SSH3 (slingshot protein phosphatase 3)

Gene

• Entrez ID: 54961
• Gene name: Slingshot protein phosphatase 3
• Gene symbol: SSH3
• Synonyms (NCBI Gene): SSH3L
• Chromosome: 11
• Chromosome location: 11q13.2
• Summary: The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004229	hsa-miR-346	Microarray	16822819
MIRT722044	hsa-miR-6796-3p	HITS-CLIP	19536157
MIRT722043	hsa-miR-4681	HITS-CLIP	19536157
MIRT722042	hsa-miR-1973	HITS-CLIP	19536157
MIRT722041	hsa-miR-3928-5p	HITS-CLIP	19536157
MIRT722040	hsa-miR-6806-3p	HITS-CLIP	19536157
MIRT722039	hsa-miR-1298-5p	HITS-CLIP	19536157
MIRT722038	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT540080	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT540079	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT540078	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540077	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT540076	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT540075	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT540074	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT540073	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT540072	hsa-miR-612	PAR-CLIP	21572407
MIRT540071	hsa-miR-6860	PAR-CLIP	21572407
MIRT540070	hsa-miR-6743-3p	PAR-CLIP	21572407
MIRT540069	hsa-miR-661	PAR-CLIP	21572407
MIRT540067	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT540068	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT540066	hsa-miR-7703	PAR-CLIP	21572407
MIRT540065	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT540080	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT540079	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT540078	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540077	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT540076	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT540075	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT540074	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT540073	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT540072	hsa-miR-612	PAR-CLIP	21572407
MIRT540071	hsa-miR-6860	PAR-CLIP	21572407
MIRT540070	hsa-miR-6743-3p	PAR-CLIP	21572407
MIRT540069	hsa-miR-661	PAR-CLIP	21572407
MIRT540067	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT540068	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT540066	hsa-miR-7703	PAR-CLIP	21572407
MIRT540065	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT441745	hsa-miR-5694	PAR-CLIP	22100165
MIRT441744	hsa-miR-3975	PAR-CLIP	22100165
MIRT441743	hsa-miR-2467-5p	PAR-CLIP	22100165
MIRT441742	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT441741	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT441739	hsa-miR-3188	PAR-CLIP	22100165
MIRT441740	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT441738	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT441737	hsa-miR-1273g-5p	PAR-CLIP	22100165
MIRT722044	hsa-miR-6796-3p	HITS-CLIP	19536157
MIRT722043	hsa-miR-4681	HITS-CLIP	19536157
MIRT722042	hsa-miR-1973	HITS-CLIP	19536157
MIRT722041	hsa-miR-3928-5p	HITS-CLIP	19536157
MIRT722040	hsa-miR-6806-3p	HITS-CLIP	19536157
MIRT722039	hsa-miR-1298-5p	HITS-CLIP	19536157
MIRT722038	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT540080	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT540079	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT540078	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540077	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT540076	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT540075	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT540074	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT540073	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT540072	hsa-miR-612	PAR-CLIP	21572407
MIRT540071	hsa-miR-6860	PAR-CLIP	21572407
