PIGX (phosphatidylinositol glycan anchor biosynthesis class X)

Gene

• Entrez ID: 54965
• Gene name: Phosphatidylinositol glycan anchor biosynthesis class X
• Gene symbol: PIGX
• Synonyms (NCBI Gene): PIG-X
• Chromosome: 3
• Chromosome location: 3q29
• Summary: This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors du

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024277	hsa-miR-215-5p	Microarray	19074876
MIRT026837	hsa-miR-192-5p	Microarray	19074876
MIRT031052	hsa-miR-21-5p	Microarray	18591254
MIRT1233644	hsa-miR-1182	CLIP-seq
MIRT1233645	hsa-miR-1193	CLIP-seq
MIRT1233646	hsa-miR-1206	CLIP-seq
MIRT1233647	hsa-miR-122	CLIP-seq
MIRT1233648	hsa-miR-1270	CLIP-seq
MIRT1233649	hsa-miR-1307	CLIP-seq
MIRT1233650	hsa-miR-130a	CLIP-seq
MIRT1233651	hsa-miR-130b	CLIP-seq
MIRT1233652	hsa-miR-142-3p	CLIP-seq
MIRT1233653	hsa-miR-1913	CLIP-seq
MIRT1233654	hsa-miR-197	CLIP-seq
MIRT1233655	hsa-miR-1976	CLIP-seq
MIRT1233656	hsa-miR-2276	CLIP-seq
MIRT1233657	hsa-miR-2392	CLIP-seq
MIRT1233658	hsa-miR-301a	CLIP-seq
MIRT1233659	hsa-miR-301b	CLIP-seq
MIRT1233660	hsa-miR-3121-5p	CLIP-seq
MIRT1233661	hsa-miR-3127-3p	CLIP-seq
MIRT1233662	hsa-miR-3152-3p	CLIP-seq
MIRT1233663	hsa-miR-3170	CLIP-seq
MIRT1233664	hsa-miR-3194-3p	CLIP-seq
MIRT1233665	hsa-miR-320e	CLIP-seq
MIRT1233666	hsa-miR-324-3p	CLIP-seq
MIRT1233667	hsa-miR-3606	CLIP-seq
MIRT1233668	hsa-miR-3666	CLIP-seq
MIRT1233669	hsa-miR-3679-3p	CLIP-seq
MIRT1233670	hsa-miR-411	CLIP-seq
MIRT1233671	hsa-miR-4279	CLIP-seq
MIRT1233672	hsa-miR-4284	CLIP-seq
MIRT1233673	hsa-miR-4295	CLIP-seq
MIRT1233674	hsa-miR-4297	CLIP-seq
MIRT1233675	hsa-miR-4497	CLIP-seq
MIRT1233676	hsa-miR-4524	CLIP-seq
MIRT1233677	hsa-miR-4531	CLIP-seq
MIRT1233678	hsa-miR-454	CLIP-seq
MIRT1233679	hsa-miR-4638-5p	CLIP-seq
MIRT1233680	hsa-miR-4659a-3p	CLIP-seq
MIRT1233681	hsa-miR-4659b-3p	CLIP-seq
MIRT1233682	hsa-miR-4662a-5p	CLIP-seq
MIRT1233683	hsa-miR-4671-3p	CLIP-seq
MIRT1233684	hsa-miR-4676-5p	CLIP-seq
MIRT1233685	hsa-miR-4695-3p	CLIP-seq
MIRT1233686	hsa-miR-4777-5p	CLIP-seq
MIRT1233687	hsa-miR-4778-3p	CLIP-seq
MIRT1233688	hsa-miR-5096	CLIP-seq
MIRT1233689	hsa-miR-518d-5p	CLIP-seq
MIRT1233690	hsa-miR-519b-5p	CLIP-seq
MIRT1233691	hsa-miR-519c-5p	CLIP-seq
MIRT1233692	hsa-miR-520c-5p	CLIP-seq
MIRT1233693	hsa-miR-526a	CLIP-seq
MIRT1233694	hsa-miR-548a-5p	CLIP-seq
MIRT1233695	hsa-miR-548ab	CLIP-seq
MIRT1233696	hsa-miR-548ak	CLIP-seq
MIRT1233697	hsa-miR-548b-5p	CLIP-seq
