311	CLIP-seq
MIRT2581909	hsa-miR-4666-3p	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT2581912	hsa-miR-510	CLIP-seq
MIRT2581913	hsa-miR-512-5p	CLIP-seq
MIRT2581916	hsa-miR-885-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11073942, 14660641, 16963496
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	14660641, 15132771, 16963496
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IMP	16963496
GO:1902570	Process	Protein localization to nucleolus	IBA
GO:1902570	Process	Protein localization to nucleolus	IMP	16963496

Other IDs

• MIM: 611534
• HGNC: 23387
• e!Ensembl: ENSG00000198000

Protein

• UniProt ID: Q76FK4
• Protein name: Nucleolar protein 8 (Nucleolar protein Nop132)
• Protein function: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	10 → 83	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. {ECO:0000269|PubMed:15132771}.
• Sequence:

  MKVNRETKRLYVGGLSQDISEADLQNQFSRFGEVSDVEIITRKDDQGNPQKVFAYINISV
  AEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREAAKAKKEESTTGNANLLEKT
  GGVDFHMKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNQHKRKIIKYDPSKYCHNLKKIGE
  DFSNTIPISSLTWELEGGNDPMSKKRRGEFSDFHGPPKKIIKVQKDESSTGSLAMSTRPR
  RVIERPPLTQQQAAQKRTCDSITPSKSSPVPVSDTQKLKNLPFKTSGLETAKKRNSISDD
  DTDSEDELRMMIAKEENLQRTTQPSINESESDPFEVVRDDFKSGVHKLHSLIGLGIKNRV
  SCHDSDDDIMRNDREYDSGDTDEIIAMKKNVAKVKNSTEFSQMEKSTKKTSFKNRENCEL
  SDHCIKLQKRKSNVESALSHGLKSLNRKSPSHSSSSEDADSASELADSEGGEEYNAMMKN
  CLRVNLTLADLEQLAGSDLKVPNEDTKSDGPETTTQCKFDRGSKSPKTPTGLRRGRQCIR
  PAEIVASLLEGEENTCGKQKPKENNLKPKFQAFKGVGCLYEKESMKKSLKDSVASNNKDQ
  NSMKHEDPSIISMEDGSPYVNGSLGEVTPCQHAKKANGPNYIQPQKRQTTFESQDRKAVS
  PSSSEKRSKNPISRPLEGKKSLSLSAKTHNIGFDKDSCHSTTKTEASQEERSDSSGLTSL
  KKSPKVSSKDTREIKTDFSLSISNSSDVSAKDKHAEDNEKRLAALEARQKAKEVQKKLVH
  NALANLDGHPEDKPTHIIFGSDSECETEETSTQEQSHPGEEWVKESMGKTSGKLFDSSDD
  DESDSEDDSNRFKIKPQFEGRAGQKLMDLQSHFGTDDRFRMDSRFLETDSEEEQEEVNEK
  KTAEEEELAEEKKKALNVVQSVLQINLSNSTNRGSVAAKKFKDIIHYDPTKQDHATYERK
  RDDKPKESKAKRKKKREEAEKLPEVSKEMYYNIAMDLKEIFQTTKYTSEKEEGTPWNEDC
  GKEKPEEIQDPAALTSDAEQPSGFTFSFFDSDTKDIKEETYRVETVKPGKIVWQEDPRLQ
  DSSSEEEDVTEETDHRNSSPGEASLLEKETTRFFFFSKNDERLQGSDLFWRGVGSNMSRN
  SWEARTTNLRMDCRKKHKDAKRKMKPK

• Sequence length: 1167

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Hepatocellular carcinoma	Uncertain significance	rs748080846	RCV005939358
Melanoma	Uncertain significance	rs748080846	RCV005939359

Associations from Text Mining
Disease Name	Relationship Type	References
Neoplasms	Stimulate	15132771
Stomach Neoplasms	Stimulate	15132771