PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)

Gene

• Entrez ID: 5495
• Gene name: Protein phosphatase, Mg2+/Mn2+ dependent 1B
• Gene symbol: PPM1B
• Synonyms (NCBI Gene): PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
• Chromosome: 2
• Chromosome location: 2p21
• Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044250	hsa-miR-106b-5p	CLASH	23622248
MIRT568918	hsa-miR-551b-5p	PAR-CLIP	20371350
MIRT568917	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT568916	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT568915	hsa-miR-8485	PAR-CLIP	20371350
MIRT568918	hsa-miR-551b-5p	PAR-CLIP	20371350
MIRT568917	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT568916	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT568915	hsa-miR-8485	PAR-CLIP	20371350
MIRT1253707	hsa-miR-128	CLIP-seq
MIRT1253708	hsa-miR-27a	CLIP-seq
MIRT1253709	hsa-miR-27b	CLIP-seq
MIRT1253710	hsa-miR-338-5p	CLIP-seq
MIRT1253711	hsa-miR-4729	CLIP-seq
MIRT1253712	hsa-miR-513a-5p	CLIP-seq
MIRT1253713	hsa-miR-654-3p	CLIP-seq
MIRT1253714	hsa-miR-216a	CLIP-seq
MIRT1253715	hsa-miR-216b	CLIP-seq
MIRT1253716	hsa-miR-323-3p	CLIP-seq
MIRT1253717	hsa-miR-4282	CLIP-seq
MIRT1253718	hsa-miR-4698	CLIP-seq
MIRT1253719	hsa-miR-513a-3p	CLIP-seq
MIRT1253720	hsa-miR-587	CLIP-seq
MIRT1253721	hsa-miR-105	CLIP-seq
MIRT1253722	hsa-miR-125a-3p	CLIP-seq
MIRT1253723	hsa-miR-1270	CLIP-seq
MIRT1253724	hsa-miR-147	CLIP-seq
MIRT1253725	hsa-miR-1913	CLIP-seq
MIRT1253726	hsa-miR-221	CLIP-seq
MIRT1253727	hsa-miR-222	CLIP-seq
MIRT1253728	hsa-miR-23a	CLIP-seq
MIRT1253729	hsa-miR-23b	CLIP-seq
MIRT1253730	hsa-miR-23c	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT1253736	hsa-miR-3120-5p	CLIP-seq
MIRT1253737	hsa-miR-3130-5p	CLIP-seq
MIRT1253738	hsa-miR-320a	CLIP-seq
MIRT1253739	hsa-miR-320b	CLIP-seq
MIRT1253740	hsa-miR-320c	CLIP-seq
MIRT1253741	hsa-miR-320d	CLIP-seq
MIRT1253716	hsa-miR-323-3p	CLIP-seq
MIRT1253742	hsa-miR-324-3p	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT1253744	hsa-miR-340	CLIP-seq
MIRT1253745	hsa-miR-3620	CLIP-seq
MIRT1253746	hsa-miR-3684	CLIP-seq
MIRT1253747	hsa-miR-3688-5p	CLIP-seq
MIRT1253748	hsa-miR-374c	CLIP-seq
MIRT1253749	hsa-miR-383	CLIP-seq
MIRT1253750	hsa-miR-3911	CLIP-seq
MIRT1253751	hsa-miR-3925-3p	CLIP-seq
MIRT1253752	hsa-miR-3934	CLIP-seq
MIRT1253717	hsa-miR-4282	CLIP-seq
MIRT1253753	hsa-miR-4313	CLIP-seq
MIRT1253754	hsa-miR-4422	CLIP-seq
MIRT1253755	hsa-miR-4429	CLIP-seq
MIRT1253756	hsa-miR-4434	CLIP-seq
MIRT1253757	hsa-miR-4474-3p	CLIP-seq
MIRT1253758	hsa-miR-4475	CLIP-seq
MIRT1253759	hsa-miR-4482	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT1253761	hsa-miR-4516	CLIP-seq
MIRT1253762	hsa-miR-4517	CLIP-seq
MIRT1253763	hsa-miR-4520a-3p	CLIP-seq
MIRT1253764	hsa-miR-4520b-3p	CLIP-seq
MIRT1253765	hsa-miR-4528	CLIP-seq
MIRT1253766	hsa-miR-4529-3p	CLIP-seq
MIRT1253767	hsa-miR-4531	CLIP-seq
MIRT1253768	hsa-miR-4719	CLIP-seq
MIRT1253769	hsa-miR-4742-3p	CLIP-seq
MIRT1253770	hsa-miR-4772-5p	CLIP-seq
MIRT1253771	hsa-miR-5096	CLIP-seq
MIRT1253772	hsa-miR-520d-5p	CLIP-seq
