SOHLH2 (spermatogenesis and oogenesis specific basic helix-loop-helix 2)

Gene

• Entrez ID: 54937
• Gene name: Spermatogenesis and oogenesis specific basic helix-loop-helix 2
• Gene symbol: SOHLH2
• Synonyms (NCBI Gene): SOSF2, SPATA28, TEB1, bHLHe81
• Chromosome: 13
• Chromosome location: 13q13.3
• Summary: This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription fact

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1379251	hsa-miR-203	CLIP-seq
MIRT1379252	hsa-miR-3611	CLIP-seq
MIRT1379253	hsa-miR-375	CLIP-seq
MIRT1379254	hsa-miR-4436b-5p	CLIP-seq
MIRT1379255	hsa-miR-4633-3p	CLIP-seq
MIRT1379256	hsa-miR-4698	CLIP-seq
MIRT1379257	hsa-miR-607	CLIP-seq
MIRT2336379	hsa-miR-4276	CLIP-seq
MIRT2336380	hsa-miR-4457	CLIP-seq
MIRT2336381	hsa-miR-4731-3p	CLIP-seq
MIRT2336382	hsa-miR-4801	CLIP-seq
MIRT2336383	hsa-miR-510	CLIP-seq
MIRT2336384	hsa-miR-512-5p	CLIP-seq
MIRT2336385	hsa-miR-624	CLIP-seq
MIRT2336386	hsa-miR-642b	CLIP-seq
MIRT2440715	hsa-miR-187	CLIP-seq
MIRT2440716	hsa-miR-3618	CLIP-seq
MIRT2440717	hsa-miR-4802-3p	CLIP-seq
MIRT2440718	hsa-miR-490-5p	CLIP-seq
MIRT2440719	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0009994	Process	Oocyte differentiation	ISS
GO:0030154	Process	Cell differentiation	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030154	Process	Cell differentiation	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0046982	Function	Protein heterodimerization activity	ISS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048477	Process	Oogenesis	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 616066
• HGNC: 26026
• e!Ensembl: ENSG00000120669

Interactions View interactions

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
SOHLH2-related disorder	Likely benign; Benign	rs762994605, rs2296968, rs9602419, rs150925868, rs150073675, rs200008856, rs76803829	RCV003964601 RCV003974497 RCV003916793 RCV003909553 RCV003909635 RCV003909804 RCV003914383

Associations from Text Mining
Disease Name	Relationship Type	References
Azoospermia Nonobstructive	Associate	32690270
Colorectal Neoplasms	Associate	36287177
Genital Diseases Male	Associate	32690270
Male Infertility with Large Headed Multiflagellar Polyploid Spermatozoa	Associate	32690270
Multiple Myeloma	Associate	33875642
Neoplasm Metastasis	Stimulate	38123542
Neoplasms	Inhibit	36287177
Ovarian Dysgenesis 2	Associate	24524832
Primary Ovarian Insufficiency	Associate	24524832
Severe Acute Respiratory Syndrome	Associate	32690270
Triple Negative Breast Neoplasms	Associate	38123542