RNF125 (ring finger protein 125)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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54941 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Ring finger protein 125 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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RNF125 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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TNORS, TRAC-1, TRAC1 |
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Chromosome
Chromosome number
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18 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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18q12.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is p |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q96EQ8 | ||||||||||||||||||||
| Protein name | E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1) | ||||||||||||||||||||
| Protein function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:25591766, PubMe | ||||||||||||||||||||
| PDB | 5DKA , 8GBQ , 8GCB | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells. {ECO | ||||||||||||||||||||
| Sequence |
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| Sequence length | 232 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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