Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	54984
Gene name	PIN2 (TERF1) interacting telomerase inhibitor 1
Gene symbol	PINX1
Synonyms (NCBI Gene)	Gno1LPTLLPTSPxr1
Chromosome	8
Chromosome location	8p23.1

105

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miRTarBase ID	miRNA	Experiments	Reference
MIRT043552	hsa-miR-331-3p	CLASH	23622248
MIRT712989	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT712988	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT712987	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT712986	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT712985	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT712984	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712983	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT712982	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT712981	hsa-miR-4279	HITS-CLIP	19536157
MIRT712980	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT712979	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT712978	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT617989	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT617989	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT712989	hsa-miR-208a-5p	HITS-CLIP	19536157
MIRT712988	hsa-miR-208b-5p	HITS-CLIP	19536157
MIRT712987	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT712986	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT712985	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT712984	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712983	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT712982	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT712981	hsa-miR-4279	HITS-CLIP	19536157
MIRT712980	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT712979	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT712978	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT617989	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT617989	hsa-miR-5589-3p	HITS-CLIP	23824327
MIRT609797	hsa-miR-8485	HITS-CLIP	23824327
MIRT609796	hsa-miR-5683	HITS-CLIP	23824327
MIRT609795	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT609794	hsa-miR-642b-3p	HITS-CLIP	23824327

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000228	Component	Nuclear chromosome	IDA	19393617
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	19393617
GO:0000776	Component	Kinetochore	IEA
GO:0000781	Component	Chromosome, telomeric region	IDA	11701125, 19265708, 21119197, 24415760
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	11701125, 15044100, 15381700, 17389648, 18202258, 19265708, 19393617, 21044950, 21119197, 21900206, 24415760, 27214791, 28255170, 32296183, 33961781, 39251607
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	11701125, 19265708, 19393617, 21119197, 24415760
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	NAS	26194824
GO:0005739	Component	Mitochondrion	IDA
GO:0005819	Component	Spindle	IDA	19393617
GO:0007004	Process	Telomere maintenance via telomerase	IDA	11701125
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	19393617
GO:0008285	Process	Negative regulation of cell population proliferation	NAS	11003615
GO:0010521	Function	Telomerase inhibitor activity	IBA
GO:0010521	Function	Telomerase inhibitor activity	IDA	11701125, 24415760
GO:0010521	Function	Telomerase inhibitor activity	IMP	21119197
GO:0010521	Function	Telomerase inhibitor activity	NAS	26194824
GO:0010521	Function	Telomerase inhibitor activity	TAS	15381700
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	IDA	11701125
GO:0031397	Process	Negative regulation of protein ubiquitination	IMP	24415760
GO:0031647	Process	Regulation of protein stability	IMP	24415760
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IDA	11701125
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IMP	21119197
GO:0044877	Function	Protein-containing complex binding	IPI	18202258
GO:0070034	Function	Telomerase RNA binding	IDA	15381700
GO:0070198	Process	Protein localization to chromosome, telomeric region	IMP	22749911
GO:1902570	Process	Protein localization to nucleolus	IDA	24415760
GO:1904357	Process	Negative regulation of telomere maintenance via telomere lengthening	NAS	26194824
GO:1904751	Process	Positive regulation of protein localization to nucleolus	IDA	19265708

MIM	HGNC	e!Ensembl
606505	30046	ENSG00000254093

Q96BK5

Protein name

PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)

Protein function

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor sup

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01585	G-patch	26 → 70	G-patch domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Sequence

MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQV
KNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKIS
KNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQE
YFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKP
ERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKK
KLQKPVEIAEDATLEETLVKKKKKKDSK

Sequence length

328

Interactions

View interactions

PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1)