MIRT540070	hsa-miR-6743-3p	PAR-CLIP	21572407
MIRT540069	hsa-miR-661	PAR-CLIP	21572407
MIRT540067	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT540068	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT540066	hsa-miR-7703	PAR-CLIP	21572407
MIRT540065	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT540080	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT540079	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT540078	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540077	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT540076	hsa-miR-4793-3p	PAR-CLIP	21572407
MIRT540075	hsa-miR-1285-3p	PAR-CLIP	21572407
MIRT540074	hsa-miR-3187-5p	PAR-CLIP	21572407
MIRT540073	hsa-miR-5189-5p	PAR-CLIP	21572407
MIRT540072	hsa-miR-612	PAR-CLIP	21572407
MIRT540071	hsa-miR-6860	PAR-CLIP	21572407
MIRT540070	hsa-miR-6743-3p	PAR-CLIP	21572407
MIRT540069	hsa-miR-661	PAR-CLIP	21572407
MIRT540067	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT540068	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT540066	hsa-miR-7703	PAR-CLIP	21572407
MIRT540065	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT441745	hsa-miR-5694	PAR-CLIP	22100165
MIRT441744	hsa-miR-3975	PAR-CLIP	22100165
MIRT441743	hsa-miR-2467-5p	PAR-CLIP	22100165
MIRT441742	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT441741	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT441739	hsa-miR-3188	PAR-CLIP	22100165
MIRT441740	hsa-miR-6765-5p	PAR-CLIP	22100165
MIRT441738	hsa-miR-1304-5p	PAR-CLIP	22100165
MIRT441737	hsa-miR-1273g-5p	PAR-CLIP	22100165
MIRT1392149	hsa-miR-1	CLIP-seq
MIRT1392150	hsa-miR-1183	CLIP-seq
MIRT1392151	hsa-miR-1225-3p	CLIP-seq
MIRT1392152	hsa-miR-1227	CLIP-seq
MIRT1392153	hsa-miR-1233	CLIP-seq
MIRT1392154	hsa-miR-1255a	CLIP-seq
MIRT1392155	hsa-miR-1255b	CLIP-seq
MIRT1392156	hsa-miR-125a-3p	CLIP-seq
MIRT1392157	hsa-miR-1264	CLIP-seq
MIRT1392158	hsa-miR-129-3p	CLIP-seq
MIRT1392159	hsa-miR-1298	CLIP-seq
MIRT1392160	hsa-miR-140-3p	CLIP-seq
MIRT1392161	hsa-miR-142-3p	CLIP-seq
MIRT1392162	hsa-miR-147b	CLIP-seq
MIRT1392163	hsa-miR-15a	CLIP-seq
MIRT1392164	hsa-miR-15b	CLIP-seq
MIRT1392165	hsa-miR-16	CLIP-seq
MIRT1392166	hsa-miR-1909	CLIP-seq
MIRT1392167	hsa-miR-1910	CLIP-seq
MIRT1392168	hsa-miR-195	CLIP-seq
MIRT1392169	hsa-miR-206	CLIP-seq
MIRT1392170	hsa-miR-2114	CLIP-seq
MIRT1392171	hsa-miR-2861	CLIP-seq
MIRT1392172	hsa-miR-3064-3p	CLIP-seq
MIRT1392173	hsa-miR-3125	CLIP-seq
MIRT1392174	hsa-miR-3144-5p	CLIP-seq
MIRT1392175	hsa-miR-3160-3p	CLIP-seq
MIRT1392176	hsa-miR-3165	CLIP-seq
MIRT1392177	hsa-miR-3166	CLIP-seq
MIRT1392178	hsa-miR-3180	CLIP-seq
MIRT1392179	hsa-miR-3180-3p	CLIP-seq
MIRT1392180	hsa-miR-3191	CLIP-seq
MIRT1392181	hsa-miR-3196	CLIP-seq
MIRT1392182	hsa-miR-3199	CLIP-seq
MIRT1392183	hsa-miR-3659	CLIP-seq
MIRT1392184	hsa-miR-3661	CLIP-seq
MIRT1392185	hsa-miR-3675-5p	CLIP-seq
MIRT1392186	hsa-miR-3689a-3p	CLIP-seq
MIRT1392187	hsa-miR-3689c	CLIP-seq
MIRT1392188	hsa-miR-3689d	CLIP-seq
MIRT1392189	hsa-miR-3690	CLIP-seq
MIRT1392190	hsa-miR-3691-5p	CLIP-seq
MIRT1392191	hsa-miR-3916	CLIP-seq
MIRT1392192	hsa-miR-3944-5p	CLIP-seq
MIRT1392193	hsa-miR-424	CLIP-seq
MIRT1392194	hsa-miR-4316	CLIP-seq
MIRT1392195	hsa-miR-4514	CLIP-seq
MIRT1392196	hsa-miR-4520a-3p	CLIP-seq
MIRT1392197	hsa-miR-4520b-3p	CLIP-seq
MIRT1392198	hsa-miR-455-3p	CLIP-seq
MIRT1392199	hsa-miR-4651	CLIP-seq
MIRT1392200	hsa-miR-4652-5p	CLIP-seq
MIRT1392201	hsa-miR-4658	CLIP-seq
MIRT1392202	hsa-miR-4667-5p	CLIP-seq
MIRT1392203	hsa-miR-4676-5p	CLIP-seq
MIRT1392204	hsa-miR-4692	CLIP-seq
MIRT1392205	hsa-miR-4700-5p	CLIP-seq
MIRT1392206	hsa-miR-4710	CLIP-seq
MIRT1392207	hsa-miR-4724-3p	CLIP-seq
MIRT1392208	hsa-miR-4728-5p	CLIP-seq
MIRT1392209	hsa-miR-497	CLIP-seq
MIRT1392210	hsa-miR-520d-5p	CLIP-seq
MIRT1392211	hsa-miR-524-5p	CLIP-seq