MIRT1233698	hsa-miR-548c-5p	CLIP-seq
MIRT1233699	hsa-miR-548d-5p	CLIP-seq
MIRT1233700	hsa-miR-548h	CLIP-seq
MIRT1233701	hsa-miR-548i	CLIP-seq
MIRT1233702	hsa-miR-548j	CLIP-seq
MIRT1233703	hsa-miR-548n	CLIP-seq
MIRT1233704	hsa-miR-548t	CLIP-seq
MIRT1233705	hsa-miR-548w	CLIP-seq
MIRT1233706	hsa-miR-548y	CLIP-seq
MIRT1233707	hsa-miR-559	CLIP-seq
MIRT1233708	hsa-miR-575	CLIP-seq
MIRT1233709	hsa-miR-577	CLIP-seq
MIRT1233710	hsa-miR-620	CLIP-seq
MIRT1233711	hsa-miR-1185	CLIP-seq
MIRT1233645	hsa-miR-1193	CLIP-seq
MIRT1233647	hsa-miR-122	CLIP-seq
MIRT1233712	hsa-miR-1279	CLIP-seq
MIRT1233653	hsa-miR-1913	CLIP-seq
MIRT1233655	hsa-miR-1976	CLIP-seq
MIRT1233713	hsa-miR-2114	CLIP-seq
MIRT1233714	hsa-miR-2278	CLIP-seq
MIRT1233657	hsa-miR-2392	CLIP-seq
MIRT1233715	hsa-miR-300	CLIP-seq
MIRT1233660	hsa-miR-3121-5p	CLIP-seq
MIRT1233662	hsa-miR-3152-3p	CLIP-seq
MIRT1233716	hsa-miR-3159	CLIP-seq
MIRT1233663	hsa-miR-3170	CLIP-seq
MIRT1233666	hsa-miR-324-3p	CLIP-seq
MIRT1233717	hsa-miR-3605-5p	CLIP-seq
MIRT1233718	hsa-miR-3679-5p	CLIP-seq
MIRT1233719	hsa-miR-381	CLIP-seq
MIRT1233720	hsa-miR-410	CLIP-seq
MIRT1233721	hsa-miR-4272	CLIP-seq
MIRT1233722	hsa-miR-4276	CLIP-seq
MIRT1233723	hsa-miR-4302	CLIP-seq
MIRT1233724	hsa-miR-4328	CLIP-seq
MIRT1233725	hsa-miR-4661-3p	CLIP-seq
MIRT1233682	hsa-miR-4662a-5p	CLIP-seq
MIRT1233726	hsa-miR-4666-3p	CLIP-seq
MIRT1233684	hsa-miR-4676-5p	CLIP-seq
MIRT1233727	hsa-miR-4760-3p	CLIP-seq
MIRT1233728	hsa-miR-4776-3p	CLIP-seq
MIRT1233729	hsa-miR-4789-5p	CLIP-seq
MIRT1233730	hsa-miR-4795-3p	CLIP-seq
MIRT1233688	hsa-miR-5096	CLIP-seq
MIRT1233731	hsa-miR-510	CLIP-seq
MIRT1233732	hsa-miR-512-5p	CLIP-seq
MIRT1233708	hsa-miR-575	CLIP-seq
MIRT1233733	hsa-miR-656	CLIP-seq
MIRT1552316	hsa-miR-3662	CLIP-seq
MIRT2068776	hsa-miR-106a	CLIP-seq
MIRT2068777	hsa-miR-106b	CLIP-seq
MIRT1233645	hsa-miR-1193	CLIP-seq
MIRT1233647	hsa-miR-122	CLIP-seq
MIRT2068778	hsa-miR-1224-3p	CLIP-seq
MIRT2068779	hsa-miR-1234	CLIP-seq
MIRT1233649	hsa-miR-1307	CLIP-seq
MIRT1233650	hsa-miR-130a	CLIP-seq
MIRT1233651	hsa-miR-130b	CLIP-seq
MIRT1233652	hsa-miR-142-3p	CLIP-seq
MIRT2068780	hsa-miR-150	CLIP-seq
MIRT2068781	hsa-miR-17	CLIP-seq
MIRT1233653	hsa-miR-1913	CLIP-seq
MIRT2068782	hsa-miR-192	CLIP-seq
MIRT1233655	hsa-miR-1976	CLIP-seq
MIRT2068783	hsa-miR-20a	CLIP-seq
MIRT2068784	hsa-miR-20b	CLIP-seq
MIRT2068785	hsa-miR-215	CLIP-seq
MIRT1233657	hsa-miR-2392	CLIP-seq