MIRT1253773	hsa-miR-524-5p	CLIP-seq
MIRT1253774	hsa-miR-548c-3p	CLIP-seq
MIRT1253775	hsa-miR-548v	CLIP-seq
MIRT1253776	hsa-miR-552	CLIP-seq
MIRT1253777	hsa-miR-570	CLIP-seq
MIRT1253778	hsa-miR-589	CLIP-seq
MIRT1253779	hsa-miR-620	CLIP-seq
MIRT1253780	hsa-miR-626	CLIP-seq
MIRT1253781	hsa-miR-644	CLIP-seq
MIRT1253782	hsa-miR-655	CLIP-seq
MIRT1253783	hsa-miR-760	CLIP-seq
MIRT1253784	hsa-miR-764	CLIP-seq
MIRT1253785	hsa-miR-766	CLIP-seq
MIRT1253786	hsa-miR-873	CLIP-seq
MIRT1253787	hsa-miR-203	CLIP-seq
MIRT1253788	hsa-miR-3128	CLIP-seq
MIRT1253789	hsa-miR-4666-3p	CLIP-seq
MIRT1253790	hsa-miR-4720-5p	CLIP-seq
MIRT1253791	hsa-miR-4735-5p	CLIP-seq
MIRT1253792	hsa-miR-4799-3p	CLIP-seq
MIRT1253721	hsa-miR-105	CLIP-seq
MIRT2074768	hsa-miR-106a	CLIP-seq
MIRT2074769	hsa-miR-106b	CLIP-seq
MIRT2074770	hsa-miR-1178	CLIP-seq
MIRT2074771	hsa-miR-1183	CLIP-seq
MIRT2074772	hsa-miR-1207-5p	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074777	hsa-miR-17	CLIP-seq
MIRT2074778	hsa-miR-1827	CLIP-seq
MIRT2074779	hsa-miR-192	CLIP-seq
MIRT2074780	hsa-miR-20a	CLIP-seq
MIRT2074781	hsa-miR-20b	CLIP-seq
MIRT2074782	hsa-miR-215	CLIP-seq
MIRT2074783	hsa-miR-302a	CLIP-seq
MIRT2074784	hsa-miR-302b	CLIP-seq
MIRT2074785	hsa-miR-302c	CLIP-seq
MIRT2074786	hsa-miR-302d	CLIP-seq
MIRT2074787	hsa-miR-302e	CLIP-seq
MIRT2074788	hsa-miR-302f	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2074790	hsa-miR-3149	CLIP-seq
MIRT2074791	hsa-miR-337-3p	CLIP-seq
MIRT2074792	hsa-miR-3646	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2074794	hsa-miR-372	CLIP-seq
MIRT2074795	hsa-miR-373	CLIP-seq
MIRT1253752	hsa-miR-3934	CLIP-seq
MIRT2074796	hsa-miR-3942-3p	CLIP-seq
MIRT2074797	hsa-miR-411	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT2074800	hsa-miR-4438	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT1253763	hsa-miR-4520a-3p	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2074802	hsa-miR-4731-5p	CLIP-seq
MIRT2074803	hsa-miR-4742-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074805	hsa-miR-4757-5p	CLIP-seq
MIRT2074806	hsa-miR-4763-3p	CLIP-seq
MIRT2074807	hsa-miR-4772-3p	CLIP-seq
MIRT2074808	hsa-miR-494	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074810	hsa-miR-5095	CLIP-seq
MIRT1253771	hsa-miR-5096	CLIP-seq
MIRT2074811	hsa-miR-512-3p	CLIP-seq
MIRT2074812	hsa-miR-519d	CLIP-seq
MIRT2074813	hsa-miR-520a-3p	CLIP-seq
MIRT2074814	hsa-miR-520b	CLIP-seq
MIRT2074815	hsa-miR-520c-3p	CLIP-seq
MIRT2074816	hsa-miR-520d-3p	CLIP-seq
MIRT2074817	hsa-miR-520e	CLIP-seq
MIRT2074818	hsa-miR-520g	CLIP-seq
MIRT2074819	hsa-miR-520h	CLIP-seq
MIRT1253774	hsa-miR-548c-3p	CLIP-seq
MIRT1253776	hsa-miR-552	CLIP-seq
MIRT2074820	hsa-miR-640	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074822	hsa-miR-93	CLIP-seq
MIRT2074823	hsa-miR-940	CLIP-seq
MIRT2074772	hsa-miR-1207-5p	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074778	hsa-miR-1827	CLIP-seq
MIRT2301667	hsa-miR-217	CLIP-seq
MIRT2301668	hsa-miR-296-3p	CLIP-seq
MIRT2301669	hsa-miR-297	CLIP-seq
MIRT2301670	hsa-miR-29a	CLIP-seq