MIRT1392212	hsa-miR-526b	CLIP-seq
MIRT1392213	hsa-miR-542-3p	CLIP-seq
MIRT1392214	hsa-miR-545	CLIP-seq
MIRT1392215	hsa-miR-548a-3p	CLIP-seq
MIRT1392216	hsa-miR-548ae	CLIP-seq
MIRT1392217	hsa-miR-548aj	CLIP-seq
MIRT1392218	hsa-miR-548am	CLIP-seq
MIRT1392219	hsa-miR-548e	CLIP-seq
MIRT1392220	hsa-miR-548f	CLIP-seq
MIRT1392221	hsa-miR-548m	CLIP-seq
MIRT1392222	hsa-miR-548x	CLIP-seq
MIRT1392223	hsa-miR-552	CLIP-seq
MIRT1392224	hsa-miR-574-5p	CLIP-seq
MIRT1392225	hsa-miR-575	CLIP-seq
MIRT1392226	hsa-miR-608	CLIP-seq
MIRT1392227	hsa-miR-613	CLIP-seq
MIRT1392228	hsa-miR-619	CLIP-seq
MIRT1392229	hsa-miR-631	CLIP-seq
MIRT1392230	hsa-miR-637	CLIP-seq
MIRT1392231	hsa-miR-642a	CLIP-seq
MIRT1392232	hsa-miR-648	CLIP-seq
MIRT2117519	hsa-miR-1185	CLIP-seq
MIRT2117520	hsa-miR-1471	CLIP-seq
MIRT1392171	hsa-miR-2861	CLIP-seq
MIRT1392174	hsa-miR-3144-5p	CLIP-seq
MIRT1392180	hsa-miR-3191	CLIP-seq
MIRT2117521	hsa-miR-3605-5p	CLIP-seq
MIRT2117522	hsa-miR-3679-5p	CLIP-seq
MIRT1392186	hsa-miR-3689a-3p	CLIP-seq
MIRT1392187	hsa-miR-3689c	CLIP-seq
MIRT1392188	hsa-miR-3689d	CLIP-seq
MIRT1392194	hsa-miR-4316	CLIP-seq
MIRT2117523	hsa-miR-4459	CLIP-seq
MIRT2117524	hsa-miR-4505	CLIP-seq
MIRT1392199	hsa-miR-4651	CLIP-seq
MIRT1392200	hsa-miR-4652-5p	CLIP-seq
MIRT2117525	hsa-miR-4661-3p	CLIP-seq
MIRT1392202	hsa-miR-4667-5p	CLIP-seq
MIRT1392203	hsa-miR-4676-5p	CLIP-seq
MIRT1392205	hsa-miR-4700-5p	CLIP-seq
MIRT1392206	hsa-miR-4710	CLIP-seq
MIRT1392208	hsa-miR-4728-5p	CLIP-seq
MIRT2117526	hsa-miR-4731-5p	CLIP-seq
MIRT2117527	hsa-miR-513a-5p	CLIP-seq
MIRT2117528	hsa-miR-544b	CLIP-seq
MIRT1392215	hsa-miR-548a-3p	CLIP-seq
MIRT1392219	hsa-miR-548e	CLIP-seq
MIRT1392220	hsa-miR-548f	CLIP-seq
MIRT1392225	hsa-miR-575	CLIP-seq
MIRT2117529	hsa-miR-597	CLIP-seq
MIRT1392226	hsa-miR-608	CLIP-seq
MIRT1392230	hsa-miR-637	CLIP-seq
MIRT1392152	hsa-miR-1227	CLIP-seq
MIRT1392154	hsa-miR-1255a	CLIP-seq
MIRT1392155	hsa-miR-1255b	CLIP-seq
MIRT1392156	hsa-miR-125a-3p	CLIP-seq
MIRT1392159	hsa-miR-1298	CLIP-seq
MIRT1392163	hsa-miR-15a	CLIP-seq
MIRT1392164	hsa-miR-15b	CLIP-seq
MIRT1392165	hsa-miR-16	CLIP-seq
MIRT1392166	hsa-miR-1909	CLIP-seq
MIRT1392168	hsa-miR-195	CLIP-seq
MIRT2339681	hsa-miR-219-1-3p	CLIP-seq
MIRT1392172	hsa-miR-3064-3p	CLIP-seq
MIRT1392176	hsa-miR-3165	CLIP-seq
MIRT2339682	hsa-miR-3177-3p	CLIP-seq
MIRT1392178	hsa-miR-3180	CLIP-seq
MIRT1392179	hsa-miR-3180-3p	CLIP-seq
MIRT1392181	hsa-miR-3196	CLIP-seq
MIRT1392183	hsa-miR-3659	CLIP-seq
MIRT1392184	hsa-miR-3661	CLIP-seq
MIRT1392188	hsa-miR-3689d	CLIP-seq
MIRT1392189	hsa-miR-3690	CLIP-seq
MIRT1392190	hsa-miR-3691-5p	CLIP-seq
MIRT1392193	hsa-miR-424	CLIP-seq
MIRT2117523	hsa-miR-4459	CLIP-seq
MIRT1392201	hsa-miR-4658	CLIP-seq
MIRT1392208	hsa-miR-4728-5p	CLIP-seq
MIRT2339683	hsa-miR-4738-3p	CLIP-seq
MIRT1392209	hsa-miR-497	CLIP-seq
MIRT2339684	hsa-miR-507	CLIP-seq
MIRT1392214	hsa-miR-545	CLIP-seq
MIRT1392223	hsa-miR-552	CLIP-seq
MIRT2339685	hsa-miR-557	CLIP-seq
MIRT1392224	hsa-miR-574-5p	CLIP-seq
MIRT2339686	hsa-miR-580	CLIP-seq
MIRT1392228	hsa-miR-619	CLIP-seq
MIRT1392229	hsa-miR-631	CLIP-seq
MIRT1392232	hsa-miR-648	CLIP-seq
MIRT1392161	hsa-miR-142-3p	CLIP-seq
MIRT1392186	hsa-miR-3689a-3p	CLIP-seq
MIRT1392187	hsa-miR-3689c	CLIP-seq
MIRT1392188	hsa-miR-3689d	CLIP-seq
MIRT1392199	hsa-miR-4651	CLIP-seq
MIRT1392208	hsa-miR-4728-5p	CLIP-seq
MIRT1392213	hsa-miR-542-3p	CLIP-seq
MIRT1392226	hsa-miR-608	CLIP-seq
MIRT1392161	hsa-miR-142-3p	CLIP-seq
MIRT1392188	hsa-miR-3689d	CLIP-seq
MIRT1392194	hsa-miR-4316	CLIP-seq
MIRT1392206	hsa-miR-4710	CLIP-seq
MIRT1392213	hsa-miR-542-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IBA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030837	Process	Negative regulation of actin filament polymerization	IBA
GO:0030837	Process	Negative regulation of actin filament polymerization	IEA

