Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Other IDs Protein Associated diseases
Entrez ID	55001
Gene name	Tetratricopeptide repeat domain 22
Gene symbol	TTC22
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p32.3
Summary	This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript var

Show/Hide all (32)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052423	hsa-let-7a-5p	CLASH	23622248
MIRT528543	hsa-miR-6858-3p	PAR-CLIP	22012620
MIRT528542	hsa-miR-4676-5p	PAR-CLIP	22012620
MIRT528541	hsa-miR-575	PAR-CLIP	22012620
MIRT528540	hsa-miR-4650-5p	PAR-CLIP	22012620
MIRT528539	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT528538	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT528543	hsa-miR-6858-3p	PAR-CLIP	22012620
MIRT528542	hsa-miR-4676-5p	PAR-CLIP	22012620
MIRT528541	hsa-miR-575	PAR-CLIP	22012620
MIRT528540	hsa-miR-4650-5p	PAR-CLIP	22012620
MIRT528539	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT528538	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT1461059	hsa-miR-1827	CLIP-seq
MIRT1461060	hsa-miR-3612	CLIP-seq
MIRT1461061	hsa-miR-380	CLIP-seq
MIRT1461062	hsa-miR-4459	CLIP-seq
MIRT1461063	hsa-miR-4690-5p	CLIP-seq
MIRT1461064	hsa-miR-4695-5p	CLIP-seq
MIRT1461065	hsa-miR-4722-5p	CLIP-seq
MIRT1461066	hsa-miR-621	CLIP-seq
MIRT1461067	hsa-miR-650	CLIP-seq
MIRT2359406	hsa-miR-218	CLIP-seq
MIRT2359407	hsa-miR-3663-5p	CLIP-seq
MIRT2359408	hsa-miR-4318	CLIP-seq
MIRT2359409	hsa-miR-4663	CLIP-seq
MIRT2359410	hsa-miR-4693-5p	CLIP-seq
MIRT2359411	hsa-miR-4728-3p	CLIP-seq
MIRT2359412	hsa-miR-550b	CLIP-seq
MIRT2359413	hsa-miR-622	CLIP-seq
MIRT2359414	hsa-miR-636	CLIP-seq
MIRT2359415	hsa-miR-892a	CLIP-seq

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q5TAA0

Protein name

Tetratricopeptide repeat protein 22 (TPR repeat protein 22)

Family and domains

Sequence

MAELEAVADDLDALIDDLDYLPGHFHLEMQLNFEPRSPAPQRARDLKLQREGLRQELQLA
AAPQRPAVRHLLGAFAFYLEELDEARECFLEVAHEHPGNLNAWANLAHVYGRLGQEEEEE
ACAARLADLMGLAEEPEAAGDPQLRAARCLAEQGYAHGFDVGCASPEERARGLAAGIALY
DKALGYGQQIPMEEKRGWYFTMATLYIRLDGIFLELGSEEQKRLPAFNRTLALLRQVLKS
EDPRHRALAWCYLGMLLERKDTFSTTPMGVHDCGYSGTDPLDCFGKAIEIAKNQPPILNR
LAKIFYFLGKQDMAIGTCNMALDVLRDPELNWQAYCTRAKIHIRAYLHDLKRAKMGLGGM
PDRNHLACAKADLEEVVRVCPGFKAYLDIGQVYYYMGVDAVQELLAVDEAALNQALVFLA
KAGESELGATLPELQLLRGKCLRIKGEDANAAACFKRAVELDDAGSSHTDGFGCLLEALL
AQWSQAQLSDGELGREVDAWLRRAQDKYPAARLRQELQRVWRGHTDEVLGLARALVAQGR
PALVRLLFETMEREGEGASAPRDRRAVSF

Sequence length

569

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL ADENOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colorectal Neoplasms	Associate	30664167	★★★★★ ★☆☆☆☆ Found in Text Mining only

TTC22 (tetratricopeptide repeat domain 22)