MIRT1233658	hsa-miR-301a	CLIP-seq
MIRT1233659	hsa-miR-301b	CLIP-seq
MIRT2068786	hsa-miR-302a	CLIP-seq
MIRT2068787	hsa-miR-302b	CLIP-seq
MIRT2068788	hsa-miR-302c	CLIP-seq
MIRT2068789	hsa-miR-302d	CLIP-seq
MIRT2068790	hsa-miR-302e	CLIP-seq
MIRT1233660	hsa-miR-3121-5p	CLIP-seq
MIRT1233662	hsa-miR-3152-3p	CLIP-seq
MIRT2068791	hsa-miR-323-3p	CLIP-seq
MIRT1233666	hsa-miR-324-3p	CLIP-seq
MIRT2068792	hsa-miR-3620	CLIP-seq
MIRT2068793	hsa-miR-3663-5p	CLIP-seq
MIRT1233668	hsa-miR-3666	CLIP-seq
MIRT2068794	hsa-miR-372	CLIP-seq
MIRT2068795	hsa-miR-373	CLIP-seq
MIRT1233670	hsa-miR-411	CLIP-seq
MIRT1233673	hsa-miR-4295	CLIP-seq
MIRT2068796	hsa-miR-4299	CLIP-seq
MIRT2068797	hsa-miR-4454	CLIP-seq
MIRT2068798	hsa-miR-4456	CLIP-seq
MIRT2068799	hsa-miR-4466	CLIP-seq
MIRT2068800	hsa-miR-4474-5p	CLIP-seq
MIRT1233678	hsa-miR-454	CLIP-seq
MIRT1233679	hsa-miR-4638-5p	CLIP-seq
MIRT1233682	hsa-miR-4662a-5p	CLIP-seq
MIRT1233683	hsa-miR-4671-3p	CLIP-seq
MIRT1233684	hsa-miR-4676-5p	CLIP-seq
MIRT1233685	hsa-miR-4695-3p	CLIP-seq
MIRT2068801	hsa-miR-4731-5p	CLIP-seq
MIRT2068802	hsa-miR-4775	CLIP-seq
MIRT1233688	hsa-miR-5096	CLIP-seq
MIRT2068803	hsa-miR-512-3p	CLIP-seq
MIRT2068804	hsa-miR-519d	CLIP-seq
MIRT2068805	hsa-miR-520a-3p	CLIP-seq
MIRT2068806	hsa-miR-520b	CLIP-seq
MIRT2068807	hsa-miR-520c-3p	CLIP-seq
MIRT2068808	hsa-miR-520d-3p	CLIP-seq
MIRT2068809	hsa-miR-520e	CLIP-seq
MIRT2068810	hsa-miR-520g	CLIP-seq
MIRT2068811	hsa-miR-520h	CLIP-seq
MIRT2068812	hsa-miR-548q	CLIP-seq
MIRT1233708	hsa-miR-575	CLIP-seq
MIRT2068813	hsa-miR-633	CLIP-seq
MIRT2068814	hsa-miR-675	CLIP-seq
MIRT2068815	hsa-miR-93	CLIP-seq
MIRT1233646	hsa-miR-1206	CLIP-seq
MIRT1233647	hsa-miR-122	CLIP-seq
MIRT1233649	hsa-miR-1307	CLIP-seq
MIRT1233653	hsa-miR-1913	CLIP-seq
MIRT1233655	hsa-miR-1976	CLIP-seq
MIRT2295849	hsa-miR-3187-3p	CLIP-seq
MIRT2295850	hsa-miR-3199	CLIP-seq
MIRT1233666	hsa-miR-324-3p	CLIP-seq
MIRT2295851	hsa-miR-3646	CLIP-seq
MIRT1233671	hsa-miR-4279	CLIP-seq
MIRT1233672	hsa-miR-4284	CLIP-seq
MIRT1233674	hsa-miR-4297	CLIP-seq
MIRT2295852	hsa-miR-4435	CLIP-seq
MIRT2295853	hsa-miR-4464	CLIP-seq
MIRT2295854	hsa-miR-4476	CLIP-seq
MIRT1233675	hsa-miR-4497	CLIP-seq
MIRT2295855	hsa-miR-4502	CLIP-seq
MIRT1233679	hsa-miR-4638-5p	CLIP-seq
MIRT1233685	hsa-miR-4695-3p	CLIP-seq
MIRT2295856	hsa-miR-4701-5p	CLIP-seq
MIRT2295857	hsa-miR-4719	CLIP-seq
MIRT2295858	hsa-miR-4722-3p	CLIP-seq
MIRT2295859	hsa-miR-4740-3p	CLIP-seq
