Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54947
Gene name Gene Name - the full gene name approved by the HGNC.
Lysophosphatidylcholine acyltransferase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LPCAT2
Synonyms (NCBI Gene) Gene synonyms aliases
AGPAT11, AYTL1, LPLAT9, LysoPAFAT
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1567390809 G>A Pathogenic Intron variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1115653 hsa-let-7a CLIP-seq
MIRT1115654 hsa-let-7b CLIP-seq
MIRT1115655 hsa-let-7c CLIP-seq
MIRT1115656 hsa-let-7d CLIP-seq
MIRT1115657 hsa-let-7e CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity IDA 20363836
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IDA 21498505
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612040 26032 ENSG00000087253
Protein
UniProt ID Q7L5N7
Protein name Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acy
Protein function Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-dia
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 125 248 Acyltransferase Family
PF13202 EF-hand_5 396 418 EF hand Domain
PF00036 EF-hand_1 432 460 EF hand Domain
Sequence
MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVL
LGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFF
SMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLR
AVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPG
VPVQPVLL
RYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPV
LFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGV
RKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGL
AVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDS
ISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSD
KKDD
Sequence length 544
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
  Acyl chain remodelling of PC