MIRT2301671	hsa-miR-29b	CLIP-seq
MIRT2301672	hsa-miR-29c	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2301673	hsa-miR-3138	CLIP-seq
MIRT2074790	hsa-miR-3149	CLIP-seq
MIRT1253716	hsa-miR-323-3p	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT2301674	hsa-miR-331-5p	CLIP-seq
MIRT2301675	hsa-miR-33a	CLIP-seq
MIRT2301676	hsa-miR-33b	CLIP-seq
MIRT1253744	hsa-miR-340	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT1253749	hsa-miR-383	CLIP-seq
MIRT1253752	hsa-miR-3934	CLIP-seq
MIRT2074797	hsa-miR-411	CLIP-seq
MIRT2301677	hsa-miR-4420	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT1253763	hsa-miR-4520a-3p	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2301678	hsa-miR-4652-3p	CLIP-seq
MIRT1253768	hsa-miR-4719	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074806	hsa-miR-4763-3p	CLIP-seq
MIRT2074807	hsa-miR-4772-3p	CLIP-seq
MIRT2301680	hsa-miR-487a	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074810	hsa-miR-5095	CLIP-seq
MIRT1253771	hsa-miR-5096	CLIP-seq
MIRT1253774	hsa-miR-548c-3p	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2301681	hsa-miR-759	CLIP-seq
MIRT2074823	hsa-miR-940	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2598305	hsa-miR-1273d	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2074776	hsa-miR-150	CLIP-seq
MIRT2598306	hsa-miR-181a	CLIP-seq
MIRT2598307	hsa-miR-181b	CLIP-seq
MIRT2598308	hsa-miR-181c	CLIP-seq
MIRT2598309	hsa-miR-181d	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2598310	hsa-miR-3185	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT2598311	hsa-miR-3647-3p	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2598312	hsa-miR-3682-5p	CLIP-seq
MIRT2598313	hsa-miR-4262	CLIP-seq
MIRT2598314	hsa-miR-4279	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT1253754	hsa-miR-4422	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2598315	hsa-miR-4646-5p	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2598316	hsa-miR-4694-3p	CLIP-seq
MIRT2598317	hsa-miR-4700-3p	CLIP-seq
MIRT2598318	hsa-miR-4709-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2598319	hsa-miR-4747-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2301680	hsa-miR-487a	CLIP-seq
MIRT2074808	hsa-miR-494	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT1253772	hsa-miR-520d-5p	CLIP-seq
MIRT1253773	hsa-miR-524-5p	CLIP-seq
MIRT2598320	hsa-miR-664	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq
MIRT2074773	hsa-miR-122	CLIP-seq
MIRT2074774	hsa-miR-1281	CLIP-seq
MIRT2074775	hsa-miR-1343	CLIP-seq
MIRT2457015	hsa-miR-139-3p	CLIP-seq
MIRT2598306	hsa-miR-181a	CLIP-seq
MIRT2598307	hsa-miR-181b	CLIP-seq
MIRT2598308	hsa-miR-181c	CLIP-seq
MIRT2598309	hsa-miR-181d	CLIP-seq
MIRT1253731	hsa-miR-30a	CLIP-seq
MIRT1253732	hsa-miR-30b	CLIP-seq
MIRT1253733	hsa-miR-30c	CLIP-seq
MIRT1253734	hsa-miR-30d	CLIP-seq
MIRT1253735	hsa-miR-30e	CLIP-seq
MIRT2074789	hsa-miR-3135b	CLIP-seq
MIRT2457016	hsa-miR-3182	CLIP-seq
MIRT2598310	hsa-miR-3185	CLIP-seq
MIRT1253743	hsa-miR-330-3p	CLIP-seq
MIRT1253710	hsa-miR-338-5p	CLIP-seq
