TRMT61B (tRNA methyltransferase 61B)

Gene

• Entrez ID: 55006
• Gene name: TRNA methyltransferase 61B
• Gene symbol: TRMT61B
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p23.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043269	hsa-miR-331-3p	CLASH	23622248
MIRT1456995	hsa-miR-1305	CLIP-seq
MIRT1456996	hsa-miR-4698	CLIP-seq
MIRT1456997	hsa-miR-4789-5p	CLIP-seq
MIRT1456998	hsa-miR-607	CLIP-seq
MIRT2137038	hsa-miR-1297	CLIP-seq
MIRT1456995	hsa-miR-1305	CLIP-seq
MIRT2137039	hsa-miR-223	CLIP-seq
MIRT2137040	hsa-miR-26a	CLIP-seq
MIRT2137041	hsa-miR-26b	CLIP-seq
MIRT2137042	hsa-miR-4465	CLIP-seq
MIRT1456998	hsa-miR-607	CLIP-seq
MIRT2137043	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21903422, 25416956, 30833792, 31515488, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	23097428
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	27184847
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006397	Process	MRNA processing	IDA	29107537
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016426	Function	TRNA (adenine) methyltransferase activity	IEA
GO:0016433	Function	RRNA (adenine) methyltransferase activity	IMP	27631568
GO:0016740	Function	Transferase activity	IEA
GO:0030488	Process	TRNA methylation	IBA
GO:0030488	Process	TRNA methylation	IEA
GO:0031167	Process	RRNA methylation	IEA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IBA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IEA
GO:0032259	Process	Methylation	IEA
GO:0061953	Function	MRNA (adenine-N1-)-methyltransferase activity	IDA	29107537
GO:0090646	Process	Mitochondrial tRNA processing	IDA	23097428
GO:0160107	Function	TRNA (adenine(58)-N1)-methyltransferase activity	IDA	23097428
GO:0160107	Function	TRNA (adenine(58)-N1)-methyltransferase activity	IEA

Other IDs

• MIM: 619404
• HGNC: 26070
• e!Ensembl: ENSG00000171103

Protein

• UniProt ID: Q9BVS5
• Protein name: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-)
• Protein function: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC)
• PDB: 2B25
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08704	GCD14	208 → 471	tRNA methyltransferase complex GCD14 subunit	Family

• Sequence:

  MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRK
  APGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSE
  DPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLL
  NSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILS
  MMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKL
  SHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYV
  VNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLD
  SQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN

• Sequence length: 477

Pathways

Reactome:

tRNA modification in the mitochondrion

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LUMINAL A BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIPLE-NEGATIVE BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Alzheimer Disease	Associate	25448601	★☆☆☆☆ Found in Text Mining only
Aneuploidy	Stimulate	35869285	★☆☆☆☆ Found in Text Mining only
Bovine Respiratory Disease Complex	Associate	32221480	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	27117709, 32221480	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	37542141	★☆☆☆☆ Found in Text Mining only
Epstein Barr Virus Infections	Associate	39953499	★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Inhibit	37531210	★☆☆☆☆ Found in Text Mining only
Leiomyoma	Associate	36948524	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35869285, 36948524, 39953499	★☆☆☆☆ Found in Text Mining only
Psoriasis	Associate	32221480	★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Inhibit	39953499	★☆☆☆☆ Found in Text Mining only