Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55035
Gene name Gene Name - the full gene name approved by the HGNC.	Nucleolar protein 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NOL8
Synonyms (NCBI Gene) Gene synonyms aliases	C9orf34, NOP132, bA62C3.3, bA62C3.4
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q22.31
Summary Summary of gene provided in NCBI Entrez Gene.	NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022317	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT028453	hsa-miR-30a-5p	Proteomics	18668040
MIRT045291	hsa-miR-186-5p	CLASH	23622248
MIRT052782	hsa-miR-1260b	CLASH	23622248
MIRT1188684	hsa-miR-302a	CLIP-seq
MIRT1188685	hsa-miR-302b	CLIP-seq
MIRT1188686	hsa-miR-302c	CLIP-seq
MIRT1188687	hsa-miR-302d	CLIP-seq
MIRT1188688	hsa-miR-302e	CLIP-seq
MIRT1188689	hsa-miR-372	CLIP-seq
MIRT1188690	hsa-miR-373	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT1188692	hsa-miR-520a-3p	CLIP-seq
MIRT1188693	hsa-miR-520b	CLIP-seq
MIRT1188694	hsa-miR-520c-3p	CLIP-seq
MIRT1188695	hsa-miR-520d-3p	CLIP-seq
MIRT1188696	hsa-miR-520e	CLIP-seq
MIRT1188697	hsa-miR-520f	CLIP-seq
MIRT2054625	hsa-miR-4282	CLIP-seq
MIRT2054626	hsa-miR-4639-3p	CLIP-seq
MIRT2054627	hsa-miR-4659a-3p	CLIP-seq
MIRT2054628	hsa-miR-4659b-3p	CLIP-seq
MIRT2054629	hsa-miR-4714-5p	CLIP-seq
MIRT2054630	hsa-miR-4766-5p	CLIP-seq
MIRT2054631	hsa-miR-4778-3p	CLIP-seq
MIRT2054632	hsa-miR-513a-3p	CLIP-seq
MIRT2581900	hsa-miR-1253	CLIP-seq
MIRT2581901	hsa-miR-1305	CLIP-seq
MIRT2581902	hsa-miR-2964a-5p	CLIP-seq
MIRT2581903	hsa-miR-300	CLIP-seq
MIRT2581904	hsa-miR-3200-3p	CLIP-seq
MIRT2581905	hsa-miR-3616-3p	CLIP-seq
MIRT2581906	hsa-miR-3664-3p	CLIP-seq
MIRT2581907	hsa-miR-381	CLIP-seq
MIRT2581908	hsa-miR-4311	CLIP-seq
MIRT2581909	hsa-miR-4666-3p	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT2581910	hsa-miR-4759	CLIP-seq
MIRT2581911	hsa-miR-498	CLIP-seq
MIRT2581912	hsa-miR-510	CLIP-seq
MIRT2581913	hsa-miR-512-5p	CLIP-seq
MIRT2581914	hsa-miR-548l	CLIP-seq
MIRT2581915	hsa-miR-548n	CLIP-seq
MIRT2581916	hsa-miR-885-5p	CLIP-seq
MIRT2581900	hsa-miR-1253	CLIP-seq
MIRT2581902	hsa-miR-2964a-5p	CLIP-seq
MIRT2581903	hsa-miR-300	CLIP-seq
MIRT2581904	hsa-miR-3200-3p	CLIP-seq
MIRT2581905	hsa-miR-3616-3p	CLIP-seq
MIRT2581906	hsa-miR-3664-3p	CLIP-seq
MIRT2581907	hsa-miR-381	CLIP-seq
MIRT2581908	hsa-miR-4311	CLIP-seq
MIRT2581909	hsa-miR-4666-3p	CLIP-seq
MIRT1188691	hsa-miR-4729	CLIP-seq
MIRT2581912	hsa-miR-510	CLIP-seq
MIRT2581913	hsa-miR-512-5p	CLIP-seq
MIRT2581916	hsa-miR-885-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11073942, 14660641, 16963496
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	14660641, 15132771, 16963496
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IMP	16963496
GO:1902570	Process	Protein localization to nucleolus	IBA
GO:1902570	Process	Protein localization to nucleolus	IMP	16963496

MIM	HGNC	e!Ensembl
611534	23387	ENSG00000198000

Protein

UniProt ID

Q76FK4

Protein name

Nucleolar protein 8 (Nucleolar protein Nop132)

Protein function

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	10 → 83	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle. {ECO:0000269|PubMed:15132771}.

Sequence

MKVNRETKRLYVGGLSQDISEADLQNQFSRFGEVSDVEIITRKDDQGNPQKVFAYINISV
AEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREAAKAKKEESTTGNANLLEKT
GGVDFHMKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNQHKRKIIKYDPSKYCHNLKKIGE
DFSNTIPISSLTWELEGGNDPMSKKRRGEFSDFHGPPKKIIKVQKDESSTGSLAMSTRPR
RVIERPPLTQQQAAQKRTCDSITPSKSSPVPVSDTQKLKNLPFKTSGLETAKKRNSISDD
DTDSEDELRMMIAKEENLQRTTQPSINESESDPFEVVRDDFKSGVHKLHSLIGLGIKNRV
SCHDSDDDIMRNDREYDSGDTDEIIAMKKNVAKVKNSTEFSQMEKSTKKTSFKNRENCEL
SDHCIKLQKRKSNVESALSHGLKSLNRKSPSHSSSSEDADSASELADSEGGEEYNAMMKN
CLRVNLTLADLEQLAGSDLKVPNEDTKSDGPETTTQCKFDRGSKSPKTPTGLRRGRQCIR
PAEIVASLLEGEENTCGKQKPKENNLKPKFQAFKGVGCLYEKESMKKSLKDSVASNNKDQ
NSMKHEDPSIISMEDGSPYVNGSLGEVTPCQHAKKANGPNYIQPQKRQTTFESQDRKAVS
PSSSEKRSKNPISRPLEGKKSLSLSAKTHNIGFDKDSCHSTTKTEASQEERSDSSGLTSL
KKSPKVSSKDTREIKTDFSLSISNSSDVSAKDKHAEDNEKRLAALEARQKAKEVQKKLVH
NALANLDGHPEDKPTHIIFGSDSECETEETSTQEQSHPGEEWVKESMGKTSGKLFDSSDD
DESDSEDDSNRFKIKPQFEGRAGQKLMDLQSHFGTDDRFRMDSRFLETDSEEEQEEVNEK
KTAEEEELAEEKKKALNVVQSVLQINLSNSTNRGSVAAKKFKDIIHYDPTKQDHATYERK
RDDKPKESKAKRKKKREEAEKLPEVSKEMYYNIAMDLKEIFQTTKYTSEKEEGTPWNEDC
GKEKPEEIQDPAALTSDAEQPSGFTFSFFDSDTKDIKEETYRVETVKPGKIVWQEDPRLQ
DSSSEEEDVTEETDHRNSSPGEASLLEKETTRFFFFSKNDERLQGSDLFWRGVGSNMSRN
SWEARTTNLRMDCRKKHKDAKRKMKPK

Sequence length

1167

Interactions

View interactions

NOL8 (nucleolar protein 8)