MIRT2295860	hsa-miR-4748	CLIP-seq
MIRT2068802	hsa-miR-4775	CLIP-seq
MIRT2295861	hsa-miR-4803	CLIP-seq
MIRT2295862	hsa-miR-548s	CLIP-seq
MIRT2295863	hsa-miR-552	CLIP-seq
MIRT2295864	hsa-miR-588	CLIP-seq
MIRT2295865	hsa-miR-590-3p	CLIP-seq
MIRT2295866	hsa-miR-606	CLIP-seq
MIRT2068799	hsa-miR-4466	CLIP-seq
MIRT2068814	hsa-miR-675	CLIP-seq
MIRT2439490	hsa-miR-4699-3p	CLIP-seq
MIRT1233647	hsa-miR-122	CLIP-seq
MIRT2593891	hsa-miR-1278	CLIP-seq
MIRT1233649	hsa-miR-1307	CLIP-seq
MIRT1233656	hsa-miR-2276	CLIP-seq
MIRT1233660	hsa-miR-3121-5p	CLIP-seq
MIRT2593892	hsa-miR-3163	CLIP-seq
MIRT1233664	hsa-miR-3194-3p	CLIP-seq
MIRT1552316	hsa-miR-3662	CLIP-seq
MIRT1233721	hsa-miR-4272	CLIP-seq
MIRT1233672	hsa-miR-4284	CLIP-seq
MIRT1233674	hsa-miR-4297	CLIP-seq
MIRT1233724	hsa-miR-4328	CLIP-seq
MIRT2593893	hsa-miR-4495	CLIP-seq
MIRT1233675	hsa-miR-4497	CLIP-seq
MIRT1233679	hsa-miR-4638-5p	CLIP-seq
MIRT1233685	hsa-miR-4695-3p	CLIP-seq
MIRT2593894	hsa-miR-4714-5p	CLIP-seq
MIRT1233727	hsa-miR-4760-3p	CLIP-seq
MIRT2593895	hsa-miR-4762-5p	CLIP-seq
MIRT1233728	hsa-miR-4776-3p	CLIP-seq
MIRT2593896	hsa-miR-494	CLIP-seq
MIRT1233731	hsa-miR-510	CLIP-seq
MIRT1233732	hsa-miR-512-5p	CLIP-seq
MIRT1233647	hsa-miR-122	CLIP-seq
MIRT2593891	hsa-miR-1278	CLIP-seq
MIRT1233724	hsa-miR-4328	CLIP-seq
MIRT2593894	hsa-miR-4714-5p	CLIP-seq
MIRT2593895	hsa-miR-4762-5p	CLIP-seq
MIRT1233731	hsa-miR-510	CLIP-seq
MIRT1233732	hsa-miR-512-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006506	Process	GPI anchor biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 610276
• HGNC: 26046
• e!Ensembl: ENSG00000163964

Protein

• UniProt ID: Q8TBF5
• Protein name: GPI alpha-1,4-mannosyltransferase I, stabilizing subunit (Phosphatidylinositol-glycan biosynthesis class X protein) (PIG-X)
• Protein function: Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylino
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08320	PIG-X	54 → 251	PIG-X / PBN1	Domain

• Sequence:

  MAARVAAVRAAAWLLLGAATGLTRGPAAAFTAARSDAGIRAMCSEIILRQEVLKDGFHRD
  LLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPN
  YLSKESEVLIYARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQEFP
  ILKCWAHSEVAAPCALENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITI
  LCSTLILVAVFKYGHFSL

• Sequence length: 258

Pathways

KEGG:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Metabolic pathways

Reactome:

Synthesis of glycosylphosphatidylinositol (GPI)