MIRT2598311	hsa-miR-3647-3p	CLIP-seq
MIRT2074793	hsa-miR-3652	CLIP-seq
MIRT2598313	hsa-miR-4262	CLIP-seq
MIRT2074798	hsa-miR-4294	CLIP-seq
MIRT1253754	hsa-miR-4422	CLIP-seq
MIRT2074799	hsa-miR-4430	CLIP-seq
MIRT1253760	hsa-miR-4495	CLIP-seq
MIRT2074801	hsa-miR-4634	CLIP-seq
MIRT2598315	hsa-miR-4646-5p	CLIP-seq
MIRT2457017	hsa-miR-4659a-3p	CLIP-seq
MIRT2457018	hsa-miR-4659b-3p	CLIP-seq
MIRT2598316	hsa-miR-4694-3p	CLIP-seq
MIRT2598317	hsa-miR-4700-3p	CLIP-seq
MIRT2598318	hsa-miR-4709-3p	CLIP-seq
MIRT2301679	hsa-miR-4727-5p	CLIP-seq
MIRT2598319	hsa-miR-4747-5p	CLIP-seq
MIRT2074804	hsa-miR-4755-3p	CLIP-seq
MIRT2301680	hsa-miR-487a	CLIP-seq
MIRT2074808	hsa-miR-494	CLIP-seq
MIRT2074809	hsa-miR-498	CLIP-seq
MIRT2688445	hsa-miR-499-3p	CLIP-seq
MIRT2688446	hsa-miR-499a-3p	CLIP-seq
MIRT1253772	hsa-miR-520d-5p	CLIP-seq
MIRT1253773	hsa-miR-524-5p	CLIP-seq
MIRT2074821	hsa-miR-720	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IBA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	20801214
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	TAS	9684878
GO:0005515	Function	Protein binding	IPI	16872604, 17620599, 18930133, 25241761, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	IMP	18930133, 22750291
GO:0006470	Process	Protein dephosphorylation	TAS	9684878
GO:0006499	Process	N-terminal protein myristoylation	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0030145	Function	Manganese ion binding	IEA
GO:0032688	Process	Negative regulation of interferon-beta production	IMP	22750291
GO:0035970	Process	Peptidyl-threonine dephosphorylation	IDA	20801214
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IBA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	18930133
GO:0043169	Function	Cation binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050687	Process	Negative regulation of defense response to virus	IMP	22750291
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IMP	18930133

Other IDs

• MIM: 603770
• HGNC: 9276
• e!Ensembl: ENSG00000138032

Protein

• UniProt ID: O75688
• Protein name: Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
• Protein function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alph
• PDB: 2P8E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	22 → 288	Protein phosphatase 2C	Family
  PF07830	PP2C_C	289 → 368	Protein serine/threonine phosphatase 2C, C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart and skeletal muscle.
• Sequence:

  MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD
  GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF
  SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI
  QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIIL
  ACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPK
  VSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKR
  NVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRL
  AKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI

• Sequence length: 479

Pathways

KEGG:

MAPK signaling pathway

Reactome:

ISG15 antiviral mechanism