Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54941
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger protein 125
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNF125
Synonyms (NCBI Gene) Gene synonyms aliases
TNORS, TRAC-1, TRAC1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
TNORS
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is p
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs370242930 C>T Pathogenic Missense variant, coding sequence variant, intron variant
rs786201014 G>A Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028944 hsa-miR-26b-5p Microarray 19088304
MIRT044723 hsa-miR-320a CLASH 23622248
MIRT043614 hsa-miR-151a-3p CLASH 23622248
MIRT715282 hsa-miR-4797-5p HITS-CLIP 19536157
MIRT715281 hsa-miR-3145-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 17990982
GO:0000209 Process Protein polyubiquitination IBA 21873635
GO:0000209 Process Protein polyubiquitination IDA 27411375
GO:0002039 Function P53 binding IPI 25591766
GO:0002250 Process Adaptive immune response IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610432 21150 ENSG00000101695
Protein
UniProt ID Q96EQ8
Protein name E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Protein function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:25591766, PubMe
PDB 5DKA , 8GBQ , 8GCB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 36 75 Domain
PF18574 zf_C2HC_14 94 126 C2HC Zing finger domain Domain
PF05605 zf-Di19 137 197 Drought induced 19 protein (Di19), zinc-binding Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells. {ECO
Sequence
MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC
IATSLKNNKWTCPYC
RAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ
KYIDKY
GPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN
PSSFSGSLIRHLQVSHT
LFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT
Sequence length 232
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  RIG-I-like receptor signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cerebral palsy Cerebral Palsy rs121918149, rs75184679, rs730880264, rs587777428, rs797045067, rs767399782, rs564185858, rs886039513
Congenital hemihypertrophy Congenital hemihypertrophy rs1575653629
Hydrocephalus Hydrocephalus rs387907320, rs369384363, rs387907321, rs372127610, rs770273135, rs797045095, rs797045707, rs769795916, rs781251438, rs922703465, rs376078512, rs1567043467, rs1587149916, rs1586841546
Macrocephaly Macrocephaly rs786204854, rs764333096, rs1557739557
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 35710093
Carcinoma Renal Cell Associate 27173324
Gallbladder Neoplasms Associate 28611292
Neoplasm Metastasis Associate 28611292