Other IDs

• MIM: 606780
• HGNC: 30581
• e!Ensembl: ENSG00000172830

Protein

• UniProt ID: Q8TE77
• Protein name: Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L)
• Protein function: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembl
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08766	DEK_C	270 → 323	DEK C terminal domain	Domain
  PF00782	DSPc	336 → 466	Dual specificity phosphatase, catalytic domain	Domain

• Sequence:

  MALVTVSRSPPGSGASTPVGPWDQAVQRRSRLQRRQSFAVLRGAVLGLQDGGDNDDAAEA
  SSEPTEKAPSEEELHGDQTDFGQGSQSPQKQEEQRQHLHLMVQLLRPQDDIRLAAQLEAP
  RPPRLRYLLVVSTREGEGLSQDETVLLGVDFPDSSSPSCTLGLVLPLWSDTQVYLDGDGG
  FSVTSGGQSRIFKPISIQTMWATLQVLHQACEAALGSGLVPGGSALTWASHYQERLNSEQ
  SCLNEWTAMADLESLRPPSAEPGGSSEQEQMEQAIRAELWKVLDVSDLESVTSKEIRQAL
  ELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILN
  MAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRS
  AATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQGILTASRQSHVWEQKV
  GGVSPEEHPAPEVSTPFPPLPPEPEGGGEEKVVGMEESQAAPKEEPGPRPRINLRGVMRS
  ISLLEPSLELESTSETSDMPEVFSSHESSHEEPLQPFPQLARTKGGQQVDRGPQPALKSR
  QSVVTLQGSAVVANRTQAFQEQEQGQGQGQGEPCISSTPRFRKVVRQASVHDSGEEGEA

• Sequence length: 659

Pathways

KEGG:

Axon guidance
Regulation of actin cytoskeleton

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Hepatocellular	Associate	33275222	★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	33275222	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36761744	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	36761744	★☆☆☆☆ Found in Text Mining only